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Survival Analysis Of Microarray Data With Microarray Measurement Subject To Measurement Error, Juan Xiong
Survival Analysis Of Microarray Data With Microarray Measurement Subject To Measurement Error, Juan Xiong
Electronic Thesis and Dissertation Repository
Microarray technology is essentially a measurement tool for measuring expressions of genes, and this measurement is subject to measurement error. Gene expressions could be employed as predictors for patient survival, and the measurement error involved in the gene expression is often ignored in the analysis of microarray data in the literature. Efforts are needed to establish statistical method for analyzing microarray data without ignoring the error in gene expression. A typical microarray data set has a large number of genes far exceeding the sample size. Proper selection of survival relevant genes contributes to an accurate prediction model. We study the …
A Microarray Study On Gene Expression Of Drosophila Melanogaster 'M Response To Multiple Cold Exposures, Jian Zhang
A Microarray Study On Gene Expression Of Drosophila Melanogaster 'M Response To Multiple Cold Exposures, Jian Zhang
Digitized Theses
In the field, insects suffer multiple cold exposures during winter. When exposed to repeated low temperatures, Drosophila melanogaster females show an increase in survival, but a reduction in reproduction. In this study, microarrays were used to analyze the gene expression of female D. melanogaster after multiple, single sustained (or single prolonged) and single short cold treatments, which exposed the flies at 0 °C for repeated 2 h, single 10 h and single 2 h respectively. Candidate genes involved in the 6 h recovery from different types of cold exposures were identified. After repeated cold exposures, candidate genes particularly included those …
Dna-Damage-Independent Mitochondrial Dysfunction Drives A Loss Of Retina Function Prior To Neuron Death In The Harlequin Mouse Model Of Aging, Alex Michael Laliberte
Dna-Damage-Independent Mitochondrial Dysfunction Drives A Loss Of Retina Function Prior To Neuron Death In The Harlequin Mouse Model Of Aging, Alex Michael Laliberte
Digitized Theses
Although there are many aging-associated retinal diseases, the aging mechanisms which initiate retinal disease remain elusive. To investigate this problem, a model of premature aging, the harlequin mouse, was examined for deficits in retinal function, anatomy and histology, as well as changes in retinal oxidative stress, gene expression and mitochondrial DNA damage. Retinal function of the harlequin mouse, as assessed by electroretinography, was compromised in advance of change in retinal anatomy and histology. Functional deficits occurred in parallel with increased oxidative stress, assessed by in situ dihydroethidium staining. Furthermore, microarray transcriptome analysis of harlequin mice identified markers of mitochondrial stress, …