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Articles 1 - 17 of 17
Full-Text Articles in Engineering
Microglia Control Vascular Architecture Via A Tgfβ1 Dependent Paracrine Mechanism Linked To Tissue Mechanics, Tejasvi Dudiki, Julia Meller, Gautam Mahajan, Huan Liu, Irina Zhevlakova, Samantha Stefl, Conner Witherow, Eugene Podrez, Chandrasekhar R. Kothapalli, Tatiana V. Byzova
Microglia Control Vascular Architecture Via A Tgfβ1 Dependent Paracrine Mechanism Linked To Tissue Mechanics, Tejasvi Dudiki, Julia Meller, Gautam Mahajan, Huan Liu, Irina Zhevlakova, Samantha Stefl, Conner Witherow, Eugene Podrez, Chandrasekhar R. Kothapalli, Tatiana V. Byzova
Chemical & Biomedical Engineering Faculty Publications
© 2020, The Author(s). Tissue microarchitecture and mechanics are important in development and pathologies of the Central Nervous System (CNS); however, their coordinating mechanisms are unclear. Here, we report that during colonization of the retina, microglia contacts the deep layer of high stiffness, which coincides with microglial bipolarization, reduction in TGFβ1 signaling and termination of vascular growth. Likewise, stiff substrates induce microglial bipolarization and diminish TGFβ1 expression in hydrogels. Both microglial bipolarization in vivo and the responses to stiff substrates in vitro require intracellular adaptor Kindlin3 but not microglial integrins. Lack of Kindlin3 causes high microglial contractility, dysregulation of ERK …
Efficient Trajectory Optimization For Curved Running Using A 3d Musculoskeletal Model With Implicit Dynamics, Marlies Nitschke, Eva Dorschky, Dieter Heinrich, Heiko Schlarb, Bjoern M. Eskofier, Anne D. Koelewijn, Antonie J. Van Den Bogert
Efficient Trajectory Optimization For Curved Running Using A 3d Musculoskeletal Model With Implicit Dynamics, Marlies Nitschke, Eva Dorschky, Dieter Heinrich, Heiko Schlarb, Bjoern M. Eskofier, Anne D. Koelewijn, Antonie J. Van Den Bogert
Mechanical Engineering Faculty Publications
Trajectory optimization with musculoskeletal models can be used to reconstruct measured movements and to predict changes in movements in response to environmental changes. It enables an exhaustive analysis of joint angles, joint moments, ground reaction forces, and muscle forces, among others. However, its application is still limited to simplified problems in two dimensional space or straight motions. The simulation of movements with directional changes, e.g. curved running, requires detailed three dimensional models which lead to a high-dimensional solution space. We
extended a full-body three dimensional musculoskeletal model to be specialized for running with directional changes. Model dynamics were implemented implicitly …
Research And Simulation Of Dc Microgrid Three-Phase Ac-Dc Converter Control Strategy Based On Double Loop, Boning Wu, Zhiqiang Gao, Xuesong Zhou, Youjie Ma, Chenglong Wang
Research And Simulation Of Dc Microgrid Three-Phase Ac-Dc Converter Control Strategy Based On Double Loop, Boning Wu, Zhiqiang Gao, Xuesong Zhou, Youjie Ma, Chenglong Wang
Electrical and Computer Engineering Faculty Publications
The new voltage and current double loop control strategy is proposed to solve the DC microgrid bus voltage fluctuation caused by loads fluctuation, parameters perturbation and unbalanced three-phase power supply. Firstly, the dq axis mathematical model of three-phase AC-DC bidirectional converter in DC microgrid is analyzed and established, and then the controllers are designed according to the dq axis mathematical model. The outer loop is a voltage loop based on variable gain linear extended state observer (VGLESO) and sliding mode theory. VGLESO can not only effectively overcome the problem of peak output of traditional high-gain LESO in the initial stage …
Reasons Of Acceptance And Barriers Of House Onsite Greywater Treatment And Reuse In Palestinian Rural Areas, Rehab A. Thaher, Nidal Mahmoud, Issam A. Al-Khatib, Yung Tse Hung
Reasons Of Acceptance And Barriers Of House Onsite Greywater Treatment And Reuse In Palestinian Rural Areas, Rehab A. Thaher, Nidal Mahmoud, Issam A. Al-Khatib, Yung Tse Hung
Civil and Environmental Engineering Faculty Publications
