Engineering Commons^™

Development Of A Single Use Device Intended To Wash Blood Clot Debris From A Stent Retriever In The Operating Room, Shane Diller

Theses and Dissertations

Ischemic stroke is a life-threatening condition that requires immediate surgical intervention to remove the blood clot that is lodged in the blood vessels of the brain. Mechanical thrombectomy, performed by an endovascular surgeon, involves inserting a stent retriever, which deploys distally and attempts to capture the clot when dragged backwards. A complication prevalent in 50% - 67% of cases is that the blood clot is only partially removed and clings to the mesh framework of the stent. The operating surgeon must either clean the debris from the stent retriever, to be reinserted or throw the stent retriever away and open …

On-Demand Electrically Induced Decomposition Of Thin-Film Nitrocellulose Membranes For Wearable Or Implantable Biosensor Systems, Benjamin M. Horstmann

Theses and Dissertations

Implantable or subcutaneous biosensors used for continuous health monitoring have a limited functional lifetime requiring frequent replacement and therefore may be highly discomforting to the patient and become costly. One possible solution to this problem is use of biosensor arrays where each individual reserve sensor can be activated on-demand when the previous one becomes inoperative due to biofouling or enzyme degradation. Each reserve biosensor in the array is housed in an individual Polydimethylsiloxane (PDMS) well and is protected from exposure to bodily fluids such as interstitial fluid ( ISF) by a thin-film nitrocellulose membrane. Controlled activation is achieved by decomposing …

Reducing Material Attractiveness Utilizing Pu-238 And U-232, Cody Lloyd

Theses and Dissertations

Decreasing the material attractiveness of uranium and plutonium materials is crucial to nuclear nonproliferation. The International Atomic Energy Agency (IAEA) implements safeguards across the world on a limited budget. Not only does decreasing material attractiveness reduce the possibility of proliferation, but also may lighten the financial burden on the IAEA if safeguards can be reduced. Two particular isotopes that have negative material attractiveness traits are ²³⁸Pu and ²³²U. Without isotopic separation technology, these isotopes cannot be removed from plutonium and uranium materials respectively. Both ²³⁸Pu and ²³²U produce large quantities of heat by alpha decay. High …

Reliable Navigation For Suas In Complex Indoor Environments, Andrew J. Fabian

Theses and Dissertations

Indoor environments are a particular challenge for Unmanned Aerial Vehicles (UAVs). Effective navigation through these GPS-denied environments require alternative localization systems, as well as methods of sensing and avoiding obstacles while remaining on-task. Additionally, the relatively small clearances and human presence characteristic of indoor spaces necessitates a higher level of precision and adaptability than is common in traditional UAV flight planning and execution. This research blends the optimization of individual technologies, such as state estimation and environmental sensing, with system integration and high-level operational planning.

The combination of AprilTag visual markers, multi-camera Visual Odometry, and IMU data can be used …

A Longitudinal Study Of The Influence Of A Stem Career Planning Course And Perceived Stress On Career Search Self-Efficacy And Retention In Engineering Undergraduate Students, Autumn Randell

Theses and Dissertations

This study investigated a) the influence of a STEM career planning course on undergraduate engineering students’ career search self-efficacy, b) the influence of perceived stress on building students’ career search self-efficacy, and c) the relationship career search self-efficacy had in predicting students’ odds of persistence in an engineering major. The researcher analyzed students’ week 1, week 6, and week 14 scores of career search self-efficacy and perceived stress. Data were collected from the Spring 2019 and Fall 2019 cohorts of a STEM career planning. As a result, the analysis included (N = 286) undergraduate engineering students. Repeated measures multilevel …

Development Of An Anatomically And Electrically Conductive Brain Phantom For Transcranial Magnetic Stimulation, Hamzah A. Magsood

Theses and Dissertations

Transcranial Magnetic Stimulation (TMS) is a non-invasive technique for diagnostics, prognostic, and treatments of various neurological diseases. However, the lack of anatomically realistic brain phantoms has made the experimental verification of stimulation strength in the form of induced electric fields/voltages in the brain tissues an impediment to developing new TMS coils, stimulators, and treatment protocols. There are significant technological, safety, and ethical limitations to test the potential TMS treatment procedures or develop enhancements and refine them on humans or animals. This work aims to bridge the gap by introducing and developing an innovative manufacturing and fabrications process to produce a …

