Digital Commons Network^™

Survival Analysis Of Microarray Data With Microarray Measurement Subject To Measurement Error, Juan Xiong

Electronic Thesis and Dissertation Repository

Microarray technology is essentially a measurement tool for measuring expressions of genes, and this measurement is subject to measurement error. Gene expressions could be employed as predictors for patient survival, and the measurement error involved in the gene expression is often ignored in the analysis of microarray data in the literature. Efforts are needed to establish statistical method for analyzing microarray data without ignoring the error in gene expression. A typical microarray data set has a large number of genes far exceeding the sample size. Proper selection of survival relevant genes contributes to an accurate prediction model. We study the …

Motion Coordination Of Aerial Vehicles, Abdelkader Abdessameud

Electronic Thesis and Dissertation Repository

The coordinated motion control of multiple vehicles has emerged as a field of major interest in the control community. This thesis addresses two topics related to the control of a group of aerial vehicles: the output feedback attitude synchronization of rigid bodies and the formation control of Unmanned Aerial Vehicles (UAVs) capable of Vertical Take-Off and Landing (VTOL). The information flow between members of the team is assumed fixed and undirected. The first part of this thesis is devoted to the attitude synchronization of a group of spacecraft. In this context, we propose control schemes for the synchronization of a …

Part I: Synthesis Of Pyrrolo[1,2-A]Indoles Part Ii: Studies Towards Arboflorine, Michael B. Johansen

Electronic Thesis and Dissertation Repository

Part one of this thesis focuses on the synthesis of pyrrolo[1,2-a]indoles from nitrones and 1,1-cyclopropanediesters, by way of tetrahydro-1,2-oxazines. A five step synthetic sequence through tetrahydro-1,2-oxazine synthesis, intramolecular Heck reaction, Krapcho dealkoxycarbonylation, reductive N-O bond cleavage, and acid catalyzed transannular alcohol displacement, is developed to access the desired pyrrolo[1,2-a]indoles. Part two of this thesis details the functionalization of indoles by installation of a malonate moiety, by means of copper catalyzed carbenoid reactivity. A wide range of malonyl indoles with varying substitution patterns is shown to be accessible through the developed method. The final chapter focuses on the application of this …

The Health Of Ontario’S Transgender Communities: Prevalence Of And Risk Factors For Depression, "Do-It-Yourself" Transitions, And Health Effects Of Cross-Sex Hormones And Surgeries, Nooshin Khobzi

Electronic Thesis and Dissertation Repository

The purpose of this dissertation was to develop an understanding of, and draw attention to, the health and service access issues faced by trans (transgender, transsexual, or transitioned) Ontarians. This thesis is based on the Trans PULSE Project, a community-based research (CBR) initiative whose goal is to improve the health of trans people. Data collection was carried out between May 2009 and April 2010 using a quantitative survey. Trans participants were recruited through respondent-driven sampling (RDS), a network-based sampling method developed for the recruitment of hidden populations. Weighted prevalence estimates and 95% confidence intervals were calculated for all variables of …

Causality And Similarity In Autobiographical Event Structure: An Investigation Using Event Cueing And Latent Semantic Analysis, Christopher M. O'Connor

Electronic Thesis and Dissertation Repository

The influence of similarity- and causally-based relations on the organization of autobiographical events was investigated using extended strings of related event memories. These strings were elicited using an event cueing paradigm in which participants generated descriptions of memories from their life, which were then presented as cues to subsequent event memories. In Experiment 1, similarity between generated events was investigated using participants’ similarity ratings, Latent Semantic Analysis, and experimenter judgements of shared event properties. For events close together in a string, event owners’ similarity ratings were higher than non-owners’, and non-owners’ ratings were comparable to similarity calculated using LSA. In …

Pharmacokinetics And Therapeutic Uses Of Mesna, Murray J. Cutler

Electronic Thesis and Dissertation Repository

In the early 1980s, significant advancement in the safety of ifosfamide therapy was achieved by co-administrating mesna (sodium 2-mercaptoethane sulfonate) to prevent dose-limiting hemorrhagic cystitis. Mesna exerts its protective effect within the urine, where its free sulfhydryl group is able to conjugate cytotoxic metabolites. Within the circulation, however, mesna exists primarily as its inactive disulfide, dimesna. Dimesna is currently undergoing clinical development as a prodrug (BNP7787) to treat cisplatin-induced nephrotoxicity. Remarkably, chemoprotection is achieved without attenuation of efficacy of co-administered anti-cancer agents. This is widely attributed to the kidney-specific disposition and stability of dimesna.

