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Full-Text Articles in Education

Small Group Multitasking In Literature Classes, Bradley Baurain Dec 2006

Small Group Multitasking In Literature Classes, Bradley Baurain

Bradley Baurain

Faced with the challenge of teaching American literature to large, multilevel classes in Vietnam, the writer developed a flexible small group framework called ‘multitasking’. ‘Multitasking’ sets up stable task categories which rotate among small groups from lesson to lesson. This framework enabled students to work cooperatively in a variety of formats and the teacher to generate a wide range of materials and activities efficiently. It also spurred students to develop more independent learning skills and the teacher to experiment more freely with new techniques. In a narrative and reflective format, in terms both of what he expected and what he …

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Decomposing Consumer Wealth Effects: Evidence On The Role Of Real Estate Assets Following The Wealth Cycle Of 1990-2002, Michael Donihue, Andriy Avramenko Dec 2006

Decomposing Consumer Wealth Effects: Evidence On The Role Of Real Estate Assets Following The Wealth Cycle Of 1990-2002, Michael Donihue, Andriy Avramenko

Michael R Donihue

During the period from 1990 to 2002, U.S. households experienced a dramatic wealth cycle, induced by a 369 percent appreciation in the value of real per capita liquid stock-market assets, followed by a 55 percent decline. However, despite predictions at the time by some analysts relying on life-cycle models of consumption, consumer spending in real terms continued to rise throughout this period. Using data that include the period from 1990 to 2005, traditional approaches to estimating macroeconomic wealth effects on consumption confront two puzzles: (i) econometric evidence of a stable cointegrating relationship among consumption, income, and wealth is weak at …

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Ect Cornerstone: Reflections On The Aect Internship Program, Sandie Waters Dec 2006

Ect Cornerstone: Reflections On The Aect Internship Program, Sandie Waters

Sandie H Waters

No abstract provided.

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Computer-Mediated Peer Response In A Level-Iv Esl Academic Writing Class: A Cultural Historical Activity Theoretical Perspective, Li Jin Dec 2006

Computer-Mediated Peer Response In A Level-Iv Esl Academic Writing Class: A Cultural Historical Activity Theoretical Perspective, Li Jin

Li Jin

Very few studies focus on how English as a second language (ESL) students’ agency and their unique histories as an integral part of the social cultural environment influence his or her participation in computer-mediated peer response tasks, particularly in a multimedia-based synchronous communication environment. Considering each ESL student as an active agency with unique historical bearings, the dissertation investigated ESL students’ participation in computer-mediated peer response (CMPR) tasks that used instant messenger (IM) as the communication technology between students from the cultural historical activity theoretical (CHAT) perspective, which views all human interaction as a dynamic developmental process. A case study …

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Connexin Overexpression Differentially Suppresses Glioma Growth And Contributes To The Bystander Effect Following Hsv-Thymidine Kinase Gene Therapy, T. Jiminez, W. Fox, C. Naus, J. Galipeau, Daniel Belliveau Dec 2005

Connexin Overexpression Differentially Suppresses Glioma Growth And Contributes To The Bystander Effect Following Hsv-Thymidine Kinase Gene Therapy, T. Jiminez, W. Fox, C. Naus, J. Galipeau, Daniel Belliveau

Daniel J. Belliveau

Neoplastic transformation is frequently associated with a loss of gap junctional intercellular communication and reduced expression of connexins. The introduction of connexin genes into tumor cells reverses the proliferative characteristics of such cells. However, there is very little comparative information on the effects of different connexins on cancer cell growth. We hypothesized that Cx26, Cx32, or Cx43 would display differential growth suppression of C6 glioma cells and uniquely modulate the bystander effect following transduction of C6 cells with HSVtk followed by suicide gene therapy. The bystander phenomenon is the death of a greater number of tumor cells than are expressing …

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Enhanced Neurite Outgrowth In Pc12 Cells Mediated By Connexin Hemichannels And Atp, Daniel Belliveau, M. Bani-Yagoub, R. Mcgirr, C. Naus, W. Rushlow Dec 2005

Enhanced Neurite Outgrowth In Pc12 Cells Mediated By Connexin Hemichannels And Atp, Daniel Belliveau, M. Bani-Yagoub, R. Mcgirr, C. Naus, W. Rushlow

