Digital Commons Network^™

Convergent Developmental Patterns Underlie The Repeated Evolution Of Adhesive Toe Pads Among Lizards, Aaron H. Griffing, Tony Gamble, Martin J. Cohn, Thomas J. Sanger

Biological Sciences Faculty Research and Publications

How developmental modifications produce key innovations, which subsequently allow for rapid diversification of a clade into new adaptive zones, has received much attention. However, few studies have used a robust comparative framework to investigate the influence of evolutionary and developmental constraints on the origin of key innovations, such as the adhesive toe pad of lizards. Adhesive toe pads evolved independently at least 16 times in lizards, allowing us to examine whether the patterns observed are general evolutionary phenomena or unique, lineage-specific events. We performed a high-resolution comparison of plantar scale development in 14 lizard species in Anolis and geckos, encompassing …

Atypical Tuning And Amplification Mechanisms In Gecko Auditory Hair Cells, Maryline Beurg, Tony Gamble, Aaron H. Griffing, Robert Fettiplace

Biological Sciences Faculty Research and Publications

The auditory papilla of geckos contains two zones of sensory hair cells, one covered by a continuous tectorial membrane affixed to the hair bundles and the other by discrete tectorial sallets each surmounting a transverse row of bundles. Gecko papillae are thought to encode sound frequencies up to 5 kHz, but little is known about the hair cell electrical properties or their role in frequency tuning. We recorded from hair cells in the isolated auditory papilla of the crested gecko, Correlophus ciliatus, and found that in both the nonsalletal region and part of the salletal region, the cells displayed …

Making (Remote) Sense Of Lianas, Geertje M. F. Van Der Heijden, Ashley D. C. Proctor, Kim Calders, Chris J. Chandler, Richard Field, Giles M. Foody, Sruthi M. Krishna Moorthy, Stefan A. Schnitzer, Catherine E. Waite, Doreed S. Boyd

Biological Sciences Faculty Research and Publications

1. Lianas (woody vines) are abundant and diverse, particularly in tropical ecosystems. Lianas use trees for structural support to reach the forest canopy, often putting leaves above their host tree. Thus they are major parts of many forest canopies. Yet, relatively little is known about distributions of lianas in tropical forest canopies, because studying those canopies is challenging. This knowledge gap is urgent to address because lianas compete strongly with trees, reduce forest carbon uptake and are thought to be increasing, at least in the Neotropics.
2. Lianas can be difficult to study using traditional field methods. Their pliable stems often twist …

Eeg And Fmri Coupling And Decoupling Based On Joint Independent Component Analysis (Jica), Nicholas Heugel, Scott A. Beardsley, Einat Liebenthal

Biomedical Engineering Faculty Research and Publications

Background

Meaningful integration of functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) requires knowing whether these measurements reflect the activity of the same neural sources, i.e., estimating the degree of coupling and decoupling between the neuroimaging modalities.

New method

This paper proposes a method to quantify the coupling and decoupling of fMRI and EEG signals based on the mixing matrix produced by joint independent component analysis (jICA). The method is termed fMRI/EEG-jICA.

Results

fMRI and EEG acquired during a syllable detection task with variable syllable presentation rates (0.25–3 Hz) were separated with jICA into two spatiotemporally distinct components, a primary …

A Continuum Damage Approach To Spallation And The Role Of Microinertia, S. B. Qamar, John A. Moore, Nathan R. Barton

Mechanical Engineering Faculty Research and Publications

Spall failure is of interest due to its prevalence in high strain rate problems in which the spallation is driven by the interaction of release waves. In this article, a porosity-based damage model that includes microinertial effects is used to examine spall failure. The model is successfully calibrated to plate impact-driven experiments and then used to evaluate experimental conditions producing more extreme strain rate conditions, such as those in laser-driven experiments. The incorporation of microinertia allows us to better understand the increase in apparent macroscopic spall strength seen at high strain rates. Correspondingly, we conclude that the incorporation of microinertial …

Exploring The Interrelationship And Roles Of Employee–Organization Relationship Outcomes Between Symmetrical Internal Communication And Employee Job Engagement, Ejae Lee, Minjeong Kang, Young Kim, Sung-Un Yang

