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Loss Of Lkb1-Nuak1 Signalling Enhances Nf-Κb Activity In A Spheroid Model Of High-Grade Serous Ovarian Cancer, Adrian Buensuceso, Jamie Lee Fritz, Olga Collins, Yudith Ramos Valdés, Matthew J. Borrelli, Gabriel E. Dimattia, Trevor G. Shepherd
Loss Of Lkb1-Nuak1 Signalling Enhances Nf-Κb Activity In A Spheroid Model Of High-Grade Serous Ovarian Cancer, Adrian Buensuceso, Jamie Lee Fritz, Olga Collins, Yudith Ramos Valdés, Matthew J. Borrelli, Gabriel E. Dimattia, Trevor G. Shepherd
Paediatrics Publications
High-grade serous ovarian cancer (HGSOC) is an aggressive malignancy often diagnosed at an advanced stage. Although most HGSOC patients respond initially to debulking surgery combined with cytotoxic chemotherapy, many ultimately relapse with platinum-resistant disease. Thus, improving outcomes requires new ways of limiting metastasis and eradicating residual disease. We identified previously that Liver kinase B1 (LKB1) and its substrate NUAK1 are implicated in EOC spheroid cell viability and are required for efficient metastasis in orthotopic mouse models. Here, we sought to identify additional signalling pathways altered in EOC cells due to LKB1 or NUAK1 loss-of-function. Transcriptome analysis revealed that inflammatory signalling …
Oncogenic Gene Expression And Epigenetic Remodeling Of Cis-Regulatory Elements In Asxl1-Mutant Chronic Myelomonocytic Leukemia, Moritz Binder, Ryan M. Carr, Terra L. Lasho, Christy M. Finke, Abhishek A. Mangaonkar, Christopher L. Pin, Kurt R. Berger, Amelia Mazzone, Sandeep Potluri, Tamas Ordog, Keith D. Robertson, David L. Marks, Martin E. Fernandez-Zapico, Alexandre Gaspar-Maia, Mrinal M. Patnaik
Oncogenic Gene Expression And Epigenetic Remodeling Of Cis-Regulatory Elements In Asxl1-Mutant Chronic Myelomonocytic Leukemia, Moritz Binder, Ryan M. Carr, Terra L. Lasho, Christy M. Finke, Abhishek A. Mangaonkar, Christopher L. Pin, Kurt R. Berger, Amelia Mazzone, Sandeep Potluri, Tamas Ordog, Keith D. Robertson, David L. Marks, Martin E. Fernandez-Zapico, Alexandre Gaspar-Maia, Mrinal M. Patnaik
Paediatrics Publications
Myeloid neoplasms are clonal hematopoietic stem cell disorders driven by the sequential acquisition of recurrent genetic lesions. Truncating mutations in the chromatin remodeler ASXL1 (ASXL1MT) are associated with a high-risk disease phenotype with increased proliferation, epigenetic therapeutic resistance, and poor survival outcomes. We performed a multi-omics interrogation to define gene expression and chromatin remodeling associated with ASXL1MT in chronic myelomonocytic leukemia (CMML). ASXL1MT are associated with a loss of repressive histone methylation and increase in permissive histone methylation and acetylation in promoter regions. ASXL1MT are further associated with de novo accessibility of distal enhancers binding ETS transcription factors, targeting important …
Surgical Interventions In Velopharyngeal Dysfunction: Comparative Perceptual Speech And Nasometric Outcomes For Three Techniques, Ryan Instrum, Agnieszka Dzioba, Anne Dworschak-Stokan, Murad Husein
Surgical Interventions In Velopharyngeal Dysfunction: Comparative Perceptual Speech And Nasometric Outcomes For Three Techniques, Ryan Instrum, Agnieszka Dzioba, Anne Dworschak-Stokan, Murad Husein
Paediatrics Publications
Background: The aim of this study was to evaluate speech outcomes following surgical intervention for velopharyngeal dysfunction (VPD). Perceptual speech outcome data were subsequently analyzed in conjunction with patient factors such as congenital abnormalities, presence of cleft lip and/or palate, and age of repair. We hope to aid in the eventual creation of treatment algorithms for VPD, allowing practitioners to tailor surgical technique selection to patient factors. Methods: A retrospective analysis was performed for all patients who underwent surgical correction of VPD at London Health Sciences Centre between the years 2005 and 2018. Two hundred and two consecutive VPD patients …
The ‘New Normal’ Includes Online Prenatal Exercise: Exploring Pregnant Women’S Experiences During The Pandemic And The Role Of Virtual Group Fitness On Maternal Mental Health, Cristina Silva-Jose, Taniya S. Nagpal, Javier Coterón, Ruben Barakat, Michelle F. Mottola
The ‘New Normal’ Includes Online Prenatal Exercise: Exploring Pregnant Women’S Experiences During The Pandemic And The Role Of Virtual Group Fitness On Maternal Mental Health, Cristina Silva-Jose, Taniya S. Nagpal, Javier Coterón, Ruben Barakat, Michelle F. Mottola
Paediatrics Publications
