Engineering Commons^™

An Analysis Of A Custom Expanding Total Femoral Prosthesis With A Rotating Hinge Knee, Ramarao Gundlapalli, V. Gundlapalli

Theses

Osteosarcoma is the most common malignant bone tumor in the pediatric age group. This thesis presents the analysis of a total femoral prosthesis implanted in a 9 year old black male. The design includes a bipolar, expanding mid-shaft component, and a rotating hinge knee used in the reconstruction of the patient's right lower limb after surgical resection of the femur. The areas being analyzed are (i) the trochanteric attachment, (ii) the expanding component, and (iii) the rotating hinge knee. The stresses acting on the cables reconnecting the greater and lesser trochanter were determined for bipedal stance, single-legged stance, stance phase …

Computer Assisted Molecular Modeling Of Thymidine Nucleoside Analog Inhibitors Of Hiv-1 Reverse Transcriptase, Mark A. Fisher

Theses

An active analog approach to receptor mapping was used to identify the three dimensional structural characteristics associated with a series of thymidine nucleoside analog inhibitors of HIV-1 reverse transcriptase (RT) that may be essential for their activity. Atomic substitutions at the 5 and 3' positions of nucleoside analogs confer global structural and electrostatic changes that result in either increased or diminished inhibitory activity. From a structural perspective, the activity differences can be attributed to the presentation of select atoms in three dimensional motifs that are common to all active compounds and absent or distorted in inactive/poorly active compounds.

The identification …

Optimization Of Flow In The Collecting Duct During The Concentrating Mode And The Diluting Mode In A Nephron Population Of Two Different Length With The Renin Angiotensin System And Adh Mechanism, Sivakumar Subramanian

Theses

Our present study is to find out how the short and long nephrons are interacting in the human kidney to adjust the flow in the collecting duct to have the maximum flow during the diluting mode and minimum flow during the concentrating mode. The best lengths for the short nephron and long nephron are calculated during the concentrating mode and the diluting mode by using the Newton-Raphson method. If one wants the kidney to perform only the above mentioned functions, a design criteria for an artificial kidney has been proposed. These studies have provided qualitative information regarding the concentrating mechanism …

A Review Of Acetabular Prostheses For Total Hip Arthroplasty, Jennifer Anne Citarella

Theses

This study explores the evolution, design, and clinical progress of contemporary prostheses used in orthopaedic reconstruction of the socket of the hip joint. A literature search was performed to study acetabular implants, as used in total hip arthroplasty. The history of the design of these implants is chronicled. Next, the anatomy of the acetabular region and the surgical technique performed to replace the hip socket are presented. A comprehensive discussion of the design features, rationale, and clinical results for commercially available cemented and cementless prostheses follows.

Hydroxyapatite, a bioceramic which has just recently been approved for applications in total hip …

An Experimental Investigation Of Wear Behavior Of Ultra-High Molecular Weight Polyethylene Under Sliding Motion, Elham Zand-Moghaddam

Theses

This project investigates the effect of sliding motion on the materials that are used as bearing surfaces of human total-joint replacement prostheses.

The tests are performed with a specially designed equipment based on pin-on-disk machine. The testing machine is designed and constructed to reproduce sliding motion, applied to spherical ended metal "Canine-Head" components such as dog hip acting on a flat polyethylene surface. The sliding motion is performed by applying different constant loads for 5,000,000 cycles. The tests are carried out with the wear specimen lubricated by deionized water.

The purpose is to produce delamination, which is the severe wear …

Comparison Of Heart Rate With Chest Wall Vibrations, Kofi M. Arbuah

Theses

A study is done using a Microwave Interferometer as a computer-assisted non-invasive cardiopulmonary monitor. The Microwave Interferometer is used to record the mechanical vibration of the anterior chest wall by recording the velocity of the displacement of the chest wall. The objective is to first, record mechanical vibrations of the anterior chest wall at different heart rates, and second, attempt to identify the relation between heart rate and chest wall vibration.

The system uses two channels, the first signal produced by the Microwave Interferometer is a record of the velocity of the displacement of the chest wall caused by the …

Blur Identification And Restoration Of Images Of Coronary Microvessel, Kuen Tak Wong

Theses

The objective of this research was to identify the blur characteristics of the blurred images of the rat coronary microvessel, and the information of the blur characteristics was used to restore the blurred images. The blur characteristics were analyzed by using the image power cepstrum. The Wiener filter was implemented to restore the images. There were two types of point spread functions proposed and studied for the restoration. They were: defocus blur PSF and motion blur PSF. The images were transferred from HP A900 system to an AVS workstation. The images were processed and manipulated by the AVS, and showed …

Study Of Emg Frequency Behavior, Mark Steven Fiedorowicz

Theses

It has previously been determined that the power spectral density of an electromyogram shifts towards lower frequencies over time during an isometric contraction. In this study the power spectral density curve was examined to see if changes would occur over a period of time as a subject walked on a treadmill at various speeds. The shapes of the power spectral densities recorded from the soleus shifted to the lower frequencies over time. The parameters associated with the curves showed trends. One of the parameters, zero crossing, demonstrated adaptation and fatigue in all four patients, for the first portion of the …

