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Dissociation Of The Effects Of Serotonin Reuptake Inhibitor Fluoxetine In Prelimbic Cortex On Disruption Of Timing And Working Memory For Time By Neutral And Negative Emotional Events, Chance Christensen

Undergraduate Honors Capstone Projects

Learning and memory abilities are altered in disorders of the serotonergic system, in disorders such as such as depression, phobias, and post-traumatic stress disorder (PTSD). Among the processes impaired by emotional distracters, and whose dysregulation is documented in affective disorders, is the ability to time in the seconds-to-minutes range, i.e., interval timing. Presentation of distracters during timing tasks result in delays in responding suggesting a failure to maintain subjective time in working memory, as proposed by the Relative Time-Sharing (RTS) model. We investigated the role of the prelimbic cortex in the detrimental effect of anxiety-inducing distracters on the cognitive ability …