Engineering Commons^™

Advancements Of A Breast Tissue Marker And Localization System, Azrin Jamison

All Theses

Breast cancer has become the most prominent cancer worldwide in women. Annual mammograms are encouraged for women of high risk to increase early detection allowing for lumpectomies rather than mastectomies to occur. Prior to a lumpectomy, a biopsy must be taken to determine if the tissue is cancerous, and a breast cancer biopsy marker (BBM) is left in the region of possible cancerous tissue. Wire localization has been the gold standard for localizing these BBMs. However, due to the reported patient discomfort and logistical inefficiencies faced by healthcare providers (HCP), non-wire localization solutions have been recently developed. This study aims …

Evaluation And Development Of Tourniquet Test Methods, Catherine Pitts

All Theses

Since the beginning of the 21^st century the general perspective on tourniquets has changed to a more positive outlook on their life saving abilities. The US has seen a greater number of mass casualty events, and conflicts across the globe have led to an increased use of tourniquets. The increased demand has also led to faulty counterfeit tourniquets and improvised tourniquets that don not properly occlude blood flow or cause significant nerve damage to the injured limb.

ASTM started designing a tourniquet testing standard with experts in the tourniquet community to cut down on the dangers of tourniquet use. …

Development Of A Cost-Affordable Thin-Layer Chromatography Testing Kit For Falsified And Substandard Pharmaceuticals In Tanzania, Eleanor Hatcher

All Theses

A significant number of pharmaceuticals supplied to Tanzania are falsified or substandard. A majority of these inadequate pharmaceuticals are medications to treat life-threatening conditions. This problem not only causes mistrust in the healthcare system but also prolonged illness and potentially death for the patients. This calls for the need for the development of a cost-affordable testing kit for falsified and substandard pharmaceuticals in Tanzania. Thin-layer chromatography (TLC) was used as the testing method since it is inexpensive and requires a low skill level to complete. Malaria, human immunodeficiency virus, hypertension, tuberculosis, and diabetes are five of the most prevalent diseases …

Broadening The Application Range Of Cell-Free Protein Expression Systems, Matthew Becker

All Theses

Centralized protein manufacturing platforms make the delivery of needed therapies to places with limited infrastructure almost impossible. Cell-free protein expression systems, systems that utilize protein production machinery extracted from cells, offer these communities a viable protein expression platform that is robust and easily deliverable to the place of need. Much work in cell-free system engineering looks to increase the hardiness of cell-free system (CFS) components, like the extract and reaction buffer, needed to carry transcription and translation of gene therapeutic targets forward. Freeze- and air-drying of extract, reaction buffer, or both with certain additives, like sugar molecules, has been proposed …

Light-Induced Phase Separation Purification For Monoclonal Antibodies, Xuyang Chen

All Theses

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Development And Evaluation Of An Arsenic Transport Model For The Maurice River Watershed, Christina Eddleman

All Theses

For many Superfund sites across the United States, arsenic is one of the most common contaminants of concern that must be cleaned up to protect human and environmental health. Past research and health studies have documented the harmful effects of inorganic arsenic on humans and the environment but selecting an appropriate remediation plan depends on several site-specific factors at each Superfund site. To assist in determining an appropriate remediation plan, sediment and contaminant transport models have been used to simulate the transport of arsenic and other contaminants of concern at contaminated sites to, e.g., make relative comparisons of the efficacy …

Analytical And Experimental Studies To Support Codification Of Lightweight Grout For Masonry Design, Cooper Banks

All Theses

Lightweight (LW) aggregates have many potential benefits in masonry construction including minimizing mass, improving thermal performance, and reducing the potential for shrinkage cracking via internal curing. The current masonry design standard, TMS 402/602-22, permits lightweight aggregate in the production of concrete masonry units (CMU), but there has been insufficient testing of masonry assemblies to permit designing with LW grout. Shrestha et al. characterized LW grouts bond to reinforcement, shear strength, tension and shear pullout behavior of anchors and proposed possible reduction factors for design. Hiner characterized the flexural bond strength LW grouted masonry assemblies and proposed possible reduction factors for …