© 2020 by the authors. In the last twenty years, house onsite wastewater management systems have been increasing in the West Bank's rural areas. The aim of this research was to reveal, in the context of providing onsite GreyWater Treatment Plants (GWTPs) for wastewater management in the rural communities in Palestine, the local population's perceptions, in the sense of acceptance of and barriers towards such a type of wastewater management, so as to figure out successes, failures and lessons. The data collection tool was a questionnaire that targeted the households served with GWTPs. The findings show that 13% of the …
Overseas Chinese Environmental Engineers And Scientists Association (Oceesa) Report, Regular Issue, February 2020, Yung-Tse Hung, Wen-Chi Ku, Lawrence K. Wang
Overseas Chinese Environmental Engineers And Scientists Association (Oceesa) Report, Regular Issue, February 2020, Yung-Tse Hung, Wen-Chi Ku, Lawrence K. Wang
Civil and Environmental Engineering Faculty Publications
This OCEESA report, which is regular issue of OCEESA Journal (Overseas Chinese Environmental Engineers and Scientists Association Journal). This report is OCEESA report number: OCEESA/JL-2020/3701, February 2020, ISSN 1072 -7248. This report is also OCEESA Journal, Volume 37, Number 1, February 2020. Yung-Tse Hung, Permanent Executive Director, OCEESA, is editor of this report. This issue includes: (A) 10 OCEESA Best Papers (B) 6 OCEESA Papers; 21.Zhang-Zhi Charlie Huang 黄长志 , Implementing Compensation System for Environmental Damages: Challenges and Solutions, 22. Hanlu Yan, Kaimin Shih施凱閔 , Quantitative X-Ray Diffraction for Characterizing P Recovery Products from Wastewater, 23. Kaimin Shih 施凱閔 , …
On The Conceptualization Of Total Disturbance And Its Profound Implications, Sen Chen, Wenyan Bai, Yu Hu, Yi Huang, Wenbing Zhao
On The Conceptualization Of Total Disturbance And Its Profound Implications, Sen Chen, Wenyan Bai, Yu Hu, Yi Huang, Wenbing Zhao
Electrical and Computer Engineering Faculty Publications
No abstract provided.
Cationic Surfactant Analysis With Good Laboratory Practice, Lawrence K. Wang, Mu-Hao Sung Wang, Nazih K. Shammas, Valerie Renak, Yung-Tse Hung
Cationic Surfactant Analysis With Good Laboratory Practice, Lawrence K. Wang, Mu-Hao Sung Wang, Nazih K. Shammas, Valerie Renak, Yung-Tse Hung
Civil and Environmental Engineering Faculty Publications
The objectives of this research are to: (a) demonstrate how to select an organic solvent (such as 1,1,1-trichloroethane) for spectrophotometric determination of cationic surfactant in water and wastewater, (b) investigate and recommend possible better organic solvents for surfactant analysis; and (c) introduce good laboratory practice for personal protection, laboratory protection and hazardous waste management. Specifically this research involves selection of alternate less toxic and greener organic solvent for use in a methyl orange method for colorimetric determination of cationic surfactants in the 0.2 to 2.0 mg/L range. The principles, steps and management of the methyl orange method include: (a) complexation …
Achieving Practical Functional Electrical Stimulation-Driven Reaching Motions In An Individual With Tetraplegia, Derek Nathaniel Wolf
Achieving Practical Functional Electrical Stimulation-Driven Reaching Motions In An Individual With Tetraplegia, Derek Nathaniel Wolf
ETD Archive
Functional electrical stimulation (FES) is a promising technique for restoring the ability to complete reaching motions to individuals with tetraplegia due to a spinal cord injury (SCI). FES has proven to be a successful technique for controlling many functional tasks such as grasping, standing, and even limited walking. However, translating these successes to reaching motions has proven difficult due to the complexity of the arm and the goaldirected nature of reaching motions. The state-of-the-art systems either use robots to assist the FES-driven reaching motions or control the arm of healthy subjects to complete planar motions. These controllers do not directly …
Developing A Multifunctional Thermo-Responsive Viral Like Particle (Vlp) Platform With New Physicochemical Characteristics, Sepehr Dejdar
Developing A Multifunctional Thermo-Responsive Viral Like Particle (Vlp) Platform With New Physicochemical Characteristics, Sepehr Dejdar
ETD Archive
