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University of Louisville

Theses/Dissertations

2014

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The Effect Of Spinal Cord Injury On Vagal Afferents., April N. Herrity Dec 2014

The Effect Of Spinal Cord Injury On Vagal Afferents., April N. Herrity

Electronic Theses and Dissertations

Spinal cord injury (SCI) is a significant public health concern that leaves patients with a multitude of life-long disabilities. Major complications of SCI apart from paralysis, include deficits in bladder and bowel function. Lower urinary tract dysfunction continues to remain a top priority issue affecting quality of life for this population. The majority of visceral organs receive a dual sensory innervation from both spinal nerves as well as the vagus nerve. Following SCI, the vagus nerve is a potential pathway through which information from regions below the level of a spinal injury can travel directly to the brainstem, bypassing the …

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Signaling Mechanisms In Regenerative Myogenesis., Sajedah M. Hindi 1986- Dec 2014

Signaling Mechanisms In Regenerative Myogenesis., Sajedah M. Hindi 1986-

Electronic Theses and Dissertations

Skeletal muscle constitutes a highly plastic and malleable tissue that rapidly and profoundly adapts to various environmental and physiological stimuli. This response takes place by means of regulated signaling transduction which elicits changes in gene expression, biochemical, and metabolic properties. Adult muscle is composed by alignment of multinucleated, post mitotic muscle fibers formed during embryonic and neonatal development. Residing in the niche of mature muscle fibers is a small population of undifferentiated muscle progenitors termed satellite cells. Satellite cells are muscle stem cells that carry out regenerative response in adult myofibers. Coordinated signaling emitting from terminally differentiated muscle fibers and …

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Predictors Of Lifestyle Behaviors, Trust Of Health Care Provider, And Utilization Of Health Services Among Adolescents Living In A Rural Area., Heather Karolyne Hardin Dec 2014

Predictors Of Lifestyle Behaviors, Trust Of Health Care Provider, And Utilization Of Health Services Among Adolescents Living In A Rural Area., Heather Karolyne Hardin

Electronic Theses and Dissertations

Background: Adolescents have elevated morbidity and mortality rates associated with risk-taking behaviors, but utilize health services at low levels. There is little evidence concerning health behavior, trust of health care provider, or utilization of health services among adolescents living in rural areas. Purpose: The purpose of this study was to examine individual characteristic variables and determine the extent to which these variables influence lifestyle behaviors, trust of health care provider (HCP), and utilization of health services among adolescents attending public high school in rural Indiana. Methods: This study used a cross-sectional, quantitative design. Instruments used in this study were …

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Evaluating The Effectiveness And Hydrological Performance Of Green Infrastructure Stormwater Control Measures., Hamidreza Kazemi Dec 2014

Evaluating The Effectiveness And Hydrological Performance Of Green Infrastructure Stormwater Control Measures., Hamidreza Kazemi

Electronic Theses and Dissertations

The Louisville and Jefferson County Metropolitan Sewer District (MSD) has developed a Long-Term Control Plan (LTCP) to address the combined sewer overflow (CSO) issue through a combination of gray and green infrastructure (GI) stormwater management practices in the city of Louisville. In support of this effort, the MSD installed a series of GI stormwater control measures (SCMs) to abate the CSO volumes in an urban sewershed basin. This research is focused on monitoring and evaluating the individual hydrological performance, which included infiltration and exfiltration processes, of two permeable pavement systems over a two year study period. It also assess the …

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The Impact Of Inflammatory And Immune Response-Related Genetic Variants On Prostate Cancer Risk Among Men Of African Descent., Dominique Zilpha Jones Dec 2014

The Impact Of Inflammatory And Immune Response-Related Genetic Variants On Prostate Cancer Risk Among Men Of African Descent., Dominique Zilpha Jones

Electronic Theses and Dissertations

Background: In the U.S., prostate cancer (PCA) metastasis is associated with a 5-yr survival rate of 29% and disproportionately affects men of African descent. Single nucleotide polymorphisms (SNPs) may serve as genetic markers to identify individuals at high risk of developing PCA. Methods: We examined main and joint effects of 119 inflammatory and immune response-associated SNPs among men of African descent (535 controls, 279 cases) via logistic regression (LR) and entropy-based-multi-factor dimensionality reduction (MDR) modeling. Results: MDR yielded highly synergistic [(TLR10, TLR6 and IRF3), (TLR2, IRAK4), (IL1R2, IL10, IL10RA)] interaction …

