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Articles 121 - 150 of 177
Full-Text Articles in Engineering
Synthesis And Biological Evaluation Of Cannabinoid Receptor Ligands, Mariah Leigh Cole
Synthesis And Biological Evaluation Of Cannabinoid Receptor Ligands, Mariah Leigh Cole
Honors Theses
The cannabinoid receptors, members of the G-protein coupled receptor (GPCR) superfamily, have been implicated in numerous human physiological functions and diseases. These receptors, cannabinoid type 1 (CB1) and cannabinoid type 2 (CB2), are most concentrated in the central nervous system and immune cells, respectively, and have each become a target of therapeutic interest. Dual CB1/CB2 agonists such as delta-9-tetrahydrocannbinol (THC) have demonstrated efficacy in the treatment of nausea, pain, and glaucoma, but suffer from psychotropic effects mediated by CB1, motivating the search for CB2 selective therapeutic agents. Selective modulation of the CB2 receptor has therapeutic potential in human health disorders …
Biochemical Variation In Caribbean Sponges Of The Genus Aplysina, Sarah L. Criddle
Biochemical Variation In Caribbean Sponges Of The Genus Aplysina, Sarah L. Criddle
Honors Theses
Sponges are among the simplest multicellular organisms, consisting of groupings of cells with similar functions rather than true tissues. Nonetheless, sponges are ecologically significant in many marine environments, including coral reefs. They are sedentary organisms that feed by filtration from the water column, which contributes to the numerous roles they play on coral reefs, including upkeep of the reef, production of usable energy, and recycling of nutrients. Like all multicellular organisms, sponges are made up of biologically significant macromolecules. These macromolecules provide the energy for the sponge, and their relative concentrations determine how sponges can store and access the energy …
Atomic Force Microscopy Of Poly(Ethylane-Oxide) Crystalization, Xavier Capaldi
Atomic Force Microscopy Of Poly(Ethylane-Oxide) Crystalization, Xavier Capaldi
Honors Theses
Polymer crystallization is a complex process which is influenced by a variety of factors. Atomic force microscopy is used to explore the material properties of polymer crystals. Poly(ethylene-oxide) is used in a variety of molecular weights as the sample. In addition, a variety of sample preparation methods and microscopy modes were tested. A relatively new imaging technique was identified for the characterization of polymer crystals: amplitude modulation-frequency modulation viscoelastic mapping. This mode was used to measure material properties such as stiffness and dissipation.
Gasoline Confined In Nano-Porous Media, Matthew Giso
Gasoline Confined In Nano-Porous Media, Matthew Giso
Honors Theses
The heat of combustion was determined for gasoline confined in nano-porous media of differing pore size by bomb calorimetry. The heat of combustion of the confined fuels was comparable to that of bulk within the experimental uncertainty. This suggests that all of the confined fuel burns without any flame quenching and no chemical interactions at the interface between pore walls and fuel mitigate combustion.
Modeling Product Cooling For Baked And Snack Crackers, Jenna Hagenloch
Modeling Product Cooling For Baked And Snack Crackers, Jenna Hagenloch
Honors Theses
The cooling of snack crackers, after the baking process is an important step prior to packaging. A model was developed for cooling the crackers. The model allows for the adjustment of multiple operating conditions, such as temperature, depth of the crackers, and the speed of the line. The completed model provides the user with the ability to predict cooling requirements and to validate pre-existing equipment operating conditions. The model will aid in the design of new equipment as well as modifications to improve existing installations to operate within the desired specifications for each process.
The Exacerbating Effect Of Coastal Erosion To Orphan Well Risk Analysis In Terrebonne Parish, Taylor Reeves
The Exacerbating Effect Of Coastal Erosion To Orphan Well Risk Analysis In Terrebonne Parish, Taylor Reeves
Honors Theses
No abstract provided.
Core-Shell Nanoparticles For The Desulfurization Of Biogas, Joshua Saltz
Core-Shell Nanoparticles For The Desulfurization Of Biogas, Joshua Saltz
Honors Theses
No abstract provided.
