Digital Commons Network^™

Biochemical Analyses Of Udgx-A Crosslinking Uracil-Dna Glycosylase, Chuan Liang

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DNA base damage is common due to exposure to various endogenous and exogenous factors. To repair the base lesions, such as uracil from cytosine deamination, enzymes from the uracil-DNA glycosylase (UDG) superfamily are critical, which can recognize the damaged base and initiate the base excision repair (BER) pathway. There used to be six families of proteins identified in the UDG superfamily until a new member, UDGX, was found in Mycobacterium smegmatis, which is a unique DNA-crosslinking UDG. In this dissertation work, a series of biochemical analyses of the newly found UDGX are performed, including the analyses of structures, functions, …

Atomistic And Mesoscale Modeling Of Microstructure Development During Solid-State Sintering, Omar Marwan Isa Hussein

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Interfaces are ubiquitous in materials systems, and they influence the processing and properties of nearly all engineering and functional materials. Examples include grain boundaries (GBs) in polycrystalline materials, free surfaces in nanoparticles, and phase boundaries in multiphase materials. Therefore, understanding and controlling interfacial processes is a key aspect of materials design and discovery efforts. Recent developments in advanced manufacturing and synthesis techniques have enabled the fabrication of materials architectures with intricate nanoscale features. Of particular interest is solid-state sintering, known for creating complex and high-precision geometries with controlled microstructures. While sintering science has been the subject of active research, very …

Leveraging Artificial Intelligence For Team Cognition In Human-Ai Teams, Beau Schelble

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Advances in artificial intelligence (AI) technologies have enabled AI to be applied across a wide variety of new fields like cryptography, art, and data analysis. Several of these fields are social in nature, including decision-making and teaming, which introduces a new set of challenges for AI research. While each of these fields has its unique challenges, the area of human-AI teaming is beset with many that center around the expectations and abilities of AI teammates. One such challenge is understanding team cognition in these human-AI teams and AI teammates' ability to contribute towards, support, and encourage it. Team cognition is …

Did That Help? Harnessing Natural Language Processing To Uncover Characteristics Of Peer Feedback And Their Impacts On Teamwork-Skills Learning., Annamaria V. Wolf

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Peer Evaluation Systems (PESs) allow members of student teams to provide one another with computer-mediated feedback in the form of qualitative, open-ended comments. The current research leverages unsupervised Natural Language Processing (NLP), namely Biterm Topic Modeling (BTM) and sentiment analysis, to uncover latent topics and degree of positivity and negativity expressed in peer feedback, respectively. BTM results revealed a 6-topic model that was reliably replicated over 10 Gibbs initializations 80% of the time. Topics were labeled Timely Communication, Idea Generation, Coordination & Adaptation, Work Quality, Team Support & Focusing, and Work Accountability. Qualitative comparison suggests that these topics demonstrate …

Computationally-Driven Insights Into The Ligand Environments Of Materials For Catalysis And Separations, Stephen Vicchio

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Designing new catalytic and sorption materials is necessary to limit global temperature rise below 1.5 ◦C by 2050, while also meeting global energy demands. Climate change and energy production are not mutually exclusive; global population growth has direct impacts on global energy demands and climate. In both catalysis and adsorption applications, new technologies are needed to address these challenges. Catalysis can provide alternate, low-energy routes for converting low-value gases into higher-value chemical commodities, thus altering our current energy production. Likewise, new sorption materials can capture previously emitted CO₂ from decades of energy production from fossil fuels, thus helping to …

Improving Sizing Resolution Of Particle Impactors In The Nanoparticle Range, Shivuday Kala

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The application of particle size measurement extends across many fields: air quality measurement, pharmaceutical studies, paint and coating production, and nanoparticle formulation to name a few. Therefore, accurate measurement of nanoparticles is critical to aerosol science. While devices currently exist that can size and count nanoparticles such as electrical mobility spectrometers, dynamic light scattering devices, and small angle X-ray scattering devices, their high costs, complex operation, and lack of outdoor usability, restrict their use in practical applications. Among the devices that can size aerosols down to the nanoscale, cascade impactors stand out because of their robustness, relatively simple design, low …