College of Communication Faculty Research and Publications

Purpose This paper aims to investigate how employee–organization relationship (EOR) outcomes – types and qualities – are interrelated and how employees' perceptions of types (exchange and communal EORs) and qualities (trust, satisfaction, commitment, and control mutuality) play a role in their evaluations of symmetrical internal communication (SIC) and employee job engagement (EJE). Design/methodology/approach This study conducted an online survey of full-time employees (N = 804) from major US industries. This study performed a confirmatory factor analysis to check the validity and reliability of the measurement model using latent variables and then conducted structural equation modeling. Findings The findings demonstrate that …

Establishment Of Common House Geckos, Hemidactylus Frenatus Duméril & Bibron, On Saint Lucia, Aaron H. Griffing, David H. Griffing, Stephen Lesmond, Tony Gamble

Biological Sciences Faculty Research and Publications

No abstract provided.

Highly Regioselective Copper-Catalyzed Transfer Hydrodeuteration Of Unactivated Terminal Alkenes, Albert Reyes, Emanuel Rivera Torres, Zoua Pa Vang, Joseph R. Clark

Chemistry Faculty Research and Publications

Catalytic transfer hydrodeuteration of unactivated alkenes is challenging because of the requirement that similar hydrogen and deuterium undergo selective insertion across a π-bond. We now report a highly regioselective catalytic transfer hydrodeuteration of unactivated terminal alkenes across a variety of heteroatom- or heterocycle-containing substrates. The base-metal-catalyzed reaction is also demonstrated on two complex natural products. Reaction studies indicate modular conditions that can also be extended to perform either an alkene transfer hydrogenation or transfer deuteration.

Complexes Of Ghrelin Ghs-R1a, Ghs-R1b, And Dopamine D1 Receptors Localized In The Ventral Tegmental Area As Main Mediators Of The Dopaminergic Effects Of Ghrelin, Gemma Navarro, William Rea, César Quiroz, Estefanía Moreno, Devan Gomez, Cody J. Wenthur, Vicent Casadó, Lorenzo Leggio, Matthew C. Hearing, Sergi Ferré

Biomedical Sciences Faculty Research and Publications

Ghrelin receptor, also known as growth hormone secretagogue receptor (GHS-R1a), is coexpressed with its truncated isoform GHS-R1b, which does not bind ghrelin or signal, but oligomerizes with GHS-R1a, exerting a complex modulatory role that depends on its relative expression. D₁ dopamine receptor (D1R) and D5R constitute the two D₁-like receptor subtypes. Previous studies showed that GHS-R1b also facilitates oligomerization of GHS-R1a with D1R, conferring GHS-R1a distinctive pharmacological properties. Those include a switch in the preferred coupling of GHS-R1a from Gq to Gs and the ability of D1R/D5R agonists and antagonists to counteract GHS-R1a signaling. Activation of ghrelin …

Task Effects On Functional Connectivity Measures After Stroke, Kaleb Vinehout, Sheila M. Schindler-Ivens, Jeffrey R. Binder, Brian D. Schmit

Physical Therapy Faculty Research and Publications

Understanding the effect of task compared to rest on detecting stroke-related network abnormalities will inform efforts to optimize detection of such abnormalities. The goal of this work was to determine whether connectivity measures obtained during an overt task are more effective than connectivity obtained during a “resting” state for detecting stroke-related changes in network function of the brain. This study examined working memory, discrete pedaling, continuous pedaling and language tasks. Functional magnetic resonance imaging was used to examine regional and inter-regional brain network function in 14 stroke and 16 control participants. Independent component analysis was used to identify 149 regions …

Disparities In The Allocation Of Inpatient Physical And Occupational Therapy Services For Patients With Covid-19, Sarah Jolley, Amy Nordon-Craft, Melissa P. Wilson, Kyle Ridgeway, Michelle R. Rauzi, Jacob J. Capin, Lauren M. Heery, Jennifer Stevens-Lapsley, Kristine M. Erlandson

Physical Therapy Faculty Research and Publications

Background

Survivors of the novel coronavirus (COVID-19) experience significant morbidity with reduced physical function and impairments in activities of daily living. The use of in-hospital rehabilitation therapy may reduce long-term impairments.

Objective

To determine the frequency of therapy referral and treatment amongst hospitalized COVID-19 patients, assess for disparities in referral and receipt of therapy, and identify potentially modifiable factors contributing to disparities in therapy allocation.

Design, Setting and Participants

Retrospective cohort study using data collected from the University of Colorado Health Data Compass data warehouse assessing therapy referral rates and estimated delivery based on available administrative billing.

