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In Society's Shadow: Identifying Structural Violence In Muna, A Burial Community From Late Intermediate Period (1100 - 1470 Ce) Pachacamac, Peru., Ashley C. Ward

Electronic Thesis and Dissertation Repository

Structural violence (SV) highlights how social structures harm communities via inequities in health, risk of trauma, and post-mortem treatment, however its applicability outside of Euroamerican capitalist contexts is unclear. Fifty-nine individuals from the MUNA cemetery (Pachacamac, Perú) from the Late Intermediate to Late Horizon Periods (1100-1532 CE) were analysed for evidence of SV. Nonspecific stress markers, osteoarthritis, pathological dental conditions, and physical trauma were recorded and compared as they related to age, sex and/or status and then contextualised using the Spanish Chronicles, ethnographic, and archaeological research. Inequities in resource or labour distribution but not amount to SV, but SV did …

Stable Carbon And Nitrogen Isotope Analysis Of Infant Feeding Practices And Stress In 18th-19th Century Pointe-Aux-Trembles, Québec, Sydney Holland

Electronic Thesis and Dissertation Repository

This thesis is a bioarchaeological study of infant feeding practices and early life stress in 18th -19th century Pointe-aux-Trembles, a rural community near Montréal, Québec that was known to practice wet nursing. Stable carbon and nitrogen isotope analyses of 62 incremental dentine samples were used to reconstruct the feeding histories of 10 infants (age) interred between 1709-1843. At least 6 of 10 infants display evidence of breastfeeding, with weaning foods (e.g., porridge, bread) typically introduced between ~1.5-5.5 months of age and weaning completion around 10.5-13.5 months. Isotopic and/or dental evidence of stress (e.g., enamel hypoplasia) was identified in 8 of …

Oral Health Inequalities In Adolescents And Young Adults In Ontario, Maria Rahman

Electronic Thesis and Dissertation Repository

Oral health is consistently linked to physiological, psychological, and social aspects of well-being in adolescents and young adults. In this thesis, I aimed to examine the social determinants of oral health and dental care utilization. First, I conducted a scoping review of the literature, demonstrated the multifaceted nature of oral health and its connections to broader social and economic factors. Then, I conducted a cross-sectional analysis of the Canadian Community Health Survey which showed a social gradient in oral health and dental care utilization among adolescents and young adults in Ontario. When stratified by age, there was a protective association …

The Significance Of Injuries And Anatomical Patterns Of Trauma In Pedestrian And Cyclist Fatalities And Their Association With Motor Vehicle Collision Dynamics And Post-Collision Kinematics, Moheem M. Halari

Electronic Thesis and Dissertation Repository

Deaths from motor vehicle collisions (MVCs) are a major global health concern, with over 1.35 million fatalities reported annually by the United Nations. More than half involve pedestrians, cyclists, and motorcyclists. Post-mortem examinations by pathologists determine the cause of death and mechanisms of injury and play a significant role in the investigation of the deaths of vulnerable road users.

The purpose of this study was to understand the injury patterns sustained by pedestrians and cyclists fatally injured in motor vehicle impacts.

This study reviews the development of injury patterns described in the medical literature and identifies their limitations in the …

Smartphones For Smart Eating: Evaluating The Effectiveness Of Smartphone Applications On Improving Adolescent Food Knowledge, Heather A. Jantzi

Electronic Thesis and Dissertation Repository

Many Canadian adolescents have unhealthy eating habits which are risk factors for developing chronic diseases later in life. Food literacy plays a role in healthy eating habits but teens in Ontario currently lack sufficient nutrition education learning opportunities in home and school environments. Across health research, smartphones have been utilized as a novel medium to promote learning and alter behaviour. This thesis seeks to understand the effectiveness of smartphone applications at improving food knowledge in adolescents through (i) a systematic review of published interventions, and (ii) by investigating the efficacy of a novel location-based smartphone application. Findings from this thesis …

Head Shapes And Toothaches: A Study Of Cranial Modification And Dental Pathology At Muna, A Late Pre-Hispanic Cemetery From The Archaeological Sanctuary Of Pachacamac (Lima, Perú)., T Naomi Nakahodo Moromizato

