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Gallic Acid, A Phenolic Compound, Exerts Anti-Angiogenic Effects Via The Pten/Akt/Hif-1Α/Vegf Signaling Pathway In Ovarian Cancer Cells, Zhiping He, Allen Y. Chen, Yon Rojanasakul, Gary O. Rankin, Yi Charlie Chen

Gary O. Rankin

Gallic acid (GA), a polyphenol, is widely found in numerous fruits and vegetables, particularly in hickory nuts. In the present study, we found that gallic acid, a natural phenolic compound isolated from fruits and vegetables, had a more potent growth inhibitory effect on two ovarian cancer cell lines, OVCAR-3 and A2780/CP70, than the effect on a normal ovarian cell line, IOSE-364. These results demonstrated that GA selectively inhibits the growth of cancer cells. Gene expression was examined by ELISA and western blot analysis, and gene pathways were examined by luciferase assay. It was found that GA inhibited VEGF secretion and …

Myricetin Inhibits Proliferation Of Cisplatin-Resistant Cancer Cells Through A P53-Dependent Apoptotic Pathway, Haizhi Huang, Allen Y. Chen, Xingqian Ye, Bingyun Li, Yon Rojanasakul, Gary O. Rankin, Yi Charlie Chen

Gary O. Rankin

Cisplatin is a commonly used drug for cancer treatment by crosslinking DNA, leading to apoptosis of cancer cells, resistance to cisplatin treatment often occurs, leading to relapse. Therefore, there is a need for the development of more effective treatment strategies that can overcome chemoresistance. Myricetin is a flavonoid from fruits and vegetables, showing anticancer activity in various cancer cells. In this study, we found myricetin exhibited greater cytotoxicity than cisplatin in two cisplatin-resistant ovarian cancer cell lines, OVCAR-3 and A2780/CP70, and it was less cytotoxic to the normal ovarian cell line IOSE-364. Myricetin selectively induced apoptosis in both cisplatin-resistant cancer …

Cerium Oxide Nanoparticle Treatment Ameliorates Peritonitis-Induced Diaphragm Dysfunction, Shinichi Asano, Ravikumar Arvapalli, Nandini D. Manne, Mani Maheshwari, Bing Ma, Kevin M. Rice, Vellaisamy Selvaraj, Eric Blough

Nandini Manne

The severe inflammation observed during sepsis is thought to cause diaphragm dysfunction, which is associated with poor patient prognosis. Cerium oxide (CeO₂) nanoparticles have been posited to exhibit anti-inflammatory and antioxidative activities suggesting that these particles may be of potential use for the treatment of inflammatory disorders. To investigate this possibility, Sprague Dawley rats were randomly assigned to the following groups: sham control, CeO₂ nanoparticle treatment only (0.5 mg/kg iv), sepsis, and sepsis+CeO₂ nanoparticles. Sepsis was induced by the introduction of cecal material (600 mg/kg) directly into the peritoneal cavity. Nanoparticle treatment decreased sepsis-associated impairments in …

Cerium Oxide Nanoparticle Treatment Ameliorates Peritonitis-Induced Diaphragm Dysfunction, Shinichi Asano, Ravikumar Arvapalli, Nandini D. Manne, Mani Maheshwari, Bing Ma, Kevin M. Rice, Vellaisamy Selvaraj, Eric Blough

Kevin M Rice

The severe inflammation observed during sepsis is thought to cause diaphragm dysfunction, which is associated with poor patient prognosis. Cerium oxide (CeO2) nanoparticles have been posited to exhibit anti-inflammatory and antioxidative activities suggesting that these particles may be of potential use for the treatment of inflammatory disorders. To investigate this possibility, Sprague Dawley rats were randomly assigned to the following groups: sham control, CeO2 nanoparticle treatment only (0.5 mg/kg iv), sepsis, and sepsis+CeO2 nanoparticles. Sepsis was induced by the introduction of cecal material (600 mg/kg) directly into the peritoneal cavity. Nanoparticle treatment decreased sepsis-associated impairments in diaphragmatic contractile (Po) function …

Cerium Oxide Nanoparticle Treatment Ameliorates Peritonitis-Induced Diaphragm Dysfunction, Shinichi Asano, Ravikumar Arvapalli, Nandini D. Manne, Mani Maheshwari, Bing Ma, Kevin M. Rice, Vellaisamy Selvaraj, Eric Blough

Eric Blough

The severe inflammation observed during sepsis is thought to cause diaphragm dysfunction, which is associated with poor patient prognosis. Cerium oxide (CeO₂) nanoparticles have been posited to exhibit anti-inflammatory and antioxidative activities suggesting that these particles may be of potential use for the treatment of inflammatory disorders. To investigate this possibility, Sprague Dawley rats were randomly assigned to the following groups: sham control, CeO₂ nanoparticle treatment only (0.5 mg/kg iv), sepsis, and sepsis+CeO₂ nanoparticles. Sepsis was induced by the introduction of cecal material (600 mg/kg) directly into the peritoneal cavity. Nanoparticle treatment decreased sepsis-associated impairments in …

