Digital Commons Network^™

When Might We Break The Rules? A Statistical Analysis Of Aesthetics In Photographs, Justin Wang, Marie A. Lee, Thomas C.M. Lee

College of the Pacific Faculty Articles

High-quality photographs often follow certain high-level rules well known to photographers, but some photographs intentionally break these rules. Doing so is usually a matter of artistry and intuition, and the conditions and patterns that allow for rule-breaks are often not well articulated by photographers. This article first applies statistical techniques to help find and evaluate rule-breaking photographs, and then from these photographs discover those patterns that justify their rule-breaking. With this approach, this article discovered some significant patterns that explain why some high-quality photographs successfully break the common photographic rules by positioning the subject in the center or the horizon …

2022/2023 University Of The Pacific General Catalog, University Of The Pacific

Catalogue, Bulletin, Catalog

No abstract provided.

2022/2023 University Of The Pacific Sacramento Catalog, University Of The Pacific

Catalogue, Bulletin, Catalog

No abstract provided.

Recent Graduates’ Perspectives On Undergraduate Kinesiology Programs In Canada, Kevin Cheng, Alexander Klas, Rebecca Ataman, Shannon Chou, Sep Pouresa

All Dugoni School of Dentistry Faculty Articles

Background: Kinesiologists are a growing group of health professionals in Canada who can enter practice after completing undergraduate kinesiology programs. Unlike other health professional programs such as physiotherapy that have well-established curricula and extensive national accreditation standards, kinesiology programs vary considerably between institutions. The resultant disparities in kinesiology graduates’ entry-level skillsets, competencies, and confidence levels contribute to their uncertainty regarding their role in healthcare and the public’s underutilization of kinesiology services. Conclusions: As former kinesiology students, and as current kinesiologists and allied health professionals, we offer our perspective on how undergraduate kinesiology programs could change to respond to the needs …

Deutetrabenazine For The Treatment Of Chorea Associated With Huntington’S Disease, Harshit Gupta, Wil Perkins, Cain Stark, Sathya Kikkeri, Juyeon Kakazu, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

This is a comprehensive review of the literature regarding the use of Deutetrabenazine in treating chorea associated with Huntington’s disease. Unfortunately, treatment has been limited for many aspects of this neurodegenerative disease. The present investigation presents the background, evidence, and indications for the use Deutetrabenazine in the setting of Huntington’s disease. Huntington’s disease is characterized by a variety of motor, psychiatric, and cognitive symptoms with chorea being one of the more notable ones. Chorea is a movement disorder present in multiple neurologic diseases that causes involuntary and irregular muscle movements theorized to be stemming from high dopamine levels. Deutetrabenazine is …

Glossopharyngeal Neuralgia: Epidemiology, Risk Factors, Pathophysiology, Differential Diagnosis, And Treatment Options, Andrew Han, Carver Montgomery, Alexandra Zamora, Emilie Winder, Adam M. Kaye, Caroline Carroll, Alfonzo Aquino, Juyeon Kakazu, Alan David Kaye

School of Pharmacy Faculty Articles

Purpose of Review
This is a comprehensive review of the most recent literature on glossopharyngeal neuralgia (GPN), a relatively rare form of neuropathic facial pain. It covers the epidemiology, risk factors, pathophysiology, and differential diagnosis given that glossopharyngeal neuralgia can often be confused with other facial pain syndromes. Finally, we extensively review recent findings regarding medical or conservative measures, minimally invasive, and surgical options for potentially treating and managing glossopharyngeal neuralgia.

Recent Findings
An in-depth analysis of the recent literature indicates that glossopharyngeal neuralgia is not only rare but its etiology and pathophysiology are complex and are often secondary to …

Peripherally Restricted Transthyretin-Based Delivery System For Probes And Therapeutics Avoiding Opioid-Related Side Effects, Md Tariqul Haque Tuhin, Dengpan Liang, Fang Liu, Hala Aldawod, Toufiq Ul Amin, Joshua S. Ho, Rasha Emara, Arjun D. Patel, Melanie A. Felmlee, Miki S. Park, James A. Uchizono, Mamoun M. Alhamadsheh

School of Pharmacy Faculty Articles

Several investigations into the sites of action of opioid analgesics have utilized peripherally acting mu-opioid receptor antagonists (PAMORAs), which have been incorrectly assumed to possess limited permeability across the blood-brain barrier. Unfortunately, the poor pharmacokinetic properties of current PAMORAs have resulted in misunderstandings of the role of central nervous system and gastrointestinal tract in precipitating side effects such as opioid-induced constipation. Here, we develop a drug delivery approach for restricting the passage of small molecules across the blood-brain barrier. This allows us to develop naloxone- and oxycodone-based conjugates that display superior potency, peripheral selectivity, pharmacokinetics, and efficacy in rats compared …

