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Full-Text Articles in Engineering

Synthesis And Characterization Of Dielectric And Multiferroic Nanocrystalline Transition Metal Oxide Materials And Nanocomposites, Frederick A. Pearsall May 2019

Synthesis And Characterization Of Dielectric And Multiferroic Nanocrystalline Transition Metal Oxide Materials And Nanocomposites, Frederick A. Pearsall

Dissertations, Theses, and Capstone Projects

Nanocrystalline transition metal oxides with unique chemical, physical, magnetic and dielectric properties have very broad applications, ranging from photocatalysis, capacitor energy storage and 4-state memory. Frequency stable, high permittivity nanocomposite capacitors produced under mild processing conditions offer an attractive replacement to MLCCs derived from conventional ceramic firing. In one project reported herein, 0-3 nanocomposites were prepared using BaTiO3 (barium titanate, BTO) nanocrystals, suspended in a poly(furfuryl alcohol) matrix, resulting in a stable, high effective permittivity, low and stable loss dielectric. Effective medium approximations were used to compare this with similar nanocomposite systems. The use of synthesized BTO nanocrystal photocatalysts …


Ligand Selectivity In The Recognition Of Protoberberine Alkaloids By Hybrid-2 Human Telomeric G-Quadruplex: Binding Free Energy Calculation, Fluorescence Binding, And Nmr Experiments, Nanjie Deng, Junchao Xia, Lauren Wickstrom, Clement Lin, Kaibo Wang, Peng He, Yunting Yin, Danzhou Yang Apr 2019

Ligand Selectivity In The Recognition Of Protoberberine Alkaloids By Hybrid-2 Human Telomeric G-Quadruplex: Binding Free Energy Calculation, Fluorescence Binding, And Nmr Experiments, Nanjie Deng, Junchao Xia, Lauren Wickstrom, Clement Lin, Kaibo Wang, Peng He, Yunting Yin, Danzhou Yang

Publications and Research

The human telomeric G-quadruplex (G4) is an attractive target for developing anticancer drugs. Natural products protoberberine alkaloids are known to bind human telomeric G4 and inhibit telomerase. Among several structurally similar protoberberine alkaloids, epiberberine (EPI) shows the greatest specificity in recognizing the human telomeric G4 over duplex DNA and other G4s. Recently, NMR study revealed that EPI recognizes specifically the hybrid-2 form human telomeric G4 by inducing large rearrangements in the 50-flanking segment and loop regions to form a highly extensive four-layered binding pocket. Using the NMR structure of the EPI-human telomeric G4 complex, here we perform molecular dynamics free …


Proceedings Of The Cuny Games Conference 5.0, Robert O. Duncan, Joe Bisz, Julie Cassidy, Kathleen Offenholley, Carolyn Stallard, Deborah Sturm, Anders A. Wallace Mar 2019

Proceedings Of The Cuny Games Conference 5.0, Robert O. Duncan, Joe Bisz, Julie Cassidy, Kathleen Offenholley, Carolyn Stallard, Deborah Sturm, Anders A. Wallace

Publications and Research

The CUNY Games Network is an organization dedicated to encouraging research, scholarship and teaching in the developing field of games-based learning. We connect educators from every campus and discipline at CUNY and beyond who are interested in digital and non-digital games, simulations, and other forms of interactive teaching and inquiry-based learning. The CUNY Games Conference distills its best cutting-edge interactive presentations into a two-day event to promote and discuss game-based pedagogies in higher education, focusing particularly on non-digital learning activities that faculty can use in the classroom every day. The conference will include workshops lead by CUNY Games Organizers on …


Rubik's Cube: A Visual And Tactile Learning Of Algorithms And Patterns, Lawrence Muller Feb 2019

Rubik's Cube: A Visual And Tactile Learning Of Algorithms And Patterns, Lawrence Muller

Open Educational Resources

This is a classroom activity report on teaching algorithms as part of a second course in computer programming. Teaching an algorithm in an introductory level programming class is often a dry task for the instructor and the rewards for the student are abstract. To make the learning of algorithms and software more rewarding, this assignment employs a Rubik’s cube.


