Digital Commons Network^™

Cell-Mediated Cytotoxicity Of Jensen Tumor In Sprague-Dawley Rats, Theodore D. Masek

Loma Linda University Electronic Theses, Dissertations & Projects

An in vitro system for the study of the cell-mediated immune response to Jensen Sarcoma (JS) is described. The tumor grew unrestricted and lead to the demise of 80% of successfully challenged Sprague-Dawley rats (persistors) while 20% of challenged rats (regressors) destroyed the tumor by an unknown mechanism(s). Lymphocytes from both persistors and regressors were shown to be cytotoxic for tumor cells in vitro. Pretreatment of tumor target cells with "immune" serum from persistors or regressors had no effect on the in vitro cytotoxicity of lymphocytes from tumor-challenged rats. Pretreatment of lymphocytes with irmnune serum, however, was shown to reduce …

An Electrophysiological Analysis Of The Primary Input To The Cat Prepyriform Cortex, George Maeda

Loma Linda University Electronic Theses, Dissertations & Projects

Properties of the lateral olfactory tract (LOT) action potential and cortical evoked potential (EPSP) were studied using discrete stimuli applied to the tract in acute and chronic preparations. Stimulus response curves for both presynaptic (action) and postsynaptic (EPSP) potentials were sigmoidal and linearly related over the entire range. Simulated action potentials were used to determine the diameter to amplitude relationship, an intermediate step for finding the threshold as a function of tract axon diameter. Our results indicate that threshold is proportional to (diameter) ^-3.4 instead of (diameter) ^-1 as found by others in frog peripheral nerve. Further work is required …

A Comparison Of Overbite Relapse To Age, Interincisal Angle And Lower Face Height In Class Ii Deepbite Cases, James E. Macalpine

Loma Linda University Electronic Theses, Dissertations & Projects

Patients with deep skeletal or dental bites before treatment have been noted to have a greater tendency towards relapsing to this deepbite following orthodontic treatment than do patients whose malocclusion showed a more ideal overbite relationship before treatment.

This study utilized patients selected from Rocky Mountain Data Systems for their deepbite trends. Three areas were compared to overbite relapse, 1) age, 2) interincisal angle 3) lower face height.

Results of this study indicate that overbite cases that have the most problems in retention were skeletal deepbites. This study also indicates that there was no disadvantage to early treatment, that the …

Immuno-Histochemical Method For Demonstration Of Lactic Dehydrogenase "M" Subunits In Rat Skeletal Muscle, Kidney And Peripheral Nerve, Luis M. Bustos-Arango

Loma Linda University Electronic Theses, Dissertations & Projects

Immunolocalization of lactic dehydrogenase (LDH) rrM'‘' sub units has been achieved using paraformaldehyde vapor phase fixation of freeze-dried sections. An antiserum to monkey LDH-M^ was found to cross react with rat LDH-M subunits. The fibers of the gastrocnemius and soleus muscles which are stained using the immuno-peroxidase procedure do not stain in the presence of 4 M urea in the conventional method. In kidney, the collecting tubules are the structures which stain most intensely with the immuno-peroxidase procedure and in peripheral nerve both the Schwann cells and axons stain. The nuclei of muscle fibers. kidney tubular cells and Schwann cells …

The Analysis Of A Substrate Preference Of Peromyscus (Rodentia: Cricetidae), Bruce E. Buttler

Loma Linda University Electronic Theses, Dissertations & Projects

The preference for a rocky situation was analyzed under laboratory conditions. In three-compartmented choice boxes, Peromyscus californicus and P. eremicus chose a compartment with rocks and a sandy floor over a compartment with just a sandy floor but P. maniculatus did not show a preference. In a similar experiment, in continual total darkness, the three species chose the compartment with the rocks. UM-key did not prefer the compartment with rocks when the rocks were encased in plastic and were under a normal light regime. When allowed a choice between an empty dark compartment and an empty lighted compartment exposed to …

Four Views Of The Nature And Role Of Women In Sixteenth Century Protestantism, Lutheranism, Calvinism, Anabaptism, And English Puritanism, Marilyn Fagal Thomsen

Loma Linda University Electronic Theses, Dissertations & Projects

Never in its fifteen-hundred year history had the Roman Catholic Church been so shaken as when, in the sixteenth century, a mere handful of men advanced the Scriptural doctrines that were to result in the rise of Protestantism. The sole authority of the Bible, the priesthood of all believers, and righteousness by faith alone rapidly took hold in a large part of Europe, especially in Germany, Switzerland, the Lowlands, and England, where the Lutherans, Calvinists, Anabaptists, and Puritans came to the fore.

