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Articles 1 - 3 of 3
Full-Text Articles in Engineering
Chitosan Nanoparticle Modifications For Improved Gene Delivery In An Oral Dna Vaccine Application, Austin Helmink
Chitosan Nanoparticle Modifications For Improved Gene Delivery In An Oral Dna Vaccine Application, Austin Helmink
Honors Theses
Vaccines represent one of the most significant medical innovations of the 20th century, resulting in the eradication or near eradication of a handful of deadly diseases. However, many infectious diseases remain resistant to effective vaccination, largely due to a lack full immune activation by traditional protein-based vaccines. A promising alternative vaccination strategy is the emerging development of DNA vaccines, which rely upon the delivery of exogenous genetic material to host cells encoding for a viral or bacterial antigen in order to induce a robust immune response by closely mimicking live infection. The delivery of genetic material requires a carrier …
Surface Charge Switchable And Ph-Responsive Chitosan/Polymer Core-Shell Composite Nanoparticles For Drug Delivery Application, W. F. Huang, C. P. Tsui, M. Yang, Linxia Gu
Surface Charge Switchable And Ph-Responsive Chitosan/Polymer Core-Shell Composite Nanoparticles For Drug Delivery Application, W. F. Huang, C. P. Tsui, M. Yang, Linxia Gu
Department of Mechanical and Materials Engineering: Faculty Publications
The mutually conflicting surface charge requirements for nanoparticles to have long circulation and good cell affinity have made the development of polymer nanoparticles for controlled drug delivery fall into a dilemma. In order to solve this problem, the first attempt has been made in this work to develop vancomycin loaded composite nanoparticles with a novel chitosan core and poly (lactide-co-glycolide) (PLGA) shell structure and with both pH-responsive and surface charge switchable properties. Spherical composite nanoparticles have been successfully fabricated through a modified emulsion-gelation method with a controllable size (316–573 nm), surface charge (–27.6–31.75 mV) and encapsulation efficiency up to 70.8%. …
Chitosan-Zein Nano-In-Microparticles Capable Of Mediating In Vivo Transgene Expression Following Oral Delivery, Eric Farris, Deborah M. Brown, Amanda Ramer-Tait, Angela K. Pannier
Chitosan-Zein Nano-In-Microparticles Capable Of Mediating In Vivo Transgene Expression Following Oral Delivery, Eric Farris, Deborah M. Brown, Amanda Ramer-Tait, Angela K. Pannier
Biological Systems Engineering: Papers and Publications
The oral route is an attractive delivery route for the administration of DNA-based therapeutics, specifically for applications in gene therapy and DNA vaccination. However, oral DNA delivery is complicated by the harsh and variable conditions encountered throughout gastrointestinal (GI) transit, leading to degradation of the delivery vector and DNA cargo, and subsequent inefficient delivery to target cells. In this work, we demonstrate the development and optimization of a hybrid-dual particulate delivery system consisting of two natural biomaterials, zein (ZN) and chitosan (CS), to mediate oral DNA delivery. Chitosan-Zein Nano-in-Microparticles (CS-ZN-NIMs), consisting of core Chitosan/DNA nanoparticles (CS/DNA NPs) prepared by ionic …