Modeling The Effects Of Mass Transport On The Electrochemical Reduction Of Co2 At Cu2o Surfaces, Edward Alexander Thistlethwaite Iii
Modeling The Effects Of Mass Transport On The Electrochemical Reduction Of Co2 At Cu2o Surfaces, Edward Alexander Thistlethwaite Iii
Honors Theses
No abstract provided.
Modeling Of Reaction Kinetics And Mass Transfer Of Carbon Dioxide Electrochemical Reduction, Sneha Seetharama
Modeling Of Reaction Kinetics And Mass Transfer Of Carbon Dioxide Electrochemical Reduction, Sneha Seetharama
Honors Theses
No abstract provided.
Single Cell Encapsulation Using A Microfluidic Droplet Generator, Seleipiri Charles
Single Cell Encapsulation Using A Microfluidic Droplet Generator, Seleipiri Charles
Honors Theses
No abstract provided.
Eliminating Magnetic Forces From The Surface Tension Measurement Of Magnetic Surfactants, Emily Koehler
Eliminating Magnetic Forces From The Surface Tension Measurement Of Magnetic Surfactants, Emily Koehler
Honors Theses
Surfactants have many applications due to their ability to reduce the surface tension between two phases. Magnetic surfactants, a relatively new form of surfactants, offer the possibility of further controlling a surfactant system by using an external magnetic field to induce alignment on the molecular level. One method of studying a magnetic field's effect on the magnetic surfactant system involves analyzing the change in surface tension at varied solution concentrations both in and outside a magnetic field. The pendent drop method uses the downward gravitational force on a droplet suspended from a needle to find the surface tension based on …
Preparation And Evaluation Of Aripiprazole-Loaded Ph-Modulated Solid Dispersion Via Hot-Melt Extrusion Technology, Haley Mcfall
Preparation And Evaluation Of Aripiprazole-Loaded Ph-Modulated Solid Dispersion Via Hot-Melt Extrusion Technology, Haley Mcfall
Honors Theses
The objective of this study was to prepare aripiprazole (ARI)-loaded solid dispersions (SDs) to enhance solubility and dissolution via hot-melt extrusion (HME) technology. ARI was chosen due to its poorly water-soluble properties. Solubility screenings of various polymers and acidifiers were performed to select appropriate excipients for the SD. Succinic acid (SA) and Kollidon 12 PF (PVP) were selected as the acidifier and the polymer, respectively. Differential scanning calorimetry and thermogravimetric analysis were used to determine the miscibility, interactions, and thermal stability of the drug and selected excipients. MODDE 8.0 is a design of experiment software that was implemented to produce …
An Evaluation Of The Relationship Between Sigma-1 And Sigma-2 Receptors And The Endocannabinoid System, Jenn Miller
An Evaluation Of The Relationship Between Sigma-1 And Sigma-2 Receptors And The Endocannabinoid System, Jenn Miller
Honors Theses
Within the past two decades, sigma receptors have become a popular area for research. Although much has been learned about their structure, subtypes, and functions; there is still much to be learned. Consisting of two receptor subtypes (sigma-1 and sigma-2), it has been discovered that sigma receptor ligands potentiate the analgesic effects of both opiates and cannabinoids, though the exact mechanism and sigma subtype on which this occurs is still unknown. The purpose of this study is to determine if potentiation of opiates and cannabinoids occurs through sigma-1 or sigma-2 receptor signaling. Tetrad assays were performed for: 1. Morphine, an …
Biological Activity Of Garcinia Kola On Hepatitis C, Madeline Dwyer
Biological Activity Of Garcinia Kola On Hepatitis C, Madeline Dwyer
Honors Theses
Hepatitis C is a liver disease caused by the hepatitis C virus (HCV). According to the World Health Organization, hepatitis C infections affect between 130-150 million people worldwide. It is a major cause of liver cirrhosis and liver cancer, and approximately 500,000 people die from hepatitis C infections or related complications each year. Although new treatments are 90% effective at curing chronic hepatitis C infections, they cost tens of thousands of dollars. Available treatments are incredibly cost prohibitive, especially considering that the regions most affected by hepatitis C are Africa and central and eastern Asia (Hepatitis C). This creates a …
Optimization Of Fluidized Bed Isothermal Reactor In A Styrene Production Process, Matthew Hamilton Peaster