Because life in the sixteenth century was so closely tied up with the church, such a revolution was …

Effects Of Temperature On Calcium Uptake In Bossiella Orbigniana Orbigniana, Carolyn M. Thomas

Loma Linda University Electronic Theses, Dissertations & Projects

The effect of temperature on calcification in Bossiena orbigniana orbigniana (Decaisne, 1842) [Manza, 1940; Silva, 1957] (Corallinaceae) was studied using calcium-45 labeling of terminal segments under laboratory conditions. B. orbigniana has optimum calcium uptake for the temperatures 17-21°C within a temperature range of 3-37°C. These results suggest that optimum calcification in B. orbigniana should take place from late spring to early autumn. Q₁₀ values for 3-21°C averaged 3.39 indicating an enzyme-governed reaction. It is proposed that thallus growth rate and calcification are not directly related. It is believed that the optimum temperatures (17-21°C) affect the enzymes towards an increase …

Hallucinogens: A Cause Of Convulsive Ergot Psychoses, Sylvia Dahl Winters

Loma Linda University Electronic Theses, Dissertations & Projects

Ergotism with vasoconstriction and gangrene has been reported through the centuries. Less well publicized are the cases of psychoses associated with convulsive ergotism. Lysergic acid amide a powerful hallucinogen having one.-tenth the hallucinogenic activity of LSD-25 is produced by natural sources. This article attempts to show that convulsive ergot psychoses are mixed psychoses caused by lysergic acid amide or similar hallucinogens combined with nervous system lesions secondary to vasoconstrictive effects of ergotoxine.

Computer Assisted Electron Spin Resonance Spectral Analysis Of Trapped Radicals, Philip Mook Wah Law

Loma Linda University Electronic Theses, Dissertations & Projects

A set of general purpose FORTRAN IV programs have been written during this study to assist in the analysis of complex spectra. An interactive approach is adopted, utilizing the computer and graphics terminals of the Scientific Computation Facility at Loma Linda University. Some procedures carried out are inversion, coordinates scaling, smoothing, differentiation and integration, correction for slanting baseline, addition and subtraction, and spectral simulation.

As an application, the programs are used to assist in the study of free radicals in gamma-irradiated single crystals of 1,2,3,- benzene tricarboxylic acid dihydrate by electron spin resonance spectroscopy. Is is found that the predominant …

Evaluation Of A Precision Filing Test For Predicting Dental Technic Performance, Douglass Roberts

Loma Linda University Electronic Theses, Dissertations & Projects

A precision filing test involving the reduction of a steel cylinder to a perfect cube with the use of a hand file and bench vise was devised as a diagnostic tool for the early detection of freshman students having technic difficulties. The test was administered to 188 freshman dental students in three classes at Loma Linda University, School of Dentistry. Subjective and objective scores were then statistically compared with subsequent technic and clinic grades of the students. The simple linear correlations between the predictor test variable and criterion grades were statistically significant for one class and for the combined classes …

Immunological Responses In The Prairie Rattlesnake Crotalus Viridis Viridis Rafinesque 1818, To Laboratory Infection With Tetrathyridia Of Mesocestoides Corti Hoeppli 1925 (Eucestoda : Mesocestoididea), Gray Bruce Hanson

Loma Linda University Electronic Theses, Dissertations & Projects

Prairie rattlesnakes, of the species Crotalus viridis virldis, were orally, infected with tetrathyridia of Mesocestoides corti to determine the host response to the parasite. Snakes were maintained at constant temperatures of 25, 30, and 35 C for 4--24 weeks. Blood chemistry evaluations of the host were made by standard hematological methods. Eosinophil counts, total proteins, and serum gamma globulins increased while packed-cell volumes and hemoglobins decreased. Autopsy studies revealed the first documented asexual multiplication of Mesocestoides corti in a laboratory infected ectothemic host, with the small intestine being the preferred organ. Pseudocyst formation was first observed to occur at 4 …

The Effect Of Planned Physical Activities On Deficient Motor Skills In Head Start Preschool Children, Darlene L. Robinson

Loma Linda University Electronic Theses, Dissertations & Projects

During the past few years many physicians, nurses, psychologists, teachers, and physical educators have begun to place more emphasis upon the developmental problems of children. As an outgrowth of this, more attention has been given the child showing mild to moderate motor problems. As a result of these more subtle difficulties going unrecognized and untreated, children may suffer from learning disorders, lack of acceptance by teachers and peers, maladaptive behavior and feelings of low self-esteem (Cratty, 1970; Kiphard, -1970; and Ferinden, 1972).

