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Photo-Characterization Of Selective Luminescent Protein Aggregate Sensors - Oligo-P-Phenylene Ethynylene (Opes), Florencia A. Monge
Photo-Characterization Of Selective Luminescent Protein Aggregate Sensors - Oligo-P-Phenylene Ethynylene (Opes), Florencia A. Monge
Biomedical Engineering ETDs
Neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease,
and related tauopathies, are a global health care challenge due to the lack of early
treatment and diagnostic options. These diseases take an emotional and physical
toll on patients, caretakers, and a rather large economic toll on taxpayer-based
health care systems. The pathologies of these diseases are characterized by the
aggregation of misfolded proteins, amyloid-β (Aβ) and tau, into β-sheet rich
structures called amyloids. Research has found that the presence of protein
aggregates predates cognitive symptoms by years. Current diagnostic tools are
based on the detection of these amyloid aggregates, historically by …