Daniel J. Belliveau

Gap junctions have traditionally been described as transmembrane channels that facilitate intercellular communication via the passage of small molecules. Connexins, the basic building blocks of gap junctions, are expressed in most mammalian tissues including the developing and adult central nervous system. During brain development, connexins are temporally and spatially regulated suggesting they play an important role in the proper formation of the central nervous system. In the current study, connexins 32 and 43 were overexpressed in PC12 cells to determine whether connexins are involved in neuronal differentiation. Both connexin 32 and 43 were appropriately trafficked to the cell membrane following …

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Designing Assessment Tasks For Deep Thinking, Gabrielle Matters May 2005

Designing Assessment Tasks For Deep Thinking, Gabrielle Matters

Dr Gabrielle Matters

I want to present some ideas about how a valid and reliable process for assessing deep thinking is not a function of the assessment regime (such as external or internal, standardised or teacher-devised), but is actually a product of the successful application of certain design criteria and the interplay of three essential elements. The argument I present rests on one simple belief that I hold: the capacity to design good assessment tasks is a vital part of an extensive professional repertoire and, as such, demands space and time, ritual and respect. (Teacher–assessors should not let anybody tell them that designing …

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Perceived Impact Of Curriculum Management Audit Recommendations On Increased Student Achievement (Dissertation), Kelly Cross Apr 2005

Perceived Impact Of Curriculum Management Audit Recommendations On Increased Student Achievement (Dissertation), Kelly Cross

Kelly L. Cross

Curriculum management audits are an intensive investigation, or audit, of a school district's daily operations, including curriculum, policies, organizational structure, financial operations, and use of assessment data. Curriculum audits are conducted by a team of certified auditors composed of professional educators and administrators. Curriculum audit findings are used to generate recommendations, which are presented to the school district in an audit report. The audit recommendations provide the district with specific recommended actions that are intended to improve district operations and to improve student achievement. This research examined whether implementation of curriculum audit recommendations, as perceived by key administrators, influenced student …

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Solving The Multilevel Dilemma, Bradley Baurain Dec 2004

Solving The Multilevel Dilemma, Bradley Baurain

Bradley Baurain

No abstract provided.

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Changes In Calcineurin Expression Induced In The Rat Brain By The Administration Of Antipsychotics, W. Rushlow, Y. Seah, Daniel Belliveau, N. Rajakumar Dec 2004

Changes In Calcineurin Expression Induced In The Rat Brain By The Administration Of Antipsychotics, W. Rushlow, Y. Seah, Daniel Belliveau, N. Rajakumar

Daniel J. Belliveau

Calcineurin (CN) was recently identified as a susceptibility gene for schizophrenia as well as showing altered RNA expression levels in the post-mortem brains of individuals with schizophrenia. CN knockout mice show a number of behaviours associated with schizophrenia, including deficits in sensorimotor gating, suggesting a link between CN and psychosis. Concurrently, we found, using genome screening techniques, that antipsychotics alter CN expression levels. Therefore, western blotting, in situ hybridization, immunocytochemistry and phosphatase assays were employed to determine what effect antipsychotics have on CN. The results indicate that clozapine, risperidone and haloperidol cause substantial reductions in the A subunit of CN …

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Nerve Growth Factor Increases Connexin43 Phosphorylation And Gap Junctional Intercellular Communication, P. Cushing, R. Bhalla, A. Johnson, W. Rushlow, S. Meakin, Daniel Belliveau Dec 2004

Nerve Growth Factor Increases Connexin43 Phosphorylation And Gap Junctional Intercellular Communication, P. Cushing, R. Bhalla, A. Johnson, W. Rushlow, S. Meakin, Daniel Belliveau

Daniel J. Belliveau

The function of gap junctions is regulated by the phosphorylation state of their connexin subunits. Numerous growth factors are known to regulate connexin phosphorylation; however, the effect of nerve growth factor on gap junction function is not understood. The phosphorylation of connexin subunits is a key event during many aspects of the lifecycle of a connexin, including open/close states, assembly/trafficking, and degradation, and thus affects the functionality of the channel. PC12 cells infected with connexin43 (Cx43) retrovirus were used as a neuronal model to characterize the signal transduction pathways activated by nerve growth factor (NGF) that potentially affect the functional …