Quantifying Hurricane Effects On Housing: Evaluating Damage, Loss, And Shelter Demands Using Historical And Simulated Storm Tracks, Adish Deep Shakya

All Theses

This research introduces an advanced framework which employs parametric wind field models for peak wind speeds, and building fragility curves, loss functions, and demographic data to estimate for estimating housing damage and loss. The uninhabitable units immediate displaced households, short-term and long-term shelter need households are determined. with a particular focus on those eligible for FEMA assistance. The framework's validity is reinforced by a high correlation in the analysis of recent hurricane events between estimated numbers of displaced households and actual FEMA aid recipients, where FEMA aids about 20-60% of the predicted long-term displaced households. A novel application of the …

Dynamics Of Link Importance Across Flood Disaster Phases And Flood Impacts On Operation Of An Industry, Navin Bhatta

All Theses

Transportation damage and disruptions will become increasingly common as the frequency of floods increases due to climate change. Given the size and cost of the transportation network construction, communities' mitigation measures should be supported by evaluations that cover both normal and disaster management phases. This thesis examines the criticality of road segments in the normal, flood response, and recovery phases, considering the effects on emergency services, healthcare, industry, education, recreation, and transit and analyses that whether a flood disrupts the operational trips of a company in Anderson County, South Carolina. A 100-year event and a 500-year flood event provides context …

Engineering Sustainable Bridge Deck Rehabilitation: Evaluating Mechanical And Electro-Chemical Properties Of Rapid-Set Patching Materials And Their Influence On Repair Durability, James Roberts

All Theses

As the state of the US infrastructure continues to deteriorate over time, a prominent issue especially in the field of reinforced concrete structures has been the ability to properly rehabilitate and extend the design service life of these structures. A majority of our existing reinforced concrete bridges were built in the construction boom during the 60’s, 70’s and 80’s, and were originally designed with a service life of approximately 50 years, thus showing that many structures are close to or have already exceeded their intended service life. Additionally, with a poor history of government infrastructure funding, it is seen to …

Depression And Anxiety: Investigating The Impacts Of Scheduling On The Mental Health Of Healthcare Workers During The Covid-19 Pandemic, Christofer Gonzaga

All Theses

Depression is a growing problem in the United States and has ballooned into a globally recognized mental health issue that affects shift workers in various fields (Lee et al., 2017). Rates of depression and anxiety have been shown to be substantially increasing and the COVID-19 pandemic amplified this prevalence of depression and anxiety. In the United States, the prevalence of depression symptoms was more than 3- fold higher during COVID-19 compared to before the pandemic (Ettman et al., 2020). The delivery of healthcare services is an ongoing and dynamic process, requiring clinicians to work in various shifts to ensure the …

A Transdisicplinary, Survivor-Centered Approach For Creating A System Dynamics Model Of Closed-Buyer Sex Trafficking Networks, Kemonte Yow

All Theses

One of the largest drivers of sex trafficking operations is the demand for commercial sex. To date, research from a quantitative side typically focuses on understanding how to best identify and remove victims from their trafficking situation and then support their healing and recovery. This may be because this is where data exists (in limited forms) to support quantitative modeling. This thesis broadens that scope to understand how demand for commercial sex impacts trafficking operations. In particular, this research implemented a transdisciplinary, survivor-centered approach to build a system dynamics model of a closed-buyer sex trafficking network, which is a network …

Modeling Of Multi-Period Disaster Logistics Planning In The State Of South Carolina, Emma Simon

