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Chemical & Biomedical Engineering Faculty Publications
Abdominal aortic aneurysm; Elastin; Matrix proteins; Cell modulus; Matrix metalloproteinases; Nitric oxide; LILAS study
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Alterations In Phenotype And Gene Expression Of Adult Human Aneurysmal Smooth Muscle Cells By Exogenous Nitric Oxide, Kurt Farrell, Phillip Simmers, Gautam Mahajana, Ludovic Boytard, Andrew Camardo, Jyotsna Joshi, Anand Ramamurthi, Florence Pine, Chandrasekhar R. Kothapalli
Alterations In Phenotype And Gene Expression Of Adult Human Aneurysmal Smooth Muscle Cells By Exogenous Nitric Oxide, Kurt Farrell, Phillip Simmers, Gautam Mahajana, Ludovic Boytard, Andrew Camardo, Jyotsna Joshi, Anand Ramamurthi, Florence Pine, Chandrasekhar R. Kothapalli
Chemical & Biomedical Engineering Faculty Publications
Abdominal aortic aneurysms (AAA) are characterized by matrix remodeling, elastin degradation, absence of nitric oxide (NO) signaling, and inflammation, influencing smooth muscle cell (SMC) phenotype and gene expression. Little is known about the biomolecular release and intrinsic biomechanics of human AAA-SMCs. NO delivery could be an attractive therapeutic strategy to restore lost functionality of AAA-SMCs by inhibiting inflammation and cell stiffening. We aim to establish the differences in phenotype and gene expression of adult human AAA-SMCs from healthy SMCs. Based on our previous study which showed benefits of optimal NO dosage delivered via S-Nitrosoglutathione (GSNO) to healthy aortic SMCs, we …