Engineering Commons^™

Surface Charge Switchable And Ph-Responsive Chitosan/Polymer Core-Shell Composite Nanoparticles For Drug Delivery Application, W. F. Huang, C. P. Tsui, M. Yang, Linxia Gu

Department of Mechanical and Materials Engineering: Faculty Publications

The mutually conflicting surface charge requirements for nanoparticles to have long circulation and good cell affinity have made the development of polymer nanoparticles for controlled drug delivery fall into a dilemma. In order to solve this problem, the first attempt has been made in this work to develop vancomycin loaded composite nanoparticles with a novel chitosan core and poly (lactide-co-glycolide) (PLGA) shell structure and with both pH-responsive and surface charge switchable properties. Spherical composite nanoparticles have been successfully fabricated through a modified emulsion-gelation method with a controllable size (316–573 nm), surface charge (–27.6–31.75 mV) and encapsulation efficiency up to 70.8%. …