The purpose of this study was to ascertain whether planned physical activities would aid in remediation and/or modification …

Soft Tissue Profile Prediction: An Evaluation Of Methods, Roger H. Zierenberg Jr.

Loma Linda University Electronic Theses, Dissertations & Projects

Forty cases demonstrating at least 3 mm of lingual movement of the upper incisors were analyzed to determine the soft-tissue prediction accuracy of the Holdaway and the Ricketts methods. Initial analysis was performed by comparing predictions based on pre-treatment cephalometric tracings to post-treatment tracings. Lack of congruency was considered error and statistical analysis followed. The Ricketts method was shown to be superior for upper lip prediction on the combined 40 cases. Neither method proved superior in predicting the lower lip.

Further analysis involved segregating the cases according to individual functional lip abnormalities and again comparing the two methods for accuracy. …

The Prediction Of Circumferential Tooth Measurements As An Aid In Orthodontic Banding, Roland D. W. Neufeld

Loma Linda University Electronic Theses, Dissertations & Projects

A correlation was established among the circumferential measurements of the teeth in a given individual. The maxillary central incisor was selected as the predictor tooth to predict the remaining teeth in the set. The circumferences of the teeth were predicted within + two band sizes 69% of the time. Agreement in prediction percentages was found using measurements taken intraorally.

Gingival Condition In Areas Of Minimal And Appreciable Widths Of Keratinized Gingiva, Myles C. Miyasato

Loma Linda University Electronic Theses, Dissertations & Projects

This investigation evaluated the gingival condition of areas with minimal (less than or equal to 1.0 millimeter) and appreciable (greater than or equal to 2.0 millimeters) widths of keratinized gingiva.

Sixteen dental, dental hygiene, and dental assisting students and dental faculty who had contralateral or unilateral areas of minimal and appreciable widths of keratinized gingiva on the mid-buccal surface of mandibular bicuspids were examined. Gingival exudate, plaque, gingival inflammation based on color change and/or swelling and bleeding on probing were evaluated. The results showed that all areas examined were plaque free. Three of 32 areas showed clinical gingival inflammation and …

The Effects Of Topically Applied Citric Acid On Periodontally Diseased Root Surfaces, John S. Garrett

Loma Linda University Electronic Theses, Dissertations & Projects

The goal of reconstructive periodontal therapy is new connective tissue attachment to periodontally diseased root surfaces. Recently Register (1973) and Register and Burdick (1975) have reported accelerated reattachment and cementogenesis when citric acid was applied to surgically created root surface defects. There are apparently no reports in the literature regarding the effects of citric acid on periodontally diseased root surfaces. This study was designed to determine the effects of topically applied citric acid on periodontally diseased root surfaces using the scanning (SEM) and transmission (TEM) electron microscopes.

Twenty three human teeth, nineteen extracted because of periodontal disease and four bicuspids …

The Treatment Timing Of Dolicofacial, Retrognathic Facial Patterns, George B. Clarke Jr.

Loma Linda University Electronic Theses, Dissertations & Projects

The general consensus among orthodontists today is that the dolicofacial, retrognathic patient can present one of the most challenging problems for conventional orthodontic therapy. It is often stated that many of these patients will have more mandibular opening rotation during orthodontic treatment than the mesofacial or brachyfacial patient. This opening rotation is compounded when the use of cervical traction and Class 11 mechanics are incorporated into the treatment plan. Because of the problems involved with the treatment of these types of patients, it has been suggested in the literature that there may be an ideal age to start orthodontic therapy …

Concurrent Infection Of Trypanosoma Musculi Kendell, 1906, And Schistosoma Mansoni Sambon, 1907 In Mice, Berhane Andeberhan

Loma Linda University Electronic Theses, Dissertations & Projects

The possible effects of ablastin on Schistosoma mansoni were investigated by (1) establishing a concurrent infection of Trypanosoma musculi and Schistosoma mansoni in mice, and (2) by obtaining Trypanosoma lewisi immune rat serum (ablastin) and injecting it into S. mansoni infected mice. These procedures were followed on days 4, 14 and 28 of S. mansoni infection. For the groups that were given immune rat serum, controls were kept into which normal rat serum was injected.