Electronic Thesis and Dissertation Repository

This thesis is a bioarchaeological analysis of cranial modification and dental pathology in a sample of human remains excavated from the pre-Hispanic MUNA cemetery. This cemetery was on the outskirts of the Archaeological Sanctuary of Pachacamac in the Lurín Valley. The cemetery was comprised of disturbed skeletal remains and relatively well preserved fardos funerarios (funerary bundles) from the Late Intermediate Period (1100-1470 CE) and early Late Horizon (1470-1532 CE). The results of this thesis show that the skeletal remains and fardos likely belonged to a single community, and the analyzed sample showed intra-site variation of the fronto-occipital cranial modification. The …

The Impact Of Access To Oral Health Care On Inadequate Oral Health And Multimorbidity, Luis Limo

Electronic Thesis and Dissertation Repository

The connection between oral health and other non-communicable chronic conditions—commonly referred in the dental literature as the oral-systemic health connection—emphasizes the role of oral health care on both oral diseases and chronic conditions, particularly in vulnerable populations like the elderly. This thesis comprises 2 studies: the first is a systematic review on the impact of oral health care interventions, as an indicator of access to oral health care, on chronic conditions of which their co-existence would result in multimorbidity; the second study is a cross-sectional investigation of the associations between oral health, access to oral health care, and multimorbidity among …

The Role Of Psychosocial Factors In Oral Health And Related Major Chronic Conditions, Abby Hensel

Electronic Thesis and Dissertation Repository

Psychosocial factors may be a common pathway that increases the susceptibility to co-occurring oral health conditions and other non-communicable chronic conditions. This thesis aimed to investigate the role of psychosocial stress in the co-occurrence of oral health conditions and systemic chronic conditions. First, a scoping review was conducted which found psychosocial stress to be positively associated with both oral and other chronic diseases. Next, a cluster analysis of oral health and multimorbidity profiles was conducted which showed middle-aged and older Canadians to have varying health profiles based on their oral health and multimorbidity status. We also found that individuals with …

Science Attitudes Of Students Enrolled In An Introductory Environmental Science Course, Rajan Brar

Electronic Thesis and Dissertation Repository

This study examines attitudes towards science for 198 students enrolled in an introductory university environmental science course. Conceptual frameworks include the theory of planned behaviour and the tripart model of attitudes to assess science attitudes. A quantitative research design, using secondary data, is used to address this purpose. Within this study, Enjoyment of Science and Science Anxiety factors of attitudes towards science, components of the affective domain of attitude are compared to student gender, faculty, and academic year using a modified mATSI:2 questionnaire. It is found that faculty displays the most significant association with science attitudes, with students from science …

A Study On The Field Of Xr Simulation Creation, Leveraging Game Engines To Develop A Vr Hospital Framework, Virat K. Tripathi

Electronic Thesis and Dissertation Repository

This thesis introduces an adaptable and extensible VR framework designed for clinicians and patients using pre-existing game development software like Blender and Unreal Engine. The framework aids patients in familiarizing themselves with hospital scenarios and environments, reducing anxiety, and improving navigation. Clinicians can use the tool to educate patients and collaboratively design new aspects of the environment. A prototype implementation demonstrates the system's effectiveness, with usability studies indicating that teleport movement is preferred over sliding for locomotion and that navigation speed can improve with subsequent trials in the VR simulator. The framework's potential for enhancing patient experience and facilitating informed …

The Modulation Of Lfp Characteristics In The Freely Moving Common Marmoset, William Jm Assis

Electronic Thesis and Dissertation Repository

The hippocampus is a neural structure critical for navigation. Neurons in this region, along with others, create a functional network which generates large-amplitude modulations known as local field potential (LFP) activity. Prior LFP research has predominantly used rodent animal models, however recent studies have shown that frequencies associated with navigation in other mammals do not correlate to those of the rodent. We hypothesized that LFP characteristics in the common marmoset are modulated by the speed and axis of travel of the animal. Two marmosets were placed in a free moving 3-dimensional environment where movement and neurological activity were recorded. Results …

The Ventilatory Response To Modified Rebreathing Is Unchanged By Hyperoxic Severity: Implications For The Hyperoxic Hyperventilation Paradox, Joshua D. Huggard

Electronic Thesis and Dissertation Repository

We measured the ventilatory response to hyperoxic CO₂ rebreathing with O₂ tension clamped at increasingly higher pressures. We hypothesized that the V̇_E versus PCO₂ relationship is fixed and independent of PO₂. Twenty participants (10 females; mean± SD age: 24±4 years) performed three repetitions of modified rebreathing in 4, randomized, isoxic-hyperoxic conditions: mild: PO₂=150 mmHg; moderate: PO₂=200 mmHg; high: PO₂=300 mmHg; and extreme: PO₂≈700 mmHg. For each rebreathing trial, the P_ETCO₂ at which V̇_E rose was identified as the ventilatory recruitment threshold (VRT, …

