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Articles 31 - 60 of 65
Full-Text Articles in Engineering
Lung Protection By Inhalation Of Exogenous Solubilized Extracellular Matrix, Jinglei Wu, Priya Ravikumar, Kytai Truong Nguyen, Connie C.W. Hsia, Yi Hong
Lung Protection By Inhalation Of Exogenous Solubilized Extracellular Matrix, Jinglei Wu, Priya Ravikumar, Kytai Truong Nguyen, Connie C.W. Hsia, Yi Hong
Bioengineering Faculty Publications
Decellularized extracellular matrix (ECM) contains complex tissue-specific components that work in concert to promote tissue repair and constructive remodeling and has been used experimentally and clinically to accelerate epithelial wound repair, leading us to hypothesize that lung-derived ECM could mitigate acute lung injury. To explore the therapeutic potential of ECM for noninvasive delivery to the lung, we decellularized and solubilized porcine lung ECM, then characterized the composition, concentration, particle size and stability of the preparation. The ECM preparation at 3.2 mg/mL with average particle size <3 μm was tested in vitro on human A549 lung epithelial cells exposed to 95% O2 for 24 hours, and in vivo by tracheal instillation or nebulization into the lungs of rats exposed intermittently or continuously to 90% O2 for a cumulative 72 hours. Our results showed that the preparation was enriched in collagen, reduced in glycosaminoglycans, and contained various bioactive molecules. Particle size was concentration-dependent. Compared to the respective controls treated with cell culture medium in vitro or saline in vivo, ECM inhalation normalized cell survival and alveolar morphology, and reduced hyperoxia-induced apoptosis and oxidative damage. This proof-of-concept study established the methodology, feasibility and therapeutic potential of exogenous solubilized ECM for pulmonary cytoprotection, possibly as an adjunct or potentiator of conventional therapy.
Automated Voxel Classification Used With Atlas-Guided Diffuse Optical Tomography For Assessment Of Functional Brain Networks In Young And Older Adults, Lin Li, Mary Cazzell, Olajide Babawale, Hanli Liu
Automated Voxel Classification Used With Atlas-Guided Diffuse Optical Tomography For Assessment Of Functional Brain Networks In Young And Older Adults, Lin Li, Mary Cazzell, Olajide Babawale, Hanli Liu
Bioengineering Faculty Publications
No abstract provided.
Interplay Between Up-Regulation Of Cytochrome-C-Oxidase And Hemoglobin Oxygenation Induced By Near-Infrared Laser, Xinlong Wang, Fenghua Tian, Sagar S. Soni, F. Gonzalez-Lima, Hanli Liu
Interplay Between Up-Regulation Of Cytochrome-C-Oxidase And Hemoglobin Oxygenation Induced By Near-Infrared Laser, Xinlong Wang, Fenghua Tian, Sagar S. Soni, F. Gonzalez-Lima, Hanli Liu
Bioengineering Faculty Publications
Photobiomodulation, also known as low-level laser/light therapy (LLLT), refers to the use of red-tonear-infrared light to stimulate cellular functions for physiological or clinical benefits. The mechanism of LLLT is assumed to rely on photon absorption by cytochrome c oxidase (CCO), the terminal enzyme in the mitochondrial respiratory chain that catalyzes the reduction of oxygen for energy metabolism. In this study, we used broadband near-infrared spectroscopy (NIRS) to measure the LLLT-induced changes in CCO and hemoglobin concentrations in human forearms in vivo. Eleven healthy participants were administered with 1064-nm laser and placebo treatments on their right forearms. The spectroscopic data were …
Prefrontal Responses To Stroop Tasks In Subjects With Post-Traumatic Stress Disorder Assessed By Functional Near Infrared Spectroscopy, Amarnath Yennu, Fenghua Tian, Alexa Smith-Osborne, Robert J. Gatchel, Fu Lye Woon, Hanli Liu
Prefrontal Responses To Stroop Tasks In Subjects With Post-Traumatic Stress Disorder Assessed By Functional Near Infrared Spectroscopy, Amarnath Yennu, Fenghua Tian, Alexa Smith-Osborne, Robert J. Gatchel, Fu Lye Woon, Hanli Liu
Bioengineering Faculty Publications
No abstract provided.