Measurements

Multivariable logistic …

Developing Peri-Operative Rehabilitation In Degenerative Cervical Myelopathy [Ao Spine Recode-Dcm Research Priority Number 6]: An Unexplored Opportunity?, Timothy F. Boerger, Allison S. Hyngstrom, Julio C. Furlan, Sukhvinder Klasi-Ryan, Armin Curt, Brian K. Kwon, Shekar N. Kurpad, Michael G. Fehlings, James S. Harrop, Bizhan Aarabi, Vafa Rahimi-Movaghar, James D. Guest, Jefferson R. Wilson, Benjamin M. Davies, Mark R. N. Kotter, Paul A. Koljonen

Physical Therapy Faculty Research and Publications

Study Design

Narrative review.

Objective

Degenerative cervical myelopathy is one of the most frequent impairments of the spinal cord encountered internationally in adults. Currently, surgical decompression is the recommended treatment for people with DCM (PwCM) presenting with moderate to severe symptoms or neurological deficits. However, despite surgical intervention, not all patients make a complete recovery due to the irreversible tissue damage within the spinal cord. The objective of this review is to describe the state and gaps in the current literature on rehabilitation for PwCM and possible innovative rehabilitation strategies.

Methods

Literature search.

Results

In other neurological disorders such as …

Academic, Interpersonal, Recreational, And Family Impairment In Children With Tourette Syndrome And Attention-Deficit/Hyperactivity Disorder, Emily J. Ricketts, Sara Beth Wolicki, Melissa L. Danielson, Michelle Rozenman, Joseph F. Mcguire, John Piacentini, Jonathan W. Mink, John T. Walkup, Douglas W. Woods, Rebecca H. Bitsko

Psychology Faculty Research and Publications

This study describes impairment in academic, interpersonal, recreational, and family financial or occupational domains across children in three mutually exclusive diagnostic groups: ever diagnosed with Tourette syndrome (TS), attention-deficit/hyperactivity disorder (ADHD), and both disorders. In 2014, parents reported on impairment and diagnostic status of children aged 4–17 years (n = 3014). Weighted analysis and pairwise t-tests showed more children with ADHD (with or without TS) experienced impairment in overall school performance, writing, and mathematics, relative to children with TS but not ADHD. More children with TS and ADHD had problematic handwriting relative to children with ADHD but not TS. More …

Believing On Eggshells: Epistemic Injustice Through Pragmatic Encroachment, Julius Schonherr, Javiera Perez Gomez

Philosophy Faculty Research and Publications

This paper defends the claim that pragmatic encroachment—the idea that knowledge is sensitive to the practical stakes of believing—can explain a distinctive kind of epistemic injustice: the injustice that occurs when prejudice causes someone to know less than they otherwise would. This encroachment injustice, as we call it, occurs when the threat of being met with prejudice raises the stakes for someone to rely on her belief when acting, by raising the level of evidential support required for knowledge. We explain this notion of encroachment injustice, connect it to the empirical literature on implicit bias, and defend it against …

Neural Control Of Stopping And Stabilizing The Arm, Shanie A. L. Jayasinghe, Robert A. Scheidt, Robert L. Sainburg

Biomedical Engineering Faculty Research and Publications

Stopping is a crucial yet under-studied action for planning and producing meaningful and efficient movements. In this review, we discuss classical human psychophysics studies as well as those using engineered systems that aim to develop models of motor control of the upper limb. We present evidence for a hybrid model of motor control, which has an evolutionary advantage due to division of labor between cerebral hemispheres. Stopping is a fundamental aspect of movement that deserves more attention in research than it currently receives. Such research may provide a basis for understanding arm stabilization deficits that can occur following central nervous …

Parent Physical Activity: A Systematic Review Of The Literature And Recommendations For Parents Of Children With Autism Spectrum Disorder, Norah L. Johnson, Abir K. Bekhet, Rachel Sawdy, Emily Zint, June Wang, Sylvia Pena, Hannah Zurcher, Nina Enea

College of Nursing Faculty Research and Publications

Background: The aims of this review were to describe exercise interventions, facilitators, and barriers to physical activity for parents of children with autism spectrum disorder.