Development Of Scope Of Services For Procurement Of Professional Consultant Services On Transportation Projects – A Study Of South Carolina Department Of Transportation, Ajay Jadhav

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Project Scoping Process (PSP) is one of the significant steps that starts at the very beginning of the project life cycle. During project initiation phase, project scoping is kicked off which includes documenting a list of project-specific goals, deliverables, tasks, costs, and deadlines. The scoping phase duration depends on the project complexity and involves various stakeholders, establishing team, confirming the project purpose and need, initiating the environmental revie process, determining the level of environmental documentation and permit requirements, conducting survey, identifying project risks and tools to mitigate them, and evaluating public involvement strategies. A well-defined PSP is therefore essential for …

Hpc-Enabled Fast And Configurable Dynamic Simulation, Analysis, And Learning For Complex Power System Adaptation And Control, Cong Wang

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This dissertation presents an HPC-enabled fast and configurable dynamic simulation, analysis, and learning framework for complex power system adaptation and control. Dynamic simulation for a large transmission system comprising thousands of buses and branches implies the latency of complicated numerical computations. However, faster-than-real-time execution is often required to provide timely support for power system planning and operation. The traditional approaches for speeding up the simulation demand extensive computing facilities such as CPU-based multi-core supercomputers, resulting in heavily resource-dependent solutions. In this work, by coupling the Message Passing Interface (MPI) protocol with an advanced heterogeneous programming environment, further acceleration can be …

Experimental And Computational Platforms For Studying Systems Mechanobiology, Brendyn Miller

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Mechanical stimulation through physical activity has been shown to play an important role in treating and preventing several non-communicable diseases such as hypertension, lower back pain (LBP), type-2 diabetes mellitus, and several cancers. This is accomplished through the regulation of cellular behavior and tissue remodeling within the body at both the micro- and macro-scale levels. The goal of mechanobiology research is to gain in-depth knowledge and understanding of how cells sense physical forces in conjunction with other biochemical cues and translate those factors into important biological functions that either maintain tissue homeostasis or lead to pathological states. Understanding these processes …

Cellular Mechanism Of Pentagalloyl Gucose-Mediated Prevention And Reversal Of Abdominal Aortic Aneurysms, Greg Halsey

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Abdominal aortic aneurysm (AAA) has been the 15th leading cause of death in persons older than 55 for the past ten years in several Western countries, with rupture resulting in an almost 100% mortality rate. AAA is a focal dilation of the aorta characterized by progressive loss of elastin and vascular smooth muscle cells (SMCs), as well as persistent inflammatory response [1]. The only treatment for AAA is surgery; however, the mortality post-procedure is still 1-4%, with a 15-30% chance of morbidity [2].

Pentagalloyl glucose (PGG) treatment is effective in the reversal of AAA. While its stabilizing interactions with extracellular …

Addressing Mercury Contamination From Artisanal Gold Mining In Colombia: Pollution Exposure, Health Risk, And Educational Efforts In The Communities Of La Toma, Colombia, Kelli Mccourt

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Artisanal and small-scale gold mining (ASGM) has become a primary environmental and public health concern in the region of Colombia known as Alto Cauca. The predominantly Afro-descendent communities of Yolombó and La Toma in Alto Cauca have experienced pollution linked to the use of mercury in the ASGM process. For the past decade, mercury has emerged as a contaminant of increasing concern in the communities due to its toxicity and ability to bioaccumulate and biomagnify. Likewise, mining in the region raises concerns over the leaching of metals into local waters. Given the complexity of risk and pollution in the communities, …

Making The Move Toward Meaningfulness In Learning Activities: Enhancing Teacher Self-Efficacy In Student Engagement Through An Instructional Coaching Approach In Improvement Science, Maureen Tiller

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Student engagement is a common problem in schools today and a challenging one to solve. Choosing to dive deeper into this complex problem at one high school, ten teachers participated in a coaching cycle designed to impact self-efficacy in student engagement with the support of the school’s instructional coach in collaboration with the principal. One overarching research question guided this improvement science study: What impact does an instructional coaching cycle focused on meaningfulness in learning activities have on teachers’ self-efficacy in student engagement? To answer the research question, I conducted a quantitative and qualitative data analysis of pre- and …