Background: Prenatal anxiety and depressive symptoms have significantly increased since the onset of the coronavirus (COVID-19) pandemic In addition, home confinement regulations have caused a drastic increase in time spent sedentary. Online group fitness classes may be an effective strategy that can increase maternal physical activity levels and improve mental health outcomes by providing an opportunity for social connectedness. The present study explores the experiences of pregnant women who participated in an online group exercise program during the pandemic and identifies relationships with maternal mental health and well-being. In addition, we present person-informed recommendations on how to improve the delivery …
Clinical Utility Of Combinatorial Pharmacogenomic Testing In Depression: A Canadian Patient- And Rater-Blinded, Randomized, Controlled Trial, Arun K. Tiwari, Clement C. Zai, C. Anthony Altar, Julie Anne Tanner, Paige E. Davies, Paul Traxler, James Li, Elizabeth S. Cogan, Matthew T. Kucera, Ana Gugila, Nicole Braganza, Heather Emmerson, Gwyneth Zai, Daniel J. Müller, Robert Levitan, Stefan Kloiber, Zafiris J. Daskalakis, Benicio N. Frey, James M. Bowen, Jean Eric Tarride, Richard Tytus, Ranjith Chandrasena, Nicholas Voudouris, Valerie H. Taylor, Raymond Tempier, Verinder Sharma
Clinical Utility Of Combinatorial Pharmacogenomic Testing In Depression: A Canadian Patient- And Rater-Blinded, Randomized, Controlled Trial, Arun K. Tiwari, Clement C. Zai, C. Anthony Altar, Julie Anne Tanner, Paige E. Davies, Paul Traxler, James Li, Elizabeth S. Cogan, Matthew T. Kucera, Ana Gugila, Nicole Braganza, Heather Emmerson, Gwyneth Zai, Daniel J. Müller, Robert Levitan, Stefan Kloiber, Zafiris J. Daskalakis, Benicio N. Frey, James M. Bowen, Jean Eric Tarride, Richard Tytus, Ranjith Chandrasena, Nicholas Voudouris, Valerie H. Taylor, Raymond Tempier, Verinder Sharma
Paediatrics Publications
The pharmacological treatment of depression consists of stages of trial and error, with less than 40% of patients achieving remission during first medication trial. However, in a large, randomized-controlled trial (RCT) in the U.S. (“GUIDED”), significant improvements in response and remission rates were observed in patients who received treatment guided by combinatorial pharmacogenomic testing, compared to treatment-as-usual (TAU). Here we present results from the Canadian “GAPP-MDD” RCT. This 52-week, 3-arm, multi-center, participant- and rater-blinded RCT evaluated clinical outcomes among patients with depression whose treatment was guided by combinatorial pharmacogenomic testing compared to TAU. The primary outcome was symptom improvement (change …
Genetic Evidence Supports The Development Of Slc26a9 Targeting Therapies For The Treatment Of Lung Disease, Jiafen Gong, Gengming He, Cheng Wang, Claire Bartlett, Naim Panjwani, Scott Mastromatteo, Fan Lin, Katherine Keenan, Julie Avolio, Anat Halevy, Michelle Shaw, Mohsen Esmaeili, Guillaume Côté-Maurais, Damien Adam, Stéphanie Bégin, Candice Bjornson, Mark Chilvers, Joe Reisman, April Price, Michael Parkins, Richard Van Wylick, Yves Berthiaume, Lara Bilodeau, Dimas Mateos-Corral, Daniel Hughes, Mary J. Smith
Genetic Evidence Supports The Development Of Slc26a9 Targeting Therapies For The Treatment Of Lung Disease, Jiafen Gong, Gengming He, Cheng Wang, Claire Bartlett, Naim Panjwani, Scott Mastromatteo, Fan Lin, Katherine Keenan, Julie Avolio, Anat Halevy, Michelle Shaw, Mohsen Esmaeili, Guillaume Côté-Maurais, Damien Adam, Stéphanie Bégin, Candice Bjornson, Mark Chilvers, Joe Reisman, April Price, Michael Parkins, Richard Van Wylick, Yves Berthiaume, Lara Bilodeau, Dimas Mateos-Corral, Daniel Hughes, Mary J. Smith
Paediatrics Publications
Over 400 variants in the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) are CF-causing. CFTR modulators target variants to improve lung function, but marked variability in response exists and current therapies do not address all CF-causing variants highlighting unmet needs. Alternative epithelial ion channel/transporters such as SLC26A9 could compensate for CFTR dysfunction, providing therapeutic targets that may benefit all individuals with CF. We investigate the relationship between rs7512462, a marker of SLC26A9 activity, and lung function pre- and post-treatment with CFTR modulators in Canadian and US CF cohorts, in the general population, and in those with chronic obstructive pulmonary disease …
High Oncostatin M Predicts Lack Of Clinical Remission For Patients With Inflammatory Bowel Disease On Tumor Necrosis Factor Α Antagonists, Angela Guo, Cameron Ross, Nilesh Chande, Jamie Gregor, Terry Ponich, Reena Khanna, Michael Sey, Melanie Beaton
High Oncostatin M Predicts Lack Of Clinical Remission For Patients With Inflammatory Bowel Disease On Tumor Necrosis Factor Α Antagonists, Angela Guo, Cameron Ross, Nilesh Chande, Jamie Gregor, Terry Ponich, Reena Khanna, Michael Sey, Melanie Beaton
