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Diagnosis Of A Chiari Malformation After A Concussion In A Junior College Football Player With A History Of Chronic Headaches: A Case Report, Takeaki Ando, Shannon Gehr, Melanie L. Mcgrath, Adam B. Rosen

Health and Kinesiology Faculty Publications

The purpose of this report is to present the case of a National Junior Collegiate Athletic Association football player diagnosed with Chiari malformation postconcussion. A Chiari malformation is characterized by the cerebellum presenting below the level of the foramen. The uniqueness of this case stems from the patient’s health history, length of symptoms, and diagnosis. The effectiveness of treatment options, and the primary means to reduce the risk of catastrophic head injury in those with Chiari malformations are debatable. Clinicians should be familiar with the potential for the presence of a Chiari malformation with persistent symptoms postconcussion.

Single-Limb Landing Biomechanics Are Altered And Patellar Tendinopathy Related Pain Is Reduced With Acute Infrapatellar Strap Application, Adam B. Rosen, Jupil Ko, Cathleen N. Brown

Health and Kinesiology Faculty Publications

Background

Patellar tendinopathy, a common condition of the knee, is often treated with patellar tendon straps to control pain during dynamic activity. Little is known regarding their effect on pain, landing kinematics and kinetics with their application. The purpose of this study was to determine if patellar tendon straps influenced pain, kinematics at landing and ground reaction forces in individuals with patellar tendinopathy versus healthy controls.

Methods

Thirty participants with patellar tendinopathy and 30 controls participated. They completed single-limb landings with and without patellar tendon straps while pain, three-dimensional kinematics and vertical ground reaction forces were measured. A multivariate …

Trpv1 Channels In Human Skeletal Muscle Feed Arteries: Implications For Vascular Function, Stephen J. Ives, Song-Young Park, Oh-Sung Kwon, Jayson R. Gifford, Robert H. I. Andtbacka, John R. Hyngstrom, Russell S. Richardson

Health and Kinesiology Faculty Publications

New Findings

• What is the central question of this study?

  We sought to determine whether human skeletal muscle feed arteries (SFMAs) express TRPV1 channels and what role they play in modulating vascular function.

• What is the main finding and its importance?

  Human SMFAs do express functional TRPV1 channels that modulate vascular function, specifically opposing α-adrenergic receptor-mediated vasocontraction and potentiating vasorelaxation, in an endothelium-dependent manner, as evidenced by the α1-receptor-mediated responses. Thus, the vasodilatory role of TRPV1 channels, and their ligand capsaicin, could be a potential therapeutic target for improving vascular function. Additionally, given the ‘sympatholytic’ effect of TRPV1 activation and …

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Wnt5a Regulates Adipose Tissue Angiogenesis Via Antiangiogenic Vegf-A165b In Obese Humans, Melissa G. Farb, Doan T.M. Ngo, Song-Young Park, Samantha M. Saggese, Naomi M. Hamburg, Brian Carmine, Donald T. Hess, Kenneth Walsh, Noyan Gokce

Health and Kinesiology Faculty Publications

Experimental studies have suggested that Wingless-related integration site 5A (WNT5A) is a proinflammatory secreted protein that is associated with metabolic dysfunction in obesity. Impaired angiogenesis in fat depots has been implicated in the development of adipose tissue capillary rarefaction, hypoxia, inflammation, and metabolic dysfunction. We have recently demonstrated that impaired adipose tissue angiogenesis is associated with overexpression of antiangiogenic factor VEGF-A165b in human fat and the systemic circulation. In the present study, we postulated that upregulation of WNT5A is associated with angiogenic dysfunction and examined its role in regulating VEGF-A165b expression in human obesity. We biopsied subcutaneous and visceral adipose …

Comparison Between Single And Combined Clinical Postural Stability Tests In Individuals With And Without Chronic Ankle Instability, Jupil Ko, Adam B. Rosen, Cathleen N. Brown

Health and Kinesiology Faculty Publications

Objective: To determine if a single or/and combined clinical tests match group membership based on self-reported ankle function.