Dimensionality Reduction Based Optimization Algorithm For Sparse 3-D Image Reconstruction In Diffuse Optical Tomography, Tanmoy Bhowmik, Hanli Liu, Zhou Ye, Soontorn Oraintara
Dimensionality Reduction Based Optimization Algorithm For Sparse 3-D Image Reconstruction In Diffuse Optical Tomography, Tanmoy Bhowmik, Hanli Liu, Zhou Ye, Soontorn Oraintara
Bioengineering Faculty Publications
No abstract provided.
Bioenergy From Wastewater-Based Biomass, Ronald C. Sims, Sean K. Bedingfield, Reese Thompson, Judith L. Sims
Bioenergy From Wastewater-Based Biomass, Ronald C. Sims, Sean K. Bedingfield, Reese Thompson, Judith L. Sims
Biological Engineering Faculty Publications
The U.S. Department of Energy (DOE) has stated that biomass is the only renewable resource that can supplant petroleum-based liquid transportation fuels in the near term. Wastewater is beginning to be viewed as a potential resource that can be exploited for biomass production and conversion to bioenergy. We suggest that using wastewater from municipalities and industries as a resource for cultivating biomass and combining wastewater treatment with the production of biomass for bioenergy would provide benefits to both industries. Two waste-based biomass production systems that currently have large nationwide infrastructures include: (1) wastewater treatment systems that can be used to …
Wavelet Coherence Analysis Of Dynamic Cerebral Autoregulation In Neonatal Hypoxic–Ischemic Encephalopathy, Fenghua Tian, Takashi Tarumi, Hanli Liu, Rong Zhang, Lina Chalak
Wavelet Coherence Analysis Of Dynamic Cerebral Autoregulation In Neonatal Hypoxic–Ischemic Encephalopathy, Fenghua Tian, Takashi Tarumi, Hanli Liu, Rong Zhang, Lina Chalak
Bioengineering Faculty Publications
Cerebral autoregulation represents the physiological mechanisms that keep brain perfusion relatively constant in the face of changes in blood pressure and thus plays an essential role in normal brain function. This study assessed cerebral autoregulation in nine newborns with moderate-to-severe hypoxic–ischemic encephalopathy (HIE). These neonates received hypothermic therapy during the first 72 h of life while mean arterial pressure (MAP) and cerebral tissue oxygenation saturation (SctO2) were continuously recorded. Wavelet coherence analysis, which is a time-frequency domain approach, was used to characterize the dynamic relationship between spontaneous oscillations in MAP and SctO2. Wavelet-based metrics of phase, coherence and gain were …
Transcranial Laser Stimulation Improves Human Cerebral Oxygenation, Fenghua Tian, Snehal Niwrutti Hase, F. Gonzalez-Lima, Hanli Liu
Transcranial Laser Stimulation Improves Human Cerebral Oxygenation, Fenghua Tian, Snehal Niwrutti Hase, F. Gonzalez-Lima, Hanli Liu
Bioengineering Faculty Publications
Transcranial laser stimulation of the brain with near-infrared light is a novel form of non-invasive photobiomodulation or low-level laser therapy (LLLT) that has shown therapeutic potential in a variety of neurological and psychological conditions. Understanding of its neurophysiological effects is essential for mechanistic study and treatment evaluation. This study investigated how transcranial laser stimulation influences cerebral hemodynamics and oxygenation in the human brain in vivo using functional near-infrared spectroscopy (fNIRS).
