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Articles 91 - 93 of 93
Full-Text Articles in Engineering
Ogt Glycosylation Of Histones In T Cells May Participate In Systemic Lupus Erythematosus, Jared Luke Ridgeway
Ogt Glycosylation Of Histones In T Cells May Participate In Systemic Lupus Erythematosus, Jared Luke Ridgeway
Honors Theses
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that primarily affects women. The etiology is not known yet, but genetics and environmental factors trigger the disease. These epigenetic changes modify gene expression and contribute to the development of the disease. It is known that T cells from patients with lupus overexpress genes that may contribute to the onset and progression of the disease. Dr. Gorelik has shown that OGT (O-linked N-acetyl-Glucosamine Transferase), which is an X-linked gene, is overexpressed in women with SLE. OGT adds b-N-acetylglucosamine (O-GlcNAc) to serine and threonine residues of proteins. …
Gq-Mediated Ca** Signals In Human Airway Smooth Muscle Cells, Hanna Viktoria Bobinger
Gq-Mediated Ca** Signals In Human Airway Smooth Muscle Cells, Hanna Viktoria Bobinger
Honors Theses
Current asthma therapies include corticosteroids, long acting β2-adrenergic receptor (β2-AR) agonists paired with corticosteroids, or short-acting β2-AR agonists used in rescue inhalers. Chronic use of β-agonists results in diminished effectiveness, and use of long-acting β-agonists can even exacerbate asthma symptoms; this is partly because anti-inflammatory therapy does not directly address the exaggerated airway narrowing due to excessive shortening of airway smooth muscle (ASM), which is the hallmark of asthma. These observations led our collaborators to investigate other potential asthma therapies – bitter taste agonists. 2 Bitter taste agonists, such as chloroquine, activate a subset of Gq-coupled receptors known as bitter …
Thermal And Thermophysical Properties Of Anionic Amines And Their Aqueous Solutions For Co2 Capture In Confined Environments, Randi Swanson
Thermal And Thermophysical Properties Of Anionic Amines And Their Aqueous Solutions For Co2 Capture In Confined Environments, Randi Swanson
Honors Theses
Air revitalization for the International Space Station (ISS) has been identified by NASA as a mission critical need which requires improvement. The current method uses13X zeolite, a solid adsorbent, to adsorb carbon dioxide. While this is effective, the zeolite adsorbent produces dust that is unwelcome on the space station. Furthermore, the adsorbentis too sensitive to humidity in moderate temperature gas streams [1]. Aqueous solutions of ionic amines show promise as a safe and efficient solution, as they do not volatilize and are not water sensitive [2]. Specifically, anionic amines have the most potential because of the amine functional group’s ability …