Observational Time Series For Lakes Azuei And Enriquillo: Surface Area, Volume, And Elevation, Mahrokh Moknatian, Michael Piasecki Jan 2019

Observational Time Series For Lakes Azuei And Enriquillo: Surface Area, Volume, And Elevation, Mahrokh Moknatian, Michael Piasecki

Publications and Research

In this report, we present historical time series of surface area, volume, and elevation for lakes Azuei (Haiti) and Enriquillo (Dominican Republic). The intention is to present a history of the lakes’ levels for both bodies of water as derived from Landsat imagery that is augmented by reports and narratives that reach further back in time. We also summarize lake level time series data collected and developed through various other efforts and compare these data sets to our time series. The time series contains 45 years’ worth of data ranging from 1972 to 2017 which we developed from Landsat imagery …


Microfluidic Study Of Gravity-Driven Drainage And Coalescence Of Aqueous Two Dimensional Foams, Justin D. Heftel Jan 2019

Microfluidic Study Of Gravity-Driven Drainage And Coalescence Of Aqueous Two Dimensional Foams, Justin D. Heftel

Dissertations and Theses

Foams, a two-phase dispersion, are staples of the cosmetic, personal care, petroleum, pharmaceutical, and other industries. Central to these applications is the stability of the dispersion against separation. Foams break down by two mechanisms: the first is bubble coalescence, which is driven by the gravity drainage of the continuous phase. The drainage acts to push the bubbles against each other, and leads to the formation of thin lamellae, which break and cause the coalescence. The second is the mass transfer of the dispersed phase through the continuous phase, which is caused by the difference in pressures between the bubbles and …


Hydroclimate Drivers And Atmospheric Dynamics Of Floods, Nasser Najibi Jan 2019

Hydroclimate Drivers And Atmospheric Dynamics Of Floods, Nasser Najibi

Dissertations and Theses

Our preliminary survey showed that most of the recent flood-related studies did not formally explain the physical mechanisms of long-duration and large-peak flood events that can evoke substantial damages to properties and infrastructure systems. These studies also fell short of fully assessing the interactions of coupled ocean-atmosphere and land dynamics which are capable of forcing substantial changes to the flood attributes by governing the exceeding surface flow regimes and moisture source-sink relationships at the spatiotemporal scales important for risk management. This dissertation advances the understanding of the variability in flood duration, peak, volume, and timing at the regional to the …


Open Source Foundations For Spatial Decision Support Systems, Jochen Albrecht Dec 2018

Open Source Foundations For Spatial Decision Support Systems, Jochen Albrecht

Publications and Research

Spatial Decision Support Systems (SDSS) were a hot topic in the 1990s, when researchers tried to imbue GIS with additional decision support features. Successful practical developments such as HAZUS or CommunityViz have since been built, based on commercial desktop software and without much heed for theory other than what underlies their process models. Others, like UrbanSim, have been completely overhauled twice but without much external scrutiny. Both the practical and the theoretical foundations of decision support systems have developed considerably over the past 20 years. This article presents an overview of these developments and then looks at what corresponding tools …


An Overview Of Smartwater Management System: Strategic Potential In Bangladesh, Muhammad Qumrul Hassan, Mir F. Karim, Nazrul I. Khandaker, Jowaher Raza Nov 2018

An Overview Of Smartwater Management System: Strategic Potential In Bangladesh, Muhammad Qumrul Hassan, Mir F. Karim, Nazrul I. Khandaker, Jowaher Raza