The Use Of Therapeutic Theater In Supporting Clients In Eating Disorder Recovery After Intensive Treatment: A Qualitative Study, Laura L. Wood

Laura L. Wood

In 2007, Wilson, Grilo, and Vitousek made a call for researchers to increase the research for eating disorders, declaring that counselors are “well positioned to make important contributions to the study of eating disorders” including exploring and identifying the “mechanisms of therapeutic change” (p. 212). The purpose of this qualitative research study was to explore experiences of participants who were part of an experimental therapeutic theater project after receiving intensive treatment for an eating disorder and to examine how the project benefited their recovery process. The research question was, “In what ways can therapeutic theater support clients in their first …

Techniques To Improve Patient Flow In A Pediatric Street Medicine Clinic., Richelle Reinhart, Carly Crowder, Nikos Karakashian, Ajay Koti Ms, Kathleen Mcfadden, Marna R. Greenberg Do, Mph, Facep

Marna R Greenberg DO, MPH, FACEP

No abstract provided.

Teaching With Cultural Competence Requires Gender Sensitivity., Marna R. Greenberg Do, Mph, Facep, Jessica Pierog Do

Marna R Greenberg DO, MPH, FACEP

No abstract provided.

Lack Of Gender Differences In Prevalence Of Homelessness In The Emergency Department (Poster)., Brett Feldman Mspas, Pa-C, Alexandra M. Craen Ba, Osman Z. Abbasi Do, Zachary M. Dillon Md, Kenneth Dzike Md, Joshua Enyart Do, Julie A. Fritzges Do, Jessica L. Glaubman Do, Emily A. Kiernan Do, Nathaniel M. Yoder Do, Timothy J. Friel Md, Stephen W. Dusza Drph, Marna R. Greenberg Do, Mph, Facep

Marna R Greenberg DO, MPH, FACEP

No abstract provided.

Vulnerable Elder Survey As A Predictor Of Falls In The Emergency Medicine Setting., Rebecca Brown Ms2, Marna R. Greenberg Do, Mph, Facep

Marna R Greenberg DO, MPH, FACEP

No abstract provided.

Development Of A Health Care Systems Curriculum., Zachary Pruitt, Rahul Mhaskar, Bryan G. Kane Md, Robert D. Barraco Md, Mph, Deborah J Dewaay, Alexander M. Rosenau Do, Kristin A. Bresnan Md, Marna R. Greenberg Do, Mph, Facep

Marna R Greenberg DO, MPH, FACEP

Background: There is currently no gold standard for delivery of systems-based practice in medical education, and it is challenging to incorporate into medical education. Health systems competence requires physicians to understand patient care within the broader health care system and is vital to improving the quality of care clinicians provide. We describe a health systems curriculum that utilizes problem-based learning across 4 years of systems-based practice medical education at a single institution.

Methods: This case study describes the application of a problem-based learning approach to system-based practice medical education. A series of behavioral statements, called entrustable professional activities, was created …

Evaluating The Effectiveness Of The 30-Second Chair Stand Test As An Ed Screening Tool For Elderly Fall Risk Assessment., Adison Weseloh, Bryan G. Kane Md, Jeanne L. Jacoby Md, Robert D. Barraco Md, Mph, Tracy M Bishop Do, Kyli Krape Do, Stephanie Merrick Md, Michael Wagner, Deirdre Warner Do, Marna R. Greenberg Do, Mph, Facep

Marna R Greenberg DO, MPH, FACEP

No abstract provided.

Identifying Demographics And Biopsychosocial Characteristics Among Emergency Youth Shelter Residents., Aleksandra Bacewicz, Elizabeth Beaty, Cristina Calogero, Carly Crowder, Ajay Koti Ms, Kathleen Mcfadden, Richelle Reinhart, Seth Vanzant, Marna R. Greenberg Do, Mph, Facep

Marna R Greenberg DO, MPH, FACEP

No abstract provided.

Gender Differences In Acute Cardiac Care: Where It's Not., Marna R. Greenberg Do, Mph, Facep

Marna R Greenberg DO, MPH, FACEP

No abstract provided.

Gender Differences In Cdc Guideline Compliance For Stis In Emergency Departments., Bryan G. Kane Md, Alexander W D Guillaume, Elizabeth M. Evans Do, Terrence E. Goyke Do, Jessica K. Eygnor Do, Lauren Semler Ms, Stephen W. Duza Drph, Marna R. Greenberg Do, Mph, Facep

Marna R Greenberg DO, MPH, FACEP

No abstract provided.

10-Year Outcome Of The Thoracic Endovascular Aortic Repair (Tevar) Procedure (Poster), Jacob Fink, Youssef Zaki, Tim S. Misselbeck Md, James K. Wu Md

James K. Wu, M.D.

No abstract provided.

Comparison Of In-Line Versus Conventional Independent Continuous Renal Replacement Therapy In Extracorporeal Membrane Oxygenation Patients, Nicole Stansbury, Taryn Samet Md, Tim S. Misselbeck Md, James K. Wu Md

James K. Wu, M.D.