Magnetic Refrigerator Device Based On La (Fexcoysi1-X-Y)13, Khushar Javed

Theses and Dissertations

Particles of Lanthanum-iron-silicide, La (Fe_xCo_ySi_1-x-y)₁₃exhibit different magnetic properties when stored in air compared to the same stored in water. The sample with a nominal composition of La(Fe0_.842Co_0.073Si_0.084)₁₃was prepared by arc-melting from elements under argon atmosphere. In recent years, there has been research conducted on different processes that could drastically reduce energy costs of cooling and replacing gas compressors with magnetocaloric materials. Magnetization measurements were carried out on this magnetocaloric material to characterize it in order to design magnetic refrigerator device based on it. The …

Systematic Model-Based Design Assurance And Property-Based Fault Injection For Safety Critical Digital Systems, Athira Varma Jayakumar

Theses and Dissertations

With advances in sensing, wireless communications, computing, control, and automation technologies, we are witnessing the rapid uptake of Cyber-Physical Systems across many applications including connected vehicles, healthcare, energy, manufacturing, smart homes etc. Many of these applications are safety-critical in nature and they depend on the correct and safe execution of software and hardware that are intrinsically subject to faults. These faults can be design faults (Software Faults, Specification faults, etc.) or physically occurring faults (hardware failures, Single-event-upsets, etc.). Both types of faults must be addressed during the design and development of these critical systems. Several safety-critical industries have widely adopted …

Implementation Of A Hierarchical, Embedded, Cyber Attack Detection System For Spi Devices On Unmanned Aerial Systems, Jeremy J. Price

Theses and Dissertations

Unmanned Aerial Systems (UAS) create security concerns as their roles expand in commercial, military, and consumer spaces. The need to secure these systems is recognized in the architecture for a Hierarchical, Embedded, Cyber Attack Detection (HECAD) system. HECAD passively monitors the communication between a flight controller and all its peripherals like sensors and actuators. It ensures the functionality of a UAS is within the set of defined behavior and reports all potential problems, whether the errors were caused by cyber attacks or other physical faults. A portion of the design for Serial Peripheral Interface (SPI) devices on board a flight …

Leveraging Peer-To-Peer Energy Sharing For Resource Optimization In Mobile Social Networks, Aashish Dhungana

Theses and Dissertations

Mobile Opportunistic Networks (MSNs) enable the interaction of mobile users in the vicinity through various short-range wireless communication technologies (e.g., Bluetooth, WiFi) and let them discover and exchange information directly or in ad hoc manner. Despite their promise to enable many exciting applications, limited battery capacity of mobile devices has become the biggest impediment to these appli- cations. The recent breakthroughs in the areas of wireless power transfer (WPT) and rechargeable lithium batteries promise the use of peer-to-peer (P2P) energy sharing (i.e., the transfer of energy from the battery of one member of the mobile network to the battery of …

Extracellular Matrix Nanoparticles Effects On The Lung In Vivo, Brittaney E. Ritchie

Theses and Dissertations

Acute respiratory distress syndrome (ARDS) is a life-threatening condition that causes diffuse alveolar damage and a loss of the extracellular matrix (ECM). This leads to pulmonary edema and lung function deterioration. Our lab has created decellularized porcine lung, electrosprayed ECM nanoparticles that have been previously shown to have pro-regenerative capabilities in vitro.

In this study, the ECM nanoparticle effects on young murine lungs were tested in vivo. An ECM nanoparticle suspension, previously used for the in vitro studies, was aerosolized intratracheally into the lungs using a microsprayer. 24 hours later, the lung mechanics, bronchoalveolar lavage fluid, and histology …

Development Of A Torque-Based Device For The Quantification Of Arm Rigidity In Patients With Parkinson’S Disease, Georgina O. Miller

Theses and Dissertations

Parkinsonian rigidity is caused by the inability of the muscles to relax and extend properly, due to reduced dopamine levels and often begins on one side of the body before spreading contralaterally. The current standard for determining joint rigidity in a clinical setting is a test completed by the clinician based on the feel of the relaxed wrist and elbow joints as they are passively flexed and extended and a series of ordinal rating scales, the Movement Disorder Society’s – Unified Parkinson’s Disease Rating Scale (MDS-UPDRS), Hoehn and Yahr Scale (H&Y), and Parkinson’s Disease Questionnaire-39 (PDQ-39). These methods are used …

Quantification And Modeling Of Bladder Biomechanics Mechanisms Linking Spontaneous Rhythmic Contractions And Dynamic Elasticity To Detrusor Overactivity, Zachary E. Cullingsworth

Theses and Dissertations

Overactive bladder (OAB) is a chronic condition affecting approximately 20% of adults in the United States. Detrusor overactivity (DO) is the presence of non-voiding contractions in the detrusor (bladder) muscle during filling and is present in some individuals with OAB. DO is currently identified visually during a urodynamics (UD) study involving pressure catheters and filling and voiding of the bladder to evaluate function. UD provides limited subtyping of DO, and an incomplete understanding of mechanisms contributing to OAB.