Design: Cross-sectional.

Setting: Biomechanics Laboratory.

Participants: From participants, 58 meeting inclusion/exclusion criteria were divided into a chronic ankle instability (CAI) group (n = 25) who reported ≤25 on the Cumberland Ankle Instability Tool (CAIT) and a history of moderate–severe ankle sprain(s) and a control group (n = 33) who reported ≥29 on the CAIT and no history of ankle sprain(s).

Interventions: Participants completed the following clinical tests: Foot Lift Test (FLT), the Star Excursion Balance Test (SEBT), the Single-Leg Hop Test (SLHT), …

Patellar Tendon Straps Decrease Pain And May Alter Lower Extremity Kinetics In Those With Patellar Tendinopathy During Jump Landing, Adam B. Rosen, Jupil Ko, Kathy J. Simpson, Cathleen N. Brown

Health and Kinesiology Faculty Publications

Patellar tendinopathy is often managed with a patellar tendon strap, however, their effectiveness is unsubstantiated. The purpose of this study was to determine if straps altered pain or lower extremity kinetics of individuals with patellar tendinopathy during landing. Thirty participants with patellar tendinopathy and 30 controls completed drop jumps with and without patellar tendon straps. Wearing the strap, tendinopathy participants demonstrated significantly decreased pain and reduced knee adductor moment; all participants displayed significantly decreased anterior ground reaction force while wearing a strap. Patellar tendon strapping may reduce pain due to alterations in direction and magnitude of loading.

Affordances In The Home Environment For Motor Development-Infant Scale, Spanish Translation, Danae Dinkel, Kailey Snyder, Priscila Cacola

Health and Kinesiology Faculty Publications

The home environment has a critical influence on an infant’s development and well-being. The Affordances in the Home Environment for Motor Development-Infant Scale (AHEMD-IS) is an instrument that has been developed to assess the home environment. This article illustrates the translation, validation, and cultural adaptation process of the AHEMD-IS from English to Spanish. The AHEMD-IS underwent a comprehensive process involving a four-phase translation process: (1) Forward translation, (2) Semantic equivalence, (3) Content equivalence testing, and (4) Final version development. Steps 1 and 2 resulted in linguistic alterations from the initial translation to enhance clarity for general public understanding. In step …

He’S Just Content To Sit: A Qualitative Study Of Mothers’ Perceptions Of Infant Obesity And Physical Activity, Danae Dinkel, Kailey Snyder, Anastasia Kyvelidou, Victoria Molfese

Health and Kinesiology Faculty Publications

Background: Rates of obesity among children ages zero to five are rapidly increasing. Greater efforts are needed to promote healthy behaviors of young children. Mothers are especially important targets for promoting health as mothers’ views play a vital role in helping their children foster healthy habits from an early age. Research has found parents’ views of infants’ weight may influence their feeding practices; however, limited research has explored mothers’ view of infants’ weight in relation to the promotion of physical activity. Therefore, the purpose of this study was to explore the perceptions of mothers of normal weight infants and overweight …

Combined Exercise Training Reduces Blood Pressure, Arterial Stiffness, And Insulin Resistance In Obese Prehypertensive Adolescent Girls, Won-Mok Son, Ki-Dong Sung, Leena P. Bharath, Kong-Jib Choi, Song-Young Park

Health and Kinesiology Faculty Publications

Childhood obesity is strongly linked to pathological processes for cardiovascular diseases in later adulthood. Obese adolescent girls with high blood pressure (BP) are reported to have increased arterial stiffness, which is associated with the development of hypertension and atherosclerosis. The present study sought to examine the impact of combined resistance and aerobic exercise (CRAE) training on BP, brachial-ankle pulse wave velocity (baPWV), insulin resistance (IR), and body composition in obese prehypertensive girls. Forty girls (age, 15 ± 1 years; systolic BP, 132 ± 2 mmHg, diastolic BP, 80 ± 5 mmHg) were randomly assigned to either a combined exercise (EX, …

Postural Control Strategies Differ In Normal Weight And Overweight Infants, Danae Dinkel, Kailey Snyder, Victoria Molfese, Anastasia Kyvelidou

Health and Kinesiology Faculty Publications

Background

Evidence suggests obesity can have a negative influence on a child’s motor development and postural control behavior. Little research has examined the impact of infant weight on gross motor behavior, particularly postural control at the onset of sitting.