Methods: A systematic review of the literature, appraising the validity of each article with Melnyk and Fineout-Overholt’s level of evidence, from different databases CINAHL, Cochrane, PsycINFO, PubMed, ProQuest, and Web of Science between 2000 and 2020 was conducted. As the initial search revealed no articles on exercise interventions and only 2 articles with children with autism spectrum disorder, the aim was widened to all parents of children.

Results: Forty-five articles were identified on barriers to …

Hippocampal Resting-State Functional Connectivity Forecasts Individual Posttraumatic Stress Disorder Symptoms: A Data-Driven Approach, Jacklynn M. Fitzgerald, Elisabeth Kate Webb, Carissa N. Weis, Ashley A. Huggins, Kenneth P. Bennett, Tara A. Miskovich, Jessica L. Krukowski, Terri A Deroon-Cassini, Christine L. Larson

Psychology Faculty Research and Publications

Background: Posttraumatic Stress Disorder (PTSD) is a debilitating disorder and there is no current accurate prediction of who develops it after trauma. Neurobiologically, individuals with chronic PTSD exhibit aberrant resting-state functional connectivity (rsFC) between the hippocampus and other brain regions (e.g., amygdala, prefrontal cortex, posterior cingulate), and these aberrations correlate with severity of illness. Prior small-scale research (n < 25) has also shown that hippocampal-rsFC measured acutely after trauma is predictive of future severity using an ROI-based approach. While a promising biomarker, to-date no study has employed a data-driven approach to test whole-brain hippocampal-FC patterns in forecasting the development of PTSD symptoms.

Methods: Ninety-eight adults at risk of PTSD were recruited from the emergency department following traumatic injury and completed resting functional magnetic resonance imaging (rsfMRI; 8min) within 1-month; 6-months later they completed the Clinician-Administered PTSD Scale (CAPS-5) for assessment of PTSD symptom …

Probiotic Interventions To Reduce Antepartum Group B Streptococcus Colonization: A Systematic Review And Meta-Analysis, Lisa Hanson, Leona Vandevusse, Emily Malloy, Mauricio Garnier-Villarreal, Lauren Watson, Alissa V. Fial, Marie Forgie, Katrina Nardini, Nasia Safdar

Library Faculty Research and Publications

Objective

To systematically review and meta-analyse studies of the efficacy of probiotics to reduce antenatal Group B Streptococcus (GBS) colonisation.

Participants

Antenatal participants with known positive GBS colonisation or unknown GBS status.

Intervention

Probiotic interventions containing species of Lactobacillus or Streptococcus.

Design

Systematic review and meta-analysis.

Measurements and findings

The systematic review included 10 studies. Five articles contained in vitro studies of probiotic interventions to determine antagonistic activity against GBS. Six clinical trials of probiotics to reduce antenatal GBS were systematically reviewed and meta-analysed. The meta-analysis revealed that the use of an antenatal probiotic decreased the probability of a …

Similarities In Virulence And Extended Spectrum Beta-Lactamase Gene Profiles Among Cefotaxime-Resistant Escherichia Coli Wastewater And Clinical Isolates, Elizabeth Liedhegner, Brandon Bojar, Rachelle E. Beattie, Caitlin Cahak, Krassimira R. Hristova, Troy Skwor

Biological Sciences Faculty Research and Publications

The World Health Organization has identified antibiotic resistance as one of the largest threats to human health and food security. In this study, we compared antibiotic resistance patterns between ESBL-producing Escherichia coli from human clinical diseases and cefotaxime-resistant environmental strains, as well as their potential to be pathogenic. Antibiotic susceptibility was tested amongst clinical isolates (n = 11), hospital wastewater (n = 22), and urban wastewater (n = 36, both influent and treated effluents). Multi-drug resistance predominated (>70%) among hospitalwastewater and urban wastewater influent isolates. Interestingly, isolates from clinical and urban treated effluents showed similar multi-drug …

Lianas Significantly Reduce Aboveground And Belowground Carbon Storage: A Virtual Removal Experiment, Sergio Estrada-Villegas, Sara Sofia Pedraza Navaez, Adriana Sanchez, Stefan A. Schnitzer

Biological Sciences Faculty Research and Publications

Lianas are a quintessential tropical plant growth-form; they are speciose and abundant in tropical forests worldwide. Lianas compete intensely with trees, reducing nearly all aspects of tree performance. However, the negative effects of lianas on trees have never been combined and quantified for multiple tropical forests. Here, we present the first comprehensive standardized quantification of the effect of lianas on trees across tropical forests worldwide. We used data from 50 liana removal experiments and quantified the effect size of lianas on tree growth, biomass accretion, reproduction, mortality, leaf water potential, sap flow velocity, and leaf area index (LAI) across different …