Publications and Research

Water loss management is becoming an increasingly important as supplies are stressed by population growth or water scarcity. A SmartWater system ensures optimum consumption and prediction of future water use. Bangladesh is one of the most vulnerable countries due to global climate change considering its rapid urbanization, inequitable land use, low income and greater reliance on climate sensitive sectors, particularly agriculture. Agricultural lands used for cropping and livestock rearing are more susceptible to degradation than non-agricultural lands. Most farmers irrigate through flooding, losing up to 75% of water to evaporation and creating a substantial drawdown of much needed water for …


The Status Of Engineering Geology: Constraints On Infrastructure Development In Bangladesh, Mir Fazlul Karim, Muhammad Qumrul Hassan, Nazrul I. Khandaker, Masud Ahmed, Belal Ahmed Sayeed Nov 2018

The Status Of Engineering Geology: Constraints On Infrastructure Development In Bangladesh, Mir Fazlul Karim, Muhammad Qumrul Hassan, Nazrul I. Khandaker, Masud Ahmed, Belal Ahmed Sayeed

Publications and Research

In recent years, megacity Dhaka is known to have one of the fastest urban population growths in Bangladesh. The population in Dhaka and other megacities has increased from 7 to 50 million during the last four decades. The rapid rate of urban population growth, along with the extreme paucity of real-estate for new infrastructure development or upgrading existing facilities, is already exacerbating the situation for the city planners and exerting tremendous pressure to come-up with viable solutions. Although practice of engineering geology, geotechnical exploration, and testing exists in Bangladesh; the system has still yet to adopt controlled quality standards with …


Nasa Maa (Murep Aerospace Academy) Stem Project At York College: Ensuring Future Stem Pipeline, Nazrul I. Khandaker, Shuayb Siddique, Matthew Khargie, Brandon Dhanraj, Zachary A. Sanichar, Mildred M. Selby, Chabenauth Ramnauth, Theresa Deepan, Yougeeta Singh, Krishna Mahabir, Sashi Singh, Omadevi Singh Nov 2018

Nasa Maa (Murep Aerospace Academy) Stem Project At York College: Ensuring Future Stem Pipeline, Nazrul I. Khandaker, Shuayb Siddique, Matthew Khargie, Brandon Dhanraj, Zachary A. Sanichar, Mildred M. Selby, Chabenauth Ramnauth, Theresa Deepan, Yougeeta Singh, Krishna Mahabir, Sashi Singh, Omadevi Singh

Publications and Research

Our ongoing K1-12 NASA-supported STEM activities has served over 5000 children since 2015, largely from groups that are undeserved and underrepresented in the sciences. These STEM activities have been successfully delivered for several years and include earth science, meteorite geology, rocketry, aerodynamics, star gazing, EV3 Mindstorm robotics, basic coding exercises, wind tunnel, 3D-printing, etc., conducted largely through our present MAA (MUREP Aerospace Academy) Project. Corporate funding from the Con Edison and National Grid ensures additional STEM dissemination to the students during the summer operation. Significant positive component of the MAA program is the availability and willingness of the former student …


The Challenges Of Geotechnical Exploration In Bangladesh For Sustainable Urban Development And Risk Reductions In Engineering Geology, Mir Fazul Karim, Nazrul I. Khandaker, Muhammad Qumrul Hasson, A.T.M. Shakhawat Hossain Nov 2018

The Challenges Of Geotechnical Exploration In Bangladesh For Sustainable Urban Development And Risk Reductions In Engineering Geology, Mir Fazul Karim, Nazrul I. Khandaker, Muhammad Qumrul Hasson, A.T.M. Shakhawat Hossain

Publications and Research

Bangladesh is a unique example of rapid urbanization where the urban population increased from 5 to 58 million in last four decades. Due to complex geology and active tectonic setting, the urban ground is impacted by fluvio-deltaic processes and regional seismicity. The densely populated cities of the country are facing risks from many natural hazards like floods, tidal surge, riverbank and coastal erosion, scour, landslides, soil collapse and foundation failures. Geologists anticipate severe seismic threats from yet-undefined tectonic structures and seek to determine their consequential geo-structural responses and conformance to the national building code. With rapid growth, demands on infrastructure …