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An Evaluation Of A Brief, Theatre-Based Intervention For The Prevention Of Adolescent Cyberbulllying And Suicide., Kathryn Laurel Hopkins Dec 2014

An Evaluation Of A Brief, Theatre-Based Intervention For The Prevention Of Adolescent Cyberbulllying And Suicide., Kathryn Laurel Hopkins

Electronic Theses and Dissertations

Quality program evaluation investigates both the process and the outcomes of an intervention in order to accurately determine its effectiveness and impact. In the present study, the effectiveness of CHOICES, a brief, applied-theatre intervention that addresses cyberbullying and suicide was evaluated. The fidelity of implementation of the intervention was assessed to determine whether the delivery of CHOICES was consistent with the original goals of the program, as well as consistent across multiple deliveries. Investigation of the fidelity of implementation revealed that CHOICES was not implemented with high levels of fidelity. The study also determined whether exposure to CHOICES led to …

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Post-Transcriptional Regulation Of The Type Iia Sodium-Phosphate Cotransporter By Parathyroid Hormone., Rebecca Dale Murray Dec 2014

Post-Transcriptional Regulation Of The Type Iia Sodium-Phosphate Cotransporter By Parathyroid Hormone., Rebecca Dale Murray

Electronic Theses and Dissertations

The type IIa sodium-phosphate cotransporter (Npt2a) is expressed in the apical membrane of the renal proximal tubule and is responsible for the reabsorption of the majority of the filtered load of phosphate. Parathyroid hormone (PTH) is secreted by the parathyroid gland in response to a decrease in serum calcium or an increase in serum phosphorus, and acutely induces phosphaturia through the rapid stimulation of endocytosis of Npt2a and its subsequent lysosomal degradation. Chronic PTH stimulation leads to sustained phosphaturia, but the mechanisms for the chronic regulation of Npt2a by PTH remain unclear. We hypothesize that PTH decreases Npt2a mRNA levels …

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An Examination Of The Relationship Between Sense Of Coherence, Engagement In Health Behaviors, And Individual Coping Style., Dean Todd Misener 1973- Dec 2014

An Examination Of The Relationship Between Sense Of Coherence, Engagement In Health Behaviors, And Individual Coping Style., Dean Todd Misener 1973-

Electronic Theses and Dissertations

Stress is a pervasive issue among traditional college students; affecting their choice in health behaviors, and overall academic performance. What is not clear is why some students, despite the pervasiveness of stressors are able to do well in school and maintain/improve their health, while other students struggle to maintain their health and do poorly in school. Aaron Antonovsky theorized that when confronted with a stressor a person with a high sense of coherence (SOC) will be motivated to cope, believe the challenge is understood and that the necessary resources to cope with the stressor are available. Overall, Antonovsky theorized that …

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Extracellular Matrix Proteins And The Liver-Lung Axis In Disease., Veronica L. Massey Dec 2014

Extracellular Matrix Proteins And The Liver-Lung Axis In Disease., Veronica L. Massey

Electronic Theses and Dissertations

No abstract provided.

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Early-Age Hydration Studies Of Portland Cement, Fengjuan Liu Dec 2014

Early-Age Hydration Studies Of Portland Cement, Fengjuan Liu

Electronic Theses and Dissertations

Our current knowledge on cement hydration during setting is based on the discrete observation of hydrated paste. An advanced micro/nano-level technique which can perform the in-situ observation on the continuous hydration of cement paste is demanded. In this study, Raman spectroscopy (RS) was chosen as such a method to continuously investigate wet pastes. The objective of this research is to explore the hydration process and microstructural development of fresh pastes with this technique. This research was conducted in three phases. First, the RS analysis was used to continuously observe the cement hydration from 20 minutes after mixing to 9 hours. …

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A Magical Country : Stories From Appalachia., James Eric Leary 1977- Dec 2014