An Integrative Approach To Managing A Species Of Conservation Concern: Resource Selection, Spatial Ecology, And Population Genetics Of The Green Salamander (Aneides Aeneus), Megan Novak

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The relationship between wildlife and the environment they inhabit is dependent on both spatial and temporal scales. It is therefore crucial that biological investigations account for ecological scale when analyzing patterns and processes established, particularly when such investigations inform conservation management plans. This dissertation provides extensive insight into the conservation biology of the green salamander (Aneides aeneus), a critically imperiled species in South Carolina. The green salamander is a species that exists in a patchy network of rock outcrops within mountainous forest landscapes, and most studies on habitat suitability for green salamanders have been conducted on the macrohabitat, …

The Effect Of Prior Virtual Reality Experience On Locomotion And Navigation In Virtual Environments, Moloud Nasiri

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VirtualReality(VR) is becoming more accessible and widely utilized in crucial disciplines like training, communication, healthcare, and education. One of the important parts of VR applications is walking through virtual environments. So, researchers have broadly studied various kinds of walking in VR as it can reduce sickness, improve the sense of presence, and enhance the general user experience. Due to the recent availability of consumer Head Mounted Displays (HMDs), people are using HMDs in all sorts of different locations. It underscores the need for locomotion methods that allow users to move through large Immersive Virtual Environments (IVEs) when occupying a small …

Developing Disinfection Strategies For Controlling Human Norovirus, Sars-Cov-2, And Clostridioides Difficile Endospores In Long-Term Care Facilities, Jinge Huang

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Long-term care facilities (LTCFs) provide an environment favorable for the transmission of three critical human pathogens: human norovirus (HuNoV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and Clostridioides difficile. Given residents in LTCFs are susceptible to infections due to their advanced ages and compromised immune systems, effective environmental surface disinfection plays a crucial role in controlling the spread of human pathogens within these settings and, therefore, mitigates the risk of infections caused by these pathogens. This dissertation aimed to assess the efficacy of various types of disinfectants against two HuNoV surrogates [feline calicivirus (FCV) and Tulane virus (TuV)], two …

Controlled Manipulation And Transport By Microswimmers In Stokes Flows, Jake Buzhardt

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Remotely actuated microscale swimming robots have the potential to revolutionize many aspects of biomedicine. However, for the longterm goals of this field of research to be achievable, it is necessary to develop modelling, simulation, and control strategies which effectively and efficiently account for not only the motion of individual swimmers, but also the complex interactions of such swimmers with their environment including other nearby swimmers, boundaries, other cargo and passive particles, and the fluid medium itself. The aim of this thesis is to study these problems in simulation from the perspective of controls and dynamical systems, with a particular focus …

The Effects Of The Esol Program On African American Vernacular Speaking Students Reading, Marquice Clark

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South Carolina’s public education system is broken. For the past several years, the State of South Carolina and the nation have somehow managed to do the nearly impossible. Both have produced more English Language Learning (ELL) students to be proficient in English Language Arts (ELA) (i.e., reading, writing, and usage) than native English speakers. The issue of low black performance on state and national standardized assessments has always been a cumbersome task for America's public school system. Although Black students comprise more than 30 percent of the total student population in America, more Limited English students are demonstrating a higher …

Damage Detection With An Integrated Smart Composite Using A Magnetostriction-Based Nondestructive Evaluation Method: Integrating Machine Learning For Prediction, Christopher Nelon

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The development of composite materials for structural components necessitates methods for evaluating and characterizing their damage states after encountering loading conditions. Laminates fabricated from carbon fiber reinforced polymers (CFRPs) are lightweight alternatives to metallic plates; thus, their usage has increased in performance industries such as aerospace and automotive. Additive manufacturing (AM) has experienced a similar growth as composite material inclusion because of its advantages over traditional manufacturing methods. Fabrication with composite laminates and additive manufacturing, specifically fused filament fabrication (fused deposition modeling), requires material to be placed layer-by-layer. If adjacent plies/layers lose adhesion during fabrication or operational usage, the strength …

