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2006

University of Kentucky

University of Kentucky Doctoral Dissertations

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Pharmaceutically Engineered Nanoparticles For Enhancing Immune Responses To Hiv-1 Tat And Gag P24 Proteins, Jigna D. Patel Jan 2006

Pharmaceutically Engineered Nanoparticles For Enhancing Immune Responses To Hiv-1 Tat And Gag P24 Proteins, Jigna D. Patel

University of Kentucky Doctoral Dissertations

These studies were aimed at investigating the potential application of nanoparticles engineered from oil-in-water microemulsion precursors for enhancing immune responses to HIV-1 Tat and Gag p24 proteins. Both of the HIV-1 proteins have been reported to be critical in the virus life cycle and are being evaluated in clinical trials as vaccine candidates. Anionic nanoparticles were prepared using emulsifying wax as the oil phase and Brij 78 and sodium dodecyl sulfate as the surfactants. The resulting nanoparticles were coated with Tat and were demonstrated to produce superior immune responses after administration to BALB/c mice compared to Tat adjuvanted with Alum. …


Bosonization Vs. Supersymmetry, Herbert Morales Jan 2006

Bosonization Vs. Supersymmetry, Herbert Morales

University of Kentucky Doctoral Dissertations

We study the conjectured equivalence between the O(3) Gross-Neveu model and the supersymmetric sine-Gordon model under a naive application of the bosonization rules. We start with a review of the equivalence between sine-Gordon model and the massive Thirring model. We study the models by perturbation theory and then determine the equivalence. We find that the dependence of the identifications on the couplings can change according to the definition of the vector current. With the operator identifications of the special case corresponding to a free fermionic theory, known as the bosonization rules, we describe the equivalence between the massless Thirring model …


The Development Of Colletotrichum Graminicola Inside Maize Stalk Tissues, Claire Marie-Pierre Venard Jan 2006

The Development Of Colletotrichum Graminicola Inside Maize Stalk Tissues, Claire Marie-Pierre Venard

University of Kentucky Doctoral Dissertations

Colleotrichum graminicola is the causal agent of anthracnose stalk rot, and is one of the most common and aggressive pathogens of maize. The goal of my Ph.D. project was to contribute to a better understanding of the biology of the interaction between C. graminicola and its host. C. graminicola produces two type of asexual spores: one is produced on the surface of infected tissues and is thought to be involved in the spread of the disease in the field. The second type of spore, oval in shape, is produced inside the infected plant tissues, and was believed to be involved …


Localization Of Diplodia Pinea In Diseased And Latently-Infected Pinus Nigra, Jennifer Lee Flowers Jan 2006

Localization Of Diplodia Pinea In Diseased And Latently-Infected Pinus Nigra, Jennifer Lee Flowers

University of Kentucky Doctoral Dissertations

Diplodia pinea causes Diplodia tip blight on more than 30 different pine species. During the past 10 years, Diplodia tip blight has emerged as a serious problem in landscape and Christmas tree farms in this region. Surveys of diseased and symptomless Austrian pines revealed that latent infections of symptomless shoots by D. pinea were common. Latent infections may account for the recently observed rapid decline of mildly diseased pines in our region. To investigate the colonization habits of D. pinea within its host, molecular cytology was attempted and traditional histology was performed on naturally infected, diseased and asymptomatic Austrian pine …


Three Essays On Exchange Rate And Monetary Policy, Lian An Jan 2006

Three Essays On Exchange Rate And Monetary Policy, Lian An

University of Kentucky Doctoral Dissertations

There are four chapters in my dissertation. Chapter one gives a brief introduction of the three essays. Chapter two empirically analyzes the interaction among conventional monetary policy, foreign exchange intervention and the exchange rate in a unifying model for Japan. I have several findings. First, the results lend support to the leaning-against-the-wind hypothesis. Second, conventional monetary policy has as great influence on the exchange rate as foreign exchange intervention in Japan. Third, intervention in Japan is ineffective or may be counter-effective, so escaping liquidity trap by intervention alone may not be a feasible way. Chapter three empirically identifies the sources …