A Magical Country : Stories From Appalachia., James Eric Leary 1977-

Electronic Theses and Dissertations

Fairy tales and other forms of fantastic literature have fascinated children and adults for generations. The scholarship on these types of works indicate that many find their folkloric origins in oral storytelling, and those roots may be quite ancient. However, some of the earliest examples of recorded literature capture stories of magic and fantasy. The interplay between the oral and literary form remains a significant area of study and development for folk literature, and new artistic productions, termed variants in the scholarship, continue to appear frequently in contemporary American culture. The criticism and creative work presented here add to the …

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A Mechanism For Trif Adaptor-Biased Signaling By Toll-Like Receptor 4., Joseph Peterson Kolb Dec 2014

A Mechanism For Trif Adaptor-Biased Signaling By Toll-Like Receptor 4., Joseph Peterson Kolb

Electronic Theses and Dissertations

Host cells respond to bacterial lipid A through Toll-like receptor 4 (TLR4). Activation of TLR4 by lipid A triggers a response that involves two main adaptor proteins, MyD88 and TRIF. MyD88-dependent gene expression is associated with proinflammatory protein production, while TRIF-dependent gene expression is essential for optimal activation of adaptive immunity by antigen-presenting cells. Detoxified, monophosphoryl lipid A agonists (MPLA or synthetic MLA) were previously suggested to elicit TRIF-biased TLR4 signaling; that is, induction of weaker MyD88-associated gene expression but relatively intact TRIF-dependent gene expression when compared to fully active diphosphoryl lipid A (lipid A). In this work, we explored …

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A Discourse On Entrepreneurial Identity : Three Essays., Krishna P. Poudel Dec 2014

A Discourse On Entrepreneurial Identity : Three Essays., Krishna P. Poudel

Electronic Theses and Dissertations

My dissertation provides theoretical insights on individual level entrepreneurial identity in three inter-related essays, drawing on multiple theories and disciplines. In the first essay, I advance a dual-process model of identity development, contributing to the debates in the broad identity literature. I articulate that the intrinsic prospection of identity is another fundamental process of identity formation, besides the social construction of identity, the prevalent notion in the literature. I propose a comprehensive conceptual framework of entrepreneurial identity. On the basis of this conceptual framework, I explain that there are within-group and between-group variations in the entrepreneurial identity of different types …

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Investigation Of Transmission Loss Through Double Wall Structures With Varying Small Air Gaps Using Modal Analysis., Richard Michael Phillips 1988- Dec 2014

Investigation Of Transmission Loss Through Double Wall Structures With Varying Small Air Gaps Using Modal Analysis., Richard Michael Phillips 1988-

Electronic Theses and Dissertations

Noise reduction testing is completed for two single steel plate constructions with different thicknesses and for two double wall constructions with different air gap thicknesses that include the same two plates used in the single plate constructions. Results compare favorably with known theory and experimental results from previous literature. These favorable comparisons include the direct relationship between mass per unit area and transmission loss for single plate constructions, the presence of a noise reduction valley near the mass-air-mass frequency, the dependency of the mass-air-mass frequency on the air gap thickness, and the existence of a bridge frequency. Despite the similarities …

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Triggered Release Of Small Molecules From Solid Supports Using Heat Or An Applied Magnetic Field., Ralph Jacob Knipp Dec 2014

Triggered Release Of Small Molecules From Solid Supports Using Heat Or An Applied Magnetic Field., Ralph Jacob Knipp

Electronic Theses and Dissertations

The reaction of an aminooxy moiety (RONH2) with an aldehyde or ketone carbonyl, an oximation reaction, results in the formation of robust oxime ether linkages. Oximation is a form of click chemistry and is chemoselective, occurs in a variety of solvents including water, and produces high yields with little to no purification. We were inspired to exploit the advantages of oximation reactions by attaching aminooxy-functionalized molecules to solid supports, thus allowing us to employ aminooxy chemistry in ways that cannot be achieved using solution phase. Chapter 1 provides a review of aminooxy chemistry, its advantages over similar reactions and its …

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Sdsf : Social-Networking Trust Based Distributed Data Storage And Co-Operative Information Fusion., Phani Chakravarthy Polina Dec 2014

Sdsf : Social-Networking Trust Based Distributed Data Storage And Co-Operative Information Fusion., Phani Chakravarthy Polina

