Digital Commons Network^™

Evolutionary Ecology Of The Native Johnny Darter (Etheostoma Nigrum) And The Invasive Round Goby (Neogobius Melanostomus): A Genomic Perspective, Abby Joyce Wicks

Wayne State University Dissertations

Round goby (Neogobius melanostomus) is an invasive fish present in all five Great Lakes and is becoming increasingly common in their tributaries. Johnny darter (Etheostoma nigrum) is a native species that often coexists with round goby. Here, I use traditional population genetic methods and genomic tools to explore the evolutionary ecology of these species. First, historic factors are addressed as a source of variation in study populations by characterizing patterns of mitochondrial DNA variation throughout Lower Michigan. Round goby populations were largely homogenous and exhibited no evidence of overarching historical genetic structure, consistent with the recent invasion and rapid expansion …

Empathy Through Inquiry: The Weaving Of (Post) Qualitative Inquiry Into Design, Preston Tyler Kelly

Wayne State University Dissertations

Learning design is moving toward more human-centered design methodologies. One key component of human-centered design is empathy. To have empathy, designers must understand their learners as people and “how they show up as learners” within our learning experiences. To do this, designers need to do learner research. One way to do this inquiry work might be to take up post qualitative inquiry because so many of the key tenets of design thinking and post qualitative methodologies are similar.

Through interviews within a post qualitative framework, this project looks at how designers go about this design research to understand their learners. …

Beyond The Rainbow: Predicting Intra And Intergroup Political Attitudes Of Latinx And Black Americans And The Potential For Cooperation And Conflict, Randall Wyatt

Wayne State University Dissertations

This dissertation uses social psychological theory and methods to better understand the political attitudes of whites, Blacks, Latinx Americans and Asian Americans in the contemporary United States. Using quantitative methodology and survey research, I estimate the potential for cooperation and conflict between racial minorities and the political implications that these measures may have. I show that perceptions of competition with immigrants are strongly associated with anti-immigration preferences even among racial minorities such as Blacks and Latinx Americans, of who have a long history of migration to the United States. However, I also show that there is potential for interracial cooperation …

Evaluating Historical Paradigms Of Sterility In Perinatal Microbiology And Ramifications For Pregnancy Outcomes, Jonathan Greenberg

Wayne State University Dissertations

Next-generation sequencing technologies, especially 16S rRNA gene and metagenomic sequencing have allowed investigations of low microbial biomass tissues of the human body. While these sequencing methodologies have provided large amounts of reliable data for higher microbial biomass sites, such as the mouth, intestine, and vagina, tissues of low microbial biomass sites are subject to specific caveats that were not appropriately considered in early investigations of these sites. Low microbial biomass sites of particular interest have included those of the reproductive and urinary systems. Utilization of DNA sequencing methodologies have allowed researchers to challenge existing paradigms of sterility around these sites …

Confirmative Evaluation - A New Cipp Model, Tia Lynnece Finney

Wayne State University Dissertations

ABSTRACT

CONFIRMATIVE EVALUATION: A NEW LEVEL TO THE CIPP PROGRAM EVALUATION MODEL

By

Tia L. Finney

August 2020

Advisor: Dr. Shlomo Sawilowsky

Major: Education, Evaluation and Research

Degree: Doctor of Philosophy

Struggling trainees often require a substantial investment of time, effort, and resources from medical educators. An emergent challenge involves developing effective ways to accurately identify struggling students and better understand the primary causal factors underlying their poor performance. Identifying the potential reasons for poor performance in medical school is a key first step in developing suitable remediation plans (Artino, et al., 2010). The SOM Modified Program is a remediation …

Frontier Freemasons: Masonic Networks Linking The Great Lakes To The Atlantic World, 1750-1820, Kevin H. Nichols

Wayne State University Dissertations

The Atlantic World as a source of historical inquiry has generated a great deal of scholarly research. Historians have changed how they look at empires, immigration, and networks of exchange. By making the ocean, and not a land mass or political entity the source of study, scholars have asked different questions and looked the past in new ways. In almost all cases, the Atlantic World ends on the Eastern Seaboard.

