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The Effect Of Dietary Sulfur On The Metabolism Of Long Chain Polyunsaturated Fatty Acids, Mei Fung Chen
The Effect Of Dietary Sulfur On The Metabolism Of Long Chain Polyunsaturated Fatty Acids, Mei Fung Chen
Doctoral Dissertations
The test hypothesis of this investigation was that methionine-supplemented diets could possibly interfere with the metabolism of polyunsaturated fatty acids, thereby altering the biosynthesis of the active metabolites, prostanoids, and the profiles of tissue phospholipids. The postulated mechanism of action for this dietary regimen would be to increase the tissue concentration of the active methyl donor, S-Adenosyl-methionine (SAM) which is also called an activated methionine. SAM is a potent inhibitor of the cycloaxygenase enzyme which is important for the synthesis of biologically active prostanoids.
The results demonstrated that liver microsomes from rats fed the methionine-supplemented diet had a statistically significant …
A Relationship Between Vitamin B12, Folate, Ascorbic Acid, And Mercury Metabolism, Nancy Elizabeth Zorn
A Relationship Between Vitamin B12, Folate, Ascorbic Acid, And Mercury Metabolism, Nancy Elizabeth Zorn
Masters Theses
The effect of megadoses of vitamin B12, folate, and vitamin C on the in vivo methylation of mercuric chloride was studied in guinea pigs. The incorporation of high levels of vitamin B12, folate, and vitamin C resulted in a decrease in both inorganic mercury and methylmercury concentrations in all tissues except the lung and heart compared to controls. However, percent methylmercury levels tended to increase with vitamin treatments.
The addition of megadoses of vitamin B12 fed either singularly or in combination with the other vitamins resulted in increased methylmercury concentrations in the liver, spleen, and …