Paediatrics Publications
The interleukin-6 family cytokine, oncostatin-M (OSM) has been associated with response to tumor necrosis factor-α antagonists (anti-TNFs) in small cohorts of patients with inflammatory bowel disease (IBD). We aimed to evaluate the association between plasma OSM concentrations and response to anti-TNFs (infliximab and adalimumab) in both ulcerative colitis (UC) and Crohn’s disease (CD). A retrospective cohort study was conducted in patients with IBD with a history of anti-TNF exposure. Blood samples, collected prior to anti-TNF exposure, were analyzed by enzyme-linked immunosorbent assay for the presence and quantity of OSM. Clinical remission was assessed at 1-year post anti-TNF exposure in addition …
Assessing Cerebral Blood Flow, Oxygenation And Cytochrome C Oxidase Stability In Preterm Infants During The First 3 Days After Birth, Ajay Rajaram, Daniel Milej, Marianne Suwalski, Lilian Kebaya, Matthew Kewin, Lawrence Yip, Sandrine De Ribaupierre, Victor Han, Mamadou Diop, Soume Bhattacharya, Keith St. Lawrence
Assessing Cerebral Blood Flow, Oxygenation And Cytochrome C Oxidase Stability In Preterm Infants During The First 3 Days After Birth, Ajay Rajaram, Daniel Milej, Marianne Suwalski, Lilian Kebaya, Matthew Kewin, Lawrence Yip, Sandrine De Ribaupierre, Victor Han, Mamadou Diop, Soume Bhattacharya, Keith St. Lawrence
Paediatrics Publications
A major concern with preterm birth is the risk of neurodevelopmental disability. Poor cerebral circulation leading to periods of hypoxia is believed to play a significant role in the etiology of preterm brain injury, with the first three days of life considered the period when the brain is most vulnerable. This study focused on monitoring cerebral perfusion and metabolism during the first 72 h after birth in preterm infants weighing less than 1500 g. Brain monitoring was performed by combining hyperspectral near-infrared spectroscopy to assess oxygen saturation and the oxidation state of cytochrome c oxidase (oxCCO), with diffuse correlation spectroscopy …
Implementation Of An E-Learning Course In Physical Activity And Sedentary Behavior For Pre- And In-Service Early Childhood Educators: Evaluation Of The Teach Pilot Study, Brianne A. Bruijns, Leigh M. Vanderloo, Andrew M. Johnson, Kristi B. Adamo, Shauna M. Burke, Valerie Carson, Rachel Heydon, Jennifer D. Irwin, Patti Jean Naylor, Brian W. Timmons, Patricia Tucker
Implementation Of An E-Learning Course In Physical Activity And Sedentary Behavior For Pre- And In-Service Early Childhood Educators: Evaluation Of The Teach Pilot Study, Brianne A. Bruijns, Leigh M. Vanderloo, Andrew M. Johnson, Kristi B. Adamo, Shauna M. Burke, Valerie Carson, Rachel Heydon, Jennifer D. Irwin, Patti Jean Naylor, Brian W. Timmons, Patricia Tucker
Paediatrics Publications
Background: Childcare-based physical activity (PA) and sedentary behavior (SB) interventions have traditionally used in-person training to supplement early childhood educators’ (ECEs) knowledge and confidence to facilitate physically active programming for the children in their care. However, this method of delivery is resource-intensive and unable to reach a high number of ECEs. The purpose of the Training pre-service EArly CHildhood educators in PA (TEACH) pilot study was to test the implementation (e.g., fidelity, feasibility, acceptability) of an e-Learning course targeting PA and SB among a sample of pre-service (i.e., post-secondary students) and in-service (i.e., practicing) ECEs in Canada. Methods: A pre-/post-study …
Change In Pre- And In-Service Early Childhood Educators’ Knowledge, Self-Efficacy, And Intentions Following An E-Learning Course In Physical Activity And Sedentary Behaviour: A Pilot Study, Brianne A. Bruijns, Leigh M. Vanderloo, Andrew M. Johnson, Kristi B. Adamo, Shauna M. Burke, Valerie Carson, Rachel Heydon, Jennifer D. Irwin, Patti Jean Naylor, Brian W. Timmons, Patricia Tucker
Change In Pre- And In-Service Early Childhood Educators’ Knowledge, Self-Efficacy, And Intentions Following An E-Learning Course In Physical Activity And Sedentary Behaviour: A Pilot Study, Brianne A. Bruijns, Leigh M. Vanderloo, Andrew M. Johnson, Kristi B. Adamo, Shauna M. Burke, Valerie Carson, Rachel Heydon, Jennifer D. Irwin, Patti Jean Naylor, Brian W. Timmons, Patricia Tucker
Paediatrics Publications