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Design Languages, Notation Systems, And Instructional Technology, Sandie Waters, Andrew Gibbons Dec 2003

Design Languages, Notation Systems, And Instructional Technology, Sandie Waters, Andrew Gibbons

Sandie H Waters

Notational systems, used in mature fields of study, are closely related to design languages. The future of a technological field depends on the ability to communicate ideas and changes with others in the field. Instructional technology is one field that can benefit from a notation system enabling designers to duplicate, execute, and communicate their ideas. In this paper, we look at several mature fields, including chemistry, musicology, and choreography, to discover elements where a mature design language and notation system have developed. We illustrate a number of dimensions that can help designers form their design languages and select the characteristics …

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Drama As A Means Of Improving The Advocacy Skills Of Non-English-Speaking-Background Students, Chamkaur Gill Dec 2003

Drama As A Means Of Improving The Advocacy Skills Of Non-English-Speaking-Background Students, Chamkaur Gill

Chamkaur Gill

This paper will discuss the problems facing overseas-Asian students who study law in Western universities and will deal with how drama can help improve their English-language oral-communication skills. A profile of the average student belonging to a high-context, relational culture will be provided with the aim of showing why such a student needs full-on immersion in oral English. An attempt will be made to suggest that the activities and materials employed by instructors using such a strategy can help lower students’ affective barriers and increase their confidence, motivation and spontaneity when speaking, while improving their non-verbal skills. The writer’s personal …

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Teaching Fellows: An Innovative Approach To Facilitate The Integration Of Research And Education At Colby College, Philip Nyhus, F Cole, David Firmage, Edward Yeterian Dec 2003

Teaching Fellows: An Innovative Approach To Facilitate The Integration Of Research And Education At Colby College, Philip Nyhus, F Cole, David Firmage, Edward Yeterian

F. Russell Cole

No abstract provided.

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Using Role Plays In The Personal Selling Class: Some Suggestions, Daniel Mcquiston Dec 2001

Using Role Plays In The Personal Selling Class: Some Suggestions, Daniel Mcquiston

Daniel H. McQuiston

Note: full-text not available due to publisher restrictions. Link takes you to an external site where you can purchase the book or borrow it from a local library.

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Addressing The Educational Needs Of Boys, Bob Lingard, Wayne Martino, Martin Mills, Mark Bahr Dec 2001

Addressing The Educational Needs Of Boys, Bob Lingard, Wayne Martino, Martin Mills, Mark Bahr

Mark Bahr

Informed by a literature review, this report, based on case studies of schools and survey data, has provided an analysis of the work of research in addressing the educational needs of boys. The report examined how systemic factors affect the educational performance and outcomes of boys and how these can be addressed in the school context. These systemic factors included family, school and community environments, peer culture, student-teacher relationships, and teacher classroom practices. The authors sought to understand how these variables affect the educational experiences and achievement of boys and girls from different socio-economic status backgrounds and to determine which …

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Retroviral Delivery Of Connexin Genes To Human Breast Tumor Cells Inhibits In Vivo Tumor Growth By A Mechanism That Is Independent Of Significant Gap Junctional Intercellular Communication, H. Qin, Q. Shao, H. Curtis, J. Galipeau, Daniel Belliveau, T. Wang, M. Alaoui-Jamali, D. Laird Dec 2001

Retroviral Delivery Of Connexin Genes To Human Breast Tumor Cells Inhibits In Vivo Tumor Growth By A Mechanism That Is Independent Of Significant Gap Junctional Intercellular Communication, H. Qin, Q. Shao, H. Curtis, J. Galipeau, Daniel Belliveau, T. Wang, M. Alaoui-Jamali, D. Laird

Daniel J. Belliveau

The mechanism by which gap junction proteins, connexins, act as potent tumor suppressors remains poorly understood. In this study human breast tumor cells were found to exhibit diverse gap junction phenotypes including (a) undetectable Cx43 and no intercellular communication (HBL100); (b) low levels of Cx43 and sparse intercellular communication (MDA-MB-231); and (c) significant levels of Cx43 and moderate intercellular communication (Hs578T). Although retroviral delivery of Cx43 and Cx26 cDNAs to MDA-MB-231 cells did not achieve an expected substantial rescue of intercellular communication, overexpression of connexin genes did result in a dramatic suppression of tumor growth when connexin-expressing MDA-MB-231 cells were …