Season-Ahead Forecasting Of Water Storage And Irrigation Requirements – An Application To The Southwest Monsoon In India, Arun Ravindranath, Naresh Devineni, Upmanu Lall, Paulina Concha Larrauri Oct 2018

Season-Ahead Forecasting Of Water Storage And Irrigation Requirements – An Application To The Southwest Monsoon In India, Arun Ravindranath, Naresh Devineni, Upmanu Lall, Paulina Concha Larrauri

Publications and Research

Water risk management is a ubiquitous challenge faced by stakeholders in the water or agricultural sector. We present a methodological framework for forecasting water storage requirements and present an application of this methodology to risk assessment in India. The application focused on forecasting crop water stress for potatoes grown during the monsoon season in the Satara district of Maharashtra. Pre-season large-scale climate predictors used to forecast water stress were selected based on an exhaustive search method that evaluates for highest ranked probability skill score and lowest root-mean-squared error in a leave-one-out cross-validation mode. Adaptive forecasts were made in the years …


A Dexterous, Glove-Based Teleoperable Low-Power Soft Robotic Arm For Delicate Deep-Sea Biological Exploration, Brennan T. Phillips, Kaitlyn P. Becker, Shunichi Kurumaya, Kevin C. Galloway, Griffin Whittredge, Daniel M. Vogt, Clark B. Teeple, Michelle H. Rosen, Vincent A. Pieribone, David F. Gruber, Robert J. Wood Oct 2018

A Dexterous, Glove-Based Teleoperable Low-Power Soft Robotic Arm For Delicate Deep-Sea Biological Exploration, Brennan T. Phillips, Kaitlyn P. Becker, Shunichi Kurumaya, Kevin C. Galloway, Griffin Whittredge, Daniel M. Vogt, Clark B. Teeple, Michelle H. Rosen, Vincent A. Pieribone, David F. Gruber, Robert J. Wood

Publications and Research

Modern marine biologists seeking to study or interact with deep-sea organisms are confronted with few options beyond industrial robotic arms, claws, and suction samplers. This limits biological interactions to a subset of “rugged” and mostly immotile fauna. As the deep sea is one of the most biologically diverse and least studied ecosystems on the planet, there is much room for innovation in facilitating delicate interactions with a multitude of organisms. The biodiversity and physiology of shallow marine systems, such as coral reefs, are common study targets due to the easier nature of access; SCUBA diving allows for in situ delicate …


Enhancing 3d Visual Odometry With Single-Camera Stereo Omnidirectional Systems, Carlos A. Jaramillo Sep 2018

Enhancing 3d Visual Odometry With Single-Camera Stereo Omnidirectional Systems, Carlos A. Jaramillo

Dissertations, Theses, and Capstone Projects

We explore low-cost solutions for efficiently improving the 3D pose estimation problem of a single camera moving in an unfamiliar environment. The visual odometry (VO) task -- as it is called when using computer vision to estimate egomotion -- is of particular interest to mobile robots as well as humans with visual impairments. The payload capacity of small robots like micro-aerial vehicles (drones) requires the use of portable perception equipment, which is constrained by size, weight, energy consumption, and processing power. Using a single camera as the passive sensor for the VO task satisfies these requirements, and it motivates the …


Academic Interests, Career Choices And Job Opportunities, Doyel Pal, Praveenkumar Khethavath Aug 2018

Academic Interests, Career Choices And Job Opportunities, Doyel Pal, Praveenkumar Khethavath

Open Educational Resources

This assignment is designed for students in First Year Seminar for Engineering and Computer Science. The main goal of the assignment is to introduce students to their major and stimulating their interests related to career choices and academics. This will give students a chance to develop integrative learning skills by making connections between their major and respective career opportunities. This assignment will use new features of ePortfolio to enhance student’s creativity by customizing everything from background, photos, fonts, text, portfolio content etc. Instead of a uniform profile, each students’ page will reflect the distinct visual representation of their personality, brand, …