Aim 1 of this study was to develop objective tools to quantify, subgroup and better understand …

Data Science Methods For Standardization, Safety, And Quality Assurance In Radiation Oncology, Khajamoinuddin Syed

Theses and Dissertations

Radiation oncology is the field of medicine that deals with treating cancer patients through ionizing radiation. The clinical modality or technique used to treat the cancer patients in the radiation oncology domain is referred to as radiation therapy. Radiation therapy aims to deliver precisely measured dose irradiation to a defined tumor volume (target) with as minimal damage as possible to surrounding healthy tissue (organs-at-risk), resulting in eradication of the tumor, high quality of life, and prolongation of survival. A typical radiotherapy process requires the use of different clinical systems at various stages of the workflow. The data generated in these …

The Effect Of Intermittent Theta Burst Stimulation On Biceps Corticomotor Excitability In Non-Impaired Individuals And Individuals With Tetraplegia, Blaize Majdic

Theses and Dissertations

Neuromodulation of the primary motor cortex (M1) in pair with physical therapy may be a promising method for improving motor outcomes after spinal cord injury (SCI). Increased excitability of the corticospinal motor pathways (i.e. corticomotor excitability) has shown to be associated with improved motor learning and skill acquisition. Intermittent theta burst stimulation (iTBS) is a form of non-invasive brain stimulation which can increase corticomotor excitability, as measured by an increase in the amplitude of motor evoked potentials (MEPs). However, the ability for iTBS to increase the corticomotor excitability of proximal muscles such as the biceps, and muscles affected by spinal …

Generation Of Warm Dense Plasma On Solar Panel Infrastructure In Exo-Atmospheric Conditions, Harrison C. Wenzel

Theses and Dissertations

The use of a weaponized thermo-nuclear device in exo-atmospheric conditions would be of great impact on the material integrity of orbiting satellite infrastructure. Particular damage would occur to the multi-layered, solar cell components of such satellites. The rapid absorption of X-ray radiation originating from a nuclear blast into these layers occurs over a picosecond time scale and leads to the generation of Warm Dense Plasma (WDP). While incredibly difficult and costly to replicate in a laboratory setting, a collection of computational techniques and software libraries may be utilized to simulate the intricate atomic and subatomic physics characteristics of such an …

Higher Tensile Forces Across Cellular Junctions And An Intact Nuclear Linc Complex Is Required For Epithelial Function And Stability, Fnu Vani Narayanan

Theses and Dissertations

Recent advances in three-dimensional (3D) cell culture systems have provided key insights into the understanding of biochemical and physiological states of native tissue. A significant progress in the field of mechanobiology involves measuring cellular traction forces in a more native 3D environment. However, the effects of mechanical forces exerted across cellular junctions and the nuclear LINC complex, in an organized 3D system has not been investigated thus far. Epithelial cells spontaneously form acini (also known as cysts or spheroids) with a single, fluid-filled central lumen, when grown in 3D matrices. The size of the lumen is dependent on apical secretion …

Development Of Near-Real Time Material Detection And Analysis By Coupling Electrochemical & Optical Spectroscopy Methods For Molten Salt Systems, Hunter Andrews

Theses and Dissertations

For both pyroprocessing and molten salt reactors (MSRs), it is desirable from a process control and nuclear safeguards perspective to monitor the species in the molten salts for material accountancy. Many traditional monitoring techniques, even simple salt sample retrieval, are time exhaustive or rendered useless for these systems due to the high thermal loads, high radiation zones, and corrosive nature of molten salts. Therefore, the main motivation for this work is the need for an online monitoring system for a molten salt system that is robust enough to handle the extreme environment yet deliver quantifiable salt concentrations. The intent of …

Peridynamic Approaches For Damage Prediction In Carbon Fiber And Carbon Nanotube Yarn Reinforced Polymer Composites, Forrest E. Baber

Theses and Dissertations

Aerospace structures are increasingly utilizing advanced composites because of their high specific modulus and specific strength. While the introduction of these material systems can dramatically decrease weight, they pose unique certification challenges, often requiring extensive experimental testing in each stage of the design cycle. The expensive and time-consuming nature of experimental testing necessitates the advancement of simulation methodologies to both aid in the certification process and assist in the exploration of the microstructure design space.

