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Genetic Algorithm Optimization Of Experiment Design For Targeted Uncertainty Reduction, Alexander Amedeo Depillis
Genetic Algorithm Optimization Of Experiment Design For Targeted Uncertainty Reduction, Alexander Amedeo Depillis
Masters Theses
Nuclear cross sections are a set of parameters that capture probability information about various nuclear reactions. Nuclear cross section data must be experimentally measured, and this results in simulations with nuclear data-induced uncertainties on simulation outputs. This nuclear data-induced uncertainty on most parameters of interest can be reduced by adjusting the nuclear data based on the results from an experiment. Integral nuclear experiments are experiments where the results are related to many different cross sections. Nuclear data may be adjusted to have less uncertainty by adjusting them to match the results obtained from integral experiments. Different integral experiments will adjust …
A Machine Learning Approach For Predicting Clinical Trial Patient Enrollment In Drug Development Portfolio Demand Planning, Ahmed Shoieb
A Machine Learning Approach For Predicting Clinical Trial Patient Enrollment In Drug Development Portfolio Demand Planning, Ahmed Shoieb
Masters Theses
One of the biggest challenges the clinical research industry currently faces is the accurate forecasting of patient enrollment (namely if and when a clinical trial will achieve full enrollment), as the stochastic behavior of enrollment can significantly contribute to delays in the development of new drugs, increases in duration and costs of clinical trials, and the over- or under- estimation of clinical supply. This study proposes a Machine Learning model using a Fully Convolutional Network (FCN) that is trained on a dataset of 100,000 patient enrollment data points including patient age, patient gender, patient disease, investigational product, study phase, blinded …