All Theses

South Carolina is one of the most vulnerable states in the United States to the impact of hurricanes. Currently, when threatened with a natural disaster such as a hurricane, the state government makes many vital decisions based on knowledge and experience. In this study, the distribution of disaster relief commodities to meet immediate needs is analyzed through two models for the case of South Carolina to generate an optimal logistics strategy that considers the social vulnerability of affected populations. The first model is a multi-objective pre-disaster logistics model that uses a four-index formulation for the multiple trip vehicle routing problem. …

Efficacy Of Virtual Reality-Based Simulations In Training Aviation Maintenance Technicians On Maintenance Procedures, Gayatri Anoop

All Theses

The COVID-19 pandemic forced institutions of higher education (IHEs) to halt in-person classes and transition to online platforms. Given the intricate process of adapting hands-on experiments to the online environment, this transition seemed particularly challenging for Science, Technology, Engineering, Mathematics, and Medicine (STEMM) labs. The abrupt nature of this transition added to the difficulties, given that the IHEs were inadequately prepared for seamless continuity during the pandemic. In the first phase of this project, a literature review was conducted to understand the impact of COVID-19 pandemic on education. Specifically, the review explored the challenges that institutions of higher education faced, …

Additive Manufacturing Of Porous Tungsten Carbide Structural Electrode Components Using Robocasting, James Bevis

All Theses

Thanks to ideal mechanical and electrochemical properties, Tungsten Carbide (WC) shows excellent potential as a structural electrode material for multifunctional devices. These devices have applications in electric vehicles, for example, structural fuel cells and massless batteries. In such a context, structural WC electrodes will also benefit from porosity to decrease their weight and increase their surface area and chemical reactivity. Porous WC is a useful material for this field because of its high strength-to-weight ratio and electrical properties. However, current manufacturing methods can be expensive, complex, and limited, so the intent is to provide a more simplistic and sustainable method …

Digital Twin In Military Ground Vehicles: Design And Predictive Maintenance, Conner W. Eddy

All Theses

Digital twin technology builds upon virtual engineering models, computer simulation, and real-time field data streaming to enable next-generation designs and predictive maintenance. A digital twin is a computer-based high-fidelity collection of models that predicts the performance of dynamic systems per operating cycles, input feature parameters, and data communication from a physical plant. Product Lifecycle Management (PLM) is growing in importance and is central to virtual design processes where the digital twin toolset fits into this emerging architecture. The product design process can be advanced using digital twin resources by eliminating the need for, and cost from, continual physical prototyping, reliability …

Deep Reinforcement Learning Of Variable Impedance Control For Object-Picking Tasks, Akshit Lunia

All Theses

The increasing deployment of robots in industries with varying tasks has accelerated the development of various control frameworks, enabling robots to replace humans in repetitive, exhaustive, and hazardous jobs. One critical aspect is the robots' interaction with their environment, particularly in unknown object-picking tasks, which involve intricate object weight estimations and calculations when lifting objects. In this study, a unique control framework is proposed to modulate the force exerted by a manipulator for lifting an unknown object, eliminating the need for feedback from a force/torque sensor. The framework utilizes a variable impedance controller to generate the required force, and an …

Improved Ballistic Impact Resistance Of Nanofibrillar Cellulose Films With Discontinuous Fibrous Bouligand Architecture, Colby Caviness

All Theses

Natural protective materials offer unparalleled solutions for impact-resistant material designs that are simultaneously lightweight, strong, and tough. Particularly, the dactyl club of mantis shrimp features chitin nanofibrils organized in a Bouligand structure, which has been shown to effectively dissipate high-impact energy during powerful strikes. The mollusk shells also achieve excellent mechanical strength, toughness, and impact resistance with a staggered, layer-by-layer structure. Previous studies have shown that hybrid designs, by combining different bioinspired microstructures, can lead to enhanced mechanical strength and energy dissipation capabilities. Nevertheless, it remains unknown whether combining Bouligand and staggered structures in nanofibrillar cellulose (NFC) films, forming a …