This dissertation extends the Atlantic World to the westernmost frontier of the Great Lakes region. Freemasons spread throughout the region during the Seven Years’ War. Military units with lodges attached …

Improved Contacts And Device Performance In Mos2 Transistors Using 2d Semiconductor Interlayers, Kraig Andrews

Wayne State University Dissertations

The rapid growth of modern electronics industry over the past half-century has been sustained by the continued miniaturization of silicon-based electronics. However, as fundamental limits approach, there is a need to search for viable alternative materials for next-generation electronics in the post-silicon era. Two-dimensional (2D) semiconductors such as transition metal dichalcogenides (TMDs) have attracted much attention due to their atomic thickness, absence of dangling bonds and moderately high carrier mobility. However, achieving low-resistance contacts has been major impediment in developing high-performance field-effect transistors (FETs) based on 2D semiconductors. A substantial Schottky barrier (SB) is often present at the metal/2D-semicondcutor interface, …

Ac Conductivity Studies Of Polyethylene-Oxide-Garnet Type Li7la3zr2o12 Hybrid Composite Solid Polymer Electrolyte For Li-Ion Battery, Parisa Bashiri

Wayne State University Dissertations

Solid electrolytes including ceramics and polymers are considered to be the ultimate substitute for organic liquid electrolytes currently used in commercialized lithium ion batteries to address the safety concerns due to Li dendrite growth and internal short circuiting. However, low ionic conductivity due to high grain boundary resistance in ceramics and semi-crystalline nature of polymers has held back the solid electrolytes from being used in Li-ion batteries. Polyethylene oxide (PEO), complexed with a Li-salt, is a well-studied polymer electrolyte showing ionic conductivity properties at room temperature. However, the coexistence of amorphous and crystalline regions at room temperature (< Tm, the melting temperature) has

-8 -6 …

An Exploration Of Strategic Alignment In Higher Education, Linda Jimenez

Wayne State University Dissertations

The aim of this study is to explore the faculty’s experience and perspective of the alignment between their research, teaching, and service to the institutional priorities. Presently, higher education faces institutional issues that are unique with varying contexts and where strategic alignment has a vital influence on organizational performance. Although faculty’s core activities are service, teaching, and research, the enduring and prevailing challenges in higher education require faculty to expand their roles of core activities and engage in broader strategic initiatives of institutions. The need for this study is driven by a shortage of evidence about whether and how faculty …

Investigation Of Physiochemical Properties And Biocompatibility Of Amourphos Calcium Polyphosphate Hydrogel Doped With Antibiotics And Injectable Polymeric Dicalcium Phosphate Dihydrate Bone Cement, Yasaman Chehreghanianzabi

Wayne State University Dissertations

Amorphous calcium polyphosphate (ACPP) is an inorganic polymer ceramic. Here we use a simple method of preparing ACPP hydrogel in the presence of excess volume of water. Essentially, water availability to polyphosphate chains accelerates water molecule ingress and microstructural transformation of ACPP hydrogels. Antibiotic delivery capacity of ACPP hydrogel increases by the specific mixing and molding method, where the VCM has higher antibiotic encapsulation efficiency with the small burst release for the compressed discs. In part of this study, we investigate impact of ACPP hydrogel replacement by monomeric calcium phosphate on the quality of final product (dicalcium phosphate dihydrates (DCPD) …

Tiling Optimization For Nested Loops On Gpus, Yuanzhe Li

Wayne State University Dissertations

Optimizing nested loops has been considered as an important topic and widely studied in parallel programming. With the development of GPU architectures, the performance of these computations can be significantly boosted with the massively parallel hardware.

General matrix-matrix multiplication is a typical example where executing such an algorithm on GPUs outperforms the performance obtained on other multicore CPUs. However, achieving ideal performance on GPUs usually requires a lot of human effort to manage

the massively parallel computation resources. Therefore, the efficient implementation of optimizing nested loops on GPUs became a popular topic in recent years. We present our work based …

Advancing Objectives-Oriented Evaluation With Participatory Evaluation Methodology – A Mixed Methods Study, Dustin R. Saalman

Wayne State University Dissertations

The ability to complete program evaluations of educational programming is typically restricted by the availability of resources, such as time, money and a trained evaluator. A mixed methods study was completed to explore the use of a participatory evaluation program evaluation with the use of the program objectives as an advanced organizer. Participatory evaluation is purported to increase organizational learning and promote evaluative thinking within an organization (Cousins & Whitmore, 1998). Objectives oriented evaluation is an easily understood evaluation method which provides a refined focus program outcome (Madaus & Stufflebeam, 1989). An explanatory sequential design was employed utilizing quantitative findings …