Ablastin does not have any effect on the development or morphology of the S. mansoni worms as tested in this study. Although ablastin inhibits glycolytic …

Comparison Of Two Techniques For Enumeration Of Human B And T Lymphocytes, William F. Forsythe Jr.

Loma Linda University Electronic Theses, Dissertations & Projects

The assay of Bursa-derived and Thymus-derived lymphocytes (B and T cells) in man has become increasingly useful during the past few years in normal and in clinical conditions. There has been quite a range reported in the literature in the percent of B and T cells in normal subjects by different investigators.

The purpose of this study was to see if monocyte contamination was one cause of non-specific rosette formation. Twenty-one subjects were used to compare the technique involving trypsin and neuraminidase treatment of erythrocytes and the technique of glass wool removal of monocytes. A peroxidase stain was used to …

Effects Of Cariogenic And Noncariogenic Diets On The Concentration Of The Parotid Hormone Releasing Factor In Rat Hypothalami, Melva Joan Brown

Loma Linda University Electronic Theses, Dissertations & Projects

Hypothalamic and cortical extracts from various cariogenically grouped rats which had been maintained on either a Purina diet or a high sucrose diet (HSD) for three months were infused intravenously into 28 days old rats to determine if there was a titer of parotid hormone releasing factor (PRF) capable of facilitating fluid movement (FM) in the teeth. The hypothalamic and cortical extracts obtained from Purina-fed rats with 0-caries and the hypothalamic extracts from BSD-fed rats conclusively demonstrated FM stimulatory ability. Other Purina-fed groups were essentially biologically ineffective, however, extracts from HSD-fed caries groups including scores 11-40 demonstrated extremely potent FM …

The Effect Of Programmed Instruction About Pacemakers Given In The Hospital Setting On The Immediate And Delayed Retention Of Information On Patients With Permanent Cardiac Pacemakers, Ann Ekroth, Eileen Zorn

Loma Linda University Electronic Theses, Dissertations & Projects

A convenience sample of nineteen patients composing group A, hospitalized for initial placement of permanent cardiac pacemakers, was studied. A programmed instructional test was prepared by the investiga- tors for this population. The question under study was, does programmed instruction for pacemaker patients affect immediate and delayed recall of information? Patients were pre-tested, presented with the programmed instruction package and given a post-test immediately upon completion of the package. They were retested later to evaluate retention level. An IQ test was administered at the same time as the pre-test. Statistical analysis using t-tests indicated significant differences between pre-test scores and …

Systematic Nursing Management Of University Students With Infectious Mononucleosis, Lillian N. Yelton

Loma Linda University Electronic Theses, Dissertations & Projects

Infectious Mononucleosis has been one of the most misdiagnosed entities in medicine. Its ability to mimic other diseases and the abundance of misconceptions about it have long confused both diagnosis and treatment. Since there is still no specific drug to combat this disease. patients with characteristic symptoms are treated symptomatically for the period of extended convalescence. This study was carried out to explore the possible effects of systematic nursing management on Infectious Mononucleosis patients, in order to evaluate those things that significantly influence the patient’s course of illness and recovery, in a university outpatient health service.

The hypothesis formulated was: …

The Functional Stress Analysis Of Post Reinforcement, Robert V. Bravin

Loma Linda University Electronic Theses, Dissertations & Projects

Research was undertaken in order to functionally test the reinforcement capabilities of several commonly used, standard manufactured posts. One hundred and ten maxillary lateral incisors were mounted in plastic, reinforced with the posts at different levels, and then restored with standardized crowns. These teeth along with control groups, were then placed in a custom, mounting jig which properly positioned them for the stress testing. The forces required for fracturing these teeth were recorded and subsequently analyzed.

The statistical analysis of the experimental results demonstrated that posts do not reinforce teeth as supposed; they may, in fact, weaken them. Analysis also …

The Effect Of Pre-Admission Crisis Nursing Intervention On The Anxiety Level Of Elderly Persons On Admission To A Nursing Home, Doreen C. K. Lee

Loma Linda University Electronic Theses, Dissertations & Projects

The experimental study attempted to determine whether pre-admission crisis nursing intervention had any effect on the level of anxiety of elderly people when they were transferred from an acute hospital to a nursing home.

