Engineering Commons^™

Enzyme Shielding In A Soft Organo-Silica Layer – Pharma/Biopharma Applications, Yves Dudal, Federica Richina, Lucas Durandi, Rita Correro, Patrick Shahgaldian

Enzyme Engineering XXIV

Enzymes, or biocatalysts, are specialty proteins. Like antibodies to antigens, enzymes exhibit remarkable specificity for their substrate and naturally facilitate many chemical conversions. However, the use of enzymes in the biotech industry ($2.3bn) is strongly limited by the fact that enzymes are highly sensitive like most proteins and usually not fitted to in vivo and process conditions. Many expensive genetically engineered or biosourced enzymes show remarkable properties but need to be made more robust for deployment in the health industry.

We have developed a unique procedure to fit enzymes to in vivo and process conditions. The process is initiated by …