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Articles 1 - 13 of 13
Full-Text Articles in Engineering
Transport Of Antibodies And Nanoparticles Across An In Vitro Blood-Brain Barrier, Lin Zhang
Transport Of Antibodies And Nanoparticles Across An In Vitro Blood-Brain Barrier, Lin Zhang
Dissertations and Theses
"The blood-brain barrier (BBB) is a dynamic interface between the blood circulation and the central nervous system (CNS). While it serves as a selective barrier to water and solutes to prevent the blood-borne toxins from entering into the brain tissue, it hinders the drug delivery to the CNS for the treatment of brain diseases. Recently therapeutic antibodies and a variety of drug-loaded nanoparticles (NPs) have been widely used to treat CNS disorders such as brain tumors, Alzheimer's disease and Parkinson's disease. To improve brain delivery efficacy of antibodies and NPs, it is necessary to quantify their transport parameters across the …
Evaluation Of A Novel Self-Assembled Nanocoating In Promoting Bone On-Growth And Apposition On Metal, Hani Ghazi
Evaluation Of A Novel Self-Assembled Nanocoating In Promoting Bone On-Growth And Apposition On Metal, Hani Ghazi
Dissertations and Theses
"Loosening of metal is the leading cause of clinical failures of orthopedic surgeries. A novel coating of self-assembled monolayer of phosphonate molecules (SAMP) that chemically enhances metallic surfaces by covalently bonding to their naturally occurring oxidized surfaces has been developed.1 The SAMP coating is chemically stable, and its in-vitro results showed that it promotes cell proliferation, osteoblast adhesion and enhances biological attachment to metal surfaces.1 The purpose of this study is to establish the efficacy of this novel chemical surface treatment in improving the fixation of metallic implants in both cortical and cancellous bone over a conventional untreated implant. We …
Bone Tissue Quality Determination Of Mice Through A Novel Reference Point Indentation Technique, Matin Lendhey
Bone Tissue Quality Determination Of Mice Through A Novel Reference Point Indentation Technique, Matin Lendhey
Dissertations and Theses
"Bone strength deteriorates with age; which increases the susceptibility to fracture. Current clinical techniques for the estimation of bone strength are largely Bone Mineral Density (BMD) based. However, toughness, which is the ability to resist crack growth, plays a critical role in bones‟ fracture resistance. Traditionally, toughness measurements involve large samples, obviating their use clinically. Recent data suggest that a reference point indentation approach provides a novel, localized measure of toughness from whole bones. In the current research, we evaluated the sensitivity of this method to discriminate small known differences in fracture toughness that exist between inbred mouse strains with …
Effects Of Estrogen Loss On The Vascular Porosity In Rat Cortical Bone, Jessica D Levy
Effects Of Estrogen Loss On The Vascular Porosity In Rat Cortical Bone, Jessica D Levy
Dissertations and Theses
"Osteoporosis is a skeletal disease that currently affects 10 million Americans, and is characterized by low bone mass and increased skeletal fragility (National Osteoporosis Foundation, 2011). Estrogen loss, which begins during menopause, is the leading cause of osteoporosis in women. Recent research has focused on changes in cortical bone microporosity due to estrogen loss, which is important for bone health; load-induced interstitial fluid flow within the lacunar-canalicular porosity surrounding osteocytes is thought to play an important role in bone maintenance, while the vascular porosity provides a pressure relaxation mechanism for the fluid flow in the lacunar-canalicular porosity. Recent high-resolution micro-CT …
Impact Of Self-Rewetting Aqueous Solutions On Boiling With Advanced Heat Transfer Applications, Mostafa Morovati
Impact Of Self-Rewetting Aqueous Solutions On Boiling With Advanced Heat Transfer Applications, Mostafa Morovati
Dissertations and Theses
"Pool boiling experiments have been conducted with self-rewetting fluids consisting of aqueous butanol and pentanol solution to study the boiling heat transfer enhancement at pressures of 1 ~ 4 bars. Although self-rewetting fluids have been used to enhance the performance of heat pipes, boiling heat transfer characteristics are yet to be fully understood especially at pressures above atmospheric. Pool boiling experiments with aqueous butanol and pentanol solutions were performed using an electrically heated platinum wire to obtain pool boiling heat transfer data up to the Critical Heat Flux (CHF). Aqueous solutions with butanol concentrations 2-7% showed enhanced heat transfer coefficients …
A Study On The Use Of Inverse Opals Composed Of Zinc Oxide Aggregate Popcorn Particles To Improve The Efficiency Of Dye- Sensitized Solar Cells, Roger Chang
Dissertations and Theses