The literature review related to trends in numbers of nursing homes and in the increase in longevity. Several articles indicated that the aged, as a group, lacked power to alter their situations. The need for patients to express their feelings and participate in their own decisions was stressed in various studies. Other theories discussed theoretical aspects and goals of crisis intervention. Several articles suggested that crisis …

Histology Of Apical Tissue : A Comparative Study Of Sargenti Formula, Short Vs. Overfill, James G. Schulze

Loma Linda University Electronic Theses, Dissertations & Projects

Four Stump-tail monkeys (Macaca spiciosa) were used for this study to analyze, on a cellular level, the apical tissue of teeth overfilled versus teeth filled short 1-3 mm. of the radiographic apex with the Sargenti formula. In each animal four incisors were filled short and four incisors were overfilled. A final sample size consisted of 28 teeth. The time periods ranged from 48 hours to 120 days. After analysis of the histology it can be stated that the teeth filled short showed no inflammation to moderate inflammation in the periapical tissues. In teeth overfilled there was a range from moderate …

The Nonenzymatic Browning Reaction Of Whole Wheat Bread, Lily S. Wilson

Loma Linda University Electronic Theses, Dissertations & Projects

Forty-eight weanling male Sprague-Dawley laboratory white rats were fed diets composed of whole wheat bread which was made with one of the three sweeteners studied and added before or after baking and adequate vitamins and minerals for the animals' needs. The rats were divided into six groups, designated A through F. Groups A, C, and E were fed bread diets that had the sweeteners honey, corn syrup, and white table sugar added respectively before baking, while Groups B, D, and F were fed bread diets with the sweeteners honey, corn syrup, and white table sugar added respectively after baking.

The …

Determination Of Lead Content In Apical Tissue Following Root Canal Obturation With Sargenti's Formula, G. Merle Hickok

Loma Linda University Electronic Theses, Dissertations & Projects

Four Stump-tail monkeys were used to help determine if the lead in Sargenti's formula diffuses out into the apical tissue while confined entirely within the root canal. In each animal two teeth were filled with Sargenti's formula 1-2 millimeters short of the radiographic apex, and two teeth were filled with gutta percha and Proco-Sol sealer for controls, making a total sample size of sixteen. The time ranged from 48 hours to 120 days. Lead analysis using the spectrophotometric method showed a higher lead content in the teeth filled with Sargenti's formula than with the gutta percha controls.

Consumer Satisfaction With Services In A Mental Health Center, Sandra M. Hare

Loma Linda University Electronic Theses, Dissertations & Projects

An exploratory study was done with descriptive comparative components to examine the levels of consumer satisfaction at a mental health center, and there was also the intent to determine if satisfaction or dissatisfaction in one area of service affected the general satisfaction level. In addition, other variables and demographic data included in the questionnaire were examined.

Data collection was done by the use of a 23-item questionnaire that was administered to three departments of service, Outpatient, Drug Abuse, and Day-care, at North Orange County Mental Health Services. The sample group consisted of any adult in treatment who had made three …

Growth Augmentation With Activators, John R. Sibley

Loma Linda University Electronic Theses, Dissertations & Projects

This research was performed to determine if bony changes could be effected by activator treatment and how stable this treatment is.

From a sample of twenty-seven cases with before activator treatment cephalometric radiographs. Rocky Mountain Data Systems provided growth projections, with and without edgewise treatment, for the period of time each patient was in treatment. These forecasts were compared to the post-treatment cephalograms to analyze the orthopedic effects of activator treatment with normal growth and with edgewise therapy.

Nine of the twenty-seven case treated sample responded to recall for post-treatment cephalograms and were analyzed for relapse.

It was apparent that …

Evaluation Of A Special Teaching Program With Ambulatory Cardiac Patients, Mary L. Mcgregor Minns

Loma Linda University Electronic Theses, Dissertations & Projects

This study was designed to test the hypotheses that ambulatory cardiac patients given a special teaching program would have increased understanding about their medication, make fewer medication errors, and know more about undesirable effects and how to handle them than patients not included in the special teaching program. Forty-one ambulatory cardiac patients were, after a random start, alternately assigned to an experimental or to a control group. All the patients were taking one or more of three different medications before hospitalization, during their hospital stay, and after their discharge. Three medications, digoxin (lanoxin), lasix, and nitroglycerin, were studied. The program …