Peridynamic (PD) theory, originating from Sandia National Lab’s in the early 2000’s, is a nonlocal continuum-based method that reformulates the equation of motion into an …

Strategies And Devices For Improving Respiratory Drug Delivery To Infants And Children With Cystic Fibrosis, Karl Bass

Theses and Dissertations

Cystic Fibrosis (CF) is a degenerative disease, which causes thickening of the airway surface liquid and reduced mucociliary clearance, which provides an ideal habitat for bacterial infections. Early treatment of CF in children can prevent chronic infection, improve quality of life, and increase life expectancy. The most predominant bacteria found in CF-diseased lungs is Pseudomonas aeruginosa (Pa), which can be treated with inhaled tobramycin. Excipient enhanced growth (EEG) powder formulations are well suited for administering tobramycin to children, as the EEG approach provides minimal upper airway loss and targeted drug delivery. This method uses an initially small aerosol for high …

Reaction Profiling Of Extracellular Protein Phosphorylation Through A Microfluidic Reactor Coupled With Raman Spectroscopy, Abigail Casey

Theses and Dissertations

Diseases and disorders in the human body are considered abnormalities of proper cellular function. Understanding the signal transduction mechanisms that cause these abnormalities is crucial to developing earlier detection methods, better treatment options and effective cures. While current diagnostic procedures are powerful tools in diagnosing diseases, they are ineffective in informing physicians on the real-time behavior of the signal transduction mechanisms associated with diseases and disorders. Currently, disease progression is monitored over time through routine patient visits and testing by one or more of the above techniques. By developing an approach that can monitor structural and conformational changes of proteins …

Improving Grid Hosting Capacity And Inertia Response With High Penetration Of Renewable Generation, Hamidreza Sadeghian

Theses and Dissertations

To achieve a more sustainable supply of electricity, utilizing renewable energy resources is a promising solution. However, the inclusion of intermittent renewable energy resources in electric power systems, if not appropriately managed and controlled, will raise a new set of technical challenges in both voltage and frequency control and jeopardizes the reliability and stability of the power system, as one of the most critical infrastructures in the today’s world. This dissertation aims to answer how to achieve high penetration of renewable generations in the entire power system without jeopardizing its security and reliability. First, we tackle the data insufficiency in …

Application Of Immobilized Palladium Monolithic Catalysts In Suzuki-Miyaura And Tsuji-Wacker Redox Reactions, Sajjad Ghobadi

Theses and Dissertations

Herein, a wholistic analysis of the viability of monolithic catalysts for redox reactions is presented. The interdisciplinary approach taken in this systematic study included preparation and investigation on Pd-on-carbon monoliths as catalysts in a flow and electrochemical settings.

The Suzuki-Miyaura reaction-focused study led to rational design, preparation, and successful application of Pd⁰-on-graphene oxide (GO) monolithic catalysts in flow conditions. In this study a combination of chemical reduction, freeze-casting, and vapor-phase reduction processes was applied to Pd-GO structures leading to the preparation of these monoliths. The Suzuki flow synthesis reactions revealed that the monolithic structure led to significantly improved …

Optical Spectroscopy And Theoretical Modelling Of Carrier Dynamics In Group-Iv Alloy Quantum Dots, Rahnuma Rahman

Theses and Dissertations

In recent years, Ge_1−xSn_x alloy quantum dots (QDs) have attracted significant interest due to their potential applications in photodetectors and light emitting devices in visible to mid IR spectral range and compatibility with silicon based platforms. While bulk Ge is an indirect bandgap semiconductor (0.66 eV), direct transitions can be made possible by incorporation of α-Sn at concentrations of ~10%, which however lowers the bandgap. Utilizing quantum confinement by reducing the size to below the Bohr radius also promotes direct transitions and more importantly increases the fundamental transition energies in GeSn alloy QDs, making them suitable for …

Sound Propagation In Viscous Flows Using Piezoelectric Sensors And Non-Destructive Propagation Techniques And Its Applications, Ahmed M. Abdulkareem

