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Increased Trans-Glycosylation Activity Of Hexosaminidases For Synthesis Of Human Milk Oligosaccharides, Jan Muschiol, Jesper Holck, Peter K. Busk, Lene Lange, Jørn D. Mikkelsen, Anne S. Meyer, Shariza B. Jamek,
Increased Trans-Glycosylation Activity Of Hexosaminidases For Synthesis Of Human Milk Oligosaccharides, Jan Muschiol, Jesper Holck, Peter K. Busk, Lene Lange, Jørn D. Mikkelsen, Anne S. Meyer, Shariza B. Jamek,
Enzyme Engineering XXIV
It is well known that the composition of human breast milk differs significantly from the one of ordinary bovine milk. Especially the presence of sialylated and fucosylated oligosaccharides contributes to its health and development promoting features for newborn infants. [1] Nevertheless, not all newborns and especially premature infants sometimes cannot be breast fed for different reasons. For those children it is important that they receive a proper balanced formula product containing the above mentioned human milk oligosaccharides (HMOs). With respect to this we are developing new enzymatic routes for synthesis of sialylated and fucosylated oligosaccharides, which can be used as …