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Aggregated Dsred-Tagged Cx43 And Over-Expressed Cx43 Are Targeted To Lysosomes In Human Breast Cancer Cells, H. Qin, Q. Shao, Daniel Belliveau, D. Laird Dec 2000

Aggregated Dsred-Tagged Cx43 And Over-Expressed Cx43 Are Targeted To Lysosomes In Human Breast Cancer Cells, H. Qin, Q. Shao, Daniel Belliveau, D. Laird

Daniel J. Belliveau

To investigate if either wild-type or aggregated Cx43 is abnormally targeted to lysosomes in human breast tumor cells, we examined the fate of DsRed-tagged Cx43 and over-expressed Cx43 in communication-deficient HBL-100 and MDA-MB-231 cells. DsRed-tagged Cx43 was assembled into gap junctions in control normal rat kidney cells that express endogenous Cx43 but not in Cx43-negative HBL-100 cells. However, when HBL-100 cells were engineered to coexpress wild-type Cx43 a population of DsRed-tagged Cx43 was rescued and assembled into gap junctions. Co-expression of wild-type Cx26 failed to rescue the assembly of DsRed-tagged Cx43 into gap junctions. Immunolocalization studies revealed that DsRed-tagged Cx43 …

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Viral Shedding And Biodistribution Of G207, A Multimutated, Conditionally Replicating Herpes Simplex Virus Type 1, After Intracerebral Inoculation In Aotus, T. Todo, F. Feigenbaum, S. Rabkin, F. Lakeman, J. Newsome, P. Johnson, E. Mitchell, Daniel Belliveau, J. Ostrove, R. Martuza Dec 1999

Viral Shedding And Biodistribution Of G207, A Multimutated, Conditionally Replicating Herpes Simplex Virus Type 1, After Intracerebral Inoculation In Aotus, T. Todo, F. Feigenbaum, S. Rabkin, F. Lakeman, J. Newsome, P. Johnson, E. Mitchell, Daniel Belliveau, J. Ostrove, R. Martuza

Daniel J. Belliveau

G207 is a multimutated, conditionally replicating herpes simplex virus type 1 (HSV-1) that is currently in clinical trial for patients with malignant glioma. G207 exhibits an efficient oncolytic activity in tumor cells, yet minimal toxicity in normal tissue when injected into the brains of HSV-susceptible mice or nonhuman primates. In this study, we evaluated the shedding and biodistribution of clinical-grade G207 after intracerebral inoculation (3 × 107 pfu) in four New World owl monkeys (Aotus nancymae). Using PCR analyses and viral cultures, neither infectious virus nor viral DNA was detected from tear, saliva, or vaginal secretion samples at any time …

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Autocrine Hepatocyte Growth Factor Provides A Local Mechanism For Promoting Axonal Growth, X. Yang, J. Toma, S. Bamji, Daniel Belliveau, J. Kohn, M. Park, F. Miller Dec 1997

Autocrine Hepatocyte Growth Factor Provides A Local Mechanism For Promoting Axonal Growth, X. Yang, J. Toma, S. Bamji, Daniel Belliveau, J. Kohn, M. Park, F. Miller

Daniel J. Belliveau

In this report, we describe a novel local mechanism necessary for optimal axonal growth that involves hepatocyte growth factor (HGF). Sympathetic neurons of the superior cervical ganglion coexpress bioactive HGF and its receptor, the Met tyrosine kinase, both in vivo and in vitro. Exogenous HGF selectively promotes the growth but not survival of cultured sympathetic neurons; the magnitude of this growth effect is similar to that observed with exogenous NGF. Conversely, HGF antibodies that inhibit endogenous HGF decrease sympathetic neuron growth but have no effect on survival. This autocrine HGF is required locally by sympathetic axons for optimal growth, as …

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Differential Expression Of Gap Junctions In Neurons And Astrocytes Dervied From P19 Embryonal Carcinoma Cells, Daniel Belliveau, J. Bechberger, K. Rodgers, C. Naus Dec 1996

