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Full-Text Articles in Engineering
Antimicrobial Activity And Mechanism Of Amyloid Proteins And Synthetic Conjugated Polyelectrolytes, Fahimeh Maghsoodi
Antimicrobial Activity And Mechanism Of Amyloid Proteins And Synthetic Conjugated Polyelectrolytes, Fahimeh Maghsoodi
Nanoscience and Microsystems ETDs
Although the exact cause of Alzheimer’s disease (AD) is still unknown, it is widely considered that the accumulation of amyloid plaques composed of the amyloid-β (Aβ) peptide in the brain is linked to neurodegeneration. Co-localization of viral DNA with Aβ plaques, the association of brain infection and AD, and research indicating the protective effect of Aβ against bacteria and fungi in mice and human cells have led to the hypothesis that Aβ expression and deposition may be central to its function as an antimicrobial peptide (AMP). In my thesis research, we seek to elucidate how Aβ functions as an AMP …
Photo-Characterization Of Selective Luminescent Protein Aggregate Sensors - Oligo-P-Phenylene Ethynylene (Opes), Florencia A. Monge
Photo-Characterization Of Selective Luminescent Protein Aggregate Sensors - Oligo-P-Phenylene Ethynylene (Opes), Florencia A. Monge
Biomedical Engineering ETDs
Neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease,
and related tauopathies, are a global health care challenge due to the lack of early
treatment and diagnostic options. These diseases take an emotional and physical
toll on patients, caretakers, and a rather large economic toll on taxpayer-based
health care systems. The pathologies of these diseases are characterized by the
aggregation of misfolded proteins, amyloid-β (Aβ) and tau, into β-sheet rich
structures called amyloids. Research has found that the presence of protein
aggregates predates cognitive symptoms by years. Current diagnostic tools are
based on the detection of these amyloid aggregates, historically by …
Tauopathies, Novel Optogenetic Tools, And The Future Of Artificial Intellience In Medicine., Jessica L. Binder
Tauopathies, Novel Optogenetic Tools, And The Future Of Artificial Intellience In Medicine., Jessica L. Binder
Biomedical Sciences ETDs
To this day, there is no cure for Alzheimer’s disease (AD) and related dementias (ADRD). With the daunting rise at an exponential rate of ADRD burden and related deaths, the necessity to find a new line of attack is vital. Pathological accumulation of microtubule associated protein tau in neurons is a major neuropathological hallmark of Alzheimer’s disease (AD) and related tauopathies. Attempts have been made to promote clearance of pathological tau (p-Tau) from neurons via autophagy. Transcription factor EB (TFEB) has shown to clear p-Tau from neurons via autophagy. However, sustained TFEB activation and autophagy can create burden on cellular …