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Physical And Geometrical Modulation Of Human Fibroblast Behaviour, Sarah M. Brooks Apr 2024

Physical And Geometrical Modulation Of Human Fibroblast Behaviour, Sarah M. Brooks

Electronic Thesis and Dissertation Repository

This thesis investigates the impact of mechanical stimuli, specifically substratum topography and elastic modulus, on dermal and gingival fibroblast behaviour associated with scarring and regeneration. Scar formation presents a significant issue for implanted biomaterials often leading to device failure. Even though scar formation is a normal end point to adult human dermal wound healing, gingival wounds are capable of tissue regeneration or scarless wound healing. Understanding how these cells respond to environmental cues, including substratum topography and elastic modulus, is central to the development of novel biomaterials for stimulation of tissue regeneration. It was hypothesized that topographic features, with submicron …


Unveiling The Interplay: Childhood Obesity, Impact Of Marketing To Kids, And The Pursuit Of Effective Regulatory Measures., Lin Jawhar Mar 2024

Unveiling The Interplay: Childhood Obesity, Impact Of Marketing To Kids, And The Pursuit Of Effective Regulatory Measures., Lin Jawhar

Electronic Thesis and Dissertation Repository

In an era of pervasive marketing, targeting children has become a subject of growing concern due to its potential impact on their well-being and consumer behaviour. The purpose of this study was both to assess and evaluate why Bill S-228, a legislation aimed at protecting children from the current state of marketing to kids (M2K), failed to become law despite initially passing through the Senate and then through the House. First, a narrative literature review was conducted to describe the current practices for restricting M2K of food products based on global data. Second, using two prominent policy change theories, Advocacy …


In Society's Shadow: Identifying Structural Violence In Muna, A Burial Community From Late Intermediate Period (1100 - 1470 Ce) Pachacamac, Peru., Ashley C. Ward Feb 2024

In Society's Shadow: Identifying Structural Violence In Muna, A Burial Community From Late Intermediate Period (1100 - 1470 Ce) Pachacamac, Peru., Ashley C. Ward

Electronic Thesis and Dissertation Repository

Structural violence (SV) highlights how social structures harm communities via inequities in health, risk of trauma, and post-mortem treatment, however its applicability outside of Euroamerican capitalist contexts is unclear. Fifty-nine individuals from the MUNA cemetery (Pachacamac, Perú) from the Late Intermediate to Late Horizon Periods (1100-1532 CE) were analysed for evidence of SV. Nonspecific stress markers, osteoarthritis, pathological dental conditions, and physical trauma were recorded and compared as they related to age, sex and/or status and then contextualised using the Spanish Chronicles, ethnographic, and archaeological research. Inequities in resource or labour distribution but not amount to SV, but SV did …


Stable Carbon And Nitrogen Isotope Analysis Of Infant Feeding Practices And Stress In 18th-19th Century Pointe-Aux-Trembles, Québec, Sydney Holland Jan 2024

Stable Carbon And Nitrogen Isotope Analysis Of Infant Feeding Practices And Stress In 18th-19th Century Pointe-Aux-Trembles, Québec, Sydney Holland

Electronic Thesis and Dissertation Repository

This thesis is a bioarchaeological study of infant feeding practices and early life stress in 18th -19th century Pointe-aux-Trembles, a rural community near Montréal, Québec that was known to practice wet nursing. Stable carbon and nitrogen isotope analyses of 62 incremental dentine samples were used to reconstruct the feeding histories of 10 infants (age) interred between 1709-1843. At least 6 of 10 infants display evidence of breastfeeding, with weaning foods (e.g., porridge, bread) typically introduced between ~1.5-5.5 months of age and weaning completion around 10.5-13.5 months. Isotopic and/or dental evidence of stress (e.g., enamel hypoplasia) was identified in 8 of …