Systemic, Institutional, And Teaching Factors In The Delivery Of Interprofessional Education Curriculum In Canada, Mohammad B. Azzam

Electronic Thesis and Dissertation Repository

The Canadian federal and several provincial governments are currently collaborating to establish ‘team-based’ primary healthcare—or interprofessional collaborative practice (IPCP), which can be effectively accomplished when interprofessional education (IPE) is sustainably delivered by health and social care (HASC) professional education programs. Indeed, achieving the intended patient/client-oriented outcomes of IPE and subsequent IPCP requires deliberate and purposeful considerations of several systemic, institutional, and teaching factors. Regrettably, the analyses of the extent to which these factors have influenced effective IPCP is currently under-researched. In this integrated-article dissertation, we took a purposeful and systematic approach to explore the extent to which these multi-tiered factors …

Mechanical Response Of The Craniofacial Skeleton To Subfracture Impacts In The Time And Frequency Domains, Paige Merko

Electronic Thesis and Dissertation Repository

Resonant frequencies have been suggested as a mechanism of brain injury since these vibrations can transfer energy into the brain. Study of the vibrational response of the craniofacial skeleton to impact is limited in literature. In this research, four cadaver specimens were impacted at five locations on the craniofacial skeleton. The mechanical response to each impact was compared in the time and frequency domains. Impacts to the maxilla and its associated soft tissues tended to be attenuated, while impacts to the cranial vault, specifically to the occipital, produced the most severe response. Results suggest that the facial skeleton and its …

Torque Expression Of Active And Passive Self-Ligating Orthodontic Brackets With Different Archwire Materials, Sidney Mugford

Electronic Thesis and Dissertation Repository

This study aimed to compare torquing moments, engagement angles, and torsional stiffness generated by stainless steel (SS), titanium molybdenum alloy (TMA) and nickel titanium (NiTi) wires in three active self-ligating (ASL), one passive self-ligating (PSL), and a conventional twin orthodontic bracket system control. Brackets were tested in simulations of buccal and palatal root torque. A custom 3D printed testing apparatus was developed to measure torque. In general, the PSL and conventionally ligated systems generated significantly larger torquing moments than ASL systems, especially with stiffer wires and greater degrees of twist. Torquing direction only influenced torque expression with ASL systems. The …

Metal Release Of Cocrmo Alloy In Protein-Rich Solutions – Effect Of Irradiation, Sliding And Manufacturing Process, Zheng Wei

Electronic Thesis and Dissertation Repository

CoCrMo alloys, which have excellent corrosion and wear resistance, are widely used for implants in the human body. Even for the most corrosion-resistant alloys, interfacial reactions occur between the metal surface and the biological environment. It is important to investigate the mechanism of corrosion behavior of CoCrMo in protein-rich solutions. This research is focused on the metal release and corrosion behavior of CoCrMo in protein-rich solutions under different simulated conditions and for different manufacturing processes. Implants can sometimes be present in patients who need to undergo cancer radiotherapy. Therefore, the effect of gamma irradiation on the metal release from CoCrMo …

Validation Study On The Differentiation Of Human Periodontal Ligament Cells In The Presence Of Cementum Protein 1 And Periostin, Deborah A. O'Reilly

Electronic Thesis and Dissertation Repository

Existing research alludes to the fact that human periodontal ligament cells differentiate into an ossifying phenotype in response to differential gene expression during orthodontic tooth movement. The purpose of this research was to validate the differentiation of human periodontal ligament cells of young individuals in the presence of specific proteins and stimuli (cementum protein, periostin and osteogenic media), which mimic the environment of the periodontal ligament. Another objective was to assess the differential gene expression within these cells under the same conditions. A protocol was developed to provide a collagen-protein scaffold on which human periodontal ligament cells were maintained for …

From Micro To Macro: Examining Potential Microbiome Mediated Influences On Human Growth And Health Outcomes Through Breastfeeding And Antibiotic Exposures, Nicole K. Phillips

Electronic Thesis and Dissertation Repository

Human microbiome research has rapidly developed over the past two decades yet absent from most research is the composition and dynamics of microbiomes within human populations. Given the limitations in longitudinal studies which requires decades of repeated microbe taxonomic testing of a population sample, an alternative option is to examine microbiomes and their influences via proxies using pre-existing health datasets. This research demonstrates preliminary associations between presumed disrupted and supportive microbiomes dynamics proxied by antibiotic and breastmilk exposure respectively. Using health record data across the life span from approximately 500,000 U.K. participants, this research demonstrates variable altered growth and health …