Multisite Effectiveness Study Of The Marquette Method Of Natural Family Planning Program, Qiyan Mu, Richard J. Fehring, Thomas Bouchard

College of Nursing Faculty Research and Publications

Women of reproductive age need reliable and effective family planning methods to manage their fertility. Natural family planning (NFP) methods or fertility awareness-based methods (FABMs) have been increasingly used by women due to their health benefits. Nevertheless, effectiveness of these natural methods remains inconsistent, and these methods are difficult for healthcare providers to implement in their clinical practice. The purpose of this study is to evaluate the effectiveness of the Marquette Model NFP system to avoid pregnancy for women at multiple teaching sites using twelve months of retrospectively collected teaching data. Survival analysis (Kaplan–Meier) was used to determine typical unintended …

Muscle-Specific Contributions To Lower Extremity Net Joint Moments While Squatting With Different External Loads, Kristof Kipp, Hoon Kim, William I. Wolf

Exercise Science Faculty Research and Publications

The purpose of this study was to determine muscle-specific contributions to lower extremity net joint moments (NJMs) during squats with different external loads. Nine healthy subjects performed sets of the back squat exercise with 0, 25, 50, and 75% of body mass as an added external load. Motion capture and force plate data were used to calculate NJMs and to estimate individual muscle forces via static optimization. Individual muscle forces were multiplied by their respective moment arms to calculate the resulting muscle-specific joint moment. Statistical parametric mapping (α = 0.05) was used to determine load-dependent changes in the time series …

Book Review Of Transnational Identity And Memory Of Making In The Lives Of Iraqi Women In Diaspora, Enaya Othman

Arabic Languages and Literatures

No abstract provided.

Craniofacial Fluctuating Asymmetry In Gorillas, Chimpanzees, And Macaques, Ashly N. Romero, D. Rex Mitchell, Siobhán B. Cooke, Claire A. Kirchhoff, Claire E. Terhune

Biomedical Sciences Faculty Research and Publications

Objectives

Craniofacial fluctuating asymmetry (FA) refers to the random deviations from symmetry exhibited across the craniofacial complex and can be used as a measure of developmental instability for organisms with bilateral symmetry. This article addresses the lack of data on craniofacial FA in nonhuman primates by analyzing FA magnitude and variation in chimpanzees, gorillas, and macaques. We offer a preliminary investigation into how FA, as a proxy for developmental instability, varies within and among nonhuman primates.

Materials and Methods

We generated 3D surface models of 121 crania from Pan troglodytes troglodytes, Gorilla gorilla gorilla, and Macaca fascicularis fascicularis …

Assessment Of Protection Offered By The Nrf2 Pathway Against Hyperoxia-Induced Acute Lung Injury In Nrf2 Knockout Rats, Said H. Audi, Elizabeth R. Jacobs, Taheri Pardis, Swetha Ganesh, Anne V. Clough

Biomedical Engineering Faculty Research and Publications

Nuclear factor erythroid 2-related factor (Nrf2) is a redox-sensitive transcription factor that responds to oxidative stress by activating expressions of key antioxidant and cytoprotective enzymes via the Nrf2-antioxidant response element (ARE) signaling pathway. Our objective was to characterize hyperoxia-induced acute lung injury (HALI) in Nrf2 knock-out (KO) rats to elucidate the role of this pathway in HALI. Adult Nrf2 wildtype (WT), and KO rats were exposed to room air (normoxia) or >95% O₂ (hyperoxia) for 48 h, after which selected injury and functional endpoints were measured in vivo and ex vivo. Results demonstrate that the Nrf2-ARE signaling pathway …

Sex-Specific Aging In Animals: Perspective And Future Directions, Anne M. Bronikowski, Richard P. Meisel, Peggy R. Biga, James R. Walters, Judith E. Mank, Erica Larschan, Gerald S. Wilkinson, Nicole Valenzuela, Ashley Mae Conard, João Pedro De Magalhães, Jingyue (Ellie) Duan, Amy E. Elias, Tony Gamble, Rita M. Graze, Kristin E. Gribble, Jill A. Kreiling, Nicole C. Riddle

