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The Effects Of Solution Condition On Virus Filtration Performance, Fnu Namila
The Effects Of Solution Condition On Virus Filtration Performance, Fnu Namila
Graduate Theses and Dissertations
Virus filtration is an integral part of the downstream purification of mammalian cell culture-derived biotherapeutics to assure the viral safety of the products. Virus filtration membranes remove viruses based on a size-exclusion mechanism. Commercial parvovirus filers possess unique membrane structure and are designed to remove smaller non-enveloped parvoviruses with size 18-26 nm. However, some filters face issues, such as pre-mature fouling, the decline of filtrate flux, and reduction in virus retention. This doctoral dissertation focused on identifying the factors that influence the filtrate flux and the virus retention capability of commercial virus filters. The effects of solution pH and ionic …
Scale-Up Of Polyaniline Cellulose Membranes, Isaac Bodemann
Scale-Up Of Polyaniline Cellulose Membranes, Isaac Bodemann
Chemical Engineering Undergraduate Honors Theses
Polyaniline coated cellulose membranes show impressive conductive properties that may be used to innovate traditional charged separation techniques, such as electrodeionization. However, these membranes are not sold to consumers, so they cannot be easily integrated into such systems. This research focuses on the scale-up and development of positively charged anion exchange membranes to be used in EDI cells. Novel cellulose membranes were made using lab-specific cellulose. These membranes were then coated using a polyaniline technique adopted from a paper titled, “Flexible Electrically Conductive Nanocomposite Membrane Based on Bacterial Cellulose and Polyaniline." This paper details the methods used to add the …
Methods For Film Coating Electrospun Fibers, Kristopher Dejean
Methods For Film Coating Electrospun Fibers, Kristopher Dejean
Williams Honors College, Honors Research Projects
Electrospinning uses high voltages to form polymer nanofiber membranes. These membranes have potential for use in filtration, tissue engineering, drug delivery, and catalysis. The nonwoven fiber mat is malleable but has a low tensile strength compared to a solid film of the same polymer. Joining the fibers with a thin film is desired to balance the strength and flexibility. Three methods of producing a film on fiber membrane were tested. The techniques are spraying then melting, spin coating, and dip coating. Electrospinning setup conditions, solvent ratios, damage to fibers, and spin coating speeds were determined. Research was abruptly stopped and …