Background: Early childhood educators (ECEs) are the primary daytime role models for many young children, and are responsible for facilitating physical activity (PA) opportunities and minimizing sedentary behaviour (SB) in childcare. However, they have reportedly received little related education in their pre-service training. The purpose of the Training pre-service EArly CHildhood educators in physical activity (TEACH) pilot study was to explore changes in pre- and in-service ECEs’ knowledge, self-efficacy, behavioural intention, and perceived behavioural control following the TEACH e-Learning course in PA and SB. Methods: Pre-service ECEs were purposefully recruited from three Canadian colleges, while in-service ECEs were recruited via …
Principles Of Dormancy Evident In High-Grade Serous Ovarian Cancer, Trevor G. Shepherd, Frederick A. Dick
Principles Of Dormancy Evident In High-Grade Serous Ovarian Cancer, Trevor G. Shepherd, Frederick A. Dick
Paediatrics Publications
In cancer, dormancy refers to a clinical state in which microscopic residual disease becomes non-proliferative and is largely refractory to chemotherapy. Dormancy was first described in breast cancer where disease can remain undetected for decades, ultimately leading to relapse and clinical presentation of the original malignancy. A long latency period can be explained by withdrawal from cell proliferation (cellular dormancy), or a balance between proliferation and cell death that retains low levels of residual disease (tumor mass dormancy). Research into cellular dormancy has revealed features that define this state. They include arrest of cell proliferation, altered cellular metabolism, and unique …
Rethinking Walkability And Developing A Conceptual Definition Of Active Living Environments To Guide Research And Practice, Melissa Tobin, Samantha Hajna, Kassia Orychock, Nancy Ross, Megan Devries, Paul J. Villeneuve, Lawrence D. Frank, Gavin R. Mccormack, Rania Wasfi, Madeleine Steinmetz-Wood, Jason Gilliland, Gillian L. Booth, Meghan Winters, Yan Kestens, Kevin Manaugh, Daniel Rainham, Lise Gauvin, Michael J. Widener, Nazeem Muhajarine, Hui Luan, Daniel Fuller
Rethinking Walkability And Developing A Conceptual Definition Of Active Living Environments To Guide Research And Practice, Melissa Tobin, Samantha Hajna, Kassia Orychock, Nancy Ross, Megan Devries, Paul J. Villeneuve, Lawrence D. Frank, Gavin R. Mccormack, Rania Wasfi, Madeleine Steinmetz-Wood, Jason Gilliland, Gillian L. Booth, Meghan Winters, Yan Kestens, Kevin Manaugh, Daniel Rainham, Lise Gauvin, Michael J. Widener, Nazeem Muhajarine, Hui Luan, Daniel Fuller
Paediatrics Publications
Background: Walkability is a popular term used to describe aspects of the built and social environment that have important population-level impacts on physical activity, energy balance, and health. Although the term is widely used by researchers, practitioners, and the general public, and multiple operational definitions and walkability measurement tools exist, there are is no agreed-upon conceptual definition of walkability. Method: To address this gap, researchers from Memorial University of Newfoundland hosted “The Future of Walkability Measures Workshop” in association with researchers from the Canadian Urban Environmental Health Research Consortium (CANUE) in November 2017. During the workshop, trainees, researchers, and practitioners …
Caliper: A Software For Blood-Free Parametric Patlak Mapping Using Pet/Mri Input Function, Praveen Dassanayake, Lumeng Cui, Elizabeth Finger, Matthew Kewin, Jennifer Hadaway, Andrea Soddu, Bjoern Jakoby, Sven Zuehlsdorf, Keith S.St Lawrence, Gerald Moran, Udunna C. Anazodo
Caliper: A Software For Blood-Free Parametric Patlak Mapping Using Pet/Mri Input Function, Praveen Dassanayake, Lumeng Cui, Elizabeth Finger, Matthew Kewin, Jennifer Hadaway, Andrea Soddu, Bjoern Jakoby, Sven Zuehlsdorf, Keith S.St Lawrence, Gerald Moran, Udunna C. Anazodo
Paediatrics Publications
Routine clinical use of absolute PET quantification techniques is limited by the need for serial arterial blood sampling for input function and more importantly by the lack of automated pharmacokinetic analysis tools that can be readily implemented in clinic with minimal effort. PET/MRI provides the ability for absolute quantification of PET probes without the need for serial arterial blood sampling using image-derived input functions (IDIFs). Here we introduce caliPER, a modular and scalable software for simplified pharmacokinetic modeling of PET probes with irreversible uptake or binding based on PET/MR IDIFs and Patlak Plot analysis. caliPER generates regional values or parametric …
Avoiding The Echo-Chamber: Embracing Qualitative Research In Obstetrics And Gynecology To Amplify Patient Voices, Taryn Taylor, Andrea N. Simpson, Rohan D’Souza
Avoiding The Echo-Chamber: Embracing Qualitative Research In Obstetrics And Gynecology To Amplify Patient Voices, Taryn Taylor, Andrea N. Simpson, Rohan D’Souza
Paediatrics Publications
No abstract provided.