Secretion Of Salivary Proteins And Their Interactions, Karla Tonelli Bicalho Crosara

Electronic Thesis and Dissertation Repository

Saliva’s clinical application for disease diagnosis and monitoring is limited by incomplete knowledge of salivary protein interactions, the effect of stimulation on the salivary proteome, and if these factors impact protein identification. This thesis expands knowledge of the salivary interactome and effects of stimulation intensity and duration on parotid saliva’s proteome. First, previous in vitro studies identified 43 proteins in the histatin 1-protein network and demonstrated histatin 1’s increased stability in whole saliva when interacting with amylase. We hypothesized that protein-protein-interaction databases could enlarge the histatin 1-protein network. A comprehensive histatin 1-protein network was created using STRING database, merging previous …

Social Determinants Of Access To Primary Care In Canada, Feben W. Alemu

Electronic Thesis and Dissertation Repository

Despite the promise of universal care, many Canadians report having unmet healthcare needs. We conducted two studies: (1) a systematic review of studies on social determinants of health (SDH) and unmet need; and (2) a secondary analysis using the Canadian Longitudinal Study on Aging (CLSA) to investigate the association of SDH and (2a) self-reported unmet need and (2b) having a family physician. The review (n=40) found a positive association between unmet need and lower income, mental health and chronic conditions, and negative association with older age, better perceived health and having a family physician. The CLSA analysis found the odds …

Mechanical Evaluation Of Gyroid Structures To Combat Orthopaedic Implant Infections, Sydney Hitchon

Electronic Thesis and Dissertation Repository

Treatment of infected orthopaedic implants often require two separate surgeries to clear the infection and install a replacement implant. Current antimicrobial drug delivery methods are inefficient, and each additional surgery increases the physiologic burden on patients, with an increased risk of infection, decreased range of motion and longer recovery times. Porous orthopaedic implants, with adequate strength for permanent implantation and the ability to house and elude more efficient antibiotic delivery systems, could result in a single surgery to treat orthopaedic infections. Therefore, finite element models of porous gyroid structures at different porosities were developed and compared with experimental results. Discrepancies …

Determination Of The Protective Capacity Of Hand Wraps In Combat Athletes Using Force Analysis, Eva M. Gusnowski

Electronic Thesis and Dissertation Repository

Upper extremity injuries are common in combat athletes, and are highest in the hand/wrist. Although protective hand gear is used, there is a paucity of research investigating its effectiveness. This study addressed this knowledge gap by measuring the level of force transmitted to the hand during striking using two types of hand wraps. This prospective cross over study included six combat athletes. A load cell was placed over the proximal phalanges/metacarpophalangeal joints and was used to measure sustained peak force during striking while covered with either standard linear or gel-reinforced hand wraps and boxing gloves. The gel reinforced wraps consistently …

Anatomical And Functional Lung Imaging With Volumetric Computed Tomography In Non-Small Cell Lung Cancer, Heather Young

Electronic Thesis and Dissertation Repository

Non-small cell lung cancer (NSCLC) is one of the most diagnosed cancers in Canada, and the leading cause of cancer deaths. A significant challenge in treating NSCLC is balancing aggressive treatment with the potentially severe side effects. In radiation therapy, the management of respiratory motion and the risks of radiation-induced lung injury (RILI) pose significant challenges. 4-dimensional computed tomography (4D-CT) is an important part of motion management, but images often suffer from motion-induced artifacts. Volumetric CT scanners with wide axial field-of-view (aFOV) may reduce these artifacts and present an opportunity to advance CT-based functional lung imaging.

Chapter 2 presents a …

Electrochemical Deposition Of Calcium Phosphate-Based Coatings Onto Porous Ti Using Organic Phosphorus Sources, Clement Lee

Electronic Thesis and Dissertation Repository

The study and commercialization of calcium phosphate (Ca-P) coatings has occurred for several decades. However, this has typically involved the use of hydroxyapatite. This thesis presents the synthesis of different Ca-P-based coatings that has not been studied. Anodic oxidation was employed to create a porous Ti substrate, while pulsed electrochemical deposition was used to deposit the coating onto the Ti. The first coating synthesized was a calcium phosphoserine (Ca-pSer) complex, which contained two different morphologies: a flower-like structure at low deposition time and a unique cubic morphology at higher deposition times. Next, an amorphous calcium phosphate coating was synthesized and …

Essays On Industrial Organization And Health Economics, Cecilia S. Diaz Campo

Electronic Thesis and Dissertation Repository

My thesis consists of three chapters studying the impact of health insurance design and public health policy on consumers’ health and health care utilization, welfare, and costs.

