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Full-Text Articles in Engineering
Evaluation Of Methods To Account For Release From Nanofiber Scaffolds, Jennifer Moy
Evaluation Of Methods To Account For Release From Nanofiber Scaffolds, Jennifer Moy
Theses
Electrospinning is a common technique utilized to form fibers from the micro- to nanometer range. Nanofibers form through electrospinning can be utilized as scaffolds since the fiber structures are similar to the structures within the extracellular matrix. Researchers use additives, such as growth factors, to help facilitate cell proliferation and function. Also, researchers are attempting to use electrospun fibers for drug delivery and as wound dressings since the electrospun fibers have high surface area to volume ratio. In both situations, the release of either the additive or the drug needs to be controlled so that the fibers would release the …
Design Of Drug Delivery Strategies Based On Well-Stirred Experiments, Kumud Kanneganti
Design Of Drug Delivery Strategies Based On Well-Stirred Experiments, Kumud Kanneganti
Theses
Drugs are generally administered to the human body via injections (IV) or through other paths such as the buccal, nasal routes. The main consideration when designing a medication schedule is to maintain a therapeutic level of the drug in the body during the course of treatment. To achieve this goal, when IV drug therapy is selected, particular importance has to given to the dose to be injected and how to maintain the concentration of the pharmaceutical active ingredient (API) in the body between a Minimum Toxic Concentration (MTC) and a Minimum Effective Concentration (MEC). This therapeutic range varies with the …