Engineering Commons^™

The Study Of Physiochemical Properties Of Cerium Oxide Nanoparticles And Its Application In Biosensors, Swetha Barkam

Electronic Theses and Dissertations

Biosensors continue to get smaller and faster with the advancement in nanotechnology through the use of nanomaterials to achieve high sensitivity and selectivity. However, the continued reliance on biomolecules or enzymes in the biosensor assembly poses the problem of reproducibility, storage and complexity. This dissertation research address some of the challenges by investigating the physiochemical properties of nanoparticles to understand its interaction with biological systems and develop enzyme free biosensors. In this study, we have demonstrated a novel strategy to integrate cerium oxide nanoparticles (CNPs) as an efficient transducer through rigorous screening for developing enzyme/label free biosensors for detecting analytes …

Redox-Active Solid State Materials And Its Biomedical And Biosensing Applications, Ankur Gupta

Electronic Theses and Dissertations

Reactive oxygen species (ROS) are byproducts of physiological processes in human body, and strengthened production of ROS is known to cause acute conditions such as inflammation, aging, Alzheimer's disease, melanoma and ovarian cancer, fibrosis and multiple sclerosis. Therefore, early detection of ROS at nanomolar concentration (at cellular level) and developing more potent antioxidants is essential for regular health monitoring. As an example, ROS are also responsible for inflammation reactions at orthopedic implants-tissue interface triggered by wear debris. Inflammation induced by ROS results in revision surgery. Coatings of redox-active materials exhibiting antioxidant properties on implants have potential to mitigate the inflammation …

Polyelectrolyte And Hydrogel Stabilized Liquid Crystal Droplets For The Detection Of Bile Acids, Jinan Deng

Electronic Theses and Dissertations

Liquid crystal (LC) droplets show great potential as an optical probe for sensor applications due to their large surface areas and stimuli-response director configurations. Bile acids with amphipathic properties, which are formed in liver and secreted into the small intestine, play an important role in the digestion of fats and fat-soluble vitamins. After the digestion process, most of bile acids are recycled back to the liver and ready for the next digestion. Only a few of them are excreted into body fluids. However, there is significant increases in the concentration level of bile acids in body fluids for patients with …

Developing An Insider Threat Experimental Environment, Eric Ortiz

Electronic Theses and Dissertations

Simulated, 3D gaming environments have been used for a wide-range of applications including training, entertainment, and experimentation in an assortment of domains for some time. This can be attributed to their unique ability to emulate multifaceted situations that may be difficult to control, while affording participants the opportunity to operate in a relatively safe environment. In cybersecurity research, investigation of insider threat behavior is an endeavor that has received little attention in terms of available environments and resources for experimental manipulation. This research effort aimed to close this gap. A simulated, 3D gaming environment and accompanying scenarios were developed for …

Anisotropy Evolution Due To Surface Treatment On 3d-Printed Fused Deposition Modeling (Fdm) Of Acrylonitrile Butadiene Styrene (Abs), Blake E. Lozinski

Honors Undergraduate Theses

Purpose: This paper will present insight to the methodology and results of the experimental characterization of Acrylonitrile Butadiene Styrene (ABS) using Fused Deposition Modeling (FDM). The work in this research explored the effects of print orientation, surface treatment, and ultraviolet (UV) light degradation with the utilization of Digital Image Correlation (DIC) on ABS tensile specimens.

Design/methodology: ABS specimens were printed at three build orientations (flat (0 degrees), 45 degrees, and up-right (90 degrees)). Each of these specimens were treated with three different surface treatments including a control (acrylic paint, Cyanoacrylate, and Diglycidyl Bisphenol A) followed by exposure to UV light …