Multiregional Functional Near-Infrared Spectroscopy Reveals Globally Symmetrical And Frequency-Specific Patterns Of Superficial Interference, Yujin Zhang, Fulun Tan, Xu Xu, Lian Duan, Hanli Liu, Fenghua Tian, Chao-Zhe Zhu
Multiregional Functional Near-Infrared Spectroscopy Reveals Globally Symmetrical And Frequency-Specific Patterns Of Superficial Interference, Yujin Zhang, Fulun Tan, Xu Xu, Lian Duan, Hanli Liu, Fenghua Tian, Chao-Zhe Zhu
Bioengineering Faculty Publications
Linear regression with short source-detector separation channels (S-channels) as references is an efficient way to overcome significant physiological interference from the superficial layer for functional nearinfrared spectroscopy (fNIRS). However, the co-located configuration of Schannels and long source-detector separation channels (L-channels) is difficult to achieve in practice. In this study, we recorded superficial interference with S-channels in multiple scalp regions. We found that superficial interference has overall frequency-specific and globally symmetrical patterns. The performance of linear regression is also dependent on these patterns, indicating the possibility of simplifying the Schannel configurations for multiregional fNIRS imaging.
Quantification And Normalization Of Noise Variance With Sparsity Regularization To Enhance Diffuse Optical Tomography, Jixing Yao, Fenghua Tian, Yothin Rakvongthai, Soontorn Oraintara, Hanli Liu
Quantification And Normalization Of Noise Variance With Sparsity Regularization To Enhance Diffuse Optical Tomography, Jixing Yao, Fenghua Tian, Yothin Rakvongthai, Soontorn Oraintara, Hanli Liu
Bioengineering Faculty Publications
Conventional reconstruction of diffuse optical tomography (DOT) is based on the Tikhonov regularization and the white Gaussian noise assumption. Consequently, the reconstructed DOT images usually have a low spatial resolution. In this work, we have derived a novel quantification method for noise variance based on the linear Rytov approximation of the photon diffusion equation. Specifically, we have implemented this quantification of noise variance to normalize the measurement signals from all source-detector channels along with sparsity regularization to provide high-quality DOT images. Multiple experiments from computer simulations and laboratory phantoms were performed to validate and support the newly developed algorithm. The …
Dynamic Functional Connectivity Revealed By Resting-State Fuctional Near-Infrared Spectroscopy, Zhen Li, Hanli Liu, Jingping Xu, Wenli Liu, Fenghua Tian, Yong He, Haijing Niu, Xuhong Liao
Dynamic Functional Connectivity Revealed By Resting-State Fuctional Near-Infrared Spectroscopy, Zhen Li, Hanli Liu, Jingping Xu, Wenli Liu, Fenghua Tian, Yong He, Haijing Niu, Xuhong Liao
Bioengineering Faculty Publications
No abstract provided.
Intraocular Pressure Changes: An Important Determinant Of The Biocompatibility Of Intravitreous Implants, Ashwin Nair, Ling Zou, Hong Weng, Yi-Ting Tsai, Zhibing Hu, Liping Tang
Intraocular Pressure Changes: An Important Determinant Of The Biocompatibility Of Intravitreous Implants, Ashwin Nair, Ling Zou, Hong Weng, Yi-Ting Tsai, Zhibing Hu, Liping Tang
Bioengineering Faculty Publications
No abstract provided.
Prostate Cancer Detection Using Combined Autofluorescence And Light Reflectance Spectroscopy: Ex Vivo Study Of Human Prostates, Vikrant Sharma, Ephrem O. Olweny, Payal Kapur, Jeffrey A. Cadeddu, Claus G. Roehrborn, Hanli Liu
Prostate Cancer Detection Using Combined Autofluorescence And Light Reflectance Spectroscopy: Ex Vivo Study Of Human Prostates, Vikrant Sharma, Ephrem O. Olweny, Payal Kapur, Jeffrey A. Cadeddu, Claus G. Roehrborn, Hanli Liu
Bioengineering Faculty Publications
This study was conducted to evaluate the capability of detecting prostate cancer (PCa) using auto-fluorescence lifetime spectroscopy (AFLS) and light reflectance spectroscopy (LRS). AFLS used excitation at 447 nm with four emission wavelengths (532, 562, 632, and 684 nm), where their lifetimes and weights were analyzed using a double exponent model. LRS was measured between 500 and 840 nm and analyzed by a quantitative model to determine hemoglobin concentrations and light scattering. Both AFLS and LRS were taken on n = 724 distinct locations from both prostate capsular (nc = 185) and parenchymal (np = 539) tissues, including PCa tissue, …
Tissue Engineering Bone Using Autologous Progenitor Cells In The Peritoneum, Jinhui Shen, Ramesh Saxena, Cheng Cheng Zhang, Joseph Borrelli Jr., Liping Tang, Ashwin Nair
Tissue Engineering Bone Using Autologous Progenitor Cells In The Peritoneum, Jinhui Shen, Ramesh Saxena, Cheng Cheng Zhang, Joseph Borrelli Jr., Liping Tang, Ashwin Nair
Bioengineering Faculty Publications
No abstract provided.