Objective

The purpose of this study was to determine whether normal weight and overweight infants differed in their postural control strategies at the onset of sitting and one-month post onset of sitting.

Methods

29 infants (n = 19 normal weight, n = 10 overweight) were recruited to participate in this study. Infant’s length and weight were measured at 3 months of …

Age-Related Endothelial Dysfunction In Human Skeletal Muscle Feed Arteries: The Role Of Free Radicals Derived From Mitochondria In The Vasculature, Song-Young Park, Robert H. I. Andtbacka, John R. Hyngstrom, Van Reese, M. P. Murphy, Russell S. Richardson

Health and Kinesiology Faculty Publications

Aim

This study sought to determine the role of free radicals derived from mitochondria in the vasculature in the recognized age-related endothelial dysfunction of human skeletal muscle feed arteries (SMFAs).

Methods

A total of 44 SMFAs were studied with and without acute exposure to the mitochondria-targeted antioxidant MitoQ and nitric oxide synthase (NOS) blockade. The relative abundance of proteins from the electron transport chain, phosphorylated (p-) to endothelial (e) NOS ratio, manganese superoxide dismutase (MnSOD) and the mitochondria-derived superoxide () levels were assessed in SMFA. Endothelium-dependent and endothelium-independent SMFA vasodilation was assessed in response to flow-induced shear stress, acetylcholine (ACh) …

Attention Is Associated With Postural Control In Those With Chronic Ankle Instability, Adam B. Rosen, Nicholas T. Than, William Z. Smith, Jennifer M. Yentes, Melanie L. Mcgrath, Mukul Mukherjee, Sara A. Myers, Arthur C. Maerlender

Health and Kinesiology Faculty Publications

Chronic ankle instability (CAI) is often debilitating and may be affected by a number of intrinsic and environmental factors. Alterations in neurocognitive function and attention may contribute to repetitive injury in those with CAI and influence postural control strategies. Thus, the purpose of this study was to determine if there was a difference in attentional functioning and static postural control among groups of Comparison, Coper and CAI participants and assess the relationship between them within each of the groups. Recruited participants performed single-limb balance trials and completed the CNS Vital Signs (CNSVS) computer-based assessment to assess their attentional function. Center …

They Just Need To Move: Teachers' Perception Of Classroom Physical Activity Breaks, Danae Dinkel, Connie Schaffer, Kailey Snyder, Jung Min Lee

Health and Kinesiology Faculty Publications

The purpose of this study was to explore 1) perceptions of preschool-8th grade teachers' in regard to classroom physical activity (PA) and 2) multiple levels of factors impacting preschool-8th grade teachers' ability to implement PA into the classroom. Sixty preschool-8th grade teachers from five school districts participated in semi-structured interviews following a guide developed from constructs of the social ecological model. All teachers implemented classroom PA but had varied levels of confidence for implementation. Teachers identified barriers to implementation and requested additional classroom PA resources. Furthermore, they identified collaboration with other teachers as an underutilized resource for promotion of classroom …

Patellar Tendon Straps Decrease Pre-Landing Quadriceps Activation In Males With Patellar Tendinopathy, Adam B. Rosen, Jupil Ko, Kathy J. Simpson, Cathleen N. Brown

Health and Kinesiology Faculty Publications

Objective: To determine if patellar tendon straps altered quadriceps’ muscle activity during a drop-jump landing in males with and without patellar tendinopathy.

Design: Case-control.

Settings: Biomechanics Research Laboratory.