Evaluating Company Culture Of Roofing Contracting Companies To Attract And Retain Women In The Industry, Gopika Viswanathan

All Theses

The US construction industry, similar to many other industries, has a low representation of women. This difference is even more pronounced in construction trades, such as the roofing industry. The admission of more women into the industry is important to address workforce shortage issues that the industry is facing. Company culture has been cited as one of the primary reasons why women choose not to enter the industry or face barriers during their careers. The main objective of this study was to evaluate the company culture of roofing companies through factors identified by literature and by women and companies in …

Laboratory Evaluation Of Remediation Alternatives For Groundwater At The Lane Street Superfund Site, Alyssa Costello

All Theses

At the Lane Street Groundwater Contamination Superfund site in Elkhart, Indiana, which includes industrial, commercial, and residential properties, a plume of contaminated groundwater was identified that requires remediation. The plume is chiefly composed of trichloroethylene (TCE) and has impacted residents’ drinking water. A microcosm study was performed to evaluate the potential of various treatment methods to remediate the Lane Street Superfund Site groundwater. The objectives of this microcosm study are to evaluate the potential for biostimulation, bioaugmentation, and abiotic degradation for implementation at this Site and to evaluate toxicity factors that have precluded natural degradation of the site contaminants. The …

Analyzing An In-Line Compression Management System For Improved Performance In A High-Performance Computing Environment, Steven Platt

All Theses

High-performance computing (HPC) has enabled advancements in computation speed and resource cost by utilizing all available server resources and using parallelization for speedup. This computation scheme encourages simulation model development, massive data collection, and AI computation models, all of which store and compute on massive amounts of data. Data compression has enhanced the performance of storing and transferring this HPC application data to enable acceleration, but the benefits of data compression can also be transferred to the active allocated memory used by the application. In-line compression is a compression method that keeps the application memory compressed in allocated memory, decompressing …

Layered Structure Protonic Ceramic Conductors Of The Form Ba5in2+Xal2zr1-Xo13-Δ, Nathan Cretegny

All Theses

In this work, the hexagonal perovskite of targeted composition Ba₅In_2+xAl₂Zr_1-xO₁₃ (x=0, 0.1, 0.2) was synthesized via a solid-state synthesis route to study the impact of oxygen vacancy concentration in layered hexagonal perovskites. Precursor oxides were mixed in stoichiometric proportions, calcined between 800-1200℃ and sintered at 1475℃. The sintered pellets were crushed into fine powders to investigate the chemistry and structure through X-ray diffraction, neutron diffraction, inductively coupled plasma mass spectrometry, and nuclear magnetic resonance. Dense pellets were used to study conductivity properties using electrochemical impedance spectroscopy.

The synthesis approach produced 100% …

Phasor-Domain Short-Circuit Analysis Of Power Transmission Systems In The Presence Of Inverter-Based Resources, Dol Kunwar

All Theses

Although a power system is nonlinear during healthy operation because of constant power loads and controlled power injections from the sources, a conventional power system fed by synchronous generators is linear during fault, and can be represented by bus impedance matrix (Z-bus), which is useful in power system analyses such as short circuit (SC) analysis. However, With increasing penetration of inverter-based resources (IBRs) in the system, the assumption of linearity of the faulted network does not hold. This impacts the analyses relying on Z-bus and Thevenin’s equivalent impedance (TEI), such as certain protection schemes set using short circuit analysis. Therefore, …

Multi-Domain Secure Dds Networks For Aerial And Ground Vehicle Communications, Daniel Pendleton

All Theses

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Analysis Of Cnn Performance Utilizing Jpeg Compressed Images Created On An Fpga, Timothy Shaughnessy

