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Articles 1 - 30 of 372
Full-Text Articles in Engineering
Lipids Affect The Diffusion Of Estradiol In Osteonal Bone, Nicholas Anthony Cimino
Lipids Affect The Diffusion Of Estradiol In Osteonal Bone, Nicholas Anthony Cimino
ETD Archive
In healthy osteonal bone, embedded osteocytes form an intercellular communication network through overlapping cell membrane extensions, possibly defining an overlooked and clinically relevant lipid-mediated transport pathway for nonpolar molecules. Previous techniques evaluating solute transport in cortical bone limit tissue analysis to microscale areas (less than 1 mm2) using tracers and assumptions that diminish clinical relevance, presenting the need for an improved method to evaluate solute diffusion in macroscale areas (greater than 1 mm2) of osteonal bone. A new diffusion system - constructed of glass and polytetrafluoroethylene - was designed and validated for this purpose, exhibiting minimal adsorption of solutes and …
Predictions Of Indentation Stiffness Of Musculoskeletal Regions Using Ultrasound, Sean Doherty
Predictions Of Indentation Stiffness Of Musculoskeletal Regions Using Ultrasound, Sean Doherty
ETD Archive
Tissue indentation response is an important metric for understanding how different musculoskeletal regions respond to loading and is a function of the tissue’s form. Modem imaging techniques provide information about the internal structures of human tissue. Ultrasound remains one of the most common imaging techniques performed, given its portability and low costs. Prior work and data collection on 100 patients involved the collection of ultrasound images at eight different locations across the musculoskeletal extremities. Given the tissue structure information that the medical imaging provided, it was hypothesized that the mechanical properties of the tissue could be predicted from this data. …
Utilizing Simulated Vehicle Trajectory Data From Connected Vehicles To Characterize Performance Measures On An Arterial After An Impactful Incident, Norris Kamugisha Novat Baraba
Utilizing Simulated Vehicle Trajectory Data From Connected Vehicles To Characterize Performance Measures On An Arterial After An Impactful Incident, Norris Kamugisha Novat Baraba
ETD Archive
Traffic incidents are unforeseen events known to affect traffic flow because they reduce the capacity of an arterial corridor segment and normally generate a temporary bottleneck. Identification of retiming requirements to enhance traffic signal operations when an incident occurs depends on operations-oriented traffic signal performance measurements. When effective and real-time traffic signal performance metrics are employed at traffic control centers, delays, fuel use, and air pollution may all be decreased. The majority of currently available traffic signal performance evaluations are based on high-resolution traffic signal controller event data, which gives data on an intersection-by-intersection basis but requires a substantial upfront …
Strengthening Effects Of Carbon Nanotubes And Graphene Nanoplatelets Reinforced Nickel Metal Matrix Composites, Amit Patil
ETD Archive
Carbon nanotubes (CNTs) and graphene nanoplatelets (GNPs) with superior mechanical, thermal, chemical, and electrical properties are appealing reinforcements for the fabrication of lightweight, high-strength, and wear-resistant metal matrix composites with outstanding mechanical and tribological performance. The nickel-carbon nanotube composites (Ni-CNT) and nickel-graphene nano-platelet composites (Ni-GNP) were processed using two separate ball milling methods, namely dry ball milling (DM) and solution ball milling (SBM), and then sintered using the spark plasma sintering (SPS) technique. The influence of the premixing process, milling time, reinforcement morphology, and concentration on matrix grain size, microstructure, dispersion in the nickel matrix, mechanical properties, and tribological performance …
An Ultrasensitive Bacterial Detection Platform For Culture-Free Diagnosis Of Infections, Xuyang Shi
An Ultrasensitive Bacterial Detection Platform For Culture-Free Diagnosis Of Infections, Xuyang Shi
ETD Archive
The current methods of the diagnosis of bloodstream infections are based on bacterial culture growth, a process that requires considerable time, e.g., 12-16 hours, to obtain a result. This long wait time for the result creates many problems, including the generation of multi-drug resistant organisms (MDROs). At the same time, infected bloodstream usually contains a very low concentration of bacteria, i.e., lower than 5 CFU/mL. The long diagnosis time and the extremely low concentration of bacteria in the infected bloodstream make such infections difficult to diagnose. Here, we demonstrate a culture-free approach for the diagnosis of bloodstream infections using a …
