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University of Massachusetts Amherst

Theses/Dissertations

2013

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Articles 31 - 34 of 34

Full-Text Articles in Engineering

Molecular And Population Level Approaches To Understand Taxus Metabolism In Cell Suspension Cultures, Rohan Anil Patil Feb 2013

Molecular And Population Level Approaches To Understand Taxus Metabolism In Cell Suspension Cultures, Rohan Anil Patil

Open Access Dissertations

Plant cell culture is an attractive platform technology for production and supply of important plant derived medicinals. A unique characteristic of plant cells is the ability to grow as multicellular aggregates in suspension. The presence of these non-uniform aggregates results in creation of distinct microenvironments, which can induce variations in cellular metabolism (e.g., growth, oxygen consumption and secondary metabolite synthesis). This heterogeneity can lead to unpredictable and suboptimal performance in large scale bioprocesses. One example is the Taxus cell culture system, which produces a widely used chemotherapeutic drug - paclitaxel (Taxol ®). Despite extensive process engineering efforts which have led …


Techno-Economic Feasibility Study Of Ammonia Plants Powered By Offshore Wind, Eric R. Morgan Feb 2013

Techno-Economic Feasibility Study Of Ammonia Plants Powered By Offshore Wind, Eric R. Morgan

Open Access Dissertations

Ammonia production with offshore wind power has the potential to transform energy and fertilizer markets within the United States. The vast offshore wind resource can be converted directly into liquid ammonia using existing technologies. The liquid ammonia can then be transported around the country via rail, truck, barge or pipeline and used as either a fertilizer or a fuel. This thesis reviews the technologies required for all-electric, wind-powered ammonia production and offers a simple design of such a system. Cost models based on the physical equipment necessary to produce ammonia with wind power are developed; offshore wind farm cost models …


Helical Ordering In Chiral Block Copolymers, Wei Zhao Feb 2013

Helical Ordering In Chiral Block Copolymers, Wei Zhao

Open Access Dissertations

The phase behavior of chiral block copolymers (BCPs*), namely, BCPs with at least one of the constituent block is formed by chiral monomers, is studied both experimentally and theoretically. Specifically, the formation of a unique morphology with helical sense, the H* phase, where the chiral block forms nanohelices hexagonally embedded in the matrix of achiral block, is investigated. Such unique morphology was first observed in the cast film of polystyrene-b-poly(L-lactide) (PS-b-PLLA) from a neutral solvent dichloromethane at room temperature with all the nanohelices being left-handed, which would switch to right-handed if the PLLA block changes to …


Determining Detailed Reaction Kinetics For Nitrogen-And Oxygen-Containing Fuels, Nicole Jeanne Labbe Feb 2013

Determining Detailed Reaction Kinetics For Nitrogen-And Oxygen-Containing Fuels, Nicole Jeanne Labbe

Open Access Dissertations

With the emergence of new biorenewable transportation fuels, the role of heteroatoms in combustion has increased tremendously. While petroleum-based fuels are primarily hydrocarbons, many biorenewable fuels contain heteroatoms such as oxygen and nitrogen, introducing new challenges associated with toxic emissions. A fundamental understanding of the chemical kinetics of combustion of these heteroatomic fuels is necessary to elucidate the pathways by which these toxic emissions are formed and may be achieved through the development of combustion models. Reaction sets, the core of these combustion models, may be assembled for individual fuels through a balance of employing vetted rate constants from prior …