Participants: Twenty recreationally-active males participated: ten (age=21.3±2.4 years, height=182.8±5.3cm, mass=81.7±8.6kg) with patellar tendinopathy; ten (age=22.0±1.6 years, height=185.7±4.5 cm, mass=82.2±9.8kg) were healthy with no history of tendinopathy.

Main Outcome Measures: Electromyography (EMG) data for the vastus medialis (VM), rectus femoris (RF), and vastus lateralis (VL) muscles were collected. Five 2-legged 40cm drop-jumps were performed wearing a patellar tendon strap and 5 with no-strap in a counterbalanced order.

Root-mean …

Leveling The Playing Field: Assessment Of Gross Motor Skills In Low Socioeconomic Children To Their Higher Socioeconomic Counterparts, Megan M. Adkins, Matthew Bice, Danae Dinkel, John P. Rech

Health and Kinesiology Faculty Publications

Background: Fundamental movements (FM) of children influence the willingness to engage in physical activity (PA). Thus, proper FM skills are the foundation for a lifespan of PA. Objective: This study examined what factors may affect children’s PA in relation to FM pattern capabilities. Methods: The study examined the influence of SES when three low-income schools were provided additional PA opportunities on days PE was not taught. FM patterns in relation to object control (OC) and locomotor skill (LC) development were evaluated on K (n = 871), 1st (n = 893), and 2nd graders (n = 829) using the Test of …

A Qualitative Exploration Of Former College Student-Athletes’ Wellness, Shane Warehime, Danae Dinkel, Abby Bjornson-Ramig, Ashley J. Blount

Health and Kinesiology Faculty Publications

College student-athletes (SAs) may experience difficulties while transitioning from college, which could reduce their overall wellness. However, it is essential to understand positive transition experiences and outcomes, as this can guide future research and intervention efforts. The purpose of this study was to explore the factors that led to higher levels of wellness in former SAs. Semi-structured interviews guided by the Indivisible Self Model were completed with former SAs (n = 12). Overall, participants displayed high levels of wellness - most prominently in terms of work and exercise. Many SAs perceived their current wellness was equal, if not better compared …

Clinical Measures And Their Contribution To Dysfunction In Individuals With Patellar Tendinopathy, Hyunjae Jeon, Melanie L. Mcgrath, Neal Grandgenett, Adam B. Rosen

Health and Kinesiology Faculty Publications

Context: Patellar tendinopathy is prevalent in physically active populations and it affects their quality of living, performance of activity, and may contribute to the early cessation of their athletic careers. A number of previous studies have identified contributing factors for patellar tendinopathy however their contributions to self-reported dysfunction remain unclear.
Objective: The purpose of this investigation was to determine if strength, flexibility, and various lower extremity static alignments contributed to self-reported function and influence the severity of patellar tendinopathy.
Design: Cross sectional research design.
Setting: University Laboratory.
Participants: 30 participants with patellar tendinopathy volunteered for this study (age: 23.4±3.6 years, …

Evidence Of Glycolysis Up-Regulation And Pyruvate Mitochondrial Oxidation Mismatch During Mechanical Unloading Of The Failing Human Heart: Implications For Cardiac Reloading And Conditioning, Nikolaos A. Diakos, Sutip Navankasattusas, E. Dale Abel, Jared Rutter, Lauren Mccreath, Peter Ferrin, Stephen H. Mckellar, Dylan V. Miller, Song-Young Park, Russell S. Richardson, Ralph Deberardinis, James E. Cox, Abdallah G. Kfoury, Craig H. Selzman, Joseph C. Fang, Dean Y. Li, Stavros Drakos

Health and Kinesiology Faculty Publications

This study sought to investigate the effects of mechanical unloading on myocardial energetics and the metabolic perturbation of heart failure (HF) in an effort to identify potential new therapeutic targets that could enhance the unloading-induced cardiac recovery. The authors prospectively examined paired human myocardial tissue procured from 31 advanced HF patients at left ventricular assist device (LVAD) implant and at heart transplant plus tissue from 11 normal donors. They identified increased post-LVAD glycolytic metabolites without a coordinate increase in early, tricarboxylic acid (TCA) cycle intermediates. The increased pyruvate was not directed toward the mitochondria and the TCA cycle for complete …

