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Full-Text Articles in Engineering
Achieving Practical Functional Electrical Stimulation-Driven Reaching Motions In An Individual With Tetraplegia, Derek Nathaniel Wolf
Achieving Practical Functional Electrical Stimulation-Driven Reaching Motions In An Individual With Tetraplegia, Derek Nathaniel Wolf
ETD Archive
Functional electrical stimulation (FES) is a promising technique for restoring the ability to complete reaching motions to individuals with tetraplegia due to a spinal cord injury (SCI). FES has proven to be a successful technique for controlling many functional tasks such as grasping, standing, and even limited walking. However, translating these successes to reaching motions has proven difficult due to the complexity of the arm and the goaldirected nature of reaching motions. The state-of-the-art systems either use robots to assist the FES-driven reaching motions or control the arm of healthy subjects to complete planar motions. These controllers do not directly …
Developing A Multifunctional Thermo-Responsive Viral Like Particle (Vlp) Platform With New Physicochemical Characteristics, Sepehr Dejdar
Developing A Multifunctional Thermo-Responsive Viral Like Particle (Vlp) Platform With New Physicochemical Characteristics, Sepehr Dejdar
ETD Archive
Smart materials are a class of material whose physical characteristics change significantly in a controllable fashion once exposed to an external stimulus such as stress, pH, light, temperature, etc. If the temperature is the external stimuli (control variable) the material is termed thermo-responsive. Out of numerous thermo-responsive materials, elastin-like polypeptide (ELP) is a well-known protein-based biopolymer. Protein cages are well-defined biological nanostructures which are highly symmetrical and monodisperse. This class of proteins are both chemically and genetically tunable, making them a suitable recipient of new properties. Protein re-engineering is the basis of developing a hybrid platform (e.g. polymer-protein) to deliver …
Interaction Between The Metabolism Of Ketone Bodies In Brain Tissue And Neurological Disorders, Chan-Chih Hsiao
Interaction Between The Metabolism Of Ketone Bodies In Brain Tissue And Neurological Disorders, Chan-Chih Hsiao
ETD Archive
Regulation of brain metabolism and cerebral blood flow involves complex control systems with several interacting variables at both cellular and organ levels. Quantitative understanding of the spatially and temporally heterogeneous brain control mechanisms during internal and external stimuli requires the development and validation of a computational (mathematical) model of metabolic processes in brain tissue. A computational model of the biochemical pathways in brain is presented in this paper. The model structure consists of neurons, astrocytes, and a surrounding capillary network. Glucose is the major oxidative energy substrate in the brain. However, under hypoglycemic conditions such as during diet or fasting …