Differential Expression Of Gap Junctions In Neurons And Astrocytes Dervied From P19 Embryonal Carcinoma Cells, Daniel Belliveau, J. Bechberger, K. Rodgers, C. Naus

Daniel J. Belliveau

The P19 embryonal carcinoma cell line represents a pluripotential stem cell that can differentiate along the neural or muscle cell lineage when exposed to different environments. Exposure to retinoic acid induces P19 cells to differentiate into neurons and astrocytes that express similar developmental markers as their embryonic counterparts. We examined the expression of gap junction genes during differentiation of these stem cells into neurons and astrocytes. Untreated P19 cells express at least two gap junction proteins, connexins 26 and 43. Connexin32 could not be detected in these cells. Treatment for 96 hr with 0.3 mM retinoic acid induced the P19 …

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Blocking Nerve Growth Factor Binding To The P75 Neurotrophin Receptor On Sympathetic Neurons Transiently Reduces Trka Activation But Does Not Affect Neuronal Survival, C. Lachance, Daniel Belliveau, P. Barker Dec 1996

Blocking Nerve Growth Factor Binding To The P75 Neurotrophin Receptor On Sympathetic Neurons Transiently Reduces Trka Activation But Does Not Affect Neuronal Survival, C. Lachance, Daniel Belliveau, P. Barker

Daniel J. Belliveau

Nerve growth factor interacts with the trkA tyrosine kinase receptor and with the p75 neurotrophin receptor. It is clear that trkA mediates most, if not all, of the stereotypical responses of sympathetic neurons to nerve growth factor but the role of the p75 neurotrophin receptor is unclear. In this study, we have asked whether a functional interaction between p75 neurotrophin receptor and trkA exists in primary sympathetic neurons by disrupting nerve growth factor binding to p75 neurotrophin receptor. Acute assays reveal that blocking antibodies directed against p75 neurotrophin receptor reduce nerve growth factor-mediated trkA tyrosine phosphorylation and reduce the amount …

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Transgenic Mice Expressing The Intracellular Domain Of The P75 Neurotrophin Receptor Undergo Neuronal Apoptosis, M. Majdan, C. Lachance, A. Gloster, R. Aloyz, C. Zeindler, S. Bamji, A. Bhakar, Daniel Belliveau, J. Fawcett, F. Miller, P. Barker Dec 1996

Transgenic Mice Expressing The Intracellular Domain Of The P75 Neurotrophin Receptor Undergo Neuronal Apoptosis, M. Majdan, C. Lachance, A. Gloster, R. Aloyz, C. Zeindler, S. Bamji, A. Bhakar, Daniel Belliveau, J. Fawcett, F. Miller, P. Barker

Daniel J. Belliveau

We have asked whether p75NTR may play a role in neuronal apoptosis by producing transgenic mice that express the p75NTR intracellular domain within peripheral and central neurons. These animals showed profound reductions in numbers of sympathetic and peripheral sensory neurons as well as cell loss in the neocortex, where there is normally little or no p75NTR expression. Developmental loss of facial motor neurons was not observed, but induced expression of the p75NTR intracellular domain within adult animals led to increased motor neuron death after axotomy. Biochemical analyses suggest that these effects were not attributable to a p75NTR-dependent reduction in trk …

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Ngf And Neurotrophin-3 Both Activate Trka On Sympathetic Neurons But Differentially Regulate Survival And Neuritogenesis, Daniel Belliveau, I. Krivko, C. Lachance, J. Kohn, D. Rusakov, D. Kaplan, F. Miller Dec 1996

Ngf And Neurotrophin-3 Both Activate Trka On Sympathetic Neurons But Differentially Regulate Survival And Neuritogenesis, Daniel Belliveau, I. Krivko, C. Lachance, J. Kohn, D. Rusakov, D. Kaplan, F. Miller

Daniel J. Belliveau

In this report we examine the biological and molecular basis of the control of sympathetic neuron differentiation and survival by NGF and neurotrophin-3 (NT-3). NT-3 is as efficient as NGF in mediating neuritogenesis and expression of growth-associated genes in NGF-dependent sympathetic neurons, but it is 20-40-fold less efficient in supporting their survival. Both NT-3 and NGF induce similar sustained, long-term activation of TrkA, while NGF is 10-fold more efficient than NT-3 in mediating acute, short-term TrkA activity. At similar acute levels of TrkA activation, NT-3 still mediates neuronal survival two- to threefold less well than NGF. However, a mutant NT-3 …