Insomnia Evaluation And Treatment During Peripartum: A Joint Position Paper From The European Insomnia Network Task Force “Sleep And Women,” The Italian Marcè Society And International Experts Task Force For Perinatal Mental Health, Laura Palagini, Alessandra Bramante, Chiara Baglioni, Nicole Tang, Luigi Grassi, Ellemarije Altena, Anna F. Johann, Pierre Alexis Geoffroy, Giovanni Biggio, Claudio Mencacci, Verinder Sharma, Dieter Riemann
Insomnia Evaluation And Treatment During Peripartum: A Joint Position Paper From The European Insomnia Network Task Force “Sleep And Women,” The Italian Marcè Society And International Experts Task Force For Perinatal Mental Health, Laura Palagini, Alessandra Bramante, Chiara Baglioni, Nicole Tang, Luigi Grassi, Ellemarije Altena, Anna F. Johann, Pierre Alexis Geoffroy, Giovanni Biggio, Claudio Mencacci, Verinder Sharma, Dieter Riemann
Paediatrics Publications
Insomnia symptoms are frequent during peripartum and are considered risk factors for peripartum psychopathology. Assessing and treating insomnia and related conditions of sleep loss during peripartum should be a priority in the clinical practice. The aim of this paper was to conduct a systematic review on insomnia evaluation and treatment during peripartum which may be useful for clinicians. The literature review was carried out between January 2000 and May 2021 on the evaluation and treatment of insomnia during the peripartum period. The PubMed, PsycINFO, and Embase electronic databases were searched for literature published according to the PRISMA guidance with several …
Digoxin Dosing And The Risk Of Toxicity In Older Adults With Ckd, Flory T. Muanda, Matthew A. Weir, Fatemeh Ahmadi, Eric Mcarthur, Jessica M. Sontrop, Richard B. Kim, Amit X. Garg
Digoxin Dosing And The Risk Of Toxicity In Older Adults With Ckd, Flory T. Muanda, Matthew A. Weir, Fatemeh Ahmadi, Eric Mcarthur, Jessica M. Sontrop, Richard B. Kim, Amit X. Garg
Paediatrics Publications
No abstract provided.
Cortical Gyrification Morphology In Asd And Adhd: Implication For Further Similarities Or Disorder-Specific Features?, Avideh Gharehgazlou, Marlee Vandewouw, Justine Ziolkowski, Jimmy Wong, Jennifer Crosbie, Russell Schachar, Rob Nicolson, Stelios Georgiades, Elizabeth Dunne, Jürgen Harreiter, Alexandra Kautzky-Willer, Peter Damm, Elisabeth R. Mathiesen, Dorte M. Jensen, Lise Lotte Andersen, Mette Tanvig, Annunziata Lapolla, Maria G. Dalfra, Alessandra Bertolotto, Ewa Wender-Ozegowska, Agnieszka Zawiejska, David Hill, Frank J. Snoek, Judith G.M. Jelsma, Gernot Desoye
Cortical Gyrification Morphology In Asd And Adhd: Implication For Further Similarities Or Disorder-Specific Features?, Avideh Gharehgazlou, Marlee Vandewouw, Justine Ziolkowski, Jimmy Wong, Jennifer Crosbie, Russell Schachar, Rob Nicolson, Stelios Georgiades, Elizabeth Dunne, Jürgen Harreiter, Alexandra Kautzky-Willer, Peter Damm, Elisabeth R. Mathiesen, Dorte M. Jensen, Lise Lotte Andersen, Mette Tanvig, Annunziata Lapolla, Maria G. Dalfra, Alessandra Bertolotto, Ewa Wender-Ozegowska, Agnieszka Zawiejska, David Hill, Frank J. Snoek, Judith G.M. Jelsma, Gernot Desoye
Paediatrics Publications
Shared etiological pathways are suggested in ASD and ADHD given high rates of comorbidity, phenotypic overlap and shared genetic susceptibility. Given the peak of cortical gyrification expansion and emergence of ASD and ADHD symptomology in early development, we investigated gyrification morphology in 539 children and adolescents (6-17 years of age) with ASD (n=197) and ADHD (n=96) compared to typically developing controls (n=246) using the local Gyrification Index (lGI) to provide insight into contributing etiopathological factors in these two disorders. We also examined IQ effects and functional implications of gyrification by exploring the relation between lGI and ASD and ADHD symptomatology …
O-Glcnacylation And Regulation Of Galectin-3 In Extraembryonic Endoderm Differentiation, Mohamed I. Gatie, Danielle M. Spice, Amritpal Garha, Adam Mctague, Mariam Ahmer, Alexander V. Timoshenko, Gregory M. Kelly
O-Glcnacylation And Regulation Of Galectin-3 In Extraembryonic Endoderm Differentiation, Mohamed I. Gatie, Danielle M. Spice, Amritpal Garha, Adam Mctague, Mariam Ahmer, Alexander V. Timoshenko, Gregory M. Kelly
Paediatrics Publications
The regulation of proteins through the addition and removal of O-linked β-N-acetylglucosamine (O-GlcNAc) plays a role in many signaling events, specifically in stem cell pluripo-tency and the regulation of differentiation. However, these post-translational modifications have not been explored in extraembryonic endoderm (XEN) differentiation. Of the plethora of proteins regulated through O-GlcNAc, we explored galectin-3 as a candidate protein known to have various intracellular and extracellular functions. Based on other studies, we predicted a reduction in global O-GlcNAcylation levels and a distinct galectin expression profile in XEN cells relative to embryonic stem (ES) cells. By conducting dot blot analysis, XEN cells …