An Application Of Game Theory In Distributed Collaborative Decision Making, Angran Xiao Jul 2018

An Application Of Game Theory In Distributed Collaborative Decision Making, Angran Xiao

Publications and Research

In a distributed product realization environment, new paradigms and accompanying software systems are necessary to support the collaborative work of geographically dispersed engineering teams from different disciplines who have different knowledge, experience, tools and resources. To verify the concept of collaboration by separation, we propose a generic information communication medium to enable knowledge representation and exchange between engineering teams, a digital interface. Across digital interfaces, each engineering team maintains its own perspective towards the product realization problem, and each controls a subset of design variables and seeks to maximize its own payoff function subject to individual constraints. Hence, we postulate …


Recent Trends In The Frequency And Duration Of Global Floods, Nasser Najibi, Naresh Devineni Jun 2018

Recent Trends In The Frequency And Duration Of Global Floods, Nasser Najibi, Naresh Devineni

Publications and Research

Frequency and duration of floods are analyzed using the global flood database of the Dartmouth Flood Observatory (DFO) to explore evidence of trends during 1985–2015 at global and latitudinal scales. Three classes of flood duration (i.e., short: 1–7, moderate: 8–20, and long: 21 days and above) are also considered for this analysis. The nonparametric Mann–Kendall trend analysis is used to evaluate three hypotheses addressing potential monotonic trends in the frequency of flood, moments of duration, and frequency of specific flood duration types. We also evaluated if trends could be related to large-scale atmospheric teleconnections using a generalized linear model framework. …


Women In Science: Why So Few? [Liberal Arts: Math And Science], Reem Jaafar, Benjamin J. Taylor Jun 2018

Women In Science: Why So Few? [Liberal Arts: Math And Science], Reem Jaafar, Benjamin J. Taylor

Open Educational Resources

This assigment was developed in the context of LaGuardia’s Center for Teaching and Learning sponsored Learning Matters mini grant “Connection Between First Year Seminar and Capstone Learning Experiences.” It provides Liberal Arts experience to students across the academic spectrum and is designed for students in LMF 101 (First-Year Seminar for Liberal Arts: Math & Science) and is conducted in conjunction with students from a capstone course, LIB 200 (Science, Technology, and Humanism). The assignment aligns with the Inquiry and Problem-Solving Core Competency and the Written Ability. In this assignment, LMF 101 students research and read several articles centered on the …


Bathymetry Data For Lakes Azuei And Enriquillo, Michael Piasecki, Mahrokh Moknatian Feb 2018

Bathymetry Data For Lakes Azuei And Enriquillo, Michael Piasecki, Mahrokh Moknatian

Publications and Research

This data set supports and forms the basis for the development of Digital Bathymetry Models (DBM) for Lakes Azuei (Haiti) and Enriquillo (Dominican Republic). Bathymetric Data is typically acquired using Sonar devices that measure the depth at specific points along a boat track and for which the longitude and latitude is recorded. From the resulting point cloud one develop a seamless representation of the floor of the lake on either a raster set (which is what we have done) or try to use a contour (vector representation) model in which the depth contours appear as polygons or -lines. The raw …


Vision-Based Assistive Indoor Localization, Feng Hu Feb 2018

Vision-Based Assistive Indoor Localization, Feng Hu

Dissertations, Theses, and Capstone Projects

An indoor localization system is of significant importance to the visually impaired in their daily lives by helping them localize themselves and further navigate an indoor environment. In this thesis, a vision-based indoor localization solution is proposed and studied with algorithms and their implementations by maximizing the usage of the visual information surrounding the users for an optimal localization from multiple stages. The contributions of the work include the following: (1) Novel combinations of a daily-used smart phone with a low-cost lens (GoPano) are used to provide an economic, portable, and robust indoor localization service for visually impaired people. (2) …