Optimization Of Fluidized Bed Isothermal Reactor In A Styrene Production Process, Matthew Hamilton Peaster
Honors Theses
The focus of this thesis is to explain the optimization of a fluidized bed isothermal reactor in a styrene production process. The first section of the thesis gives a summary of chemical process optimization in general. The next portion of the thesis gives an introduction to chemical process simulation software, and it explains how simulation software aids in the design and optimization of chemical processes. The third section of the thesis gives a brief overview of an optimization project of a styrene production process that was completed in the previous semester with a group of three. The final section explains …
The Creation Of Instructional Video Tutorials For Chemical Engineering Process Simulation Software, Nishal Bhikha
The Creation Of Instructional Video Tutorials For Chemical Engineering Process Simulation Software, Nishal Bhikha
Honors Theses
Process simulation software is rapidly becoming a necessity in today's world. Often, learning how to use such a complex tool can be difficult and can take a significant period of time. This thesis outlines efforts to aid in the instruction of this type of software at the University of Mississippi.
Optimization Of Single And Multiple Unit Chemical Processes: A Case Study On The Optimization Of A Styrene Plant Design, Piero Bracamonte
Optimization Of Single And Multiple Unit Chemical Processes: A Case Study On The Optimization Of A Styrene Plant Design, Piero Bracamonte
Honors Theses
Optimizing a chemical plant revolves around achieving an efficiency that takes into account operating constraints and costs, along with production requirements and addressing environmental concerns. The first part of this thesis focuses on the team's optimization of a styrene production plant. The goal was to determine what changes from the base case minimize cost to produce the required amount of styrene while adhering to operating constraints. The team used PRO/II, a steady state process simulator, in order to simulate multiple unit operations included in the plant. The measure by which proposed design changes were compared was the calculated net present …
Design Of A Caustic Injection System In A Crude Distillation Unit, Andrew R. Cope
Design Of A Caustic Injection System In A Crude Distillation Unit, Andrew R. Cope
Honors Theses
Caustic Injection is a high-risk chemical process utilized in many refineries across the world to control overhead corrosion in the atmospheric distillation column of the Crude Distillation Unit. This thesis discusses the considerations that need to be accounted for in the design of a caustic injection system, as well as my own work at an internship where I was a member of a design team that worked to design a caustic injection system for a nearby refinery.
Exploration Of Compound Viability As An Organ-Selective Anti-Metastatic Therapeutic Treatment For Triple Negative Breast Cancer, Ashley E. Noblin
Exploration Of Compound Viability As An Organ-Selective Anti-Metastatic Therapeutic Treatment For Triple Negative Breast Cancer, Ashley E. Noblin
Honors Theses
Phenformin and metformin are compounds that are currently used to treat Type II Diabetes and have been shown to suppress breast cancer metastasis. These compounds were tested, after extensive research and screening of current approved oncology drugs, in various experiments with the cell lines MDA-MB-231, LM, and BoM, with MDA-MB-231 being the parental cell line, LM being the lung metastatic line, and BoM being the bone metastatic line. The cells were treated with compound addition at various concentrations and subject to a two-day concentration response viability study in order to determine any inhibitory effects, followed by a five-day assay in …
A Practical Guide To Chemical Process Optimization: Analysis Of A Styrene Plant, Fleur Phelps
A Practical Guide To Chemical Process Optimization: Analysis Of A Styrene Plant, Fleur Phelps
Honors Theses