Mechanistic Understanding Of Phase Stability, Transformation, And Strengthening Mechanisms In Lightweight High Entropy Alloys And High Entropy Ceramics, Ganesh Walunj
ETD Archive
High-entropy alloys (HEAs) are a novel family of solid-solution alloys that have gained international interest due to their exceptional characteristics. Because of the need from the transportation and defense sectors, lightweight HEAs have attracted researcher’s curiosity as prospective advanced materials. Low-weight high entropy alloy synthesizes using arc melting with a mass ratio of AlCrFeMnTix(0.1,0.15,0.2). The synthesized HEA is comprised of a mixture of body center cubic (bcc) and ordered bcc (L21) solid solution phases. The synthesized HEAs have heat treated at 650C, 800C, and 1150C for 1hr, 4hr after solutionized at 1150C for 2 hr to understand the effect of …
An Improved Polynomial Chaos Expansion Based Response Surface Method And Its Applications On Frame And Spring Engineering Based Structures, Mhd A. Hafez
ETD Archive
In engineering fields, computational models provide a tool that can simulate a real world response and enhance our understanding of physical phenomenas. However, such models are often computationally expensive with multiple sources of uncertainty related to the model’s input/assumptions. For example, the literature indicates that ligament’s material properties and its insertion site locations have a significant effect on the performance of knee joint models, which makes addressing uncertainty related to them a crucial step to make the computational model more representative of reality. However, previous sensitivity studies were limited due to the computational expense of the models. The high computational …
Development, Characterization, And Modeling Of Physical, Mechanical, And Durability Properties Of Sustainable Ultra-High Performance Concrete, Tawsif M. Hasan
Development, Characterization, And Modeling Of Physical, Mechanical, And Durability Properties Of Sustainable Ultra-High Performance Concrete, Tawsif M. Hasan
ETD Archive
Ultra-High Performance Concrete (UHPC) is an advanced concrete material with superior mechanical strength, high tensile ductility, and exceptional durability, including negligible permeability. Despite these excellent material properties, the use of UHPC in structural applications is limited because of the high cost of commercially available UHPC products. Therefore, developing non-proprietary UHPC mixtures using local materials is a viable way to reduce the initial cost of UHPC. In this research, sustainable and cost-effective UHPC mixtures were developed using locally sourced materials so that UHPC may be more affordable to a wider variety of applications. Specifically, locally available Type I-II cement, local sand …
Mechanistic Undrestanding Of Amorphization In Iron-Based Soft Magnetic Materials, Taban Larimian
Mechanistic Undrestanding Of Amorphization In Iron-Based Soft Magnetic Materials, Taban Larimian
ETD Archive
Iron-based magnetic alloys possess very good magnetic and mechanical properties. Among these alloys Fe-Si-B-based alloys show outstanding saturation magnetization and coercivity which makes them great candidates for many industrial applications. Addition of certain elements to the Fe-Si-B base is proven to improve the homogeneity and fineness of microstructure as well as enhance the magnetic behavior of these alloys. In this research work, we have studied the effect of adding copper and niobium to the Fe-Si-B base alloy. Previous studies have shown that magnetic alloys show better magnetic properties when their microstructure consists of nanocrystals embedded in an amorphous matrix. In …
Viability And Accessibility Of Urban Heat Island And Lake Microclimate Data Over Current Tmy Weather Data For Accurate Energy Demand Predictions., Irena A. Weclawiak
Viability And Accessibility Of Urban Heat Island And Lake Microclimate Data Over Current Tmy Weather Data For Accurate Energy Demand Predictions., Irena A. Weclawiak
ETD Archive
Building Energy Simulations (BES) are necessary for designing energy-efficient systems. Open-source simulation software developed by the Department of Energy (DOE), EnergyPlus (EP) provides Typical Meteorological Year (TMY) weather data that consists of a 15-year average. Two major concerns about this data are the inability to detect extreme conditions and limited data locations. There is a greater number of Microclimate (MC) stations that can be used for simulations, but it involves time-consuming data preparation to match the EP format. This study investigated the effects of Urban Heat Island (UHI) and the MC of Lake Erie. A comparison of the MC data …