Wnt5a-Jnk Regulation Of Vascular Insulin Resistance In Human Obesity, Melissa G. Farb, Shakun Karki, Song-Young Park, Samantha M. Saggese, Brian Carmine, Donald T. Hess, Caroline Apovian, Jessica L. Fetterman, Rosa Breton-Romero, Naomi M. Hamburg, Jose J. Fuster, Maria A. Zuriaga, Kenneth Walsh, Noyan Gokce

Health and Kinesiology Faculty Publications

Obesity is associated with the development of vascular insulin resistance; however, pathophysiological mechanisms are poorly understood. We sought to investigate the role of WNT5A-JNK in the regulation of insulin-mediated vasodilator responses in human adipose tissue arterioles prone to endothelial dysfunction. In 43 severely obese (BMI 44±11 kg/m2) and five metabolically normal non-obese (BMI 26±2 kg/m2) subjects, we isolated arterioles from subcutaneous and visceral fat during planned surgeries. Using videomicroscopy, we examined insulin-mediated, endothelium-dependent vasodilator responses and characterized adipose tissue gene and protein expression using real-time polymerase chain reaction and Western blot analyses. Immunofluorescence was used to quantify endothelial nitric oxide …

Accuracy And Precision Of Quantitative 31p-Mrs Measurements Of Human Skeletal Muscle Mitochondrial Function, Gwenael Layec, J. R. Gifford, Joel D. Trinity, Corey R. Hart, Ryan S. Garten, Song-Young Park, Yann Le Fur, Eun-Kee Jeong, Russell S. Richardson

Health and Kinesiology Faculty Publications

Although theoretically sound, the accuracy and precision of 31P-magnetic resonance spectroscopy (31P-MRS) approaches to quantitatively estimate mitochondrial capacity are not well documented. Therefore, employing four differing models of respiratory control [linear, kinetic, and multipoint adenosine diphosphate (ADP) and phosphorylation potential], this study sought to determine the accuracy and precision of 31P-MRS assessments of peak mitochondrial adenosine-triphosphate (ATP) synthesis rate utilizing directly measured peak respiration (State 3) in permeabilized skeletal muscle fibers. In 23 subjects of different fitness levels, 31P-MRS during a 24-s maximal isometric knee extension and high-resolution respirometry in muscle fibers from the vastus lateralis was performed. Although significantly …

Mitochondrial Function In Heart Failure: The Impact Of Ischemic And Non-Ischemic Etiology, Song-Young Park, Joel D. Trinity, J. R. Gifford, Nikolaos A. Diakos, Lauren Mccreath, Stavros Drakos, Russell S. Richardson

Health and Kinesiology Faculty Publications

Background

Although cardiac mitochondrial dysfunction is associated with heart failure (HF), this is a complex syndrome with two predominant etiologies, ischemic HF (iHF) and non-ischemic HF (niHF), and the exact impact of mitochondrial dysfunction in these two distinct forms of HF is unknown.

Methods and results

To determine the impact of HF etiology on mitochondrial function, respiration was measured in permeabilized cardiac muscle fibers from patients with iHF (n = 17), niHF (n = 18), and healthy donor hearts (HdH). Oxidative phosphorylation capacity (OXPHOS), assessed as state 3 respiration, fell progressively from HdH to niHF, to iHF (Complex I + …

Impact Of Aerobic And Anaerobic Exercise Training On Oxidative Stress And Antioxidant Defense In Athletes, Song-Young Park, Yi Sub Kwak

Health and Kinesiology Faculty Publications

Exercise mediates an excessive free radical production leading to oxidative stress (OS). The body has natural antioxidant systems that help decrease OS, and these systems may be enhanced with exercise training. However, only a few studies have investigated the differences in resting OS and antioxidant capacity (AOC) between aerobically trained athletes (ET), anaerobically trained athletes (RT), and untrained individuals (UT). Therefore, this study sought to investigate the resting and postexercise OS and AOC in ET, RT, and UT. Sixty healthy young males (26.6±0.8 yr) participated in this study. Subjects were divided into three groups, ET, RT, and UT by distinct …