Atlas-Guided Volumetric Diffuse Optical Tomography Enhanced By Generalized Linear Model Analysis To Image Risk Decision-Making Responses In Young Adults, Zi-Jing Lin, Lin Li, Mary Cazzell, Hanli Liu
Atlas-Guided Volumetric Diffuse Optical Tomography Enhanced By Generalized Linear Model Analysis To Image Risk Decision-Making Responses In Young Adults, Zi-Jing Lin, Lin Li, Mary Cazzell, Hanli Liu
Bioengineering Faculty Publications
No abstract provided.
Prefrontal Responses To Digit Span Memory Phases In Patients With Post-Traumatic Stress Disorder (Ptsd): A Functional Near Infrared Spectroscopy Study, Fenghua Tian, Amarnath Yennu, Alexa Smith-Osborne, F. Gonzalez-Lima, Carol S. North, Hanli Liu
Prefrontal Responses To Digit Span Memory Phases In Patients With Post-Traumatic Stress Disorder (Ptsd): A Functional Near Infrared Spectroscopy Study, Fenghua Tian, Amarnath Yennu, Alexa Smith-Osborne, F. Gonzalez-Lima, Carol S. North, Hanli Liu
Bioengineering Faculty Publications
Neuroimaging studies of post-traumatic stress disorder (PTSD)-related memory impairments have consistently implicated abnormal activities in the frontal and parietal lobes. However, most studies have used block designs and could not dissociate the multiple phases of working memory. In this study, the involvement of the prefrontal cortex in working memory phases was assessed among veterans with PTSD and age-/ gender-matched healthy controls. Multichannel functional near infrared spectroscopy (fNIRS) was utilized to measure prefrontal cortex hemodynamic activations during memory of neutral (i.e., not trauma-related) forward and backward digit span tasks. An event-related experimental design was utilized to dissociate the different phases (i.e., …
Metacom: Automated Data Processing And Analysis Of Metagenomic Community Sequences, Cody A. Tramp, Charles D. Miller
Metacom: Automated Data Processing And Analysis Of Metagenomic Community Sequences, Cody A. Tramp, Charles D. Miller
Browse all Datasets
Advances in next generation sequencing technology have allowed metagenomic researchers to study the composition of bacterial communities through analysis of the vast numbers of sequence reads that these technologies generate. It is not feasible to analyze and interpret this large amount of data manually and individual research groups must create automated scripts and programs to analyze this data. Here, we present MetaCom, a program that offers a common set of analysis and organizational tools that can be used by research groups in the analysis of environmental samples. MetaCom is an open-source software tool that can process next generation sequencing output, …
Mesenchymal Stem Cells As Targeted Cell Vehicles To Deliver Drug-Loaded Nanoparticles For Cancer Therapy, Kytai Truong Nguyen
Mesenchymal Stem Cells As Targeted Cell Vehicles To Deliver Drug-Loaded Nanoparticles For Cancer Therapy, Kytai Truong Nguyen
Bioengineering Faculty Publications
No abstract provided.