Feasibility Of Using High-Alkali Natural Pozzolans And Reclaimed Fly Ash As Alternative Supplementary Cementitious Materials In Concrete, Weiqi Wang

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Due to the shortage of supplementary cementitious materials (SCMs) in the concrete industry, it is necessary to seek a new alternative. This study evaluates the feasibility of high-alkali SCMs, which were not recommended previously due to potentially exacerbating alkali-silica reaction (ASR) in concrete. The study addresses theSCMs’ ASR mitigation performance, evaluated by ASTM C1567, C1293, and AASHTO T380. Other concrete durability tests, including ASTM C596 drying shrinkage test, ASTM C1012 sulfate resistance test, and ASTM C1202 rapid chloride ions penetration test, were also conducted in this study. The ASTM C311 strength activity index test, thermal gravimetric analysis (TGA), and ASTM …

Studies On Electrochemical Hydrogen Isotope Separation, Liyanage Mayura Sankalpa Silva

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Graphene-integrated Proton Exchange Membrane (PEM) electrochemical cells have emerged as a novel area of scientific investigation in the realm of hydrogen isotope separation. Chemical Vapor Deposited (CVD) graphene has been especially useful due to its large-scale production capability for scaling-up purposes. The research described in this dissertation explores the role that inadvertent introduction of cations, notably ammonium and copper, during the CVD graphene transfer onto PEM substrates, such as Nafion, might play in affecting hydrogen ion transport and isotope separation in PEM electrochemical cells. An extensive review of existing literature exposed a gap concerning unintentional cation introductions during graphene transfer, …

The Use Of The South Carolina School Improvement Model - Quick Cycles In Sixth-Grade Science Classrooms, Jennifer Gnann

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Using data to make informed decisions about instruction strengthens a teacher’s delivery of content within the classroom. However, many teachers have not been taught how to properly use a model of rapid improvement cycles to analyze data and apply it to their classroom instruction. I modified the South Carolina School Improvement Model so that it could be used in short cycles to see how teachers used it to plan for, monitor, and adjust instruction in their classrooms.

I conducted a single case study over a six-week period in which I instructed two sixth-grade science teachers on how to use the …

Deep Reinforcement Learning For The Design Of Structural Topologies, Nathan Brown

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Advances in machine learning algorithms and increased computational efficiencies have given engineers new capabilities and tools for engineering design. The presented work investigates using deep reinforcement learning (DRL), a subset of deep machine learning that teaches an agent to complete a task through accumulating experiences in an interactive environment, to design 2D structural topologies. Three unique structural topology design problems are investigated to validate DRL as a practical design automation tool to produce high-performing designs in structural topology domains.

The first design problem attempts to find a gradient-free alternative to solving the compliance minimization topology optimization problem. In the proposed …

Force Displacement, Forced Perspective: The Rhetorics Of Refugee Experience, Jonathan Burgess

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This dissertation interrogates the intersection of digital media, displacement, and human rights within the contemporary geopolitical landscape, with a specific focus on the MENA region. From a perspective firmly rooted rhetoric, it dissects the complex relationship between technology and displaced populations, emphasizing the role of transmedia storytelling in shaping refugee experiences and narratives and the potential for transmedia storytelling to facilitate greater insights into needs and gaps for displaced people. Central to the analysis is the paradox of digital tools both as emancipatory devices and tools of surveillance and control, which are further elucidated through case studies.

Engaging with thinkers …

An Investigation Of The Accretion Processes In T Tauri And Herbig Ae/Be Systems Using High Resolution Optical And Near-Infrared Spectroscopy, Joshua Kern

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Star and planet formation is intimately tied to the accretion of material from the environments in which they form. During the formation process, disks of gas and dust develop in young stellar objects through which material is facilitated to the star and forming planets. Theoretical models of these accretion processes invoke viscous spreading via hydrodynamics, as well as more complex interactions with magnetic fields be it from the stellar component or the formation environment in order to catalyze these mass flows. These accretion models predict various scenarios including magnetospheric accretion as well as supersonic accretion flows in the disk atmosphere …