Exercise Training Improves Vascular Mitochondrial Function, Song-Young Park, Matthew J. Rossman, J. R. Gifford, Leena P. Bharath, Johann Bauersachs, Russell S. Richardson, E. Dale Abel, J. David Symons, Christian Riehle

Health and Kinesiology Faculty Publications

Exercise training is recognized to improve cardiac and skeletal muscle mitochondrial respiratory capacity; however, the impact of chronic exercise on vascular mitochondrial respiratory function is unknown. We hypothesized that exercise training concomitantly increases both vascular mitochondrial respiratory capacity and vascular function. Arteries from both sedentary (SED) and swim-trained (EX, 5 wk) mice were compared in terms of mitochondrial respiratory function, mitochondrial content, markers of mitochondrial biogenesis, redox balance, nitric oxide (NO) signaling, and vessel function. Mitochondrial complex I and complex I + II state 3 respiration and the respiratory control ratio (complex I + II state 3 respiration/complex I state …

Impact Of Age On The Vasodilatory Function Of Human Skeletal Muscle Feed Arteries, Song-Young Park, S. J. Ives, J. R. Gifford, R. H. I. Andtbacka, John R. Hyngstrom, Van Reese, Gwenael Layec, Leena P. Bharath, J. David Symons, Russell S. Richardson

Health and Kinesiology Faculty Publications

Although advancing age is often associated with attenuated skeletal muscle blood flow and skeletal muscle feed arteries (SMFAs) have been recognized to play a regulatory role in the vasculature, little is known about the impact of age on the vasodilatory capacity of human SMFAs. Therefore, endothelium-dependent and -independent vasodilation were assessed in SMFAs (diameter: 544 ± 63 μm) obtained from 24 (equally represented) young (33 ± 2 yr) and old (71 ± 2 yr) subjects in response to three stimuli: 1) flow-induced shear stress, 2) ACh, and 3) sodium nitropusside (SNP). Both assessments of endothelium-dependent vasodilation, flow …

Effects Of Whole Body Vibration Training On Body Composition, Skeletal Muscle Strength, And Cardiovascular Health, Song-Young Park, Won-Mok Son, Oh-Sung Kwon

Health and Kinesiology Faculty Publications

Whole body vibration training (WBVT) has been used as a supplement to conventional exercise training such as resistance exercise training to improve skeletal muscle strength, specifically, in rehabilitation field. Recently, this exercise modality has been utilized by cardiovascular studies to examine whether WBVT can be a useful exercise modality to improve cardiovascular health. These studies reported that WBVT has not only beneficial effects on muscular strength but also cardiovascular health in elderly and disease population. However, its mechanism underlying the beneficial effects of WBVT in cardiovascular health has not been well documented. Therefore, this review highlighted the impacts of WBVT …

The Effects Of Aerobic Exercise Training On Blood Lipid Profiles, Fibrinolytic Activities, And Nitric Oxide Levels In High-Fat-Diet Induced Rats, Won-Mok Son, Do-Yeon Kim, Ki-Dong Sung, Yi Sub Kwak, Yeong Ho Baek, Song-Young Park

Health and Kinesiology Faculty Publications

Although exercise training has been utilized to improve vascular function in animals and humans, the impact of moderate intensity exercise training on fibrinolytic activities and nitric oxide (NO) bioavailability has not been well documented. Therefore, the purpose of the current study was to examine the impact of moderate intensity aerobic exercise training on fat mass, blood lipid profiles, fibrinolytic activity, and NO levels in high-fat-diet induced rats. The body weight, fat mass, blood lipid profiles, fibrinolytic activity, and nitrite/nitrate were measured pre- and postexercise (10 weeks) training. The body weight and fat mass reduced significantly in the exercise (EX) group …