Nanomaterials For Photo-Based Diagnostic And Therapeutic Applications, Baohong Yuan, Jyothi Unnikrishna Menon, Khanh Vu, Parth V. Jadeja, Kytai Truong Nguyen, Pranjali P. Tambe
Nanomaterials For Photo-Based Diagnostic And Therapeutic Applications, Baohong Yuan, Jyothi Unnikrishna Menon, Khanh Vu, Parth V. Jadeja, Kytai Truong Nguyen, Pranjali P. Tambe
Bioengineering Faculty Publications
Photo-based diagnosis and treatment methods are gaining prominence due to increased spatial imaging resolution, minimally invasive modalities involved as well as localized treatment. Recently, nanoparticles (NPs) have been developed and used in photo-based therapeutic applications. While some nanomaterials have inherent photo-based imaging capabilities, others including polymeric NPs act as nanocarriers to deliver various fluorescent dyes or photosensitizers for photoimaging and therapeutic applications. These applications can vary from Magnetic Resonance Imaging (MRI) and optical imaging to photothermal therapy (PTT) and chemotherapy. Materials commonly used for development of photo-based NPs ranges from metal-based (gold, silver and silica) to polymer- based (chitosan, dextran, …
Auto-Fluorescence Lifetime And Light Reflectance Spectroscopy For Breast Cancer Diagnosis: Potential Tools For Intraoperative Margin Detection, Vikrant Sharma, Shivaranjani Shivalingaiah, Yan Peng, David Euhus, Zygmunt Gryczynski, Hanli Liu
Auto-Fluorescence Lifetime And Light Reflectance Spectroscopy For Breast Cancer Diagnosis: Potential Tools For Intraoperative Margin Detection, Vikrant Sharma, Shivaranjani Shivalingaiah, Yan Peng, David Euhus, Zygmunt Gryczynski, Hanli Liu
Bioengineering Faculty Publications
This study investigates the use of two spectroscopic techniques, auto-fluorescence lifetime measurement (AFLM) and light reflectance spectroscopy (LRS), for detecting invasive ductal carcinoma (IDC) in human ex vivo breast specimens. AFLM used excitation at 447 nm with multiple emission wavelengths (532, 562, 632, and 644 nm), at which autofluorescence lifetimes and their weight factors were analyzed using a double exponent model. LRS measured reflectance spectra in the range of 500-840 nm and analyzed the spectral slopes empirically at several distinct spectral regions. Our preliminary results based on 93 measured locations (i.e., 34 IDC, 31 benign fibrous, 28 adipose) from 6 …
Sparsity Enhanced Spatial Resolution And Depth Localization In Diffuse Optical Tomography, Venkaiah C. Kavuri, Zi-Jing Lin, Fenghua Tian, Hanli Liu
Sparsity Enhanced Spatial Resolution And Depth Localization In Diffuse Optical Tomography, Venkaiah C. Kavuri, Zi-Jing Lin, Fenghua Tian, Hanli Liu
Bioengineering Faculty Publications
No abstract provided.
Improving Optical Contact For Functional Near-Infrared Brain Spectroscopy And Imaging With Brush Optodes, Bilal Khan, Chester Wildey, Robert Francis, Fenghua Tian, Mauricio R. Delgado, Hanli Liu, Duncan Macfarlane, George Alexandrakis
Improving Optical Contact For Functional Near-Infrared Brain Spectroscopy And Imaging With Brush Optodes, Bilal Khan, Chester Wildey, Robert Francis, Fenghua Tian, Mauricio R. Delgado, Hanli Liu, Duncan Macfarlane, George Alexandrakis
Bioengineering Faculty Publications
A novel brush optode was designed and demonstrated to overcome poor optical contact with the scalp that can occur during functional near infrared spectroscopy (fNIRS) and imaging due to light obstruction by hair. The brush optodes were implemented as an attachment to existing commercial flat-faced (conventional) fiber bundle optodes. The goal was that the brush optodes would thread through hair and improve optical contact on subjects with dense hair. Simulations and experiments were performed to assess the magnitude of these improvements. FNIRS measurements on 17 subjects with varying hair colors (blonde, brown, and black) and hair densities (0–2.96 hairs/mm2 ) …
