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Articles 61 - 90 of 94
Full-Text Articles in Engineering
3d-Printed Culture Plate Insert With Agarose Barrier For The Evaluation Of Stem-Cancer Cell Signaling., Erika M. Lewis
3d-Printed Culture Plate Insert With Agarose Barrier For The Evaluation Of Stem-Cancer Cell Signaling., Erika M. Lewis
Honors Theses
No abstract provided.
Material Analysis Of A Tympanostomy Myringotomy Simulator, Abishek Stanley
Material Analysis Of A Tympanostomy Myringotomy Simulator, Abishek Stanley
Honors Theses
No abstract provided.
Generation Of Silver Nanoparticle Pharmacokinetic Profiles In A Lung Model, Rachel Galaska
Generation Of Silver Nanoparticle Pharmacokinetic Profiles In A Lung Model, Rachel Galaska
Honors Theses
Nanomaterial technologies are becoming increasingly prevalent in consumer and industrial applications, including drug delivery, energy harvesting, environmental applications, and medicine due to their unique physiochemical properties. As nanomaterial use increases, so too does human exposure. This has made it progressively more important to understand the toxicological effects of nanomaterials and their interactions with the human body. Silver nanoparticles (AgNPs) are one of the most commonly used nanomaterials due to their antibacterial properties. As inhalation is one of the most common exposure routes, understanding the toxicity of these AgNPs on lung tissue was studied. Using A549 cells for a lung tissue …
Effect Of Activated Carbon On The Performance Of A Solar Thermal Adsorptive Refrigerator (Star) Using Activated Carbon-Ethanol, Joshua Romo
Honors Theses
The Solar Thermal Adsorptive Refrigerator (STAR) project at the University of Dayton seeks to bridge sustainability and the need for reliable refrigeration in developing communities. Cost-effective construction, operation, and maintenance as well as the use of a sustainable adsorption pair, activated carbon-ethanol, give STAR great potential in the realm of humanitarian engineering. This project explores the effect of using two activated carbon brands, 8x16 and CocoPlus, on the cyclic performance of the STAR system. Although both brands have similar specifications given by the manufacturer, one (8x16) inhibited successful performance while the other (CocoPlus) enabled it. This project highlights both the …
Implementation Of A Particle Image Velocimetry System For Evaluation Of Microfluidic Chip Flows, Sheila Mallenahalli
Implementation Of A Particle Image Velocimetry System For Evaluation Of Microfluidic Chip Flows, Sheila Mallenahalli
Honors Theses
No abstract provided.
Prevention Of Access Recirculation During Hemodialysis Treatment, Brendan Laing, Emma Merlino, Charles Nelson
Prevention Of Access Recirculation During Hemodialysis Treatment, Brendan Laing, Emma Merlino, Charles Nelson
Honors Theses
Approximately 660,000 Americans are being treated for kidney failure or end stage renal disease annually. Access recirculation can happen to any patient, varying from treatment to treatment, as it is a problem with the current technology of two butterfly needles used during a dialysis procedure and not with the patient. Access Recirculation severely decreases the efficiency of dialysis while having the potential to lead to a variety of complications.There is a clear need for a device that can be implemented during hemodialysis treatments to reduce the percentage of recirculated blood, thusly reducing the occurrence of treatment for an individual and …
Cuffed Pediatric Endotracheal Tubes, Jennifer Nutter, Emmanuela Oppong, Colleen Pouliot
Cuffed Pediatric Endotracheal Tubes, Jennifer Nutter, Emmanuela Oppong, Colleen Pouliot
Honors Theses
Endotracheal tubes (ET) are used to provide patients with an adequate airway when they are unable to breathe on their own. ET tubes can be used in emergency situations, surgical procedures, and on-floor intubations. The two main types of ET tubes are cuffed and uncuffed. Due to the fragile structure of a child's throat, uncuffed tubes are primarily used in pediatric patients. Uncuffed tubes can slip out of place resulting in air leakage and improper oxygenation. In contrast, cuffed ET tubes provide a proper seal to the airway and prevent against aspiration. The following work proposes an improved design for …
Dynamic Classification Of Moisture Stress Using Canopy And Leaf Temperature Responses To A Step Changes Of Incident Radiation, Erin E. Stevens, George E. Meyer, Ellen T. Paparozzi