Smart materials are a class of material whose physical characteristics change significantly in a controllable fashion once exposed to an external stimulus such as stress, pH, light, temperature, etc. If the temperature is the external stimuli (control variable) the material is termed thermo-responsive. Out of numerous thermo-responsive materials, elastin-like polypeptide (ELP) is a well-known protein-based biopolymer. Protein cages are well-defined biological nanostructures which are highly symmetrical and monodisperse. This class of proteins are both chemically and genetically tunable, making them a suitable recipient of new properties. Protein re-engineering is the basis of developing a hybrid platform (e.g. polymer-protein) to deliver …
Interaction Between The Metabolism Of Ketone Bodies In Brain Tissue And Neurological Disorders, Chan-Chih Hsiao
Interaction Between The Metabolism Of Ketone Bodies In Brain Tissue And Neurological Disorders, Chan-Chih Hsiao
ETD Archive
Regulation of brain metabolism and cerebral blood flow involves complex control systems with several interacting variables at both cellular and organ levels. Quantitative understanding of the spatially and temporally heterogeneous brain control mechanisms during internal and external stimuli requires the development and validation of a computational (mathematical) model of metabolic processes in brain tissue. A computational model of the biochemical pathways in brain is presented in this paper. The model structure consists of neurons, astrocytes, and a surrounding capillary network. Glucose is the major oxidative energy substrate in the brain. However, under hypoglycemic conditions such as during diet or fasting …
Application Of Ionizing Radiation In Wastewater Treatment: An Overview, Yung-Tse Hung
Application Of Ionizing Radiation In Wastewater Treatment: An Overview, Yung-Tse Hung
Civil and Environmental Engineering Faculty Publications
© 2019 by the authors. Technological applications of nuclear science and technology in different sectors have proved their reliabilities and sustainability over decades. These applications have supported various human civilization needs, ranging from power generation to industrial, medical, and environmental applications. Environmental applications of radiation sources are used to support decision making processes in many fields; including the detection and analysis of pollutant transport, water resources management, and treatment of municipal and industrial wastewaters. This work reviewed recent advances in the research and applications of ionizing radiation in treating different wastewater euents. The main objective of the work is to …
Treatment Of Combined Acid Black 48 And Coffee Wastewater By Low-Cost Adsorbents, Yung-Tse Hung
Treatment Of Combined Acid Black 48 And Coffee Wastewater By Low-Cost Adsorbents, Yung-Tse Hung
Civil and Environmental Engineering Faculty Publications
© 2020, Kaunas University of Technology. All rights reserved. Removal of synthetic dyes from wastewater is essential both from the environmental and human health point of view. A small concentration of synthetic dyes can reduce water transparency and consequently influence photosynthesis and alter aquatic ecosystems. Acid black 48 is an Azo dye that falls under the category of synthetic dyes used in the textile industry. With dyes, coffee wastewater has high chemical oxygen demand (COD) that can affect dissolved oxygen (DO) in surface waters. A mixture of wastes in surface waters creates a need to investigate the efficiency of existing …
Mixing Optimization In Grooved Serpentine Microchannels, Tyler Rhoades, Chandrasekhar R. Kothapalli, Petru S. Fodor
Mixing Optimization In Grooved Serpentine Microchannels, Tyler Rhoades, Chandrasekhar R. Kothapalli, Petru S. Fodor
Chemical & Biomedical Engineering Faculty Publications
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Computational fluid dynamics modeling at Reynolds numbers ranging from 10 to 100 was used to characterize the performance of a new type of micromixer employing a serpentine channel with a grooved surface. The new topology exploits the overlap between the typical Dean flows present in curved channels due to the centrifugal forces experienced by the fluids, and the helical flows induced by slanted groove-ridge patterns with respect to the direction of the flow. The resulting flows are complex, with multiple vortices and saddle points, leading to enhanced mixing across the section …