Non-Canonical Targets, Reaction Kinetics, And Cellular Potency Of Amino Acid-Linked Platinum(Ii) Compounds, Bett Kimutai

Wayne State University Dissertations

DNA serve as an ideal target where drugs such as cisplatin (cisPt) bind and exert their anticancer activities. CisPt is known to preferentially coordinate with DNA leading to formation of cisPt-deoxyguanosine (dGuo) adducts. The adducts distort the DNA structure and contribute to inhibition of DNA-mediated cellular functions and ultimately cancer cell death. Despite its utilization as an anticancer drug, cisPt has a number of drawbacks, which include toxic side effects and cellular resistance. Resistance occurs through processes such as repair of damaged DNA and inactivation of cisPt present in the cell. To overcome these challenges, the aim of this thesis …

The Use Of Code-Switching By African-American Teachers In Inner-City Classrooms, Yvonne Wilson

Wayne State University Dissertations

Language and its use in classrooms has a significant impact on student motivation and self-perception (Delpit, 1988; Lei, 2009). Even more curious and significant is the motivation of teachers that intentionally use culturally-specific language and affectations, also known as code-switching, as an instructional device. This dissertation will examine the use of code-switching by African-American or Black teachers in urban, non-White classrooms. It will explore the foundations of sociolinguistics, specifically, language as a social construct (Gumperz; 1982; Gal, 2014; Levinson, 2015), as well as a communicative tool. In the span of the research contained in this dissertation, 12 African-American teachers will …

Influence Of Conformational Restriction On The Antibacterial Activity And Ribosomal Selectivity Of Aminoglycoside Antibiotics, Michael Gabriel Pirrone

Wayne State University Dissertations

The ever-increasing threat posed by multidrug-resistant infectious bacteria necessitates

the development of novel antibiotics. Aminoglycoside antibiotics are growing in interest due to

their broad spectrum of activity, lack of known drug related allergies, low manufacturing cost,

and their well-studied mechanism of action. The simplification of rational drug design due to the

well-studied mechanism of action is the key to overcoming the issues presented by these drugs,

namely ototoxicity and nephrotoxicity.

A study of the effect of the conformation of the aminoglycoside ring I side chain is

described wherein it was discovered that an increase in a particular conformation augments the …

Why They Care: An Exploration Of Adjunct Faculty Loyalty, Sara Elizabeth Barnwell

Wayne State University Dissertations

Higher education is always evolving and striving to be more effective and efficient. Over time, the use of part-time or adjunct faculty members has increased in an effort to achieve that goal. In this dissertation, the concept of adjunct faculty loyalty is explored using Intuitive Empathic Exploration which is a newly constructed qualitative methodology. Intuitive Empathic Exploration was created for this research study with the hope that it can be used in future research. It draws primarily from the concepts of phenomenology, empathy, intuitive inquiry, and in-depth interviewing. The focus of the research is to consider how adjunct faculty members …

Addressing The Issue Of Missing Heritability: The Importance Of Apoptosis In Hereditary Breast And Ovarian Cancer And Functional Assessment Of Tp53i3-S252*, Sophia Chaudhry

Wayne State University Dissertations

A quarter of all cases of ovarian cancer (OVCA) cases are due to inherited factors. However, much of the genetic risk remains unknown. We have previously established the importance of whole exome sequencing to answer the question for missing heritability. We identified clinically actionable and novel risk loci in the DNA repair and cell cycle regulation pathways by assessing a cohort of women diagnosed with OVCA, wildtype for BRCA1/BRCA2 and suspected to be hereditary due to family history of breast cancer/OVCA. Equally as important was the exploration and discovery of novel risk loci in the apoptosis pathway. A total of …

Psychosocial Outcomes Among College Students With Learning Disorders, Bobbi Isaac

Wayne State University Dissertations

Specific learning disorders, also known as learning disabilities, are defined as neurodevelopmental disorders in which long-term difficulties with learning and using academic skills occur within the context of one or multiple academic areas (i.e., reading, mathematics, writing). As our understanding of learning disorders (LD) has evolved beyond a focus on childhood diagnosis, a limited body of research has emerged examining adult outcomes for individuals with learning disorders in regards to higher education, employment, psychosocial, and health outcomes. Much of the results of this research seems to indicate that individuals with LDs may have poorer outcomes in adulthood across these domains. …