Real-Time Detection Of Implant-Associated Neutrophil Responses Using A Formyl Peptide Receptor-Targeting Nir Nanoprobe, Jun Zhou, Tsai Yi-Ting, Hong Weng, Ewin N. Tang, Ashwin Nair, Dave P. Digant, Liping Tang
Real-Time Detection Of Implant-Associated Neutrophil Responses Using A Formyl Peptide Receptor-Targeting Nir Nanoprobe, Jun Zhou, Tsai Yi-Ting, Hong Weng, Ewin N. Tang, Ashwin Nair, Dave P. Digant, Liping Tang
Bioengineering Faculty Publications
Neutrophils play an important role in implant-mediated inflammation and infection. Unfortunately, current methods which monitor neutrophil activity, including enzyme measurements and histological evaluation, require many animals and cannot be used to accurately depict the dynamic cellular responses. To understand the neutrophil interactions around implant-mediated inflammation and infection it is critical to develop methods which can monitor in vivo cellular activity in real time. In this study, formyl peptide receptor (FPR)-targeting nearinfrared nanoprobes were fabricated. This was accomplished by conjugating near-infrared dye with specific peptides having a high affinity to the FPRs present on activated neutrophils. The ability of FPR-targeting nanoprobes …
Cytotoxicity Evaluation Of Methacrylate-Based Resins For Clinical Endodontics In Vitro, Chul Ahn, Aniket S. Wadajkar, Qiang Zhu, Esteban G. Garza, Lynn A. Opperman, Larry L. Bellinger, Takashi Komabayashi
Cytotoxicity Evaluation Of Methacrylate-Based Resins For Clinical Endodontics In Vitro, Chul Ahn, Aniket S. Wadajkar, Qiang Zhu, Esteban G. Garza, Lynn A. Opperman, Larry L. Bellinger, Takashi Komabayashi
Bioengineering Faculty Publications
This study examines the cytotoxicity of Super-Bond C&B (SB-C&B), Super-Bond RC Sealer (SB-RC), MetaSEAL (Meta), and AH Plus Sealer (AH+). Freshly mixed and set materials (100 mg) were prepared in vitro and placed in cell culture medium (1 mL) for the working time and for 6 h, respectively. L929 cells seeded into 96-well plates at 5,000 cells/ well were incubated with the eluted medium (200 μL) for 24 h. Cells cultured with medium alone served as the control. Cytotoxicity was evaluated by MTS assay and analyzed with ANOVA. In the freshly mixed group, the average ± SD (%) for cell …
Biophysical Assessment Of Single Cell Toxicity: Diesel Exhaust Particle-Treated Human Aortic Endothelial Cells, Kytai Truong Nguyen, Hao Xu, Yangzhe Wu, Anhong Zhou, Tian Yu, Timothy A. Gilbertson
Biophysical Assessment Of Single Cell Toxicity: Diesel Exhaust Particle-Treated Human Aortic Endothelial Cells, Kytai Truong Nguyen, Hao Xu, Yangzhe Wu, Anhong Zhou, Tian Yu, Timothy A. Gilbertson
Bioengineering Faculty Publications
Exposure to diesel exhaust particles (DEPs), a major source of traffic-related air pollution, has become a serious health concern due to its adverse influences on human health including cardiovascular and respiratory disorders. To elucidate the relationship between biophysical properties (cell topography, cytoskeleton organizations, and cell mechanics) and functions of endothelial cells exposed to DEPs, atomic force microscope (AFM) was applied to analyze the toxic effects of DEPs on a model cell line from human aortic endothelial cells (HAECs). Fluorescence microscopy and flow cytometry were also applied to further explore DEP-induced cytotoxicity in HAECs. Results revealed that DEPs could negatively impair …
Multifunctionality Of Indocyanine Green-Loaded Biodegradable Nanoparticles For Enhanced Optical Imaging And Hyperthermia Intervention Of Cancer, Kytai Truong Nguyen, Ronak H. Patel, Nimet L. Patel, Venkaiah C. Kavuri, Hanli Liu