17Β-Estradiol Treatment Improves Acetylcholine-Induced Relaxation Of Mesenteric Arteries In Ovariectomized Uc Davis Type 2 Diabetes Mellitus Rats In Prediabetic State, Md Rahatullah Razan, Farjana Akther, Rifat Ara Islam, James L. Graham, Kimber L. Stanhope, Peter J. Havel, Roshanak Rahimian

School of Pharmacy Faculty Articles

We recently reported sex differences in mesenteric arterial function of the UC Davis type-2 diabetes mellitus (UCD-T2DM) rats as early as the prediabetic state. We reported that mesenteric arteries (MA) from prediabetic male rats exhibited a greater impairment compared to that in prediabetic females. However, when females became diabetic, they exhibited a greater vascular dysfunction than males. Thus, the aim of this study was to investigate whether the female sex hormone, estrogen preserves mesenteric arterial vasorelaxation in UCD-T2DM female rats at an early prediabetic state. Age-matched female Sprague Dawley and prediabetic (PD) UCD-T2DM rats were ovariectomized (OVX) and subcutaneously implanted …

Juneteenth Isn’T Just For African Americans. It’S A Celebration, And A Warning, For Everyone, Mary J. Wardell-Ghiraduzzi

Office of Diversity, Equity, and Inclusion Publications

Strawberry soda. Savory BBQ. Collard greens. Sweet corn. Watermelon. Cherry pie.

My father was a Black Texan. My mother was a Black Arkansan. When they migrated to California, they brought with them traditions passed down through ancestors from West Africa and the Congo. My parents understood the powerful symbol the color red expressed on the table: a reminder of the sacrifices endured.

This is my Juneteenth.

This month, the nation will join in celebrating Juneteenth, a federal holiday that acknowledges when enslaved Black people in Texas were finally freed on June 19, 1865 — more than two years after President …

Aligning The Diversity Requirement In General Education With A Broader Institutional Dei Agenda, Qingwen Dong, Jeffrey Hole, Angel Zhong, Christopher D. Goff

Office of Diversity, Equity, and Inclusion Webinar Recordings and Conversations

In this workshop, we will describe the recent effort currently underway at University of the Pacific to revisit and revise the learning outcomes for courses meeting our Diversity Requirement. We plan to share our process from start to the present, from identifying stakeholders to including student voices, and how we were able to align with university-wide efforts at all levels to arrive where we are today. There will be time to strategize how similar efforts might work at your institution, including how to identify allies, include students, etc. to drive institutional change.

Speakers from the University of the Pacific:

• Qingwen …

Juneteenth: An American Holiday For All, Mary J. Lomax-Ghirarduzzi

Office of Diversity, Equity, and Inclusion Publications

No abstract provided.

Evaluation Of Smartphone Usage As A Predictor Of Social Jetlag In University Students, Rajkumar Sevak

School of Pharmacy Faculty Articles

Background: Individual sleep and activity patterns show large variations and are interfered considerably by social schedules. Social jetlag (SJL) is the difference between intrinsic circadian rhythm and extrinsically enforced sleep-wake cycle. However, little is known about the variables affecting the severity of SJL. Methodology: We evaluated whether sleep- or smartphone-related variables affected the severity of SJL among college students in India. A total of 1175 students from medicine, dental, engineering, paramedical, and other colleges in Gujarat, India, completed a web-based survey. The survey included demographic questions and questions from the Smartphone Addiction Scale-Short Version (SAS-SV), reduced Horne and Ostberg Morningness-Eveningness …

May Community Letter: Integrating Pacific's Dei Framework Of Excellence, Mary J. Lomax-Ghirarduzzi

Office of Diversity, Equity, and Inclusion Publications

No abstract provided.

Alternative Options For Complex, Recurrent Pain States Using Cannabinoids, Psilocybin, And Ketamine: A Narrative Review Of Clinical Evidence, Amber N. Edinoff, Juliana M. Fort, Christina Singh, Sarah E. Wagner, Jessica R. Rodriguez, Catherine A. Johnson, Elyse M. Cornett, Kevin S. Murnane, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

With emerging information about the potential for morbidity and reduced life expectancy with long-term use of opioids, it is logical to evaluate nonopioid analgesic treatments to manage pain states. Combinations of drugs can provide additive and/or synergistic effects that can benefit the management of pain states. In this regard, tetrahydrocannabinol (THC) and cannabidiol (CBD) modulate nociceptive signals and have been studied for chronic pain treatment. Psilocybin, commonly known as "magic mushrooms", works at the serotonin receptor, 5-HT. Psilocybin has been found in current studies to help with migraines since it has a tryptamine structure and works similarly to triptans. Psilocybin …