This report acts as a beginner's guide to chemical processes optimization. Performed universally, optimization merely entails improving an existing process, situation, device or system. For a chemical engineer, optimization typically aims to maximize potential economics of a chemical process by manipulating decision variables while staying within known constraints. In order to maximize the overall economics of a chemical process, individual equipment or stream conditions are examined. The chemical process is implemented in simulation software The optimization of individual components of the process may aim to maximize or minimize an outcome specific to that component, but still ultimately maximizes economic potential. …
Design And Synthesis Of Dual Opioids/Npff Ligands As Novel Analgesics With Reduced Tolerance Potential, John N. Yi
Design And Synthesis Of Dual Opioids/Npff Ligands As Novel Analgesics With Reduced Tolerance Potential, John N. Yi
Honors Theses
Opioid use has become prevalent in today's culture. As a treatment for acute and chronic pain, opioids permeate in the public sphere as a seemingly easy solution. However, problems that come from the increased use of opiates, especially in the last fifteen years, have shown detrimental effects in society. Not only are all opioid-based analgesics considered addictive, but the nature of such painkillers also enables a phenomenon known as tolerance, where the body adapts to the use of exogenous opioids. This creates a situation where a more potent dose of painkiller is required for the same analgesic effect. The focus …
G-Quadruplex Mediated Splicing Of P53 Mrna, Melissa Holy
G-Quadruplex Mediated Splicing Of P53 Mrna, Melissa Holy
Honors Theses
The protein p53 is a master regulator of the cell cycle and its mutation/inactivation is associated with over 50% of cancer cases. Mutations in p53 are associated with worse survival rates, resistance to therapies, and other risk factors in breast cancer specifically. p53 is encoded by the TP53 gene and is expressed as several transcripts. In the G-rich portion of intron 3, secondary DNA structures known as G-quadruplexes are able to form. The stabilization of these G-quadruplexes leads to correct splicing of intron 2, thus making a functional p53 protein. A known quadruplex-stabilizing compound (TMPyP4) was tested to determine its …
The Effects Of Genistein, Thymoquinone, Epigallocatechin-3-Gallate,5-Fluorouracil, And Low Level Laser Therapy On Fadu Hypopharyngeal And Laryngeal Carcinoma Cells, Osasu Adah
Honors Theses
Laryngeal and hypopharyngeal carcinoma are two types of head and neck squamous cell carcinomas. The location of the tumor makes it hard to detect without complex tests. Overall, these types of cancer are not common, and there are no simple screening tests for such cancers. Due to this issue, laryngeal and hypopharyngeal carcinoma are usually diagnosed when signs and symptoms occur, such as sore throat, trouble swallowing, and constant coughing. With the use of FaDu, a head and neck cancer cell line of the hypopharyngeal origin, experimentation can be performed in order to initiate possible treatments. The standard treatments for …
The Effects Of Colorimetry And Spectroscopy Using The Iso M0, M1 And M2 Modes, Kaylee Flannery
The Effects Of Colorimetry And Spectroscopy Using The Iso M0, M1 And M2 Modes, Kaylee Flannery
Honors Theses
The use of Optical Brightening Agents (OBA’s) in printing and proofing papers has drastically increased and, while the use of OBA’s has improved the appearance for end-use consumers, it represents great challenges to those attempting to successfully color manage the print. Therefore, standards have been created in order to assist in the measurement of these papers, and can be found within ISO 13655-2009: Spectral Measurement and Colorimetric Computation for Graphic Arts Images. This newly defined measurement standard is referred to as the “M” series. While this new standard has its advantages, it also poses some disadvantages. This report will …
Substantiate Percent Yield Within Aerosol Personal Care Plant, Gregory Maxwell
Substantiate Percent Yield Within Aerosol Personal Care Plant, Gregory Maxwell
Honors Theses
The project identified losses of bulk product throughout the mix and packaging process substantiating percent yield. Support data for yield calculations was found by mapping multiple equipment trains, collecting and weighing samples, tracking waste streams, and executing engineering studies. The completed studies identified and verified product loss ensuring the accuracy of yield calculations. This project identified potential cost savings to the facilities.