We sought to evaluate the role …

Stopover Biology Of Migratory Landbirds In A Heavily Urbanized Landscape, The New York Metropolitan Area, Chad L. Seewagen

Electronic Thesis and Dissertation Repository

Migration routes of many Nearctic-Neotropical landbirds pass through the most urbanized regions of North America. Migrants use urban habitat fragments as stopover sites and commonly occur in cities at exceptional density. Yet, knowledge of migrant stopover biology and refueling opportunities in such places is severely limited. This dissertation examined several aspects of migrant stopover biology in the New York metropolitan area to gain a more holistic understanding of how migratory landbirds utilize urban stopover sites, and ultimately to assess the quality of urban habitats as stopover sites. I first generated morphometric predictive models using salvaged bird specimens to allow me …

Graphomania: Composing Subjects In Late-Victorian Gothic Fiction And Technology, Gregory D. Brophy

Electronic Thesis and Dissertation Repository

This dissertation explores the varied phenomena of “automatic writing” in Victorian Gothic fiction, reading the genre’s fascination with the irrepressible signifying practices of the body in light of the medical, criminological and scientific discourses that underwrite the “scriptural economy” of the late nineteenth century with their own arsenal of automatic writing machines. I have titled the project "Graphomania," and I consider the term a keyword of late-Victorian culture—one that names a distinctly Victorian pathology of compulsive writing, but that alludes also to the widespread epistemic hope that writing could render objectively the internal and subjective experiences of individuals.

In a …

Mutations Et Glissements Du Roman Francais Au Roman Africain Francophone., Ibrahima Bano Diallo

Electronic Thesis and Dissertation Repository

Résumé et mots-clés. Notre travail s’articule autour de trois grands axes. L’analyse des trois parties de notre thèse a cherché à montrer comment s’opère ce que nous avons nommé mutations et glissements du roman français au roman africain francophone au fur et à mesure que les auteurs de notre corpus se démarquent des normes d’écriture imposées. La première partie révèle comment les écrivains francophones africains tirent profit de leur héritage culturel tant traditionnel qu’occidental pour mettre en œuvre une esthétique d’écriture tout à fait originale. Cette nouvelle forme d’écriture, qui tranche d’avec ce qui est érigé comme préceptes à la …

Collision Detection And Merging Of Deformable B-Spline Surfaces In Virtual Reality Environment, Harish Pungotra

Electronic Thesis and Dissertation Repository

This thesis presents a computational framework for representing, manipulating and merging rigid and deformable freeform objects in virtual reality (VR) environment. The core algorithms for collision detection, merging, and physics-based modeling used within this framework assume that all 3D deformable objects are B-spline surfaces. The interactive design tool can be represented as a B-spline surface, an implicit surface or a point, to allow the user a variety of rigid or deformable tools. The collision detection system utilizes the fact that the blending matrices used to discretize the B-spline surface are independent of the position of the control points and, therefore, …

Object And Relations Uncertainty: Two Components Of Perceived Environmental Uncertainty, Anthony Francolini

Electronic Thesis and Dissertation Repository

I contend that perceived environmental uncertainty should be divided into a new pair of uncertainty components, which I label object and relations uncertainty. Object uncertainty is defined as an actor’s inability to predict the future accurately due to a lack of information about object items (i.e., tangible, reducible, asocial items). Relations uncertainty is defined as an actor’s inability to predict the future accurately due to a lack of information about relations items (abstract, reduction-resistant, social items).