Chapter 2 studies an overlooked dynamic incentive that encourages health care utilization, which I term \textit{dynamic moral hazard}. Typical health plans feature high deductibles and caps on consumers' out-of-pocket spending, which generate nonlinear pricing. These nonlinearities, coupled with the uncertainty intrinsic to future health care demand, encourage consumers to increase spending since current utilization lowers future expected prices. Standard models study health care utilization decisions through the lens of annual models, which abstract …

Extrinsic And Intrinsic Factors Influencing Homeostasis And Repair In Oral Tissues, Georgia Nikoloudaki

Electronic Thesis and Dissertation Repository

The oral tissues, including gingiva and buccal mucosa, heal rapidly with minimal scar formation. Although in the oral cavity, the palatal mucosa is associated with excessive scarring in response to injury. In this thesis, first, I investigated the complex relationship between cells and their microenvironment using wound healing models in which extracellular matrix composition and mechanical stiffness affect cellular responses during acute wound repair. I also determined how intrinsic differences of cells recruited during healing contribute to wound resolution.

In Chapter 2, I first investigated cell-extrinsic factors, specifically the influence of the pro-fibrotic matricellular protein periostin on palatal healing. Using …

Biomechanical Investigation Of Complete And Partial Medial Collateral Ligament Injuries, Callahan Doughty

Electronic Thesis and Dissertation Repository

The medial collateral ligament (MCL) is composed of two major components: the deep MCL (dMCL) and superficial MCL (sMCL). Recent indications have raised questions as to the validity of previous descriptions of the MCL’s role in knee stability. Despite the relative likelihood of partial injuries to the sMCL, as opposed to complete tears, the impact of these injuries remains largely misunderstood. This thesis set out to (1) interpret the roles of the sMCL and dMCL; and (2) investigate the effect of partial sMCL injuries on knee stability.

A joint motion simulator was used to determine the role of the dMCL …

Dental Health In The Aqllakuna From Farfán (Peru): A New Perspective On An Inca Female Institution (Ca. 1470-1532 A.D.) Using Micro-Ct And Histological Analysis, Émy Roberge

Electronic Thesis and Dissertation Repository

This research aims to explore the lifeways of an underrepresented subgroup of females while reducing the use of destructive methods in bioarchaeology. The excavation of Farfán on the North Coast of Peru revealed a rare aqlla cemetery from the Late Horizon (1470-1532 A.D.). The aqlla was an Inca religious institution where young females were sequestered to brew chicha and weave in their aqllawasi. According to ethnohistorical sources, these “Chosen Women” were expected to represent a homogenous and advantaged subset of the population. This hypothesis is assessed by comparing their dental lesions to the general population using macroscopy, micro-CT, and …

Evaluating The Utility Of S100a7 In Identifying Oral Dysplastic Lesions That Will Progress To Oral Squamous Cell Carcinoma, Jeff Soparlo

Electronic Thesis and Dissertation Repository

Title: Evaluating the utility of S100A7 in identifying oral dysplastic lesions that will progress to oral squamous cell carcinoma Introduction: Recently, S100A7 has been shown to be a potential useful marker for identifying oral lesions at risk of transformation from dysplasia to squamous cell carcinoma. Our hypothesis is that high S100A7 protein expression predicts the transformation of oral epithelial dysplasia to malignancy. The objective of our study is to semi-quantitatively evaluate the level of S100A7 expression in dysplastic lesions which have transformed into oral squamous cell carcinoma using immunohistochemistry, and correlate these results with other methods of analysis including the …

A Molecular Dynamics Study Of Polymer Chains In Shear Flows And Nanocomposites, Venkat Bala

Electronic Thesis and Dissertation Repository

In this work we study single chain polymers in shear flows and nanocomposite polymer melts extensively through the use of large scale molecular dynamics simulations through LAMMPS. In the single polymer chain shear flow study, we use the Lattice Boltzmann method to simulate fluid dynamics and also include thermal noise as per the \emph{fluctuation-dissipation} theorem in the system. When simulating the nanocomposite polymer melts, we simply use a Langevin thermostat to mimic a heat bath. In the single polymer in shear flow study we investigated the margination of a single chain towards solid surfaces and how strongly the shear flow …