A Call To Action: A Need For Initiatives That Increase Equitable Access To Covid-19 Therapeutics, Jacinda C. Abdul-Mutakabbir, Elizabeth B. Hirsch, Caroline L. Ko, Britny R. Brown, Aiman Bandali, Jason Mordino, Leah H. Yoke, Taison Bell, Talia H. Swartz, Uzma Syed, Matifadza Hlatshwayo, Ila M. Saunders

School of Pharmacy Faculty Articles

Structural racism is endemic in the United States and causes inequitable health outcomes that have been amplified throughout the COVID-19 pandemic. Non-Hispanic Black, Hispanic/Latino, and Native American individuals have been disproportionately affected, and are twice as likely to be hospitalized or die from COVID-19 or related morbidities when compared to White Americans. Social determinants of health inequities contribute to these disparate outcomes, given that minoritized individuals are more likely to occupy essential worker roles and to live in high-density settings. Despite their higher risk of severe COVID-19 illness, racially and ethnically minoritized individuals are less likely to receive potentially lifesaving …

Dataset For Study: Validity Of The Kiersma-Chen Empathy Scale In Health Sciences Students, David B. Gillette, Todd E. Davenport, J. Mark Vanness, Rupa Balachandran, Edward L. Rogan, Deepti Vyas, Suzanne M. Galal, Tracey Delnero, Elisa M. Chávez, Jeannene M. Ward-Lonergan, Paul Subar, Thomas Koesterer

Physical Therapy Faculty & Staff Datasets

Purpose: Empathy is the ability to understand and identify with another person’s feelings, and is important to develop in students. It is often measured using the Jefferson Scale of Empathy in Health Professions Students (JSE-HPS), which has significant cost. The Kiersma-Chen Empathy Scale (KCES) was developed to measure empathy at no cost. Initial reliability was determined from a cohort of pharmacy and nursing students. The purpose of this study was to determine psychometric properties of the KCES, comparing it to the JSE-HPS for validity for students in pursuing a career in healthcare-related fields.

Subjects: Students in healthcare fields of …

A Myth Of The Well-Stirred Model: Is The Well-Stirred Model Good For High Clearance Drugs?, Jin Dong, Miki S. Park

School of Pharmacy Faculty Articles

Understanding the rationale of the well-stirred model (WSM), borrowed from chemical engineering, has been ongoing through the history of pharmacokinetics (PK) as an independent discipline. Extensive arguments around the WSM and 1977′s lidocaine data re-emerged recently. It was proposed that Pang and Rowland's lidocaine data analysis was confounded by four intermingled confounding factors which may lead to contradictory conclusions or inconclusive dilemma. This re-visit of 1977′s lidocaine data analysis was challenged by Pang and coauthors. This commentary is our responses to their comments focusing on the lidocaine data analysis and the IVIVE by the WSM. In addition, the disadvantage of …

Creating A Multidisciplinary Collaboration Service-Learning Experience In Design Education, Sacha M. Joseph-Mathews, Marie A. Lee, N. Kreidler

College of the Pacific Faculty Articles

The design process in most organizations is often collaborative and interdisciplinary in nature. Yet most institutions of higher learning do not offer students the opportunity to work in multidisciplinary teams. This study follows an experiential service-learning project over 3 years to explore the role of multidisciplinary project teams on design education outcomes. Findings suggest that the quality of designs improved over time and students consider experiential learning in multidisciplinary teams to be a valuable component in their education, increasing their job readiness upon graduation.

2022 Commencement, University Of The Pacific

Commencement Programs

No abstract provided.

A Month Filled With Faith-Based, Cultural And Diversity Celebrations, Mary J. Lomax-Ghirarduzzi

Office of Diversity, Equity, and Inclusion Publications

No abstract provided.

...Of Cabbages And Kings, Spring 2022, Emeriti Society, University Of The Pacific

Emeriti Newsletter: "...Of Cabbages and Kings"

"...Of Cabbages and Kings" is the newsletter of the University of the Pacific Emeriti Society. Read more about the Emeriti Society of Pacific by clicking here.

