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Experimental Investigation Of The Fluid Velocity Distribution In Stirred Tank Reactors Equipped With Retreat-Blade Impellers Using Laser Doppler Velocimetry, Deepak Rajesh Madhrani
Experimental Investigation Of The Fluid Velocity Distribution In Stirred Tank Reactors Equipped With Retreat-Blade Impellers Using Laser Doppler Velocimetry, Deepak Rajesh Madhrani
Theses
Stirred tank reactors are commonly used in the pharmaceutical industry for synthesis of Active Pharmaceutical Ingredients (API's) and their intermediates. Typically, these vessels are glass-lined and are provided with a single retreat-blade glass-lined impeller and a single baffle. Despite their ubiquitous utilization in the pharmaceutical industry for at least the past 40 years, the mixing characteristics of these systems have not been studied to any great extent, making it difficult to predict mixing performance in any given operation.
In this work, the velocity distribution inside the typical glass-lined vessel/impeller system was experimentally quantified using Laser Doppler Velocimetry (LDV), which is …
Ultra-Fine Particle Formation Using Principle Of Rapid Expansion Of Supercritical Solutions`, Miraj Minesh Sheth
Ultra-Fine Particle Formation Using Principle Of Rapid Expansion Of Supercritical Solutions`, Miraj Minesh Sheth
Theses
There are indications in the chemical and pharmaceutical industries that the reduction in size of a crystalline particle can lead to better performance of the drug compound, particularly for water insoluble drugs, in the final dosage form. Many particle formation techniques have been investigated in recent years by researchers to obtain desired particulate sizes and size distributions. Supercritical fluid technologies have been successfully investigated for particle formation due to its unique gas/liquid properties in the supereritical state. In this report, results of particle formation using the principles of Rapid Expansion of Supercritical Solutions (RESS) have been documented.
In the RESS …