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Leveraging Inflammatory Responses Toward Advancing Alzheimer’S Disease Treatments And Biomaterial Implantation, Mihyun Lim Waugh

Theses and Dissertations

Inflammation is a body’s physiological response to pathogens, foreign materials, or tissue injury. When immune system is triggered, activated leukocytes produce cytokines and chemokines that promote migration of neutrophils and macrophages to the inflammatory regions. At early stages of injury, acute inflammation occurs immediately to fight off the pathogens and restore tissues to homeostasis. However, if the inflammation-inducing stimulus is not removed and thus cells and tissues do not return to its homeostatic state, the prolonged inflammatory responses become a chronic condition. Recent studies have indicated that the receptor for advanced glycation end-products (RAGE), a key receptor of innate immune …