The Illusion Of Agency In Human–Computer Interaction, Michael Madary

College of the Pacific Faculty Articles

This article makes the case that our digital devices create illusions of agency. There are times when users feel as if they are in control when in fact they are merely responding to stimuli on the screen in predictable ways. After the introduction, the second section of the article offers examples of illusions of agency that do not involve human–computer interaction in order to show that such illusions are possible and not terribly uncommon. The third and fourth sections of the article cover relevant work from empirical psychology, including the cues that are known to generate the sense of agency. …

The Possible Application Of Ketamine In The Treatment Of Depression In Alzheimer's Disease, Islam Mohammad Shehata, Waniyah Masood, Nouran Nemr, Alexandra Anderson, Kamal Bhusal, Amber N. Edinoff, Elyse M. Cornett, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Depression is a leading cause of disability globally, with a prevalence of 3.8% among the whole population, 5% of the adult population, and 5.7% of the elderly population over 60 years of age. There is evidence that depression is linked to certain neurodegenerative diseases, one being Alzheimer's disease (AD). The efficacy of conventional antidepressants to treat depression in AD is conflicting, especially regarding selective serotonin reuptake inhibitors (SSRIs). A recent systemic review and meta-analysis of 25 randomized controlled trials including fourteen antidepressant medications showed no high efficacy in treating AD patients' symptoms. However, ketamine, a nonselective N-methyl-D-aspartate (NMDA) receptor antagonist, …

Antipsychotic Polypharmacy-Related Cardiovascular Morbidity And Mortality: A Comprehensive Review, Amber N. Edinoff, Emily D. Ellis, Laura M. Nussdorf, Taylor W. Hill, Elyse M. Cornett, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Schizophrenia is a psychotic disorder that exists at the more extreme end of a spectrum of diseases, and significantly affects daily functioning. Cardiovascular adverse effects of antipsychotic medications are well known, and include changes in blood pressure and arrhythmias. Sudden cardiac death is the leading cause of death worldwide, and antipsychotic medications are associated with numerous cardiac side effects. A possible link exists between antipsychotic medications and sudden cardiac death. Common prescribing patterns that may influence cardiovascular events include the use of multiple antipsychotics and/or additional drugs commonly prescribed to patients on antipsychotics. The results of this review reflect an …

Optimizing The Best Play In Basketball Using Deep Learning, Leili Javadpour, Jessica Blakeslee, Mehdi A. Khazaeli, Peter J. Schroeder

Eberhardt School of Business Faculty Articles

In a close game of basketball, victory or defeat can depend on a single shot. Being able to identify the best player and play scenario for a given opponent’s defense can increase the likelihood of victory. Progress in technology has resulted in an increase in the popularity of sports analytics over the last two decades, where data can be used by teams and individuals to their advantage. A popular data analytic technique in sports is deep learning. Deep learning is a branch of machine learning that finds patterns within big data and can predict future decisions. The process relies on …

Tufts University Executive Named Pacific Cfo, Christopher Callahan

Presidential Communications

No abstract provided.

Her Dream Deferred No More: Reimagining Joy, Love, And Resilience For Black Women And Girls, Mary J. Lomax-Ghirarduzzi

Gender Studies Colloquium

No abstract provided.

Pacific Welcomes Its New Eberhardt School Of Business Dean, Christopher Callahan

Presidential Communications

No abstract provided.

Imidazole-Based Ph-Sensitive Convertible Liposomes For Anticancer Drug Delivery, Ruiqi Huang, Vijay Gyanani, Shen Zhao, Yifan Lu, Xin Guo

School of Pharmacy Faculty Articles

In efforts to enhance the activity of liposomal drugs against solid tumors, three novel lipids that carry imidazole-based headgroups of incremental basicity were prepared and incorporated into the membrane of PEGylated liposomes containing doxorubicin (DOX) to render pH-sensitive convertible liposomes (ICL). The imidazole lipids were designed to protonate and cluster with negatively charged phosphatidylethanolamine-polyethylene glycol when pH drops from 7.4 to 6.0, thereby triggering ICL in acidic tumor interstitium. Upon the drop of pH, ICL gained more positive surface charges, displayed lipid phase separation in TEM and DSC, and aggregated with cell membrane-mimetic model liposomes. The drop of pH also …

Naltrexone Implant For Opioid Use Disorder, Amber N. Edinoff, Catherine A. Nix, Claudia V. Orellana, Samantha M. Stpierre, Erin A. Crane, Blaine T. Bulloch, Elyse M. Cornett, Rachel L. Kozinn, Adam M. Kaye, Kevin S. Murnane, Alan David Kaye

School of Pharmacy Faculty Articles

The continued rise in the availability of illicit opioids and opioid-related deaths in the United States has left physicians, researchers, and lawmakers desperate for solutions to this ongoing epidemic. The research into therapeutic options for the treatment of opioid use disorder (OUD) began with the introduction of methadone in the 1960s. The approval of oral naltrexone initially showed much promise, as the drug was observed to be highly potent in antagonizing the effects of opioids while producing no opioid agonist effects of its own and having a favorable side effect profile. Patients that routinely take their naltrexone reported fewer days …