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Assessment Of Antipsychotic Medication Effects On Dynamic Functional Network Connectivity In Patients With Schizophrenia, Kristin Lottman
Assessment Of Antipsychotic Medication Effects On Dynamic Functional Network Connectivity In Patients With Schizophrenia, Kristin Lottman
All ETDs from UAB
Schizophrenia, a psychiatric disorder affecting approximately 1% of the population, is often characterized as a disorder of dysconnectivity. Evaluation of the dysconnectivity hypothesis of schizophrenia has been extensively examined via functional neuroimaging studies in order to enhance insight into the disorder’s pathology. In particular, resting-state functional connectivity analyses have reported widespread aberrant network connectivity between brain regions in patients; however, consistencies in the directionality of abnormalities are often variable across studies. Recent investigations have begun to analyze functional connectivity dynamically as it is likely these inconsistencies may be a result of the static nature of traditional connectivity measures. In this …
Mesocorticolimbic Abnormalities In Schizophrenia: A Magnetic Resonance Spectroscopy And Diffusion Tensor Imaging Study, Meredith A. Reid
Mesocorticolimbic Abnormalities In Schizophrenia: A Magnetic Resonance Spectroscopy And Diffusion Tensor Imaging Study, Meredith A. Reid
All ETDs from UAB
Schizophrenia is a complex, often debilitating chronic mental disorder that affects approximately 1% of people worldwide. Recently, there has been growing interest in identifying non-invasive biomarkers of schizophrenia. Understanding the molecular and structural mechanisms underlying clinical features of schizophrenia and patients' drug response is an important step in identifying biomarkers and potential targets for novel medications, treatment strategies, and interventions. The primary objective of this dissertation research was to use non-invasive magnetic resonance imaging techniques, specifically magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI), to examine the neurochemical and structural correlates of symptoms, cognition, and treatment response to antipsychotic …