Nanoporous Carbon-Based Co2 Reduction Catalysts: Exploring The Combined Effects Of Surface Chemistry And Porosity, Wanlu Li Feb 2018

Nanoporous Carbon-Based Co2 Reduction Catalysts: Exploring The Combined Effects Of Surface Chemistry And Porosity, Wanlu Li

Dissertations, Theses, and Capstone Projects

For the first-time sulfur-doped, nitrogen-doped and sulfur, nitrogen-codoped nanoporous carbons were systematically studied as catalysts for CO2 electrochemical reduction reaction (CO2ERR). The Faradaic efficiencies (FE) of CO and CH4 formation were calculated to evaluate the performance of these carbons. The best catalysts showed the FE of CO and CH4 formation of 29% and 0.76%, respectively. It was found that the overall performance in CO2ERR dramatically increased upon the reduction pretreatment of the carbons in N2-saturated electrolyte before the CO2 reduction process. The pretreated carbon showed the maximum FE of CO …


Communication Based Control For Dc Microgrids, Mahmoud S. Saleh, Yusef Esa, Ahmed Mohamed Jan 2018

Communication Based Control For Dc Microgrids, Mahmoud S. Saleh, Yusef Esa, Ahmed Mohamed

Publications and Research

Centralized communication-based control is one of the main methods that can be implemented to achieve autonomous advanced energy management capabilities in DC microgrids. However, its major limitation is the fact that communication bandwidth and computation resources are limited in practical applications. This can be often improved by avoiding redundant communications and complex computations. In this paper, an autonomous communication-based hybrid state/event driven control scheme is proposed. This control scheme is hierarchical and heuristic, such that on the primary control level, it encompasses state-driven local controllers, and on the secondary control level, an event-driven MG centralized controller (MGCC) is used. This …


Computational Methods In Civil Engineering, Nir Krakauer Jan 2018

Computational Methods In Civil Engineering, Nir Krakauer

Open Educational Resources

No abstract provided.


Developing A 3d In Vitro Model By Microfluidics, Hung-Ta Chien Jan 2018

Developing A 3d In Vitro Model By Microfluidics, Hung-Ta Chien

Dissertations and Theses

In vitro tissue models play an important role in providing a platform that mimics the realistic tissue microenvironment for stimulating and characterizing the cellular behavior. In particular, the hydrogel-based 3D in vitro models allow the cells to grow and interact with their surroundings in all directions, thus better mimicking in vivo than their 2D counterparts. The objective of this thesis is to establish a 3D in vitro model that mimics the anatomical and functional complexity of the realistic cancer microenvironment for conveniently studying the transport coupling in porous tissue structures. We pack uniform-sized PEGDA-GelMA microgels in a microfluidic chip to …


Breadcrumbs: Privacy As A Privilege, Prachi Bhardwaj Dec 2017

Breadcrumbs: Privacy As A Privilege, Prachi Bhardwaj

Capstones

Breadcrumbs: Privacy as a Privilege Abstract

By: Prachi Bhardwaj

In 2017, the world saw more data breaches than in any year prior. The count was more than the all-time high record in 2016, which was 40 percent more than the year before that.

That’s because consumer data is incredibly valuable today. In the last three decades, data storage has gone from being stored physically to being stored almost entirely digitally, which means consumer data is more accessible and applicable to business strategies. As a result, companies are gathering data in ways previously unknown to the average consumer, and hackers are …


Assessment Of Differences Between Near-Surface Air And Soil Temperatures For Reliable Detection Of High-Latitude Freeze And Thaw States, Farjana Shati, Satya Prakash, Hamid Norouzi, Reginald Blake Oct 2017