I contend that the object-relations uncertainty component-set is supported by uncertainty research and categorization theory. First, these two components are supported by the works …

The Information Practices Of People Living With Depression: Constructing Credibility And Authority, Tami Oliphant

Electronic Thesis and Dissertation Repository

Depressive episodes and chronic depression often provide the impetus for both online and offline everyday life information-seeking and sharing and the seeking of support. While allopathic medication, psychiatric, and other biomedical services are the standard treatments for depression, people often use complementary and alternative medicine (CAM) to supplement or supplant biomedical treatments. Depression is a nebulous disorder with varying causes, illness trajectories, and a wide variety of potentially effective treatments. Often, treating and managing depression forms a project for life (Wikgren, 2001) where the need for information is continuous.

In the present study, I have used a constructionist, discourse analytic …

The Lotus Japonicus Cytokinin Receptor Gene Family And Its Role In Nitrogen-Fixing Symbiosis, Mark A. Held

Electronic Thesis and Dissertation Repository

Nitrogen is the most abundant element in our atmosphere, yet has become increasingly limited in agricultural lands. Legume plants offer a possible solution to this problem due to their innate ability to symbiotically interact with nitrogen-fixing bacteria called rhizobia. In particular, a histidine kinase cytokinin receptor from the model legume Lotus japonicus (LHK1) has been clearly placed at the core of these interactions. Loss-of-function mutants in LHK1 fail to initiate timely cortical cell divisions in response to abundant bacterial infection, and gain-of-function mutations in the same locus cause L. japonicus plants to form spontaneous nodules in the absence of rhizobia, …

Procurement Of Information Technology And Canadian Municipalities, Umera Ali

MPA Major Research Papers

This paper examines the trends for the attainment of information technology (IT) and the barriers to the successful procurement of IT. A literature review, survey of IT managers in Ontario municipalities, and three interviews with municipal IT professionals were conducted. The findings reveal that Ontario municipalities are satisfied with their IT projects for using detailed plans, engaging in formal strategic planning, introducing mechanism controls to avoid risks, and using letters of agreement with formally established terms and conditions for projects, all of which are steps towards a successful procurement process. Nevertheless, there are still some barriers for small local governments …

Surface Modifications Of Poly(Dimethylsiloxane) For Biological Application Of Microfluidic Devices, Jessica M. Dechene

Electronic Thesis and Dissertation Repository

The spatial control of cellular adhesion is fundamental to the development of studies of cell interaction, cellular microarrays, and cell based biosensors. The ability to pattern cell adhesion on flat substrates and in microfluidic channels is important for locating cell near microdetectors in cell based biosensor devices. Cell adhesion can be controlled by patterning a material's wettability, as cells are able to adhere to hydrophilic surface and will generally avoid hydrophobic materials.

This thesis focuses on patterning the surface wettability of poly(dimethylsilox-ane) (PDMS) in order to spatially control cell adhesion. The polymer is selectively modifed by the deposition of aluminum …

Characterizing And Diagnosing Architectural Degeneration Of Software Systems From Defect Perspective, Zude Li

Electronic Thesis and Dissertation Repository

The architecture of a software system is known to degrade as the system evolves over time due to change upon change, a phenomenon that is termed architectural degeneration. Previous research has focused largely on structural "deviations" of an architecture from its baseline. However, another angle to observe architectural degeneration is software defects, especially those that are architecturally related. Such an angle has not been scientifically explored until now. Here, we ask two relevant questions: (1) What do defects indicate about architectural degeneration? and (2) How can architectural degeneration be diagnosed from the defect perspective? To answer question (1), we conducted …

Model Selection With Information Criteria, Changjiang Xu

Electronic Thesis and Dissertation Repository

This thesis is on model selection using information criteria. The information criteria include generalized information criterion and a family of Bayesian information criteria. The properties and improvement of the information criteria are investigated.

We analyze nonasymptotic and asymptotic properties of the information criteria for linear models, probabilistic models, and high dimensional models, respectively. We give probability of selecting a model and compute the probability by Monte Carlo methods. We derive the conditions under which the criteria are consistent, underfitting, or overfitting.

We further propose new model selection procedures to improve the information criteria. The procedures combine the information criteria with …

Atomic Force Microscopy For Better Probing Surface Properties At Nanoscale: Calibration, Design And Application, Yu Liu

Electronic Thesis and Dissertation Repository

To measure force by AFM with high resolution requires accurate calibration of optic – lever detection sensitivity and spring constant. On biological AFM force mode, the coupling effects of the liquid environment, spot size of laser beam and laser spot location on AFM cantilever backside, must be considered to correlate the static sensitivities from force curves in air and in liquid for calibration. An effective model has been developed first and experimentally elucidated to calibrate the static sensitivity in liquid. The proposed model eliminates inconvenience of static sensitivity calibration in liquid with possible contamination sources.

