Art Practice Commons^™

Design And Analysis Of An Innovative Semi-Flexible Hybrid Personal-Body-Armor System, Daniel Jeffrey Miller

USF Tampa Graduate Theses and Dissertations

Current military-grade rifle body armor technology uses hard ballistic plates positioned on top of flexible materials, such as woven Kevlar® to stop projectiles and absorb the energy of the impact. However, absorbing the impact energy and stopping a rifle projectile comes at a cost to the wearer - mobility. In this thesis, a new concept for personal body armor is proposed - a semi-flexible hybrid body armor. This hybrid armor is comprised of two components that work as a system to effectively balance the flexibility offered by a soft fabric based armor with the protection level of hard plated armor. …

Lead Discovery And Optimization Strategies Towards The Development Of 4(1h)-Quinolones And 1,2,3,4-Tetrahydroacridone Analogs With Antimalarial Activity, Richard Matthew Cross

USF Tampa Graduate Theses and Dissertations

The goal of our research endeavor was to successfully employ modern lead discovery and optimization strategies towards the development and identification of compounds possessing antimalarial activity. Preliminary data from in vitro screening at the Walter Reed Army Institute of Research identified several chemotypes including 4(1H)-quinolones and 1,2,3,4-tetrahydroacridones to have potent antimalarial activities. Multiple synthetic routes were devised and implemented which enabled the rapid preparation and isolation of over 400 structurally diverse 4(1H)-quinolones and 1,2,3,4-tetrahydroacridones.

Our research towards discovering and optimizing antimalarials was inspired from the severe impact malaria has had on our planet especially on impoverished countries. There are over …