When Fake Is Good: The Benefits Of Deceptive Responsiveness In Relationships, Isabel Cantarella

Wayne State University Dissertations

Responsiveness is integral for successful relationship functioning (Reis & Shaver, 1988); however, it can be quite challenging to be a responsive partner (Reis & Patrick, 1996). Additionally, there may be an assumption that individuals need to be honest in their communication for their responses to be perceived as responsive. The goal of the present research is to determine if deceptive responses can be perceived as responsive and have beneficial consequences. The present research introduces the construct deceptive responsiveness, which we define as intentionally withholding information or providing false statements with the intent to make someone feel validated, supported, and cared …

Timing And Duration Of Folate Restriction Differentially Impacts Colon Carcinogenesis., Ali M. Fardous

Wayne State University Dissertations

Colorectal cancer (CRC) constitutes a major burden on the healthcare system as the second most commonly diagnosed cancer in the developed world. Dietary folate is considered an important modulator of colorectal cancer. Folate restriction has been implicated in increasing CRC incidence by disrupting nucleotide synthesis, Impacting DNA methylation and inducing genetic instability. Our research shows that the timing and duration of dietary folate restriction can differentially impact Colorectal cancer initiation. Acclimating mice to folate restriction for 8 weeks results in a reduced number of preneoplastic lesions compared to mice placed of folate restriction for 1 week prior to initiating the …

Customer Choice Modeling For Retail Category Assortment Planning And Product-Line Extension, Elham Nosratmirshekarlou

Wayne State University Dissertations

Growing competitiveness and increasing availability of data is generating great interest in data-driven analytics across industries. One of the areas that has gained a lot of attention is Customer choice modeling, which aims to explain the choices individual customers make in choosing from a set of products based on their preferences. While effective customer choice modeling is essential to a wide variety of application domains, including retail, it is challenging in practice due to limitations around the quality of the data available for modeling and potentially complex choice behaviors. This dissertation presents a hybrid modeling approach that relies on both …

Exploring Bullying And Peer Victimization Among African American Adolescents In Chicago’S Southside, Jeoung Min Lee

Wayne State University Dissertations

Adolescent bullying is a serious concern for adolescents, parents, teachers, school officials, and the public. While many studies have explored serious forms of violence (e.g., gang violence and homicide) among urban adolescents, relatively few studies have examined “less serious forms of violence,” such as bullying among these adolescents. This dissertation research, which is divided into three studies, aims to examine antecedents of bullying and peer victimization as well as psychosocial outcomes of peer victimization from a sample of 639 urban African American adolescents in Chicago’s Southside. The first study applies Bronfenbrenner’s ecological systems perspective and explores factors that are correlated …

Durability Performance Of Geopolymer Concrete Beams And Columns Exposed To Hygrothermal Environment, Najeb Hasen Sh Sawsi

Wayne State University Dissertations

Among the most important advances of research and technological development for viable applications of coal-fired fly ash, the development of new inorganic polymeric materials, named alkali activated cement or “Geopolymers”, seems to gain increasing attention during the last twenty years. The present investigation intends to study the effect of hot weather environments (either by changing relative humidity and temperature is kept constant, or by changing temperature but relative humidity is maintained same) on the durability performance of geopolymer concrete beams and columns. The study include the long term influence of moisture, high temperature, and combined hygrothermal conditions on the mechanical …

Computational Analysis Of Oxidative Stress In Endothelial Dysfunction: Insights On The Role Of Tetrahydrobiopterin, Ascorbate And Glutathione, Sheetal Kedar Panday

Wayne State University Dissertations

Oxidative stress and endothelial dysfunction are reported in the cardiovascular and neurovascular diseases. Oxidative stress is caused due to an increase in the generation of reactive oxygen (ROS) and nitrogen species (RNS) and incapacity of antioxidant systems to eliminate ROS and RNS. Endothelial dysfunction is characterized by a reduction in nitric oxide (NO) bioavailability. NO is constitutively produced by enzyme endothelial nitric oxide synthase (eNOS). A reduction in tetrahydrobiopterin (BH4), which is an essential cofactor of eNOS, can lead to eNOS uncoupling. There is complex interplay between the ROS/RNS and antioxidant system underlying pathophysiologies of vascular diseases, however our quantitative …