The static sensitivity based on …

Mitotic Regulation Of Protein Kinase Ck2, Nicole A. St. Denis

Electronic Thesis and Dissertation Repository

Protein kinase CK2 is a serine/threonine kinase with a multitude of substrates and roles in many cellular processes, including mitosis. CK2 is constitutively active, yet we hypothesize that CK2 is indeed regulated in mitosis through subtle means, enabling CK2 to perform its functions unique to cell division. Our aims were to examine the roles of mitotic phosphorylation, subcellular localization, and interplay with mitotic kinases in the regulation of CK2 activity.

We first examined the role of four highly conserved mitotic phosphorylation sites located in the unique C-terminus of CK2α. Phosphospecific antibodies generated against the sites show that CK2α phosphorylation is …

Simulation-Based Valuation And Counterparty Exposure Estimation Of American Options, Kin Hung Kan

Electronic Thesis and Dissertation Repository

Valuing American options is a central problem in option pricing since the early-exercise feature is very common among financial or insurance derivatives products. For high-dimensional American options, Monte Carlo simulation is generally regarded as the only viable approach to price them, and this is the focus of our work. We propose a new regression-based Monte Carlo algorithm for pricing American options. This method typically generates an upper bound of the option value. It is computationally efficient and generates accurate price estimates.

To improve the convergence rate, we apply a bias reduction technique to the least-squares Monte Carlo estimators of American …

Fall-Related Stigma In Older Adulthood: A Mixed Methods Approach To Understanding The Influence Of Stigma On Older Adults' Reported Attitudes And Behaviours Regarding Falls, Heather M. Hanson

Electronic Thesis and Dissertation Repository

Falls during older adulthood present a major threat to the health and wellbeing of older adults and a challenge to society. While effective fall prevention strategies have been developed to address risk factors for falls, older adults commonly resist participation in such programming and dissociate from the topic of falls in general. After reviewing research findings and the theoretical literature, support was found for approaching falls as a stigmatizing topic for older adults. Three mixed methods experiments were completed to test the influence of stigma on older adults‟ attitudes, opinions, and behaviours. Experiments 1 and 2 tested the labelling aspect …

La Crónica De Potosí Y Sus Milagros: Complejidad Cultural Y Modelación De Relaciones Simbólicas, Shiddarta Vasquez Cordoba

Electronic Thesis and Dissertation Repository

This thesis focuses on an analysis of the religious world of colonial Potosí through the study of the rituals and miracles described in the History of the Imperial City of Potosi written by Bartolome Arzans de Orsua y Vela in the first half of the eighteenth century. After a detailed reading of the text, this works proposes a schema to understand the basic but repetitive ritualistic cycles that organize the life in the city and uses tools such as Topic Maps and the modelling system called NetLogo to visualize the social and cultural networks that give life to the narration. …

Outlawry And The Experience Of The (Im)Possible: Deconstructing Biopolitics, Mary J. Bunch

Electronic Thesis and Dissertation Repository

Outlawry is a legal penalty that banishes wrongdoers from the community; it refers to a refusal to obey the law and a withdrawal of legal rights. Although outlawry is obsolete in western criminal law, Giorgio Agamben links it to modern biopolitics. As outlawry is appropriated to preserve the law, and as the law takes life as its object, the subject of politics disappears. Yet biopolitics also occurs alongside a threat to sovereignty posed by outlawry, and a shift away from the subject as a site of emancipatory politics, toward a politics of difference. Taking a post-structural approach, this project examines …

Numerical Assessment Of Roof Panel Uplift Capacity Under Wind Load, Weixian He

Electronic Thesis and Dissertation Repository

ABSTRACT

The integrity of the roof system is essential for ensuring the safety of inhabitants and preventing excessive damage to light-frame wood structures. The uplift capacity of fastened roof panels has been investigated using experimental tests and numerical models, where monotonic uniform static pressures are often applied to the roof panel models. The verification is needed for the adequacy of using static uniformly distributed pressure representing the wind load. Moreover, the uncertainty of nail withdrawal behaviour has not been included in existing numerical models, and the effect due to construction errors has not been addressed rationally.