The Clinical Evaluation Between Overtraining Syndrome And Exercise-Related Immunity, Song-Young Park, Yi Sub Kwak, Seung-Jun Choi

Health and Kinesiology Faculty Publications

The present study was performed to analyze and review the physical and immune responses to overtraining syndrome in humans. Overreaching refers to the initial phage of overtraining syndrome and has been known as a physical fatigue which is mainly from metabolic imbalance. It has been known that overtraining also results in a loss of adaptability which may lead to an attenuation of exercise performance, sleeping disorder, central fatigue, neurohormonal changes, difficulty recovery to physical stress, and immunological changes. Additionally, overtraining syndrome is characterized by persistent fatigue, poor performance in sport due to the prolonged and strenuous physical training. Also, previous …

Quadriceps Exercise Intolerance In Patients With Chronic Obstructive Pulmonary Disease: The Potential Role Of Altered Skeletal Muscle Mitochondrial Respiration, J. R. Gifford, Joel D. Trinity, Gwenael Layec, Ryan S. Garten, Song-Young Park, Matthew J. Rossman, Steen Larsen, Flemming Dela, Russell S. Richardson

Health and Kinesiology Faculty Publications

This study sought to determine if qualitative alterations in skeletal muscle mitochondrial respiration, associated with decreased mitochondrial efficiency, contribute to exercise intolerance in patients with chronic obstructive pulmonary disease (COPD). Using permeabilized muscle fibers from the vastus lateralis of 13 patients with COPD and 12 healthy controls, complex I (CI) and complex II (CII)-driven State 3 mitochondrial respiration were measured separately (State 3:CI and State 3:CII) and in combination (State 3:CI+CII). State 2 respiration was also measured. Exercise tolerance was assessed by knee extensor exercise (KE) time to fatigue. Per milligram of muscle, State 3:CI+CII and State 3:CI were reduced …

Low Intensity Resistance Exercise Training With Blood Flow Restriction: Insight Into Cardiovascular Function, And Skeletal Muscle Hypertrophy In Humans, Song-Young Park, Yi Sub Kwak, Andrew Harveson, Joshua C. Weavil, Kook E. Seo

Health and Kinesiology Faculty Publications

Attenuated functional exercise capacity in elderly and diseased populations is a common problem, and stems primarily from physical inactivity. Decreased function and exercise capacity can be restored by maintaining muscular strength and mass, which are key factors in an independent and healthy life. Resistance exercise has been used to prevent muscle loss and improve muscular strength and mass. However, the intensities necessary for traditional resistance training to increase muscular strength and mass may be contraindicated for some at risk populations, such as diseased populations and the elderly. Therefore, an alternative exercise modality is required. Recently, blood flow restriction (BFR) with …

Α1- And Α2-Adrenergic Responsiveness In Human Skeletal Muscle Feed Arteries: The Role Of Trpv Ion Channels In Heat-Induced Sympatholysis, J. R. Gifford, S. J. Ives, Song-Young Park, R. H. I. Andtbacka, John R. Hyngstrom, Michelle T. Mueller, Gerald S. Treinman, Christopher Ward, Joel D. Trinity, Russell S. Richardson

Health and Kinesiology Faculty Publications

The purpose of this study was to determine if heat inhibits α2-adrenergic vasocontraction, similarly to α1-adrenergic contraction, in isolated human skeletal muscle feed arteries (SMFA) and elucidate the role of the temperature-sensitive vanilloid-type transient receptor potential (TRPV) ion channels in this response. Isolated SMFA from 37 subjects were studied using wire myography. α1 [Phenylephrine (PE)]- and α2 [dexmedetomidine (DEX)]-contractions were induced at 37 and 39°C with and without TRPV family and TRPV4-specific inhibition [ruthenium red (RR) and RN-1734, respectively]. Endothelial function [acetylcholine (ACh)] and smooth muscle function [sodium nitroprusside (SNP) and potassium chloride (KCl)] were also assessed under these conditions. …