Electronic Theses and Dissertations

As of 2014, about 2.5 quintillion bytes of data are created each day, and 90% of the data in the world was created in the last two years alone. The storage of this data can be on external hard drives, on unused space in peer-to-peer (P2P) networks or using the more currently popular approach of storing in the Cloud. When the users store their data in the Cloud, the entire data is exposed to the administrators of the services who can view and possibly misuse the data. With the growing popularity and usage of Cloud storage services like Google Drive, …

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The Role Of Porphyromonas Gingivalis In The Regulation Of Epithelial-Mesenchymal Transition Markers In Migration., Akintunde Ojo 1981- Dec 2014

The Role Of Porphyromonas Gingivalis In The Regulation Of Epithelial-Mesenchymal Transition Markers In Migration., Akintunde Ojo 1981-

Electronic Theses and Dissertations

A relationship between periodontal disease and oral squamous cell carcinoma (OSCC) has been demonstrated in recent studies. Porphyromonas gingivalis’ antigen have been found in oral cancer cells. The embryonic program “epithelial-mesenchymal transition” (EMT) is thought to trigger cancer invasion by allowing tumor cell propagation. The objective of this study was to examine the role of P. gingivalis in the expression of ZEB1, vimentin, and repression of miRNA-200 family as EMT prognostic markers in cancer cell metastasis. Human telomerase immortalized gingival keratinocytes (TIGK) cells were challenged with P. gingivalis strain ATCC 33277 in vitro for 24h at MOI 50 and 100. …

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Effects Of Step Training On The Kidneys Following Spinal Cord Injury In Rats., Pradeepa Poudyal Dec 2014

Effects Of Step Training On The Kidneys Following Spinal Cord Injury In Rats., Pradeepa Poudyal

Electronic Theses and Dissertations

Detrusor-sphincter dyssynergia after chronic spinal cord injury (SCI) leads to over-distention, high bladder pressures and vesico-ureteric reflux into the kidney, resulting in repeated infections and pyelonephritis. Given the importance/limited knowledge of SCI effects on the upper urinary tract, this study assessed expression of two proteins in the kidneys of contused (T9) male rats relative to controls that are indicative of tissue stress/damage (TGFβ, CD11b). The impact of two therapeutic rehabilitation strategies, 60 minutes of step training and general exercise, was then assessed on these protein levels relative to non-trained SCI controls, plus the effectiveness of a shorter training duration (30 …

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Lunasin Reduces The Melanoma Stem Cell Population In Vitro And Inhibits Tumor Proliferation In Vivo., Christopher Paul Shidal Dec 2014

Lunasin Reduces The Melanoma Stem Cell Population In Vitro And Inhibits Tumor Proliferation In Vivo., Christopher Paul Shidal

Electronic Theses and Dissertations

Lunasin is a 44 amino acid peptide derived from the soybean seed that has been shown to have cancer chemopreventive and chemotherapeutic properties. In this study, we investigated the potential utility of lunasin as a chemotherapeutic in a melanoma model. Initial studies showed that lunasin has little activity against established melanoma cell lines in vitro using adherent culture methods; however, lunasin’s in vitro activity was significantly higher in non-adherent colony-forming assays in soft agar and oncosphere assays. These results led us to investigate whether lunasin selectively affects cancer initiating cells (CIC) that are known to be present in these melanoma …

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Biomarker Discovery Of Liver Diseases Using Mass Spectrometry-Based Metabolomics., Xue Shi Dec 2014

Biomarker Discovery Of Liver Diseases Using Mass Spectrometry-Based Metabolomics., Xue Shi

Electronic Theses and Dissertations

Metabolomics has emerged as one of the latest of the "-omics" disciplines that can detect metabolite biomarkers in biological samples. The diverse characteristics of metabolites make the analytical platform challenging in metabolomics. Two bioanalytical platforms were developed in this study to investigate metabolite abundance changes under different biological conditions. We first developed a bioanalytical platform that coupled linear trap quadruple - Fourier transform ion cyclotron mass spectrometer (LTQ-FTICR MS) with direct infusion chip-based nano-electrospray ionization (DI-nESI) and applied it to study polychlorinated biphenyls (PCB) effects on non-alcoholic fatty liver disease (NAFLD). We also employed this platform in conjunction with in …