All Theses

JPEG (Joint Photographic Experts Group) was formed in 1986 to create a method to reduce image size primarily for ease of transfer on the Internet. Released to the public in 1992, JPEG compression is a form of lossless compression that has been a staple for compressing images. JPEG is the go-to image compressor because it provides high compression ratios while maintaining visual integrity for the human eye. Growing image sizes have made JPEG compression increasingly relevant. It is vital to keep up with growing data sizes for improved image handling performance on an edge device like a Field-Programmable Gate Array …

Defining And Labeling Traversable Space In A Forested Environment, James Nguyen

All Theses

This thesis investigates the problem of identifying traversable terrain in outdoor conditions. We are motivated by research in recent years toward identifying drivable space for the purpose of developing autonomous vehicles. Our motivating application is similar but also different. We envision a “Hiker Helper” that assists humans with dismounted navigation in forested terrain. A common challenge in this type of environment is identifying a viable path for moving through terrain that is congested with trees, bushes, other flora, and natural obstacles that would make navigation difficult. We envision training an artificial intelligence (AI) model to automatically analyze images of this …

Radiation Exposure Calibration Of The Al2o3:C With Radium-226 And Cesium-137 Using The Osl Method, Selma Tepeli Aydin

All Theses

Optically stimulated luminescence (OSL) dosimetry was utilized to calibrate Al₂O₃:C powder dosimeters, available commercially as the nanoDot® from Landauer Inc., and compare the dosimeter response to radium-226 (²²⁶Ra) and cesium-137 (¹³⁷Cs). The signal from the OSL was quantified using a microSTARii^® OSL reader also produced by Landauer Inc. Dose-response curves were developed for ²²⁶Ra and ¹³⁷Cs experiments (5 dosimeters each) at thirteen absorbed doses. Individual dosimeter response was tracked by serial number. Linear regression analysis was performed to determine if there were significant differences between the intercepts of the …

Detection Of Myofascial Trigger Points With Ultrasound Imaging And Machine Learning, Benjamin Formby

All Theses

Myofascial Pain Syndrome (MPS) is a common chronic muscle pain disorder that affects a large portion of the global population, seen in 85-93% of patients in specialty pain clinics [10]. MPS is characterized by hard, palpable nodules caused by a stiffened taut band of muscle fibers. These nodules are referred to as Myofascial Trigger Points (MTrPs) and can be classified by two states: active MTrPs (A-MTrPs) and latent MtrPs (L-MTrPs). Treatment for MPS involves massage therapy, acupuncture, and injections or painkillers. Given the subjectivity of patient pain quantification, MPS can often lead to mistreatment or drug misuse. A deterministic way …

The Generation Of A Physics Informed Machine Learning Model To Predict Defect Evolution In Materials & On The Thermally Activated Regime Of Dislocation Motion: A Simulation Driven Study On The Mechanical Behavior Of Crystals, Liam Myhill

All Theses

Line defects in crystals, known as dislocations, govern the mechanisms of plastic deformation at the micro-meso scale. The study of dislocations has proliferated the field of materials science and engineering for since the 1950’s, and modern studies show increasing utilization of computational methods to model the evolution of line defects in material systems. In keeping with modern research practice, the studies herewith demonstrate the use of advanced computing to generate models which can be used to better understand the behaviors of dislocations within crystal matrices. An advanced high-throughput model for a physically informed machine learning graph neural network (PIML-GNN) is …

Experimental Investigation Of Low Thermal Inertia Thermal Barrier Coatings For Spark Ignition Engines, John Gandolfo

All Theses

The application of thermal barrier coatings (TBCs) in spark ignition (SI) engines has historically been avoided due to the knock penalty associated with higher surface temperatures induced by the ceramic layer. However, advances in low thermal inertia coatings (i.e., temperature swing coatings) that combine low thermal conductivity with low volumetric heat capacity can prevent excessively high surface temperatures during the intake stroke and reduce or avoid knock while improving performance and efficiency. This thesis experimentally evaluates the effectiveness of these low thermal inertia coatings in a single-cylinder research engine representative of modern SI engines.

First, four pistons coated with a …