An Evaluation And Economic Analysis Of A Water Main Geothermal System In A Residential Space, Brian L. Kohut
An Evaluation And Economic Analysis Of A Water Main Geothermal System In A Residential Space, Brian L. Kohut
ETD Archive
Iron-based magnetic alloys possess very good magnetic and mechanical properties. Among these alloys Fe-Si-B-based alloys show outstanding saturation magnetization and coercivity which makes them great candidates for many industrial applications. Addition of certain elements to the Fe-Si-B base is proven to improve the homogeneity and fineness of microstructure as well as enhance the magnetic behavior of these alloys. In this research work, we have studied the effect of adding copper and niobium to the Fe-Si-B base alloy. Previous studies have shown that magnetic alloys show better magnetic properties when their microstructure consists of nanocrystals embedded in an amorphous matrix. In …
An Analytical Methodology To Security Constraints Management In Power System Operation, Shubo Zhang
An Analytical Methodology To Security Constraints Management In Power System Operation, Shubo Zhang
ETD Archive
In a deregulated electricity market, Independent System Operators (ISOs) are responsible for dispatching power to the load securely, efficiently, and economically. ISO performs Security Constrained Unit Commitment (SCUC) to guarantee sufficient generation commitment, maximized social welfare and facilitating market-driven economics. A large number of security constraints would render the model impossible to solve under time requirements. Developing a method to identify the minimum set of security constraints without overcommitting is necessary to reduce Mixed Integer Linear Programming (MILP) solution time. To overcome this challenge, we developed a powerful tool called security constraint screening. The proposed approach effectively filters out non-dominating …
Implementation Of Microfluidic Mixers For The Optimization Of Polymeric, Gold, And Perovskite Nanomaterials Synthesis, Alexa Roberts
Implementation Of Microfluidic Mixers For The Optimization Of Polymeric, Gold, And Perovskite Nanomaterials Synthesis, Alexa Roberts
ETD Archive
I would like to thank Dr. Chandra Kothapalli for the opportunity to participate in this research project and the continuous guidance he has given me in all aspects of the lab work. I would like to acknowledge the entire Chemical and Biomedical Engineering Department for their assistance throughout the program, for partially supporting my tuition and stipend through teaching assistantships, and the opportunities to present and discuss my research project with other interested students and faculty. I would like to acknowledge Dr. Petru Fodor and Dr. Geyou Ao for their support as members of my defense committee. Additionally, I would …
Achieving Practical Functional Electrical Stimulation-Driven Reaching Motions In An Individual With Tetraplegia, Derek Nathaniel Wolf
Achieving Practical Functional Electrical Stimulation-Driven Reaching Motions In An Individual With Tetraplegia, Derek Nathaniel Wolf
ETD Archive
Functional electrical stimulation (FES) is a promising technique for restoring the ability to complete reaching motions to individuals with tetraplegia due to a spinal cord injury (SCI). FES has proven to be a successful technique for controlling many functional tasks such as grasping, standing, and even limited walking. However, translating these successes to reaching motions has proven difficult due to the complexity of the arm and the goaldirected nature of reaching motions. The state-of-the-art systems either use robots to assist the FES-driven reaching motions or control the arm of healthy subjects to complete planar motions. These controllers do not directly …
Developing A Multifunctional Thermo-Responsive Viral Like Particle (Vlp) Platform With New Physicochemical Characteristics, Sepehr Dejdar
Developing A Multifunctional Thermo-Responsive Viral Like Particle (Vlp) Platform With New Physicochemical Characteristics, Sepehr Dejdar
ETD Archive
Smart materials are a class of material whose physical characteristics change significantly in a controllable fashion once exposed to an external stimulus such as stress, pH, light, temperature, etc. If the temperature is the external stimuli (control variable) the material is termed thermo-responsive. Out of numerous thermo-responsive materials, elastin-like polypeptide (ELP) is a well-known protein-based biopolymer. Protein cages are well-defined biological nanostructures which are highly symmetrical and monodisperse. This class of proteins are both chemically and genetically tunable, making them a suitable recipient of new properties. Protein re-engineering is the basis of developing a hybrid platform (e.g. polymer-protein) to deliver …