Secondary Metabolites Isolated From Perovskia Atriplicifolia And Their In Vitro Binding Affinity For Human Opioid And Cannabinoid Receptors, Ashli Fitzpatrick
Secondary Metabolites Isolated From Perovskia Atriplicifolia And Their In Vitro Binding Affinity For Human Opioid And Cannabinoid Receptors, Ashli Fitzpatrick
Honors Theses
Plants and their natural products have been utilized for thousands of years in the treatment of many human diseases. Because of their structural diversity, natural products are ideal lead compounds for drug development. In this thesis, the natural products of the plant Perovskia atriplicifolia were investigated, specifically their in vitro binding affinity to receptors in opioid and cannabinoid classes. Extracts that demonstrated good selective opioid and cannabinoid receptor binding were subjected to bioassay-guided fractionation. Four active compounds were identified from the crude extract in Perovskia atriplicifolia: 1) 5-hydroxy-3',4',6,7-tetramethoxy flavone, 2) 5,7-dihydroxy-3',4',6,-trimethoxy flavone, 3) 5-hydroxy-4',6,7-trimethoxy flavone, and 4) 5,7-dihydroxy-4',6,-dimethoxy flavone. Each …
Optimization Of An Ethylbenzene Process, Garrison Padgett Morgan
Optimization Of An Ethylbenzene Process, Garrison Padgett Morgan
Honors Theses
In industry, chemical plants should be running at optimal performance in order to maximize profit. However, this is frequently not the case. Optimization is the process of improving an existing situation, device, or, in the case of chemical engineers, a chemical process. Furthermore, there are numerous strategies to optimize a chemical process, and it is up to the engineer to decide what to change in order to make the optimization worthwhile. Last semester, I was able to show my knowledge of optimization by applying changes to an existing ethylbenzene producing plant. I simulated the base case for this plant and …
Delivery Of A Fatty Acid Signal Via Rtil For Biofilm Dispersion, Rachaud M. Keyes
Delivery Of A Fatty Acid Signal Via Rtil For Biofilm Dispersion, Rachaud M. Keyes
Honors Theses
A number of proposed applications for ionic liquids involve ionic liquid/water interfaces, such as, chemical separations or drug delivery systems. Therefore, an understanding of the solubility and micellar behavior of ionic liquids in an aqueous environment is critical fundamental knowledge. The long term goal of our study was ionic liquids for delivery of biological active agents; therefore, we chose the anion, bis(trifluoromethanesulfonyl)imide (Tf2N) since it promotes water stability and forms water immiscible RTILs. The study then paired the Tf2N-anion with three different classes of cations. By adding apolar substituents (-CH2-) to the cation, the size of the molecule increases in …
Targeting G-Quadruplexes Within The Adam-15 Promoter: A Novel Therapeutic Approach For Breast Cancer, Rachel L. Jenkins
Targeting G-Quadruplexes Within The Adam-15 Promoter: A Novel Therapeutic Approach For Breast Cancer, Rachel L. Jenkins
Honors Theses
ADAM-15 is a protein that is up-regulated in many diseases, particularly breast cancer; its over-expression is correlated with more aggressive and invasive phenotypes. The critical core promoter region of ADAM-15 is capable of forming a secondary DNA structure known as a G-quadruplex. The stabilization of this G-quadruplex has the potential to decrease the transcription of the over-expressed ADAM-15 protein. Six hundred forty compounds were screened for their ability to cause a shift in the melting temperature of an ADAM-15 oligonucleotide using FRET melt. Two compounds, NSC 146771 and NSC 260594, produced a significant shift in the melting temperature; further experimentation, …
A Guide To Process Optimization, Shannon Leeann Kynerd
A Guide To Process Optimization, Shannon Leeann Kynerd
Honors Theses
Optimization is improving upon an existing process. Generally, the motivation behind optimization is economical. Companies are always looking for ways to improve their process in order to maximize their profit. There are several key steps and strategies that need to be followed in order to guarantee an optimized process and ultimately the maximum profit. An analysis of the base case is essential to optimization. If the starting point is not fully known, then the amount of progress is not known. The top-down and bottom-up strategies determine the overall procedure for optimization. Top-down begins with the big picture while bottom-up starts …