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Full-Text Articles in Engineering
Evaluating Neuroimaging Modalities In The A/T/N Framework: Single And Combined Fdg-Pet And T1-Weighted Mri For Alzheimer’S Diagnosis, Peiwang Liu
McKelvey School of Engineering Theses & Dissertations
With the escalating prevalence of dementia, particularly Alzheimer's Disease (AD), the need for early and precise diagnostic techniques is rising. This study delves into the comparative efficacy of Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) and T1-weighted Magnetic Resonance Imaging (MRI) in diagnosing AD, where the integration of multimodal models is becoming a trend. Leveraging data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), we employed linear Support Vector Machines (SVM) to assess the diagnostic potential of these modalities, both individually and in combination, within the AD continuum. Our analysis, under the A/T/N framework's 'N' category, reveals that FDG-PET consistently outperforms T1w-MRI across …
Uniting Cognitive Models And Ai: Early Alzheimer’S Screening Through Language Analysis, Ziming Liu
Uniting Cognitive Models And Ai: Early Alzheimer’S Screening Through Language Analysis, Ziming Liu
Doctoral Dissertations
Alzheimer's Disease (AD) and related dementias (PwADRD) often lead to memory issues, language difficulties, and cognitive impairments. These symptoms can cause social isolation, anxiety, depression, accelerating cognitive decline, and negatively impacting quality of life. Traditional diagnostic and rehabilitation methods, relying on Artificial Intelligence (AI) or clinical observations, sometimes lack transparency and explainability for the growing population affected by AD. My research aims to address these challenges by developing AI systems that analyze affective states and cognitive deficits in PwADRD interactions. This involves creating more precise diagnostic tools and rehabilitation methods, as well as trustworthy AI agents to improve PwADRD's quality …
Antimicrobial Activity And Mechanism Of Amyloid Proteins And Synthetic Conjugated Polyelectrolytes, Fahimeh Maghsoodi
Antimicrobial Activity And Mechanism Of Amyloid Proteins And Synthetic Conjugated Polyelectrolytes, Fahimeh Maghsoodi
Nanoscience and Microsystems ETDs
Although the exact cause of Alzheimer’s disease (AD) is still unknown, it is widely considered that the accumulation of amyloid plaques composed of the amyloid-β (Aβ) peptide in the brain is linked to neurodegeneration. Co-localization of viral DNA with Aβ plaques, the association of brain infection and AD, and research indicating the protective effect of Aβ against bacteria and fungi in mice and human cells have led to the hypothesis that Aβ expression and deposition may be central to its function as an antimicrobial peptide (AMP). In my thesis research, we seek to elucidate how Aβ functions as an AMP …
Photo-Characterization Of Selective Luminescent Protein Aggregate Sensors - Oligo-P-Phenylene Ethynylene (Opes), Florencia A. Monge
Photo-Characterization Of Selective Luminescent Protein Aggregate Sensors - Oligo-P-Phenylene Ethynylene (Opes), Florencia A. Monge
Biomedical Engineering ETDs
Neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease,
and related tauopathies, are a global health care challenge due to the lack of early
treatment and diagnostic options. These diseases take an emotional and physical
toll on patients, caretakers, and a rather large economic toll on taxpayer-based
health care systems. The pathologies of these diseases are characterized by the
aggregation of misfolded proteins, amyloid-β (Aβ) and tau, into β-sheet rich
structures called amyloids. Research has found that the presence of protein
aggregates predates cognitive symptoms by years. Current diagnostic tools are
based on the detection of these amyloid aggregates, historically by …
Tauopathies, Novel Optogenetic Tools, And The Future Of Artificial Intellience In Medicine., Jessica L. Binder
Tauopathies, Novel Optogenetic Tools, And The Future Of Artificial Intellience In Medicine., Jessica L. Binder
Biomedical Sciences ETDs
To this day, there is no cure for Alzheimer’s disease (AD) and related dementias (ADRD). With the daunting rise at an exponential rate of ADRD burden and related deaths, the necessity to find a new line of attack is vital. Pathological accumulation of microtubule associated protein tau in neurons is a major neuropathological hallmark of Alzheimer’s disease (AD) and related tauopathies. Attempts have been made to promote clearance of pathological tau (p-Tau) from neurons via autophagy. Transcription factor EB (TFEB) has shown to clear p-Tau from neurons via autophagy. However, sustained TFEB activation and autophagy can create burden on cellular …