Interaction Between The Metabolism Of Ketone Bodies In Brain Tissue And Neurological Disorders, Chan-Chih Hsiao
Interaction Between The Metabolism Of Ketone Bodies In Brain Tissue And Neurological Disorders, Chan-Chih Hsiao
ETD Archive
Regulation of brain metabolism and cerebral blood flow involves complex control systems with several interacting variables at both cellular and organ levels. Quantitative understanding of the spatially and temporally heterogeneous brain control mechanisms during internal and external stimuli requires the development and validation of a computational (mathematical) model of metabolic processes in brain tissue. A computational model of the biochemical pathways in brain is presented in this paper. The model structure consists of neurons, astrocytes, and a surrounding capillary network. Glucose is the major oxidative energy substrate in the brain. However, under hypoglycemic conditions such as during diet or fasting …
Control Of Rigid Robots With Large Uncertainties Using The Function Approximation Technique, Donald Ebeigbe
Control Of Rigid Robots With Large Uncertainties Using The Function Approximation Technique, Donald Ebeigbe
ETD Archive
This dissertation focuses on the control of rigid robots that cannot easily be modeled due to complexity and large uncertainties. The function approximation technique (FAT), which represents uncertainties as finite linear combinations of orthonormal basis functions, provides an alternate form of robot control - in situations where the dynamic equation cannot easily be modeled - with no dependency on the use of model information or training data. This dissertation has four aims - using the FAT - to improve controller efficiency and robustness in scenarios where reliable mathematical models cannot easily be derived or are otherwise unavailable. The first aim …
Design, Control, And Optimization Of Robots With Advanced Energy Regenerative Drive Systems, Poya Khalaf
Design, Control, And Optimization Of Robots With Advanced Energy Regenerative Drive Systems, Poya Khalaf
ETD Archive
We investigate the control and optimization of robots with ultracapacitor based regenerative drive systems. A subset of the robot joints are conventional, in the sense that external power is used for actuation. Other joints are energetically self-contained passive systems that use ultracapacitors for energy storage. An electrical interconnection known as the star configuration is considered for the regenerative drives that allows for direct electric energy redistribution among joints, and enables higher energy utilization efficiencies. A semi-active virtual control strategy is used to achieve control objectives. We find closed-form expressions for the optimal robot and actuator parameters (link lengths, gear ratios, …
Thenar Muscle And Transverse Carpal Ligament Relationship, Jeremy Granieri Loss
Thenar Muscle And Transverse Carpal Ligament Relationship, Jeremy Granieri Loss
ETD Archive
The transverse carpal ligament (TCL) acts as a partial origin for the thenar muscles (abductor pollicis brevis (APB), flexor pollicis brevis (FPB), opponens pollicis (OPP)). The attachment between the thenar muscles and TCL implies a relationship between the tissues. The thenar muscles rely on their origins for thumb motion and force production. However, individual thenar origin information is lacking. Further information regarding the anatomical relationship between the individual thenar muscles and TCL may provide insight into thenar muscle function. In addition, the TCL responds to thenar muscle contraction as shown by volar migration of the TCL during various thumb movements. …
Three-Dimensional Human Neural Stem Cell Culture For High-Throughput Assessment Of Developmental Neurotoxicity, Pranav Joshi
Three-Dimensional Human Neural Stem Cell Culture For High-Throughput Assessment Of Developmental Neurotoxicity, Pranav Joshi
ETD Archive
Only a few hundred of compounds, among tens of thousands of commercially available compounds, have been tested for developmental neurotoxicity (DNT) due to the limitations of current guidelines for DNT which are based entirely on in vivo experiments. In vivo studies are highly expensive and time-consuming, which often do not correlate to human outcomes. There is a key gap in our ability to predict in vivo outcomes accurately and robustly using in vitro assays. This is particularly the case for predicting the toxicity of chemicals on the developing human brains. Conventional in vitro assays are typically performed in two-dimensional (2D) …