"In this work, modifications applicable to the working electrode of a dye--‐sensitized solar cell (DSSC) are explored in order to enhance efficiency. Certain compositional and structural changes to the architecture of the electrode are examined. First, the ZnO nanoparticles that are commonly utilized in DSSCs are replaced with ZnO nanoparticle aggregates, also known as ZnO popcorn particles. Subsequently, electrophoretic deposition (EPD) is used to assemble the popcorn particles into an inverse opal structure. This is a unique application of EPD, which has previously been used to infiltrate nanoparticles (d ≤20nm range) Into opal templates, demonstrating the applicability of the technique …
Development Of An Approach To Increase Drug Uptake To Bone Tumors Using Non-Invasive Mechanical Loading, Paolo E. Palacio
Development Of An Approach To Increase Drug Uptake To Bone Tumors Using Non-Invasive Mechanical Loading, Paolo E. Palacio
Dissertations and Theses
This thesis develops an approach to enhance drug delivery to bone tumors by implementing a non-invasive mechanical loading technique. An imaging protocol that characterizes the load-enhanced drug uptake is also presented. The long-term goal of this work is to develop a clinical protocol that enhances the delivery of therapeutic agents to bone tumors by utilizing load-bearing activity. This easy-to-implement approach could help increase drug uptake into the tumor interstitial fluid space as well as into tumor cells, thereby enhancing a drug's clinical effect while decreasing systemic drug dosage and unwanted side effects. This thesis details the process used to grow …
Proteomic Analysis Of Human Mesenchymal Stem Cell Aging During Serial Sub-Culture, Pawan Kc
Proteomic Analysis Of Human Mesenchymal Stem Cell Aging During Serial Sub-Culture, Pawan Kc
Dissertations and Theses
"Human mesenchymal stem cells (hMSCs) hold great potential for clinical applications in regenerative medicine. However, hMSCs occur at a very low frequency in bone marrow so the clinical use as cellular therapeutics requires suitable techniques for isolation and expansion. Furthermore, these cells can be expanded in vitro for only limited passage numbers before they reach a senescent state. Previous studies have shown that long term culture of hMSCs results in the decrease in proliferation rates, changes in genomic expressions, increase in cell sizes, and other morphological changes. Currently the mechanisms of hMSC aging and biomarkers associated with it have not …
Towards A Better Monitoring Of Soil Moisture Using A Combination Of Estimates From Passive Of Microwave And Infrared Observations, Zulamet Z. Vega-Martinez
Towards A Better Monitoring Of Soil Moisture Using A Combination Of Estimates From Passive Of Microwave And Infrared Observations, Zulamet Z. Vega-Martinez
Dissertations and Theses
No abstract provided.
Evaluation Of Quikscat Data For Monitoring Vegetation Phenology, Doralee Pellot
Evaluation Of Quikscat Data For Monitoring Vegetation Phenology, Doralee Pellot
Dissertations and Theses
No abstract provided.
Validation Of Noaa Interactive Snow Maps In The North American Region With National Climatic Data Center Ground-Based Data, Christine Chen
Validation Of Noaa Interactive Snow Maps In The North American Region With National Climatic Data Center Ground-Based Data, Christine Chen
Dissertations and Theses
"Both the areal coverage of snow and the volume of water in its subsequent melt are of concern for the creation and maintenance of both hydroelectric power and local water supply. The interactive multisensor snow and ice mapping system (IMS) is a geographic interactive system that allows for both the viewing of various sensor data and the mapping daily both snow and sea ice extent by an analyst on one platform. This thesis investigates the agreement between the National Oceanic and Atmospheric Administration’s (NOAA) interactive multisensor snow and ice mapping system (IMS) and snow depth values obtained from the National …
High-Resolution Numerical Simulation Of Tidal Enegry Distribution Along The New Jersey Coastline And Influence Of Sea-Level Rise, Simon Kraatz
Dissertations and Theses
No abstract provided.
Adiabatic Air-Water Two Phase Flow Experimental Facilities Design, Construction And Operation, Saman Reshadi
Adiabatic Air-Water Two Phase Flow Experimental Facilities Design, Construction And Operation, Saman Reshadi
Dissertations and Theses
"Experimental studies are conducted to predict the phenomenon(s) and to describe some kind of causation. The design of experiment and the experimental facility is a rigorous method. A well designed, manufactured and operated experimental facility is robust under criticism. Thermal hydraulic characteristics of air-water two-phase flows in a vertical tube (poly-dispersed) and also annulus (mono-dispersed) have been subjected to be studied in detail. The hydrodynamics modeling and simulations need a detailed comparison and verification with experimental results. Obviously, a well-designed experimental facility is required to provide a set of highly accurate and reliable data. To do so, two different research …