No abstract provided.

Retrospective Study On The Effects Of Septal Myectomy Surgery On The Mitral-Aortic Valve Angle., Jacob Fink, Theodore Tucker, Kennedy Gallagher, James K. Wu Md, Matthew W. Martinez Md

James K. Wu, M.D.

No abstract provided.

Retrospective Study On Outcomes Of Veno-Venous And Veno-Arterial Extracorporeal Membrane Oxygenation, Kennedy Gallagher, Rachel Wills, Tim S. Misselbeck Md, James K. Wu Md

James K. Wu, M.D.

No abstract provided.

Creatinine Trends In Transcatheter Aortic Valve Replacement Patients., Sydney Pickering, Taryn Samet Md, James K. Wu Md

James K. Wu, M.D.

No abstract provided.

A Retrospective Analysis Of The Outcomes Of Extracorporeal Cardiopulmonary Resuscitation (Ecpr)., Rachel Wills, Kennedy Gallagher, James A. Burke Md, Phd, Tim S. Misselbeck Md, James K. Wu Md

James K. Wu, M.D.

No abstract provided.

10-Year Outcome Of The Thoracic Endovascular Aortic Repair (Tevar) Procedure, James K. Wu Md, Tim S. Misselbeck Md, Jacob Fink, Youssef Zaki

James K. Wu, M.D.

No abstract provided.

Feasability Study To Assess Addition Of A Prophylactic Antiarrhythmic Regimen To Post-Operative Open-Heart Surgery Management., Cameron St. Hilaire, Travis Gaskill Pa-C, Sarah Dolcemascolo Pa-C, James K. Wu Md

James K. Wu, M.D.

No abstract provided.

Outcomes Of Thoracic Endovascular Aortic Repair (Tevar) In Cases Of Traumatic Aortic Injury., Theodore Tucker, Rachel Wills, James K. Wu Md

James K. Wu, M.D.

No abstract provided.

Long Term Survival Rate Of Tavr With And Without Dialysis, Taryn Samet Md, Sydney Pickering, James K. Wu Md, Tim S. Misselbeck Md, Raymond L. Singer Md

James K. Wu, M.D.

No abstract provided.

Challenges To Aligning Coordination Technology With Organizations, People, And Processes In Healthcare, Susan Sherer, Chad Meyerhoefer, Donald Levick

Donald Levick MD, MBA, CPHIMS

Healthcare coordination has proven difficult to achieve, even with new coordination technologies such as shared electronic health records. Successful coordination requires alignment of information technology with new organizational structures, reskilled personnel, and reengineering of work processes. We suggest that this is more challenging in the healthcare industry as a result of the need for integrating information across care cycles, payment and regulatory mechanisms, high degree of professional control, failure impact and privacy concerns, and information granularity across the care cycle. We illustrate these challenges with several examples from a qualitative study of the integration of electronic health records between hospital …

Development Of A Health Care Systems Curriculum., Zachary Pruitt, Rahul Mhaskar, Bryan G. Kane Md, Robert D. Barraco Md, Mph, Deborah J Dewaay, Alexander M. Rosenau Do, Kristin A. Bresnan Md, Marna R. Greenberg Do, Mph, Facep

Bryan G Kane MD

Background: There is currently no gold standard for delivery of systems-based practice in medical education, and it is challenging to incorporate into medical education. Health systems competence requires physicians to understand patient care within the broader health care system and is vital to improving the quality of care clinicians provide. We describe a health systems curriculum that utilizes problem-based learning across 4 years of systems-based practice medical education at a single institution.

Methods: This case study describes the application of a problem-based learning approach to system-based practice medical education. A series of behavioral statements, called entrustable professional activities, was created …

Dreaming Big: Library-Led Digital Scholarship For Undergraduates At A Small Institution, Janelle Wertzberger, R.C. Miessler

Janelle Wertzberger

In the summer of 2016, Gettysburg College’s Musselman Library piloted a student-focused, library-led initiative designed to promote creative undergraduate research: the Digital Scholarship Summer Fellowship. The fellowship is a ten-week, paid summer program for rising sophomores and juniors that introduces the student fellows to digital scholarship, exposes them to a range of digital tools, and provides space for them to converse with appropriate partners about research practices and possibilities. Unlike other research fellowship opportunities, the Digital Scholarship Summer Fellowship is programmatic, based on a curriculum designed to provide students a broad introduction to digital scholarship. Digital tools, project management, documentation, …

Stuck In The Middle: Re-Defining What Successful Scholarly Communications Programs Look Like, Janelle Wertzberger

Janelle Wertzberger

What are the goals of your scholarly communications programs and services, and how do you define success? Critics and proponents alike often attempt to paint the scholarly communications movement with a broad brush. Both groups seem to push for a common definition of what the movement should look like and how success should be defined. In the world we live in today, these loudest voices are often amplified through their use of social media, listservs and prominent roles on the conference circuit, leaving some in the middle to question their own success and whether they have a place in this …

The Resurrection (1 Corinthians 15).Pdf, Charles Sabo

Charles Sabo