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Shape/Image Registration For Medical Imaging : Novel Algorithms And Applications., Ahmed Magdy Shalaby 1982- Dec 2014

Shape/Image Registration For Medical Imaging : Novel Algorithms And Applications., Ahmed Magdy Shalaby 1982-

Electronic Theses and Dissertations

This dissertation looks at two different categories of the registration approaches: Shape registration, and Image registration. It also considers the applications of these approaches into the medical imaging field. Shape registration is an important problem in computer vision, computer graphics and medical imaging. It has been handled in different manners in many applications like shapebased segmentation, shape recognition, and tracking. Image registration is the process of overlaying two or more images of the same scene taken at different times, from different viewpoints, and/or by different sensors. Many image processing applications like remote sensing, fusion of medical images, and computer-aided surgery …

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The Effect Of Infrastructure Changes On Railway Operations., Martin J.R. Schmidt 1966- Dec 2014

The Effect Of Infrastructure Changes On Railway Operations., Martin J.R. Schmidt 1966-

Electronic Theses and Dissertations

This paper makes use of standard simulation programs in combination with the tools of applied statistics to simulate railway operations. The purpose of the use of this tool is to evaluate and compare different possible kinds of railway infrastructure, like different types of signaling procedures, different network configuration or operational procedures. A railway system is a logistic network and because of the demand for improved railway operation, much work has been undertaken lately in this scientific field. However the author postulates the hypothesis based on a literature review that in a lot of these works there is a lack of …

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Troglitazone Suppresses Glutamine Metabolism And Tumor Cell Growth Through A Ppar-Independent Mechanism., Miriam R. Reynolds 1965- Dec 2014

Troglitazone Suppresses Glutamine Metabolism And Tumor Cell Growth Through A Ppar-Independent Mechanism., Miriam R. Reynolds 1965-

Electronic Theses and Dissertations

In tumor cells, glutamine metabolism provides anaplerotic carbon for the TCA cycle, fatty acid synthesis, and precursors for the production of nucleotides and glutathione. This metabolic alteration is primarily driven by disruptions in oncogenic or tumor suppressor function and results in glutamine dependency for tumor cell survival. Troglitazone, a PPARγ agonist, has been reported to alter glutamine metabolism. This thesis project addresses whether troglitazone treatment could disrupt glutamine metabolism in glutamine-dependent tumor cells. Results obtained with troglitazone treatment include: dose-dependent inhibition of cell proliferation, glutamine uptake, glutaminolytic protein expression, steady-state ATP levels, and glutamine carbon flux into the TCA cycle. …

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Modulation Of The Ovarian Cancer Humoral Response By Tumor-Derived Exosomes., Carolyn Denise Roberson Dec 2014

Modulation Of The Ovarian Cancer Humoral Response By Tumor-Derived Exosomes., Carolyn Denise Roberson

Electronic Theses and Dissertations

The pathogenesis of epithelial ovarian cancer is complicated by its diagnosis during the latter stages of the disease resulting from lack of symptoms or from presence of symptoms that mimic other conditions. Because of the often fatal prognosis by the time of actual detection, efforts are being made to better understand the host immune response to ovarian cancer. In this study, the contributions of the humoral immune response were investigated by focusing on the role of tumor-derived exosomes and their ability to modulate humoral immune responses. First, ovarian cancer patient-derived free circulating antibodies were investigated for immunoreactivity to patient antigen. …

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Development Of Models For The Study Of The Molecular Mechanisms Of Host Restriction And Adaptation Of Hantaviruses., Ryan Carroll Mcallister 1988- Dec 2014

Development Of Models For The Study Of The Molecular Mechanisms Of Host Restriction And Adaptation Of Hantaviruses., Ryan Carroll Mcallister 1988-

Electronic Theses and Dissertations

Hantaviruses, family Bunyaviridae, are present throughout the globe in a variety of mouse, rat, mole, vole, shrew, or bat species. Hantaviruses persist for the lifetime of the animal reservoir, while causing no signs or symptoms of disease. Only the rodent-borne hantaviruses cause disease in humans. In contrast, a “spillover” infection of a hantavirus into a nonreservoir rodent species results in an asymptomatic acute infection. We and others in the field are interested in understanding the biology of these virus-host interactions and mechanisms that underlie these three very different outcomes. The second chapter of my thesis focused on probing the intrahost …