Determinants Of Successful Diabetes Self-Management Behaviors Among Women Of Arab Descent With Type 2 Diabetes, Mona R. Alanzi

Wayne State University Dissertations

ABSTRACT

Type 2 Diabetes (T2D) continues to be an escalating public health problem that contributes to increased morbidity and mortality worldwide (American Diabetes Association, 2017b). According to the National Diabetes Statistics Report (2017), approximately 30.3 million (9.4%) Americans have T2D. It accounted for 252,806 deaths in 2015 in the United States. Although the complications of T2D is a major threat to the health of women of Arab descent, there is lack of information about the health practices and diabetes self-management behaviors of this population. The purpose of this dissertation is to examine the impact of diabetes knowledge, social/family support, acculturation, …

Faculty Experiences Of Using Student Response System In Saudi Arabian Universities, Abdulsalam Alkhabra

Wayne State University Dissertations

This study aimed to explore the state of SRS use among faculty members in Saudi universities. Specifically, the study investigated factors that influence faculty members to accept or reject the use of SRS by utilizing the theoretical framework of UTAUT. Furthermore, the study examined faculty members’ experience dealing with SRS in teaching in relation to Gagne’s Nine Events of Instruction. The survey was administered to 306 faculty members affiliated with Saudi Arabian universities. The study showed that 74.2% of participants did not report SRS use while 25.8% of participants reported using SRS in their teaching. Effort Expectancy and Facilitating Conditions …

Termination-Independent Role Of Rat1 In Cotranscriptional Splicing In Budding Yeast, Zuzer Hakimuddin Dhoondia

Wayne State University Dissertations

Rat1 is a 5′→3′ exoribonuclease in budding yeast belonging to the XRN-family of nucleases. It is a highly conserved protein with homologs being present in fission yeast, flies, worms, mice and humans. Rat1 and its homolog in metazoan have been shown to function in multiple facets of RNA metabolism. In this study, we report a novel role of Rat1 in splicing of pre-mRNA in budding yeast. In the absence of the functional Rat1 in the nucleus, an increase in the level of unspliced transcripts was observed in yeast cells. Strand-specific TRO analysis revealed that the accumulation of unspliced transcripts upon …

Transformation Of The St. Clair Maritime Cultural Landscape From The Seventeenth To The Twentieth Centuries, Daniel Frederick Harrison

Wayne State University Dissertations

The St. Clair system—a river, delta and lake between Lake Huron and the Detroit River—offers significant opportunities to study long-term maritime landscape formation, and to preserve a unique resource. Few maritime landscapes in the Great Lakes remain so deeply and clearly inscribed by successive cultures. This permits both focused and comprehensive analyses and comparisons of the ideologies, technologies and practices of indigenous, colonial, and modern societies as each created its unique place in the environment through four processes: cognition, dwelling, movement, and representation. The socially-conditioned perception of environmental resources and constraints, and resulting strategies to exploit the former while minimizing …

Toward An Ecofeminist Embodied Pedagogy: A Study Of Difference In Online And Offline Community Writing Courses, Rachel Dortin

Wayne State University Dissertations

Toward an Ecofeminist Embodied Pedagogy: A Study of Difference in Online and Offline Community Writing Courses argues that service-learning and community-engaged learning (SCEL) often fail to present community partners as real, embodied beings. Rather, students often believe that there is an “us” (the university) and a “them” (the community). Entering community partnerships with this perspective can be damaging, for both students and community partners, and result in unsuccessful collaborations. My dissertation responds to this problem by offering an ecofeminist, embodied pedagogy (EEP) as a solution. I argue that students are eager to learn about difference and that instructors need to …

A Study Of Self-Evaluation And Estimator Error In Internal Medicine Residents And Its Influence On The Academic Achievement Of Medical Knowledge, William Morse

Wayne State University Dissertations

The main objective of this study is to address the research question—how does a sample of internal medicine residents self-evaluate and what, if any, influence does this have on their academic achievement of medical knowledge? The research builds on and extends our understanding of the self-evaluation process through the moderating effects between competency-related beliefs and academic achievement of medical knowledge. The study design is quantitative, cross-sectional survey research using a non-random sample of 58 internal medicine residents at Henry Ford Hospital in Detroit, Michigan. The primary sources for data collection included a study survey that measured competency-related beliefs as a …