Dynamic Classification Of Moisture Stress Using Canopy And Leaf Temperature Responses To A Step Changes Of Incident Radiation, Erin E. Stevens, George E. Meyer, Ellen T. Paparozzi
Honors Theses
Environmental conditions affect plant productivity and understanding how plants respond to drought stress can be measured in different ways. This study focused on measuring leaf response time to induced water stress. Leaf response time to a step increase and step decrease in radiation was computed for four species of well-watered and water-stressed plants in a controlled environment. The canopy temperature was measured with an infrared thermometer and a thermal imaging camera. Thermal images were analyzed to determine the average temperature of a selected single, unobstructed leaf at the top of the canopy. Both the canopy response time and the single …
A Strategic Audit Of Medtronic Plc, Jozzy Carter
A Strategic Audit Of Medtronic Plc, Jozzy Carter
Honors Theses
Humans will always have a need for healthcare, and as the world continues to innovate in the tech space, consumers will demand advances in medicine and medical devices. Medtronic is at the forefront of this innovation but faces intense competition in the medical technologies industry. This poses the question: what can Medtronic do to continue its growth and stay competitive in this space? This paper offers an analysis of Medtronic as a medical device company by offering insight to its competitive advantage, financials, business mix, and value chain. It also analyzes the forces that affect Medtronic using SWOT, PEST, and …
Chitosan Nanoparticle Modifications For Improved Gene Delivery In An Oral Dna Vaccine Application, Austin Helmink
Chitosan Nanoparticle Modifications For Improved Gene Delivery In An Oral Dna Vaccine Application, Austin Helmink
Honors Theses
Vaccines represent one of the most significant medical innovations of the 20th century, resulting in the eradication or near eradication of a handful of deadly diseases. However, many infectious diseases remain resistant to effective vaccination, largely due to a lack full immune activation by traditional protein-based vaccines. A promising alternative vaccination strategy is the emerging development of DNA vaccines, which rely upon the delivery of exogenous genetic material to host cells encoding for a viral or bacterial antigen in order to induce a robust immune response by closely mimicking live infection. The delivery of genetic material requires a carrier …
Pentaerythritol Triacrylate-Co-Trimethylolpropane Nanocomposite Scaffolds As Osteogenic Components For Bone Tissue Engineering, Mollie Marie Smoak
Pentaerythritol Triacrylate-Co-Trimethylolpropane Nanocomposite Scaffolds As Osteogenic Components For Bone Tissue Engineering, Mollie Marie Smoak
Honors Theses
No abstract provided.
Zein Nanoparticle Interaction With Soybean Plants, Kurt Ristroph
Zein Nanoparticle Interaction With Soybean Plants, Kurt Ristroph
Honors Theses
No abstract provided.
Aconitic Acid, Glycerol And Cinnamic Acid Polyester Characterization For Bone Tissue Engineering, Katie Joanna Hogan
Aconitic Acid, Glycerol And Cinnamic Acid Polyester Characterization For Bone Tissue Engineering, Katie Joanna Hogan
Honors Theses
No abstract provided.
Design Of A Double-Dose Epinephrine Auto-Injector Using 3d-Printing, Timothy Calvin Sheehan
Design Of A Double-Dose Epinephrine Auto-Injector Using 3d-Printing, Timothy Calvin Sheehan
Honors Theses
This project involved the design and prototyping of an epinephrine auto-injector capable of administering two separate doses. Epinephrine auto-injectors are used in the treatment of patients undergoing anaphylaxis, an allergic reaction causing the restriction of airways and a drop in blood pressure. The timely administration of epinephrine counteracts these symptoms and can be lifesaving. Currently the only devices available to consumers administer one unit dose of epinephrine and are then no longer usable. In 30% of cases where patients undergo these symptoms a second dose of epinephrine is required. My design was based partially off the concept behind currently available …
Synthesis, Functionalization, And Characterization Of Metallic And Organic Nanoparticles For Biomedical Applications, Christopher Brian Sylvester
Synthesis, Functionalization, And Characterization Of Metallic And Organic Nanoparticles For Biomedical Applications, Christopher Brian Sylvester
Honors Theses
No abstract provided.