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Prankster Questionaire., Matthew Landan 1972- Dec 2014

Prankster Questionaire., Matthew Landan 1972-

Electronic Theses and Dissertations

The creative thesis that I have written is a memoir. It is not complete in its detail or ambition but instead focuses on themes and topics of self-transformation, reinvention and the unintentional consequences of several nervous breakdowns and experiments with psychedelic substances. This thesis is just a beginning for a longer more drawn out memoir that will explore the themes above but also discuss family, one’s sense of self worth in the world and how patterns between fathers and sons repeat themselves. I hope to eventually publish this work in a commercial setting.

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Transient Heat Transfer Between A Magnetocaloric Packed Particle Bed And Stagnant Interstitial Fluid., Michael G. Schroeder 1988- Dec 2014

Transient Heat Transfer Between A Magnetocaloric Packed Particle Bed And Stagnant Interstitial Fluid., Michael G. Schroeder 1988-

Electronic Theses and Dissertations

In the field of magnetocaloric heat pumps, many system models have been made. What most of these models lack is heat transfer occurring while there is no fluid motion. It is the objective of this paper to analytically determine and experimentally verify heat transfer with no bulk fluid motion. The addition of a pure dwell period to the typical magnetocaloric cycle was shown to have a positive performance impact in specific conditions. These conditions correspond to regenerators that are heat transfer rate limited in operation. The heat transfer mechanism for this particular case was shown to be pure conduction via …

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Portrayals Of Mental Illness And Physical Disability In 21st Century Children's Animation., Amy Sue Marie Miller Dec 2014

Portrayals Of Mental Illness And Physical Disability In 21st Century Children's Animation., Amy Sue Marie Miller

College of Arts & Sciences Senior Honors Theses

The objective of this study was to evaluate the presence of mental and physical disability in children's animation, and to understand image of mental or physical disability the animation portrayed. Three animated movies and one 61 episode animated series were coded for verbal references to mental illness and physical disability. Visual images and thematic elements portraying disability were also examined. All of the animations contained verbal as well as visual references to disability. Verbal references appeared with an average of 13.2 references per hour of animation. The connotations of these references often went against negative stereotypes of disability. These findings …

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Cultural Capital And The Family-School Mesosystem : A Multiple Groups Analysis Of School-Based Parent Involvement Types And Their Relations With Early Student Achievement., Emily R. Dickinson 1974- Dec 2014

Cultural Capital And The Family-School Mesosystem : A Multiple Groups Analysis Of School-Based Parent Involvement Types And Their Relations With Early Student Achievement., Emily R. Dickinson 1974-

Electronic Theses and Dissertations

This dissertation study explored the relationship between school-based parent involvement and early reading outcomes by positing that different types of parent involvement activities reflect access to different forms of cultural capital and therefore should be analyzed as separate constructs. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) techniques were used to establish the factor structure underlying measures of school-based parent involvement available in the Early Childhood Longitudinal Study-Kindergarten Cohort of 2011 (ECLS-K: 2011). Also of interest were the variations in the amount of participation in different types of involvement between families from various sociocultural backgrounds, as well as the …

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Enzyme Kinetics : 6-Phosphofructo-2-Kinase/2,6-Bisphosphatase., Jennifer Clark Dec 2014

Enzyme Kinetics : 6-Phosphofructo-2-Kinase/2,6-Bisphosphatase., Jennifer Clark

Electronic Theses and Dissertations

Altered energy metabolism is an established hallmark of cancer cells. Fructose-2,6-bisphosphate is an allosteric activator of glycolysis and its concentration in a cell is dictated by the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFB1-4) family of bifunctional enzymes. The PFKFB family of enzymes are characterized by their different kinase: bisphosphatase activities and were originally determined to be tissue-specific. More recent data however suggest that multiple isoforms are co-expressed in both normal and neoplastic tissues. PFKFB4 is highly expressed in human cancer, strongly induced by hypoxia, and required for the survival of cancer cells. However, it remains unclear whether the kinase or phosphatase activity of human …

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