Assessment Of Differences Between Near-Surface Air And Soil Temperatures For Reliable Detection Of High-Latitude Freeze And Thaw States, Farjana Shati, Satya Prakash, Hamid Norouzi, Reginald Blake

Publications and Research

Near-surface air temperature and the underlying soil temperature are among the key components of the Earth’s surface energy budget, and they are important variables for the comprehensive assessment of global climate change. Better understanding of the difference in magnitude between these two variables over high-latitude regions is also crucial for accurate detections of freeze and thaw (FT) states. However, these differences are not usually considered and included in current remote sensing-based FT detection algorithms. In this study, the difference between near-surface air temperature at the 2-meter height and soil temperature at the 5-centimeter depth is assessed using ground-based observations that …


Learning About Women In Stem For First-Year Students [Liberal Arts: Math And Science], Reem Jaafar, Ian Alberts Oct 2017

Learning About Women In Stem For First-Year Students [Liberal Arts: Math And Science], Reem Jaafar, Ian Alberts

Open Educational Resources

This assignment was designed for students in the first year seminar and aligns with the Inquiry and Problem Solving core competency, with a focus on “framing the issues” (identifies and/or addresses questions problems and/or hypothesis informed by knowledge of context) and “evidence gathering” (assembles, reviews and synthesizes evidence from diverse sources of relevant knowledge). Both assignments rely on writing and one may include an oral component. In writing, the focus is on “Content Development and Organization,” as well as “Control of Language, Syntax, and Mechanics.”

LaGuardia’s Core Competencies and Communication Abilities

Main Course Learning Objectives:

  • The LMF course for Liberal …


Nonlinear Optical Studies Of Defects And Domain Structures In Perovskite-Type Dielectric Ceramics, David J. Ascienzo Sep 2017

Nonlinear Optical Studies Of Defects And Domain Structures In Perovskite-Type Dielectric Ceramics, David J. Ascienzo

Dissertations, Theses, and Capstone Projects

In order to improve future generations of dielectric capacitors a deeper understanding of voltage-induced dielectric breakdown and electrical energy storage limitations is required. This dissertation presents the use of far-field optical second harmonic generation (SHG) polarimetry for probing structural defects and polar domains in linear and nonlinear perovskite dielectric ceramics. We investigated the formation of electric field-induced structural distortions at pristine Fe-doped SrTiO3 (Fe:STO) electrode interfaces, structural defect and strain formation due to oxygen vacancy migration in electrodegraded Fe:STO single crystals, and mixed tetragonal and rhombohedral phase domains in ferroelectric Zr-doped BaTiO3 (BZT) films exhibiting excellent …


Chelator-Free Radiolabeling Of Serrs Nanoparticles For Whole-Body Pet And Intraoperative Raman Imaging, Matthew A. Wall, Travis Shaffer, Stefan Harmsen, Darjus-Felix Tschaharganeh, Chun-Hao Huang, Scott W. Lowe, Charles Michael Drain, Moritz F. Kircher Jul 2017

Chelator-Free Radiolabeling Of Serrs Nanoparticles For Whole-Body Pet And Intraoperative Raman Imaging, Matthew A. Wall, Travis Shaffer, Stefan Harmsen, Darjus-Felix Tschaharganeh, Chun-Hao Huang, Scott W. Lowe, Charles Michael Drain, Moritz F. Kircher

Publications and Research

A single contrast agent that offers whole-body non-invasive imaging along with the superior sensitivity and spatial resolution of surface-enhanced resonance Raman scattering (SERRS) imaging would allow both pre-operative mapping and intraoperative imaging and thus be highly desirable. We hypothesized that labeling our recently reported ultrabright SERRS nanoparticles with a suitable radiotracer would enable pre-operative identification of regions of interest with whole body imaging that can be rapidly corroborated with a Raman imaging device or handheld Raman scanner in order to provide high precision guidance during surgical procedures. Here we present a straightforward new method that produces radiolabeled SERRS nanoparticles for …