Computer Simulation Of Intracranial Hemodynamics During The Induction Phase Of Anesthesia, Gopinath P. Sundaram

Theses

The induction of general anesthesia is associated with severe hemodynamic compromises which, in turn, may cause acute elevation of intracranial pressure (ICP). Quantitative assessment of cerebrovascular responses arising from multiple mechanical and pharmacological interventions occurring in a short time interval require a large number of human studies which are difficult to perform. The purpose of this project is to evaluate the effect of various stimuli on the intracranial hemodynamics during induction using a mathematical model of cerebrovascular circulation.

A five compartmental model of the cerebrovascular system is used for our simulation. Autoregulation is modeled by adjusting arterial-arteriolar resistance in order …

A Multicompartmental Model For The Simulation Of Soluble Gas Exchange In The Lungs, Chitaranjan Varadhan

Theses

No abstract provided.

Fingerprint Pattern Recognition For Medical Uses, Feng You

Theses

The purpose of my research is to provide a method to automatically classify fingerprints into three subgroups: whorl, loop and arch, which can help medical scientists to study the relationship between fingerprint patterns and medical disorders. In the research, two different kinds of approaches were developed. The first one is performing pattern recognition in the frequency domain, which uses the feature of Fourier spectrum. That is, prominent peaks in the spectrum give the principal direction of fingerprint patterns. Using the above feature, we can obtain the principal direction of every subregion, after which the pattern of the whole image can …

A Study Of Pulsation Of Chest Wall Using Microwave Interferometer, Paul Zeno

Theses

The microwave interferometer is utilized to pick up vibrations of the anterior chest wall produced by the cardiac activity. The objective of this project is to find the causes of different peaks in the output of the microwave interferometer. The output of the microwave interferometer is recorded simultaneously with EKG and jugular pressure pulses. Eighteen subjects had their mechanical vibrations of the chest wall, EKG and jugular pressure pulses recorded. The processed interferometer data, when compared with EKG and jugular pressure pulses appear to have a close relation to the mechanical events in the cardiac cycle. Four peaks in the …

The Thermal Model Of The Rat Under Hemorrhagic Shock Hypothermia With Microwave Intervention, Liu Zhe

Theses

A whole body thermal model simulating heat distribution and temperature regulation in rats during hemorrhagic shock and during post-shock microwave core rewarming period was developed. An electrical circuit was used to simulate the thermal system and a software named PSpice? was used to analyze the circuit. The temperature regulation as the result of the simulation is demonstrated to match the measured temperature histories of rats in hemorrhagic shock and the microwave rewarming experiment.

The blood pressure drop and cardiac output decrease were considered in the simulation and the so called "set point temperature" was investigated in the model. Linear decrease …

Computer Aided Finite Element Stress Analysis Of A Three Dimension Mandibular Bone Model Using I-Deas Software, Yixiong Xu

Theses

A three dimensional model of half of the mandibular bone, with 487 tetrahedra elements and 1,047 nodes, is established and analyzed by means of I-DEAS software. The masseter muscle is assumed to be 15° deviation from y-axis, and the Umetani boundary conditions are allowed to be varied. A 337 lb force was applied along the midline of the mandible to simulate a trauma force caused by the auto accident. The maximum principal stress is 18,400 psi and the minimum principal stress is -1,340 psi. Depending on the experimental results of dispalcement and maximum principal stress, the conclusions are drawn: 1) …

Dynamics Of Blood Coagulation, Jie Gao

Theses

In this paper we present a new method to analyze whole blood coagulation dynamics. Using a PC-286 computer equipped with a DASH-16 AID board.

The row data from a SONOCLOT analyzer is amplified and digitized on the DASH-16 A/D board and stored in the PC-286 hard disk. The data is filtered through a digital Butterworth filter. The filtered data is then fit to mathematical relationship by the least square method. The coefficients which define the mathematical relationships are used to identify blood specimens with normal coagulation dynamics as distinguished from specimens with abnormal dynamics.

The digital filter and curve-fitting routine …

A Review Of Energy Storing Prosthetic Feet And Computer Aided Structural Optimization Of A Below-Knee Prosthesis, Poonam Gope Lalwani

Theses

Because people with physical disabilities have shown an interest in participation in sports, a new class of prosthetic feet known as "energy storing prosthetic feet" has been developed. These new developments in prosthetic foot design utilize energy storage and return to improve ambulation. This thesis reviews the design, materials, advantages and disadvantages of various energy storing prosthetic feet. Research studies, comparing gait in below-knee amputees using different prosthetic designs, can be applied to the design of prosthetic feet that are lighter, stronger and more reliable. Comparisions among these feet are reviewed in the context of functional capability and patient satisfaction. …