Engineering Commons^™

A Machine Learning Approach For Predicting Clinical Trial Patient Enrollment In Drug Development Portfolio Demand Planning, Ahmed Shoieb

Masters Theses

One of the biggest challenges the clinical research industry currently faces is the accurate forecasting of patient enrollment (namely if and when a clinical trial will achieve full enrollment), as the stochastic behavior of enrollment can significantly contribute to delays in the development of new drugs, increases in duration and costs of clinical trials, and the over- or under- estimation of clinical supply. This study proposes a Machine Learning model using a Fully Convolutional Network (FCN) that is trained on a dataset of 100,000 patient enrollment data points including patient age, patient gender, patient disease, investigational product, study phase, blinded …

A Numerical Optimization Study Of A Novel Electrospray Emitter Design, Joshua H. Howell

Masters Theses

The low thrust and high specific impulse of electric propulsion has been brought to the forefront for CubeSat and small spacecraft applications. Electrospray thrusters, which operate via electrostatic principles, have seen much research, development, and application in recent years. The small sizes of the spacecraft that utilize electrospray thrusters has focused development into the miniaturization of this technology to the micro-scale. Miniaturization introduces design challenges that must be addressed, including power supply mass and footprint requirements. This consequence requires investigation into the effects of design choices on the thruster onset voltage, defined as the voltage at which ion emission begins. …

Improving Ventricular Catheter Design Through Computational Fluid Dynamics, Sofy Hefets Weisenberg

Masters Theses

Cerebrospinal fluid (CSF) shunts are fully implantable medical devices that are used to treat patients suffering from conditions characterized by elevated intracranial pressure, such as hydrocephalus. In cases of shunt failure or malfunction, patients are often required to endure one or more revision surgeries to replace all or part of the shunt. One of the primary causes of CSF shunt failure is obstruction of the ventricular catheter, a component of the shunt system implanted directly into the brain's ventricular system. This work aims to improve the design of ventricular catheters in order to reduce the incidence of catheter obstruction and …

Optimizing Boat Hull And Deck Mold Storage Scheduling With Linear Programming, Tron Bjorn Dareing

Masters Theses

With a wide range of products, Sea Ray uses a vast amount of large boat molds for each of the different boat models. Storing and transporting these molds can be an issue with introducing high variability in the production process. One of the largest problems deals with the utilization of the employees’ time with the large amount of boat production. Having the boat molds being ready for production is a critical part of the manufacturing of quality boats. There is non-value added time spent on preparing the molds for the lamination process and storing them in various areas. This problem …

A Stochastic Model For Self-Scheduling Problem, Lili Zhang

Masters Theses

The unit commitment (UC) problem is a typical application of optimization techniques in the power generation and operation. Given a planning horizon, the UC problem is to find an optimal schedule of generating units, including on/off status and production level of each generating unit at each time period, in order to minimize operational costs, subject to a series of technical constraints. Because technical constraints depend on the characteristics of energy systems, the formulations of the UC problem vary with energy systems. The self-scheduling problem is a variant of the UC problem for the power generating companies to maximize their profits …

Optimization And Design For Heavy Lift Launch Vehicles, Paul Andreas Ritter

Masters Theses

The simulation and evaluation of an orbital launch vehicle requires consideration of numerous factors. These factors include, but are not limited to the propulsion system, aerodynamic effects, rotation of the earth, oblateness, and gravity. A trajectory simulation that considers these different factors is generated by a code developed for this thesis titled Trajectories for Heavy-lift Evaluation and Optimization (THEO). THEO is a validated trajectory simulation code with the ability to model numerous launch configurations. THEO also has the capability to provide the means for an optimization objective. Optimization of a launch vehicle can be specified in terms of many different …

Comparative Study On Posture And Its Influences On Horizontal Ground Reaction Forces Generated By Muscles: Implications For Crouch Gait, Hoa Xuan Hoang

Masters Theses

Crouch gait decreases walking efficiency due to the increased knee and hip flexion during the stance phase of gait. Crouch gait is generally considered to be disadvantageous for patients with cerebral palsy; however, a crouched posture may afford biomechanical advantages that lead some patients to adopt a crouch gait.

To investigate one possible advantage of crouch gait, a musculoskeletal model created in OpenSim was placed in 15 different postures from upright to severe crouch during initial, middle, and final stance of the gait cycle. A series of optimizations were performed for each posture to maximize ground reaction forces for the …

Unit Commitment Methods To Accommodate High Levels Of Wind Generation, Alexander Charles Melhorn

Masters Theses

The United State’s renewable portfolio standards call for a large increase of renewable energy and improved conservation efforts over today’s current system. Wind will play a ma jor role in meeting the renewable portfolio standards. As a result, the amount of wind capacity and generation has been growing exponentially over the past 10 to 15 years. The proposed unit commitment method integrates wind energy into a scheduable resource while keeping the formulation simple using mixed integer programming. A reserve constraint is developed and added to unit commitment giving the forecasted wind energy an effective cost. The reserve constraint can be …