Theses and Dissertations

Structural non-destructive evaluation techniques are applied to viscous flows to detect fluid property changes. The main operating principle consists of an actuator which provides a stimulus, and a sensor to receive a signal traveling to a fluid domain. The main challenge of the operating principle consists of investigating waves traveling in a viscous flow. Traveling waves utilizing a piezoelectric actuator-sensor pair are modeled and the results are validated experimentally. ANSYS models, coupled with a two-way fluid-solid interaction model, are built to investigate how far a signal travels and what frequency ranges are of interest. The numerical model includes modeling three …

Beneficiation Of Coal Using Supercritical Water And Carbon Dioxide Extraction, Matthew Decuir Virginia Commonwealth University Cl

Theses and Dissertations

This work explores the use of carbon dioxide, water, and their mixtures as solvent for the pre-combustion beneficiation of raw coal without using any toxic mineral acids in the temperature range of 200-400℃. The fluid polarity, ionic constant, and supercritical point can be adjusted by H₂O/CO₂ ratio and temperature. Adding carbon dioxide to hydrothermal fluid also increases the ionization by forming carbonic acid. Extractions with supercritical fluids have several benefits including enhanced mass transport, ease of separation and recycle, wide range of extractive capability and tunability, better inherent safety, and in the case of carbon dioxide and …

Self-Assembled Metal Nanoparticle/Polymer Nanocomposites As Nanoreactors For One-Pot Reactions, Andrew Harrison

Theses and Dissertations

Polymer nanoreactors incorporating gold nanoparticle catalysts were self-assembled via Flash Nanoprecipitation. The incorporated gold nanoparticles maintained catalytic activity, which was evaluated using reduction of 4-nitrophenol with sodium borohydride as a model reaction. The diffusion coefficient for 4-nitrophenol was determined by NMR and used to calculate the second Damköhler number, which indicated that the systems were not diffusion limited. Despite similar diffusion coefficients, catalytic performance was strongly affected by the co-precipitant. For example, the apparent reaction rate per surface area using castor oil was over 8-fold greater than polystyrene. Thus, we measured the partition coefficient of 4-nitrophenol between water and castor …

Evaluating The Effectiveness Of Aerospace Materials, Vehicle Shape And Astronaut Position At Lowering The Whole Body Effective Dose Equivalent In Deep Space, Daniel K. Bond

Theses and Dissertations

As future crewed, deep space missions are being planned, it is important to assess how spacecraft design can be used to minimize radiation exposure. Collectively with shielding material, vehicle shape and astronaut position must be used to protect astronauts from the two primary sources of space radiation: Galactic Cosmic Rays (GCR) and Solar Particle Events (SPE). GCRs, which are composed of low intensity, highly energetic, and fully ionized stable and meta-stable isotopes, are considered a chronic source of radiation risk to the astronauts. SPEs, which originate from solar coronal mass ejections, are composed mostly of high intensity protons that can …

Multilevel Runtime Verification For Safety And Security Critical Cyber Physical Systems From A Model Based Engineering Perspective, Smitha Muralidhar Gautham

Theses and Dissertations

Advanced embedded system technology is one of the key driving forces behind the rapid growth of Cyber-Physical System (CPS) applications. CPS consists of multiple coordinating and cooperating components, which are often software-intensive and interact with each other to achieve unprecedented tasks. Such highly integrated CPSs have complex interaction failures, attack surfaces, and attack vectors that we have to protect and secure against. This dissertation advances the state-of-the-art by developing a multilevel runtime monitoring approach for safety and security critical CPSs where there are monitors at each level of processing and integration. Given that computation and data processing vulnerabilities may exist …

Formulation And Validation Of Nanoparticle Controlled Delivery For Chemotherapeutic Drug Products, Shani L. Levit

Theses and Dissertations

Taxol, a formulation of paclitaxel (PTX), is one of the most widely used anticancer drugs, particularly for treating recurring ovarian carcinomas following surgery. Clinically, PTX is used in combination with other drugs such as lapatinib (LAP) to increase treatment efficacy. Delivering drug combinations with nanoparticles has the potential to improve chemotherapy outcomes. In this study, we use Flash NanoPrecipitation, a rapid, scalable process to encapsulate weakly hydrophobic drugs (logP in vitro. Encapsulating either PTX or LAP into nanoparticles increases drug potency. When PTX and LAP are co-loaded in the same nanoparticle, they have a synergistic effect that is greater than …