Engineering Commons^™

Development Of A Nucleus Pulposus Implant For Intervertebral Disc Repair, Joshua Dillon Walters

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The intervertebral disc (IVD) is a fibrocartilaginous tissue connecting adjacent vertebrae in the spinal column. It comprises three distinct tissues: a gelatinous core known as the nucleus pulposus (NP), concentric fibrous rings encircling the NP known as the annulus fibrosus (AF), and the superior/inferior cartilaginous endplates (CEPs). The complex mechanical interplay of these tissues allows the IVD to withstand complex loading in the spine while maintaining trunk stability and flexibility. IVD pathologies, such as IVD degeneration (IDD) and herniation, are associated with cell-mediated inflammation in vivo. This inflammation creates a catabolic environment which degrades the extracellular matrix (ECM) of the …

Multi-Scale Assessment Of Binding Geometries And Energetics Of Aqueous Phase Reforming Of Glycerol And Methanol: Towards Realistic, Accurate, And Computationally Tractable Strategies, Tianjun Xie

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No abstract provided.

Cavopulmonary Support For Failing Fontan Patients: Computational And In Vitro Assessment, Masoud Farahmand

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Congenital heart defects are responsible for the mortality of approximately 300,000 newborn each year. One study in 2010 estimated that over 2 million patients were living with congenital heart defects in the United States. Congenital heart defects have the highest hospitalization cost among other birth defect categories. The damage on the U.S economy in 2013 was estimated $6.1 billion. The most complex and severe form of these defects results in single ventricle physiology. Fortunately, over the last 50 years, these patients have been able to survive into adulthood as a result of three stages of surgeries culminating with Fontan operation. …

Evaporator Modeling And An Optimal Control Strategy Development Of An Organic Rankine Cycle Waste Heat Recovery System For A Heavy Duty Diesel Engine Application, Dhruvang Rathod

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The Organic Rankine Cycle (ORC) has proven to be a promising technology for Waste Heat Recovery (WHR) systems in heavy duty diesel engine applications. However, due to the highly transient heat source, controlling the working fluid flow through the ORC system and maximizing the heat recovery is a challenge for real time application. To that end, this research resulted in the following main developments.

The first new development is in the area of heat exchanger modeling. The heat exchanger is a key component within the WHR system and it governs the dynamics of the complete ORC system. The heat exchanger …

Silicon Based Schottky Diodes And Mos Capacitors For Sensing Singly And Multiply Charged Ions With Low Kinetic Energy, Daniel Blaine Cutshall Iii

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This study provides the foundation for the development of radiation detection technology of slow ions by investigating the fundamental interactions of slow ion beams with electronic devices. Silicon samples with a 50 nm oxide layer were irradiated with 1 keV Ar^Q+ beams (Q = 4, 8, and 11) at normal incidence in order to investigate the relatively unexplored effects of slow highly charged ions (HCIs) on electronic devices. After irradiation, an array of metal contacts was deposited onto the oxidized silicon samples to create metal oxide semiconductor (MOS) capacitors, which were then characterized using high frequency capacitance-voltage (C-V) measurements. …