Multifunctionality Of Indocyanine Green-Loaded Biodegradable Nanoparticles For Enhanced Optical Imaging And Hyperthermia Intervention Of Cancer, Kytai Truong Nguyen, Ronak H. Patel, Nimet L. Patel, Venkaiah C. Kavuri, Hanli Liu
Bioengineering Faculty Publications
The aim of this study was to develop and characterize multifunctional biodegradable and biocompatible poly lactic-co-glycolic acid (PLGA) nanoparticles loaded with indocyanine green (ICG) as an optical-imaging contrast agent for cancer imaging and as a photothermal therapy agent for cancer treatment. PLGA-ICG nanoparticles (PIN) were synthesized with a particle diameter of 246 11 nm, a polydispersity index of 0.10 0.03, and ICG loading efficiency of 48.75 5.48%. PIN were optically characterized with peak excitation and emission at 765 and 810 5 nm, a fluorescence lifetime of 0.30 0.01 ns, and peak absorbance at 780 nm. The cytocompatibility study of PIN …
Predictive Mathematical Model For Polyhydroxybutyrate Synthesis In Escherichia Coli, Angela Dixon
Predictive Mathematical Model For Polyhydroxybutyrate Synthesis In Escherichia Coli, Angela Dixon
Engineering Datasets
Polyhydroxybutyrate has been studied as a potential biodegradable replacement for petrochemical plastics. Polyhydroxybutyrate synthesis is not native to Escherichia coli, but the genes have successfully been inserted through plasmids. However, polyhydroxybutyrate production needs to be more cost-effective before it can be commercially produced. A mathematical model for polyhydroxybutyrate synthesis was developed to identify genes that could be altered to increase polyhydroxybutyrate production. The major metabolic pathways included in the model were glycolysis, acetyl coenzyme-A synthesis, tricarboxylic acid cycle, glyoxylate bypass, and polyhydroxybutyrate synthesis. Reactions were modeled using kinetic mechanisms identified for each enzyme. The transcriptional network was incorporated into the …
Looking Below The Surface Of Breast Tissue During Surgery, A Mahadevan-Jansen, Md Keller, Elizabeth Vargis, B Caldwell, T-Q Nguyen, Ndm Granja, M Sanders, Mc Kelley
Looking Below The Surface Of Breast Tissue During Surgery, A Mahadevan-Jansen, Md Keller, Elizabeth Vargis, B Caldwell, T-Q Nguyen, Ndm Granja, M Sanders, Mc Kelley
Biological Engineering Faculty Publications
In this article, we present a method that provides prompt detection of the presence of cancer cells inside the 2-mm margin of tissue surrounding the tumor after excision using spatially offset Raman spectroscopy (SORS). SORS was developed to detect subtle changes in soft tissue spectra in the 100–2000 μm range and tested on excised breast tissues. The results display a very high specificity and sensitivity (100% and 95%, respectively) of classification between positive and negative tumor margins. SORS is a clinically feasible method, suitable for the real-time, intraoperative assessment of tumor margins at the micrometer level.
Targeted Nanoparticles For Cancer Therapy: Promises And Challenge, Kytai Truong Nguyen
Targeted Nanoparticles For Cancer Therapy: Promises And Challenge, Kytai Truong Nguyen
Bioengineering Faculty Publications
No abstract provided.
Quantification Of Functional Near Infrared Spectroscopy To Assess Cortical Reorganization In Children With Cerebral Palsy, Fenghua Tian, Mauricio R. Delgado, Bilal Khan, Sameer C. Dhamne, George Alexandrakis, Mario I. Romero, Linsley Smith, Dahlia Reid, Hanli Liu, Nancy J. Clegg
Quantification Of Functional Near Infrared Spectroscopy To Assess Cortical Reorganization In Children With Cerebral Palsy, Fenghua Tian, Mauricio R. Delgado, Bilal Khan, Sameer C. Dhamne, George Alexandrakis, Mario I. Romero, Linsley Smith, Dahlia Reid, Hanli Liu, Nancy J. Clegg
Bioengineering Faculty Publications
No abstract provided.