Assessment Of Surrogate Markers For Cardiovascular Disease In Familial Mediterranean Fever-Related Amyloidosis Patients Homozygous For M694v Mutation In Mefv Gene, Sezgin Sahin, Micol Romano, Ferhat Guzel, David Piskin, Dimitri Poddighe, Siren Sezer, Ozgur Kasapcopur, C. Thomas Appleton, Ilker Yilmaz, Erkan Demirkaya
Assessment Of Surrogate Markers For Cardiovascular Disease In Familial Mediterranean Fever-Related Amyloidosis Patients Homozygous For M694v Mutation In Mefv Gene, Sezgin Sahin, Micol Romano, Ferhat Guzel, David Piskin, Dimitri Poddighe, Siren Sezer, Ozgur Kasapcopur, C. Thomas Appleton, Ilker Yilmaz, Erkan Demirkaya
Paediatrics Publications
Cardiovascular disease (CVD) remains underestimated in familial Mediterranean fever-associated AA amyloidosis (FMF-AA). We aimed to compare early markers of endothelial dysfunction and atherosclerosis in FMF-AA with a homozygous M694V mutation (Group 1 = 76 patients) in the Mediterranean fever (MEFV) gene and in patients with other genotypes (Group 2 = 93 patients). Measures of increased risk for future CVD events and endothelial dysfunction, including flow-mediated dilatation (FMD), pentraxin-3 (PTX3), and carotid intima-media thickness (cIMT), and fibroblast growth factor 23 (FGF23) as a marker of atherosclerotic vascular disease were compared between groups. The frequency of clinical FMF manifestations did not differ …
Cardiovascular Response To Postural Perturbations Of Different Intensities In Healthy Young Adults, Patrick Siedlecki, J. Kevin Shoemaker, Tanya D. Ivanova, S. Jayne Garland
Cardiovascular Response To Postural Perturbations Of Different Intensities In Healthy Young Adults, Patrick Siedlecki, J. Kevin Shoemaker, Tanya D. Ivanova, S. Jayne Garland
Paediatrics Publications
The ability to regain control of balance is vital in limiting falls and injuries. Little is known regarding how the autonomic nervous system responds during recovery from balance perturbations of different intensities. The purpose of this study was to examine the cardiovascular response following a standing balance perturbation of varying intensities, quantify cardiac baroreflex sensitivity (cBRS) during standing perturbations, and to establish the stability of the cardiac baroreflex during quiet standing before and after balance disturbances. Twenty healthy participants experienced three different perturbation intensity conditions that each included 25 brief posteriorly-directed perturbations, 8–10 s apart. Three perturbation intensity conditions (low, …
Children’S School-Day Nutrient Intake In Ontario: A Cross-Sectional Observational Study Comparing Students’ Packed Lunches From Two School Schedules, Lisa J. Neilson, Lesley A. Macaskill, Jonathan M.H. Luk, Navreeti Sharma, Marina I. Salvadori, Jamie A. Seabrook, Paula D.N. Dworatzek
Children’S School-Day Nutrient Intake In Ontario: A Cross-Sectional Observational Study Comparing Students’ Packed Lunches From Two School Schedules, Lisa J. Neilson, Lesley A. Macaskill, Jonathan M.H. Luk, Navreeti Sharma, Marina I. Salvadori, Jamie A. Seabrook, Paula D.N. Dworatzek
Paediatrics Publications
This study compared the caloric and nutrient values of packed lunch contents and consumption in the Balanced School Day (BSD) (two 20 min eating periods) versus the Traditional Schedule (TS) (one 20 min lunch). Foods consumed during school were assessed by direct food observation in 321 grade 3 and 4 students, aged 7–10 years, at 9 BSD and 10 TS elementary schools in Ontario. Packed lunch contents in the BSD were significantly higher than the TS in energy (3128.14 ± 1100.36 vs. 2658.98 ± 951.34 kJ, p < 0.001, respectively). Similarly, carbohydrates, total sugar, protein, fat, saturated fatty acids (SFA), calcium, iron, and sodium were significantly higher in the BSD versus TS packed lunches. Correspondingly, students in the BSD consumed significantly more energy, carbohydrates, total sugar, and SFA compared to the TS. Overall, lunches brought by students in the BSD schedule provided more energy across all macronutrients, with only a few micronutrients showing increased amounts, suggesting two 20 min eating opportunities could contribute to excess caloric intake during school, potentially contributing to the prevalence of childhood overweight and obesity in Canada. Furthermore, packed lunches in both schedules had excess amounts of nutrients of concern and much work is needed to ensure that children in Canada receive nutritious lunches at school.
