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On The Orders Of Magnitude Of Epigenic Dynamics And Monoclonal Antibody Production, Joanne M. Savinell (Belovich), Gyun Min Lee, Bernhard O. Palsson
On The Orders Of Magnitude Of Epigenic Dynamics And Monoclonal Antibody Production, Joanne M. Savinell (Belovich), Gyun Min Lee, Bernhard O. Palsson
Chemical & Biomedical Engineering Faculty Publications
The hybridoma cell's maximum capacity for monoclonal antibody (MAb) production is estimated to be 2300–8000 MAb molecules/cell/s, using measured rates of transcription and translation, and the limitations imposed by the size of the polymerase molecule and the ribosome. Nearly all the production rates reported in the literature fall into or below this range of production rates. Data from batch cultures of hybridomas demonstrate a constant specific rate of MAb production until the time integral of the viable cell concentration reaches about 108 cells · h/cm3. At this point, some essential nutrients from the standard media …
Mixed Convection In Vertical Internal Flow Of A Micropolar Fluid, Rama Subba Reddy Gorla, Bahman Ghorashi, Prapat Wangskarn
Mixed Convection In Vertical Internal Flow Of A Micropolar Fluid, Rama Subba Reddy Gorla, Bahman Ghorashi, Prapat Wangskarn
Chemical & Biomedical Engineering Faculty Publications
The theory of micropolar fluids due to Eringen is used to formulate a set of equations for the flow and heat transfer characteristics of the combined convection micropolar flow in vertical channels. It is found that the microstructure and substructure parameters have significant effects on the flow and thermal fields. By making the Newtonian solvent more and more micropolar, it is possible to obtain drag reduction as well as reduced heat transfer characteristics.