An Extensive Set Of Kinematic And Kinetic Data For Individuals With Intact Limbs And Transfemoral Prosthesis Users, Seyed Abolfazl Fakoorian, Arash Roshanineshat, Poya Khalaf, Vahid Azimi, Daniel J. Simon, Elizabeth Hardin
An Extensive Set Of Kinematic And Kinetic Data For Individuals With Intact Limbs And Transfemoral Prosthesis Users, Seyed Abolfazl Fakoorian, Arash Roshanineshat, Poya Khalaf, Vahid Azimi, Daniel J. Simon, Elizabeth Hardin
Electrical and Computer Engineering Faculty Publications
This paper introduces an extensive human motion data set for typical activities of daily living. These data are crucial for the design and control of prosthetic devices for transfemoral prosthesis users. This data set was collected from seven individuals, including five individuals with intact limbs and two transfemoral prosthesis users. These data include the following types of movements: (1) walking at three different speeds; (2) walking up and down a 5-degree ramp; (3) stepping up and down; (4) sitting down and standing up. We provide full-body marker trajectories and ground reaction forces (GRFs) as well as joint angles, joint velocities, …
Treatment Of Vegetable Oil Refining Wastes, D. Kaya, Yung-Tse Hung
Treatment Of Vegetable Oil Refining Wastes, D. Kaya, Yung-Tse Hung
Civil and Environmental Engineering Faculty Publications
The common vegetable oils are soybean, sesame, sunflower, corn, canola, and cotton seeds. Their yields, compositions and physical and chemical properties determine their usefulness in various applications aside edible uses. Crude oils obtained by pressing of such vegetable seeds are not usually considered to be edible before the removal of various nonglyceride compounds through operations known as refining. The refining processes remove undesirable materials such as phospholipids, monoacylglycerols, diacylglycerols, free fatty acids, colour and pigments, oxidised materials, etc., but, may also remove valuable minor components such as antioxidants and vitamins (carotenes and tocopherols). The major steps involved in chemical refining …
Integral Mass Balance (Imb) Method For Measuring Multicomponent Gas Adsorption Equilibria In Nanoporous Materials, Darren P. Broom, Orhan Talu, Michael J. Benham
Integral Mass Balance (Imb) Method For Measuring Multicomponent Gas Adsorption Equilibria In Nanoporous Materials, Darren P. Broom, Orhan Talu, Michael J. Benham
Chemical & Biomedical Engineering Faculty Publications
© 2020 American Chemical Society. To assess the performance of an adsorbent for a particular gas separation, and for process design, it is necessary to determine multicomponent gas adsorption equilibria, either experimentally or from predictions based on models or theory. The experimental techniques commonly used for this purpose, however, are time-consuming and typically require large samples. In this article, we describe a new approach, called the Integral Mass Balance (IMB) method, which combines the controlled flow of a gas mixture with in situ gravimetric measurement and gas composition analysis using quadrupole mass spectrometry. The IMB method allows very rapid equilibrium …
Cnn-Based Estimation Of Sagittal Plane Walking And Running Biomechanics From Measured And Simulated Inertial Sensor Data, Eva Dorschky, Marlies Nitschke, Christine F. Martindale, Antonie J. Van Den Bogert, Anne D. Koelewijn, Bjoern M. Eskofier
Cnn-Based Estimation Of Sagittal Plane Walking And Running Biomechanics From Measured And Simulated Inertial Sensor Data, Eva Dorschky, Marlies Nitschke, Christine F. Martindale, Antonie J. Van Den Bogert, Anne D. Koelewijn, Bjoern M. Eskofier
Mechanical Engineering Faculty Publications
Machine learning is a promising approach to evaluate human movement based on wearable sensor data. A representative dataset for training data-driven models is crucial to ensure that the model generalizes well to unseen data. However, the acquisition of sufficient data is time-consuming and often infeasible. We present a method to create realistic inertial sensor data with corresponding biomechanical variables by 2D walking and running simulations. We augmented a measured inertial sensor dataset with simulated data for the training of convolutional neural networks to estimate sagittal plane joint angles, joint moments, and ground reaction forces (GRFs) of walking and running. When …