Freedom From Discrimination Or Freedom To Discriminate? Discursive Tensions Within Discrimination Policies In Medical Education, Javeed Sukhera, Helly Goez, Allison Brown, Wael Haddara, Saleem Razack
Freedom From Discrimination Or Freedom To Discriminate? Discursive Tensions Within Discrimination Policies In Medical Education, Javeed Sukhera, Helly Goez, Allison Brown, Wael Haddara, Saleem Razack
Paediatrics Publications
The importance of advancing equity, diversity, and inclusion for all members of the academic medical community has gained recent attention. Academic medical organizations have attempted to increase broader representation while seeking structural reforms consistent with the goal of enhancing equity and reducing disproportionality. However, efforts remain constrained while minority groups continue to experience discrimination. In this study, the authors sought to identify and understand the discursive effects of discrimination policies within medical education. The authors assembled an archive of 22 texts consisting of publicly available discrimination and harassment policy documents in 13 Canadian medical schools that were active as of …
Insights About Cannabis And Psychosis Using Video Games For Young People With A First Episode Of Psychosis, Particularly Those From Black Racialized Communities: Protocol For A Mixed Methods Study, Suzanne Archie, Lena Palaniyappan, Andrew T. Olagunju, Natasha Johnson, Nicole Kozloff, Elham Sadeh, Andrea Bardell, Alexandra Baines, Kelly K. Anderson, Oyedeji Ayonrinde, Manuela Ferrari
Insights About Cannabis And Psychosis Using Video Games For Young People With A First Episode Of Psychosis, Particularly Those From Black Racialized Communities: Protocol For A Mixed Methods Study, Suzanne Archie, Lena Palaniyappan, Andrew T. Olagunju, Natasha Johnson, Nicole Kozloff, Elham Sadeh, Andrea Bardell, Alexandra Baines, Kelly K. Anderson, Oyedeji Ayonrinde, Manuela Ferrari
Paediatrics Publications
Background: Cannabis use disorder among young people with a first episode of psychosis contributes to relapse, hospitalization, and impaired functioning. However, few studies have examined what young people with early phase psychosis, particularly those from Black racialized communities, understand or appreciate about this relationship, even though they may be at risk. There are no formally tested knowledge translation strategies that disseminate these research findings for young people with emerging psychosis from Black racialized communities. Objective: This study aims to conceptualize what young people with early phase psychosis/cannabis use disorder understand about the relationship between cannabis and psychosis, focusing on people …
Oral Health Inequality In Canada, The United States And United Kingdom, Malini Chari, Vahid Ravaghi, Wael Sabbah, Noha Gomaa, Sonica Singhal, Carlos Quiñonez
Oral Health Inequality In Canada, The United States And United Kingdom, Malini Chari, Vahid Ravaghi, Wael Sabbah, Noha Gomaa, Sonica Singhal, Carlos Quiñonez
Paediatrics Publications
The objective of this study was to quantify the magnitude of absolute and relative oral health inequality in countries with similar socio-political environments, but differing oral health care systems such as Canada, the United States (US), and the United Kingdom (UK), in the first decade of the new millennium. Clinical oral health data were obtained from the Canadian Health Measures Survey 2007–2009, the National Health and Nutrition Examination Survey 2007–2008, and the Adult Dental Health Survey 2009, for Canada, the US and UK, respectively. The slope index of inequality (SII) and relative index of inequality (RII) were used to quantify …
Assessment Of Surrogate Markers For Cardiovascular Disease In Familial Mediterranean Fever-Related Amyloidosis Patients Homozygous For M694v Mutation In Mefv Gene, Sezgin Sahin, Micol Romano, Ferhat Guzel, David Piskin, Dimitri Poddighe, Siren Sezer, Ozgur Kasapcopur, C. Thomas Appleton, Ilker Yilmaz, Erkan Demirkaya
Assessment Of Surrogate Markers For Cardiovascular Disease In Familial Mediterranean Fever-Related Amyloidosis Patients Homozygous For M694v Mutation In Mefv Gene, Sezgin Sahin, Micol Romano, Ferhat Guzel, David Piskin, Dimitri Poddighe, Siren Sezer, Ozgur Kasapcopur, C. Thomas Appleton, Ilker Yilmaz, Erkan Demirkaya
Paediatrics Publications
Cardiovascular disease (CVD) remains underestimated in familial Mediterranean fever-associated AA amyloidosis (FMF-AA). We aimed to compare early markers of endothelial dysfunction and atherosclerosis in FMF-AA with a homozygous M694V mutation (Group 1 = 76 patients) in the Mediterranean fever (MEFV) gene and in patients with other genotypes (Group 2 = 93 patients). Measures of increased risk for future CVD events and endothelial dysfunction, including flow-mediated dilatation (FMD), pentraxin-3 (PTX3), and carotid intima-media thickness (cIMT), and fibroblast growth factor 23 (FGF23) as a marker of atherosclerotic vascular disease were compared between groups. The frequency of clinical FMF manifestations did not differ …
Renal Volume Of Five-Year-Old Preterm Children Are Not Different Than Full-Term Controls, Jaime M. Restrepo, Laura Torres-Canchala, Juan Carlos Arias Cadavid, Michael Ferguson, Adriana Villegas, Oscar Ramirez, Martin Rengifo, Guido Filler
Renal Volume Of Five-Year-Old Preterm Children Are Not Different Than Full-Term Controls, Jaime M. Restrepo, Laura Torres-Canchala, Juan Carlos Arias Cadavid, Michael Ferguson, Adriana Villegas, Oscar Ramirez, Martin Rengifo, Guido Filler
Paediatrics Publications