In Vivo Evaluation Of An Automated Pressure Sore Reducer, Linda J. Cross
In Vivo Evaluation Of An Automated Pressure Sore Reducer, Linda J. Cross
Honors Theses
No abstract provided.
Cryoprotectant Loading In A Microchannel, Shelby Pursley
Cryoprotectant Loading In A Microchannel, Shelby Pursley
Honors Theses
No abstract provided.
Computational Modeling Of Drug Release From Bone Scaffolds, Corey Landry
Computational Modeling Of Drug Release From Bone Scaffolds, Corey Landry
Honors Theses
No abstract provided.
Development Of Biomechanical Analysis Techniques For Fatigue Of Transtibial Prosthetic Socket And Pylon Interactions, Thomas Z. Sudbury
Development Of Biomechanical Analysis Techniques For Fatigue Of Transtibial Prosthetic Socket And Pylon Interactions, Thomas Z. Sudbury
Honors Theses
The lack of formal, engineering based information is prevalent in the prosthetic industry. Currently, very few prosthetic manufacturing companies can definitively tell their patients how long their products will last. Because of this lack of information, many amputee patients will experience failure of their transtibial prosthetic device during daily activities. One such failure occurs from the fatigue of everyday use. Fatigue failures originate from the repeated application of certain loading conditions. These repeated loads usually occur for millions of cycles before a transtibial prosthetic catastrophically fails. The purpose of this study is to develop a testing procedure and apparatus that …
Subtalar Fusion Fixture Design And Test, Nathan Ortiz
Subtalar Fusion Fixture Design And Test, Nathan Ortiz
Honors Theses
Subtalar arthrodesis is performed when cartilage in the talo-calcaneal (the ankle) joint is degraded in a patient and there are multiple approaches to this surgery. Using synthetic bone material, fixtures were cast from aluminum, using the process of evaporation pattern casting, and epoxy. This casting was used to grip the calcaneus bone of the foot in order to load it mechanically, simulating different scenarios that would be encountered during walking. The relative displacement of the ankle joint was measured using a digital image correlation (DIC) program that was modified to work in both two- and three-dimensional space. This program can …
History Of Concussion Research In American Football, Timothy Hersey
History Of Concussion Research In American Football, Timothy Hersey
Honors Theses
Concussions have been the topic of discussion in the news and media in recent years for their profound impact on today’s sport industry. Athletes have become bigger, faster, and stronger then in the past, increasing the chance of injury. This can been seen in all sports. Contact sports specifically have seen a rise in mild traumatic brain injuries (MTBIs) over the years. Extensive research has been done to determine the causes of concussion, the short and long term effects of brain injury, and better ways to reduce the risk in sports. Concussion research in athletics has mainly focused on American …
Studying The Material Properties Of The Embryonic Chicken Heart, Kyra Burnett
Studying The Material Properties Of The Embryonic Chicken Heart, Kyra Burnett
Honors Theses
Congenital heart disease is the number one cause of birth defects in the United States, affecting approximately 40,000 newborns each year. Research has shown that serious structural defects of the heart can occur due to abnormal looping. Looping refers to the positional and morphological changes of the early embryo heart and is divided into different phases. Although progress has been made in identifying the genetic processes behind heart looping, the forces involved with the developmental process are still not fully understood. In this research, the chicken embryo heart was used as the experimental model and certain material properties were characterized. …
Mechanical Characterization Of An External Fixator For Use In A Mouse Model, Thomas Albano
Mechanical Characterization Of An External Fixator For Use In A Mouse Model, Thomas Albano
Honors Theses