Congestion Mitigation Strategy: Modeling The Effect Of Different Geometric Configurations Of A Two-Lane On-Ramp On Capacity Using Vissim, Rhizlane Brachmi
Congestion Mitigation Strategy: Modeling The Effect Of Different Geometric Configurations Of A Two-Lane On-Ramp On Capacity Using Vissim, Rhizlane Brachmi
ETD Archive
Freeway on-ramps are critical components of freeway systems since they control the entry of traffic to the mainline. According to the Highway Capacity Manual (HCM), a two-lane on-ramp configuration will achieve less turbulence than a similar one-lane on-ramp but little guidance on the desired lengths of the acceleration lanes or their effect on the operation of the influence area is provided. An experiment was designed to investigate the effect of the lengths of the acceleration lanes of isolated, two-lane on-ramps on the operation of the ramp influence area. The Highway Capacity Software (HCS) was used to calculate the density of …
Advanced Processing Of Nickel-Titanium-Graphite Based Metal Matrix Composites, Amit K. Patil
Advanced Processing Of Nickel-Titanium-Graphite Based Metal Matrix Composites, Amit K. Patil
ETD Archive
A new class of in situ titanium carbide (TiC)/graphite (C) reinforced nickel matrix composites with variation in composition particularly varying C/Ti ratio have been processed using two different processing techniques. Firstly, via mechanical alloying (MA) followed by spark plasma sintering (SPS), i.e. solid-state processing. Secondly, using Laser engineered net shaping (LENSTM) technique, i.e. metal additive manufacturing technique. Mechanical alloying has gained special attention as a powerful non-equilibrium process for fabricating amorphous and nanocrystalline materials, whereas spark plasma sintering is a unique technique for processing dense and near net shape bulk alloys with homogeneous microstructure. Laser engineered net shaping (LENSTM) is …
A Reticulation Of Skin-Applied Strain Sensors For Motion Capture, Christopher A. Schroeck
A Reticulation Of Skin-Applied Strain Sensors For Motion Capture, Christopher A. Schroeck
ETD Archive
The purpose of this research is to develop a system of motion capture based on skin-applied strain sensors. These elastic sensors are of interest because they can be applied to the body without restricting motion and are well suited to operate in more practical environments, such as sports fields, gymnasiums, and outdoor areas. This combination is currently not available in the field of motion capture. The current issues with strain sensor motion capture technology is the accurate is not sufficient for motion analysis and axial rotation monitoring of joints is not available. This project will build and test a sensor …
Robust Impedance Control Of A Four Degree Of Freedom Exercise Robot, Santino Joseph Bianco
Robust Impedance Control Of A Four Degree Of Freedom Exercise Robot, Santino Joseph Bianco
ETD Archive
The CSU 4OptimX exercise robot provides a platform for future research into advanced exercise and rehabilitation. The robot and its control system will autonomously modify reference trajectories and impedances on the basis of an optimization criterion and physiological feedback. To achieve this goal, a robust impedance control system with trajectory tracking must be implemented as the foundational control scheme. Two control laws will be compared, sliding mode and H-infinity control. The above robust control laws are combined with underlying impedance control laws to overcome uncertain plant model parameters and disturbance anomalies affecting the input signal. The sliding mode control law …
Catalytic Waste Gasification: Water-Gas Shift & Selectivity Of Oxidation For Polyethylene, Mason J. Lang
Catalytic Waste Gasification: Water-Gas Shift & Selectivity Of Oxidation For Polyethylene, Mason J. Lang
ETD Archive
As landfills approach capacity and take up valuable land space, metropolitan areas have realized the need for waste disposal alternatives. Thus, there has been a widespread use of waste incinerators in Europe and the United States [1]; [2]. Although newer technology has made incinerators more efficient, there is an increasing interest in formulating `greener’ alternatives to incinerators. Gasification converts organic and carbonaceous materials into a combination of gaseous products known as “syngas,” or synthetic gas. This process greatly reduces the amount of hazardous emissions. The syngas produced by gasifiers has a wide range of uses, including their conversion into diesel, …