Objective: In previous studies, smaller renal volumes were reported in prematurely born infants, however, these renal volumes were not corrected for body surface area, the main determinant of renal size. Given the rapid growth of the renal cortex after premature birth, the authors hypothesized that corrected volumes would not differ from healthy controls. Methods: Ambispective cohort study with prospective follow-up of prematurely born babies in a large specialized center and retrospectively recruited healthy control group. Children were assessed for renal length and renal volumes at age 5 by three independent ultrasonographers. Detailed anthropometry, blood pressure and renal function were also …
Autologous, Lentivirus-Modified, T-Rapa Cell “Micropharmacies” For Lysosomal Storage Disorders, Murtaza S. Nagree, Tania C. Felizardo, Mary L. Faber, Jitka Rybova, C. Anthony Rupar, S. Ronan Foley, Maria Fuller, Daniel H. Fowler, Jeffrey A. Medin
Autologous, Lentivirus-Modified, T-Rapa Cell “Micropharmacies” For Lysosomal Storage Disorders, Murtaza S. Nagree, Tania C. Felizardo, Mary L. Faber, Jitka Rybova, C. Anthony Rupar, S. Ronan Foley, Maria Fuller, Daniel H. Fowler, Jeffrey A. Medin
Paediatrics Publications
T cells are the current choice for many cell therapy applications. They are relatively easy to access, expand in culture, and genetically modify. Rapamycin-conditioning ex vivo reprograms T cells, increasing their memory properties and capacity for survival, while reducing inflammatory potential and the amount of preparative conditioning required for engraftment. Rapamycin-conditioned T cells have been tested in patients and deemed to be safe to administer in numerous settings, with reduced occurrence of infusion-related adverse events. We demonstrate that ex vivo lentivirus-modified, rapamycin-conditioned CD4+ T cells can also act as next-generation cellular delivery vehicles—that is, “micropharmacies”—to disseminate corrective enzymes for multiple …
A Distinct Metabolite Signature In Military Personnel Exposed To Repetitive Low-Level Blasts, Michael R. Miller, Alicia Dibattista, Maitray A. Patel, Mark Daley, Catherine Tenn, Ann Nakashima, Shawn G. Rhind, Oshin Vartanian, Maria Y. Shiu, Norleen Caddy, Michelle Garrett, Doug Saunders, Ingrid Smith, Rakesh Jetly, Douglas D. Fraser
A Distinct Metabolite Signature In Military Personnel Exposed To Repetitive Low-Level Blasts, Michael R. Miller, Alicia Dibattista, Maitray A. Patel, Mark Daley, Catherine Tenn, Ann Nakashima, Shawn G. Rhind, Oshin Vartanian, Maria Y. Shiu, Norleen Caddy, Michelle Garrett, Doug Saunders, Ingrid Smith, Rakesh Jetly, Douglas D. Fraser
Paediatrics Publications
Military Breachers and Range Staff (MBRS) are subjected to repeated sub-concussive blasts, and they often report symptoms that are consistent with a mild traumatic brain injury (mTBI). Biomarkers of blast injury would potentially aid blast injury diagnosis, surveillance and avoidance. Our objective was to identify plasma metabolite biomarkers in military personnel that were exposed to repeated low-level or sub-concussive blast overpressure. A total of 37 military members were enrolled (18 MBRS and 19 controls), with MBRS having participated in 8–20 breaching courses per year, with a maximum exposure of 6 blasts per day. The two cohorts were similar except that …
Molecular And Cellular Mechanisms Controlling Integrin-Mediated Cell Adhesion And Tumor Progression In Ovarian Cancer Metastasis: A Review, Dolly Dhaliwal, Trevor G. Shepherd
Molecular And Cellular Mechanisms Controlling Integrin-Mediated Cell Adhesion And Tumor Progression In Ovarian Cancer Metastasis: A Review, Dolly Dhaliwal, Trevor G. Shepherd
Paediatrics Publications
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy in the developed world. EOC metastasis is unique since malignant cells detach directly from the primary tumor site into the abdominal fluid and form multicellular aggregates, called spheroids, that possess enhanced survival mechanisms while in suspension. As such, altered cell adhesion properties are paramount to EOC metastasis with cell detachment from the primary tumor, dissemination as spheroids, and reattachment to peritoneal surfaces for secondary tumor formation. The ability for EOC cells to establish and maintain cell–cell contacts in spheroids is critical for cell survival in suspension. Integrins are a family …
Mostly Worse, Occasionally Better: Impact Of Covid-19 Pandemic On The Mental Health Of Canadian Children And Adolescents, Katherine Tombeau Cost, Jennifer Crosbie, Evdokia Anagnostou, Catherine S. Birken, Alice Charach, Suneeta Monga, Elizabeth Kelley, Rob Nicolson, Jonathon L. Li, Tomonori Kaneko, Martin R. Schiller
Mostly Worse, Occasionally Better: Impact Of Covid-19 Pandemic On The Mental Health Of Canadian Children And Adolescents, Katherine Tombeau Cost, Jennifer Crosbie, Evdokia Anagnostou, Catherine S. Birken, Alice Charach, Suneeta Monga, Elizabeth Kelley, Rob Nicolson, Jonathon L. Li, Tomonori Kaneko, Martin R. Schiller
Paediatrics Publications
This large cross-sectional study examined the impact of COVID-19 emergency measures on child/adolescent mental health for children/adolescents with and without pre-existing psychiatric diagnoses. Using adapted measures from the CRISIS questionnaire, parents of children aged 6–18 (N = 1013; 56% male; 62% pre-existing psychiatric diagnosis) and self-reporting children/adolescents aged 10–18 (N = 385) indicated changes in mental health across six domains: depression, anxiety, irritability, attention, hyperactivity, and obsessions/compulsions. Changes in anxiety, irritability, and hyperactivity were calculated for children aged 2–5 years using the Strengths and Difficulties Questionnaire. COVID-19 exposure, compliance with emergency measures, COVID-19 economic concerns, and stress from social isolation …