A Social-Ecological Systems Inquiry For Understanding Environmental Change In Los Angeles Outer-Ring Suburbs, Farnaz Kamyab

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Within the framework of the city's green infrastructure, urban and suburban green coverage play a pivotal role in delivering substantial benefits to health, economy, and the environment. However, the permanence of these green coverage is threatened by dynamic changes in neighborhood socio-economic, spatial, and ecological elements and their loss or degradation presents a problematic issue. Social-Ecological System Theory (SES) offers a comprehensive framework for understanding the potential correlations between socio-economic trends and the degradation of green coverage. This research is based on a case study of the highly diverse megacity, Los Angeles (LA), which encompasses a wide array of built-environments, …

Leveraging Professional Learning To Impact Leadership Of Technology Integration, Tennille Woodward

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School and district leaders lack awareness of the depth and complexity of the International Society for Technology in Education (ISTE) Standards for Education Leaders and how the implementation of the leader standards provides for students and teachers to learn relevant skills and strategies. Continuing the work of Schoenbart’s 2019 dissertation, the Education Leaders Technology Survey (ELTS) provides a self-assessment for education leaders to reflect on their leadership of technology integration and provides baseline data for this study. Professional learning around the ISTE Standards for Education Leaders provided through a Canvas course provides education leaders with a theory of action to …

Characterization Of The Effects Of The Pyrazolopyrimidine Inhibitor Grassofermata (Nav-2729) In The Eukaryotic Pathogen Trypanosoma Brucei, Kristina Marie Parman

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The protozoan pathogen, Trypanosoma brucei, is the causative agent of sleeping sickness in humans and nagana in livestock in sub-Saharan Africa. T. brucei cycles between tsetse fly and mammalian hosts, and it is adapted to survive in diverse host tissues. Variant Surface Glycoprotein (VSG) plays a key role in immune evasion in the mammalian host. The VSG membrane anchor requires two myristates, 14-carbon saturated fatty acids (FAs) that are scarce in the host. T. brucei can synthesize FAs de novo, but also readily takes up exogenous FAs, despite lacking homologs to fatty acid uptake proteins found in other …

Atomistic And Mesoscale Modeling Of Microstructure Development During Solid-State Sintering, Omar Hussein

All Dissertations

Interfaces are ubiquitous in materials systems, and they influence the processing and properties of nearly all engineering and functional materials. Examples include grain boundaries (GBs) in polycrystalline materials, free surfaces in nanoparticles, and phase boundaries in multiphase materials. Therefore, understanding and controlling interfacial processes is a key aspect of materials design and discovery efforts.

Recent developments in advanced manufacturing and synthesis techniques have enabled the fabrication of materials architectures with intricate nanoscale features. Of particular interest is solid-state sintering, known for creating complex and high-precision geometries with controlled microstructures. While sintering science has been the subject of active research, very …

The Effects Of Math Pathways On Pupils In Poverty, Edward Kameen

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This was a Mixed Methods study that evaluated the implementation of a Math Pathways Program at Crestview High School. The study leveraged Improvement Science and a long-range PDSA cycle with the aim of improving outcomes for Pupils in Poverty in Dual Credit math courses. This study sought to answer three research questions. The first two research questions were answered with quantitative data and the final research question was answered with qualitative data. The research questions that guided this study were (1) What effects did the Math Pathways Program have on the enrollment of Pupils in Poverty in Dual Credit math? …

Impact Of Copper-Containing Products And Irrigation On Hybrid Bermudagrass (Cynodon Dactylon (L.) Pers X C. Transvaalensis Burtt-Davy), Adam Gore

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Copper (Cu) is an often-seen component in various turf industry products including fungicides, algaecides, and colorants. Though an essential micronutrient in plants, excessive levels of Cu has been shown in various plant commodities to cause phytotoxicity and plant death. With the increasing use of pigments on hybrid bermudagrass [Cynodon dactylon (L.) Pers x. C. transvaalensis Burtt-Davy] putting greens to replace overseeding practices during traditional dormant periods combined with regular applications of fungicide, algaecide and spray additives containing Cu, the objective of this study was to investigate the potential impact of individual and combined copper-containing treatments on hybrid bermudagrass and …