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Centrifugo-Pneumatic Valving Utilizing Dissolvable Films, Robert Gorkin Iii, Charles Nwankire, Jennifer Gaughran, Xin Zhang, Gerard Donohoe, Martha Rook, Richard O'Kennedy, Jens Ducree
Centrifugo-Pneumatic Valving Utilizing Dissolvable Films, Robert Gorkin Iii, Charles Nwankire, Jennifer Gaughran, Xin Zhang, Gerard Donohoe, Martha Rook, Richard O'Kennedy, Jens Ducree
Robert Gorkin III
In this article we introduce a novel technology that utilizes specialized water dissolvable thin films for valving in centrifugal microfluidic systems. In previous work (William Meathrel and Cathy Moritz, IVD Technologies, 2007), dissolvable films (DFs) have been assembled in laminar flow devices to form efficient sacrificial valves where DFs simply open by direct contact with liquid. Here, we build on the original DF valving scheme to leverage sophisticated, merely rotationally actuated vapour barriers and flow control for enabling comprehensive assay integration with low-complexity instrumentation on "lab-on-a-disc" platforms. The advanced sacrificial valving function is achieved by creating an inverted gas-liquid stack …