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Adenovirus-Mediated Gene Transfer Of The Tumor Suppressor, P53, Induces Apoptosis In Postmitotic Neurons, R. Slack, Daniel Belliveau, M. Rosenberg, J. Atwal, H. Lochmuller, R. Aloyz, A. Haghighi, B. Lach, P. Seth, E. Cooper, F. Miller Dec 1995

Adenovirus-Mediated Gene Transfer Of The Tumor Suppressor, P53, Induces Apoptosis In Postmitotic Neurons, R. Slack, Daniel Belliveau, M. Rosenberg, J. Atwal, H. Lochmuller, R. Aloyz, A. Haghighi, B. Lach, P. Seth, E. Cooper, F. Miller

Daniel J. Belliveau

Programmed cell death is an ongoing process in both the developing and the mature nervous system. The tumor suppressor gene, p53, can induce apoptosis in a number of different cell types. Recently, the enhanced expression of p53 has been observed during acute neurological disease. To determine whether p53 overexpression could influence neuronal survival, we used a recombinant adenovirus vector carrying wild type p53 to transduce postmitotic neurons. A control consisting of the same adenovirus vector background but carrying the lacZ reporter expression cassette was used to establish working parameters for the effective genetic manipulation of sympathetic neurons. We have found …

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Cortical Type 2 Astrocytes Are Not Dye Coupled Nor Do They Express The Major Gap Junction Genes Found In The Central Nervous System, Daniel Belliveau, C. Naus Dec 1993

Cortical Type 2 Astrocytes Are Not Dye Coupled Nor Do They Express The Major Gap Junction Genes Found In The Central Nervous System, Daniel Belliveau, C. Naus

Daniel J. Belliveau

The O‐2A progenitor cell first described from the rat optic nerve is a bipotential precursor of oligodendrocytes and type 2 astrocytes. Each cell expresses specific markers that distinguish them as unique cell types. O‐2A progenitors cultured in high serum preferentially differntiate into type 2 astrocytes and when exposed to defined medium or low serum develop along the oligodendrocyte lineage. We analyzed the gap junction gene expression of type 2 astrocytes to determine if they are coupled to form a syncytium, like their type 1 astrocyte counterparts. Dye coupling experiments demonstrated that cortical type 2 astrocytes are not coupled, while type …

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In Vivo Growth Of C6 Glioma Cells Transfected With Connexin43 Cdna, C. Naus, K. Elisevich, D. Zhu, Daniel Belliveau, R. Del Maestro Dec 1991

In Vivo Growth Of C6 Glioma Cells Transfected With Connexin43 Cdna, C. Naus, K. Elisevich, D. Zhu, Daniel Belliveau, R. Del Maestro

Daniel J. Belliveau

In order to examine the possible role of intercellular communication via gap junctions in the control of tumor growth, we have transfected C6 glioma cells with connexin43 cDNA. We obtained several clones with variable expression of connexin43. The growth rate of these clones in culture was inversely related to the degree of expression of the transfected cDNA. To examine the growth of these transfected cells in vivo, cells were grown in spinner culture flasks to form spheroids 250–300 µm in diameter. Spheroids of nontransfected C6 cells produced large gliomas. Immunohistochemical and in situ hybridization analyses revealed relatively high levels of …

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Regional Differences In Connexin32 And Connexin43 Messenger Rnas In Rat Brain, C. Naus, Daniel Belliveau, J. Bechberger Dec 1989

Regional Differences In Connexin32 And Connexin43 Messenger Rnas In Rat Brain, C. Naus, Daniel Belliveau, J. Bechberger

Daniel J. Belliveau

The regional distribution of gap junction mRNAs was examined in the adult rat brain. The level of connexin43 mRNA is more abundant than connexin32, being homogeneously distributed throughout different regions of brain. In contrast, there is dramatic heterogeneity in the level of connexin32 mRNA, with the highest level in the hindbrain. These results suggest that the gap junction genes are differentially expressed in regions of the adult rat brain.

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