A nonlinear Finite Element …

Cambodian National Education Policy: Global Wants And/Or Local Needs?, Kelly T. Crowley Dr.

Electronic Thesis and Dissertation Repository

This thesis is broadly concerned with the impact of globalization on education policy making in Cambodia, a post-conflict, developing country. Cambodia’s education system was almost entirely wiped out by the 1990’s because of various military and social conflicts that had plagued the country. As such, Cambodia provides an excellent case of post-conflict educational reconstruction. The thesis will explore how multinational financial organizations such as the World Bank and Asian Development Bank are influencing the direction of national education policy in Cambodia, using a globalization theoretical perspective. The focus will be on a policy analysis of several key policy documents and …

Public Participation In Canadian Local Government: A Study Of The Meadowlily Secondary Plan Process In London, Ontario, Michael Hurley

MPA Major Research Papers

This paper examines whether the facilitation of public participation in local government is a worthwhile objective, using public engagement in the Meadowlily Secondary Plan in London, Ontario as a case study. An online survey was administered to citizens who participated in the City’s land use planning process. The findings reveal that by participating in decision-making, citizens learned about the processes and responsibilities of municipal government, in addition to other forms of learning, which demonstrates that the facilitation of public participation in municipal government is indeed a worthwhile objective.

Credit Default Swaps - Essays On Model And Market Efficiency, Muhammad F. Farooqi

Electronic Thesis and Dissertation Repository

Essay 1 tests the ability of a commercial structural credit default swap pricing model to predict market spreads. Consistent with several previous studies testing other models, we find our model unable to price credit risk precisely and observe an illiquidity premium reflecting a credit risk component which should be incorporated into future pricing models. We also identify macroeconomic and stock market factors that help explain movements in CDS spreads beyond the levels suggested by the model.

Essay 2 looks at bid and ask spreads to find evidence of quote shading where dealers manipulate their quotes in order to attract sell …

The Roles Of Nitric Oxide Synthases (Nos) In Endochondral Bone Formation, Qian Yan

Electronic Thesis and Dissertation Repository

Longitudinal growth of endochondral bones is controlled by the cartilage growth plate. Chondrocyte proliferation and hypertrophy, vascular invasion, formation of ossification centers and cartilage replacement by bone tissue are all important processes required for normal growth. These biological processes have to be tightly regulated or disturbances will lead to skeletal diseases. A large number of genes, growth factors and hormones have been implicated in the regulation of growth plate biology, however, less is known about the intracellular signaling pathways involved. Nitric oxide (NO) has been identified as a regulator of cellular proliferation, differentiation, migration, survival and metabolism in multiple cell …

Ontological View-Driven Semantic Integration In Open Environments, Yunjiao Xue

Electronic Thesis and Dissertation Repository

In an open computing environment, such as the World Wide Web or an enterprise Intranet, various information systems are expected to work together to support information exchange, processing, and integration. However, information systems are usually built by different people, at different times, to fulfil different requirements and goals. Consequently, in the absence of an architectural framework for information integration geared toward semantic integration, there are widely varying viewpoints and assumptions regarding what is essentially the same subject. Therefore, communication among the components supporting various applications is not possible without at least some translation. This problem, however, is much more than …

Feeling, Impulse And Changeability: The Role Of Emotion In Hume's Theory Of The Passions, Katharina A. Paxman

Electronic Thesis and Dissertation Repository

Hume’s “impressions of reflection” is a category made up of all our non-sensory feelings, including “the passions and other emotions.” These two terms for affective mental states, ‘passion’ and ‘emotion’, are both used frequently in Hume’s work, and often treated by scholars as synonymous. I argue that Hume’s use of both ‘passion’ and ‘emotion’ in his discussions of affectivity reflects a conceptual distinction implicit in his work between what I label ‘attending emotions’ and ‘fully established passions.’ The former are the transient, changeable, valenced feelings that flow between perceptions and constitute their felt nature and impulse. The latter are the …