Adsorption Induced Solid Phase Transition Of Mil-53(Al), Rushik G. Bandodkar
Adsorption Induced Solid Phase Transition Of Mil-53(Al), Rushik G. Bandodkar
ETD Archive
Metal organic frameworks (MOFs) are nano-porous solids with potential applications in a wide range of fields including gas separation and catalysis. A number of metal organic frameworks show structural transformation and exceptional flexibility on changing the temperature, pressure and adsorption of certain guest molecules. On the contrary, most of the porous solids like zeolites and activated carbon used in applications are rigid. The structural flexibility makes MOF materials very interesting to study and show promise in applications such as sensors, actuators, membrane separation and adsorptive separation. In this study, we examine the chemical potential difference (Δμ) of MIL-53 (Al), a …
Measurement Of Red Blood Cell Oxygenation State By Magnetophoresis, Nina A. Smith
Measurement Of Red Blood Cell Oxygenation State By Magnetophoresis, Nina A. Smith
ETD Archive
Magnetophoresis of red blood cells (RBCs) at varying partial pressures of oxygen (pO2) is hypothesized to rejuvenate stored blood to be utilized beyond the FDA regulated 42-day storage time. Magnetophoresis is a particle or cells motion induced by an applied magnetic field in a viscous media. The average magnetophoretic mobility of an oxygenated RBC is -0.126x10-6 mm3-s/kg, and a deoxygenated RBC is 3.66x10-6 mm3-s/kg, presenting magnetophoresis as a resource for RBC rejuvenation in hopes of storing it longer than 42 days. The main objective of this paper was to determine if controlling the pO2 within an RBC suspension, can singly- …
Feasibility Of Using An Equilibrium Point Strategy To Control Reaching Movements Of Paralyzed Arms With Functional Electrical Stimulation, Matthew Huffman
Feasibility Of Using An Equilibrium Point Strategy To Control Reaching Movements Of Paralyzed Arms With Functional Electrical Stimulation, Matthew Huffman
ETD Archive
Functional electrical stimulation (FES) is a technology capable of improving the quality of life for those with the loss of limb movement related to spinal cord injuries. Individuals with high-level tetraplegia, in particular, have lost all movement capabilities below the neck. FES has shown promise in bypassing spinal cord damage by sending electrical impulses directly to a nerve or muscle to trigger a desired function. Despite advancements in FES, full-arm reaching motions have not been achieved, leaving patients unable to perform fundamental tasks such as eating and grooming. To overcome the inability in current FES models to achieve multi-joint coordination, …
Improving The Security Of Mobile Devices Through Multi-Dimensional And Analog Authentication, Jonathan Gurary
Improving The Security Of Mobile Devices Through Multi-Dimensional And Analog Authentication, Jonathan Gurary
ETD Archive
Mobile devices are ubiquitous in today's society, and the usage of these devices for secure tasks like corporate email, banking, and stock trading grows by the day. The first, and often only, defense against attackers who get physical access to the device is the lock screen: the authentication task required to gain access to the device. To date mobile devices have languished under insecure authentication scheme offerings like PINs, Pattern Unlock, and biometrics-- or slow offerings like alphanumeric passwords. This work addresses the design and creation of five proof-of-concept authentication schemes that seek to increase the security of mobile authentication …
Characterizing The Effects Of High-Intensity Exercise On Balance And Gait Under Dual-Task Conditions In Parkinson’S Disease, El Iva Baron
Characterizing The Effects Of High-Intensity Exercise On Balance And Gait Under Dual-Task Conditions In Parkinson’S Disease, El Iva Baron
ETD Archive
Parkinson’s disease (PD) is a neurodegenerative disorder, characterized by four cardinal motor symptoms including bradykinesia, tremor, rigidity, and postural instability, and non-motor symptoms including cognitive impairment. Daily activities, such as walking and maintaining balance, are impacted due to impairments in motor function, and are further exacerbated with the addition of cognitive loading, or dual-tasking (DT). High-intensity exercise has demonstrated centrally-mediated improvements of PD symptoms, with additional positive effects on overall health. The goal of this project was to identify changes in dynamic balance recovery and gait function under conditions with and without increased cognitive load after a high-intensity exercise intervention …