Biological Sciences Faculty Research and Publications

Sex differences in aging occur in many animal species, and they include sex differences in lifespan, in the onset and progression of age-associated decline, and in physiological and molecular markers of aging. Sex differences in aging vary greatly across the animal kingdom. For example, there are species with longer-lived females, species where males live longer, and species lacking sex differences in lifespan. The underlying causes of sex differences in aging remain mostly unknown. Currently, we do not understand the molecular drivers of sex differences in aging, or whether they are related to the accepted hallmarks or pillars of aging or …

Laterality Of The Activation Of The Vastus Lateralis Muscle In Females With Parkinson's Disease During The Medication State Compared With Healthy Controls, Yuichi Nishikawa, Kohei Watanabe, Tetsuya Takahashi, Noriaki Maeda, Hirofumi Maruyama, Shinobu Tanaka, Allison S. Hyngstrom

Physical Therapy Faculty Research and Publications

This study quantified the laterality of motor unit activation properties in females with Parkinson’s disease during force production (low to high-intensity contraction) using high-density surface electromyography. Sixteen females with Parkinson’s disease (age = ± 7.6 years, disease duration = 4.9 ± 5.1 years) and 14 healthy female subjects (age = 68.6 ± 3.6 years) performed submaximal ramp-up contractions during isometric knee extension. High-density surface electromyography signals were recorded from both vastus lateralis muscles. The level of heterogeneity was calculated in the spatial distribution patterns of the high-density surface electromyography signals to determine the modified entropy, coefficient of variation of the …

Racial Discrimination And Resting-State Functional Connectivity Of Salience Network Nodes In Trauma-Exposed Black Adults In The United States, E. Kate Webb, Claire Maria Bird, Terri A Deroon-Cassini, Carissa N. Weis, Ashley A. Huggins, Jacklynn M. Fitzgerald, Tara A. Miskovich, Kenneth P. Bennett, Jessica L. Krukowski, Lucas Torres, Christine L. Larson

Psychology Faculty Research and Publications

Importance For Black US residents, experiences of racial discrimination are still pervasive and frequent. Recent empirical work has amplified the lived experiences and narratives of Black people and further documented the detrimental effects of racial discrimination on both mental and physical health; however, there is still a need for further research to uncover the mechanisms connecting experiences of racial discrimination with adverse health outcomes.

Objective To examine neurobiological mechanisms that may offer novel insight into the association of racial discrimination with adverse health outcomes.

Design, Setting, and Participants This cross-sectional study included 102 Black adults who had recently experienced a …

Paper Mill Sludge Biochar To Enhance Energy Recovery From Pyrolysis: A Comprehensive Evaluation And Comparison, Zhongzhe Liu, Matthew Hughes, Yiran Tong, William Kreutter, Hugo Cortes Lopez, Simcha L. Singer, Daniel Zitomer, Patrick J. Mcnamara

Civil and Environmental Engineering Faculty Research and Publications

Bio-oil and pyrolysis gas (py-gas) are two pyrolysis products available for potential energy recovery. Crude bio-oil, however, is typically corrosive and unstable, requiring special combustion equipment or catalytic upgrading to produce drop-in-grade fuel. In contrast, py-gas is readily useable in standard equipment for energy recovery. Previous research revealed that Ca-impregnated biochar catalyst improved bio-oil to py-gas conversion. Biochar produced from paper mill sludge (p-sludge) has very high Ca content. In this study, the catalytic ability of p-sludge biochar was systematically evaluated for the first time in pyrolysis. P-sludge biochar resulted in higher py-gas yield (40 wt% of total pyrolysis products) …

A Comparison Of Two Generalizations To The Linear Sampling Method For Inverse Scattering, Yeasmin Sultana, James E. Richie

Electrical and Computer Engineering Faculty Research and Publications

The linear sampling method (LSM) is a very popular method for determining the boundary of an object from the scattered field. However, there are instances where LSM provides the convex hull of the boundary rather than the true boundary. There are two common generalizations to LSM: the Generalized Linear Sampling Method (GLSM) and the Multipoles-based Linear Sampling Method (MLSM). In this paper, the ability of GLSM and MLSM to overcome some of the deficiencies of LSM are investigated. It is found that GLSM may be ideal for imaging thin features of scatterers and that MLSM can provide an improvement over …