Understanding the process of bone healing has become a fundamental part of medical research due to the approximately one million fractures which occur annually in the United States. The current methods of fracture fixation which use intramedullary rods, external fixators, and fracture plates are effective but not ideal. These fracture fixation methods can lead to mal-union or non-union due to improper callus formation stemming from inadequate fixation and support. When mal-union and non-union occur, the structural integrity of the bone becomes greatly sacrificed and the patient is left to deal with continual pain. Previous studies have suggested that the mechanical …
Measuring The Strain Field Gradients On The Surface Of A Model Human Skull While Axially Loaded To Simulate Head-Loading, Matthew Graveley
Measuring The Strain Field Gradients On The Surface Of A Model Human Skull While Axially Loaded To Simulate Head-Loading, Matthew Graveley
Honors Theses
Head-loading is a means of transporting heavy loads accross rough, rural terrains practiced by many peoples in Third World countries. Years of practicing head-loading is said to result in increase spinal bone density and permantly grooved skulls. The most infamous people who practice head-loading are the porters of Nepal, who carry loads by means of a head sling straped across their foreheads, and South African women, who carry loads directly on their heads. To simulate and measure the instantaneous micro deformations occurring on the surface of the skull due to head-loading, a test procedure has been developed using a plastic …
Coupling Of Audio Signals Into Afm Images, Matthew Manning
Coupling Of Audio Signals Into Afm Images, Matthew Manning
Honors Theses
It is well known that Atomic Force Microscopy imaging is capable of yielding high resolution results with of surfaces at the nanoscale. However, despite the device capabilities and vast applications, AFM microscopy is possibly the most prone to the creation of image artifacts. AFM imaging can easily, and is often, corrupted by various external forces. The most obvious and measurable form of external interference is of course the presence of ambient noise. Most AFM manufactures attempt to counter the effects of such noise on the imaging process through use of noise-proof or noise-resistant shields that cover the microscope aperture. Without …
Engineering Design Of A Prototype Ammonia Absorption Tower, Andrew Warren Calogero
Engineering Design Of A Prototype Ammonia Absorption Tower, Andrew Warren Calogero
Honors Theses
No abstract provided.
Design And Validation Of An External Fixator For Use In In Vivo Fracture Studies, Marc S. Nash
Design And Validation Of An External Fixator For Use In In Vivo Fracture Studies, Marc S. Nash
Honors Theses
This thesis explores how a new external fixator effects the healing process in the fracture site of a mouse tibia. Studies have shown that the amount of time it takes a fracture to heal can vary based on the type of fixator used. An external fixator was designed using SolidWorks and fabricated by Medical Micro Machining (Colfax, Washington). Rubber disks where created from a mold and inserted in the bottom piece of each fixator. Using a dental drill and a variety of clamps, the fixator was attached to an already removed tibia. A Dremel saw was used to create a …
Traumatic Vs. Pathological Achilles Tendon Ruptures: A Look Into The Importance Of The Collagen Matrix And The Preferred Method Of Repair, Kathleen M. Mclean
Traumatic Vs. Pathological Achilles Tendon Ruptures: A Look Into The Importance Of The Collagen Matrix And The Preferred Method Of Repair, Kathleen M. Mclean
Honors Theses
The Achilles tendon is the largest, strongest, and thickest tendon in the human body. While it may be the strongest, the Achilles tendon is also among one of the most frequently ruptured. These lower limb injuries arise as a result of athletically induced trauma or pathologically and steroidal induced trauma. While the manner in which athletic ruptures occurs can be determined on a case to case basis through the use of clinical examination, ultrasonography, and magnetic resonance imaging (MRI), the method in which the injury should be treated remains controversial. The two main methods of repair include a conservative approach …
Adhesion Of Jurkat Cells In Defined Media And Substrates, Sarah De Leo
Adhesion Of Jurkat Cells In Defined Media And Substrates, Sarah De Leo
Honors Theses
No abstract provided.
Site-Specific Deoxyribonucleic Acid Modifications For Use With Chemical Cages, John P. Casey Jr
Site-Specific Deoxyribonucleic Acid Modifications For Use With Chemical Cages, John P. Casey Jr
Honors Theses
No abstract provided.